LARS FREDRIK JARSKOG

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint A 12-week randomized controlled trial of twice-daily intranasal oxytocin for social cognitive deficits in people with schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Schizophr Res . 2017
  2. ncbi request reprint Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 161:109-15. 2004
  3. ncbi request reprint Apoptotic mechanisms in the pathophysiology of schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:846-58. 2005
  4. ncbi request reprint Schizophrenia: new pathological insights and therapies
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Annu Rev Med 58:49-61. 2007
  5. ncbi request reprint Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina, Chapel Hill 27599 7160, USA
    Curr Opin Psychiatry 19:307-12. 2006
  6. ncbi request reprint Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 32:95-102. 2007
  7. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
  8. ncbi request reprint Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 138:49-55. 2003
  9. ncbi request reprint Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 159:106-12. 2005
  10. pmc Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex
    Maile A Henson
    Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27705, USA
    Cereb Cortex 18:2560-73. 2008

Research Grants

Collaborators

Detail Information

Publications19

  1. doi request reprint A 12-week randomized controlled trial of twice-daily intranasal oxytocin for social cognitive deficits in people with schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Electronic address
    Schizophr Res . 2017
    ..Further testing is needed to clarify whether oxytocin has therapeutic potential for social cognitive deficits and/or negative symptoms in people with schizophrenia...
  2. ncbi request reprint Apoptotic proteins in the temporal cortex in schizophrenia: high Bax/Bcl-2 ratio without caspase-3 activation
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599 7160, USA
    Am J Psychiatry 161:109-15. 2004
    ..It was hypothesized that the Bax/Bcl-2 ratio, but not caspase-3, would be high in the temporal cortex of patients with chronic schizophrenia...
  3. ncbi request reprint Apoptotic mechanisms in the pathophysiology of schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Prog Neuropsychopharmacol Biol Psychiatry 29:846-58. 2005
    ..Although the exact role of apoptosis in schizophrenia remains uncertain, the potential involvement of non-lethal localized apoptosis is intriguing, especially in earlier stages of the illness...
  4. ncbi request reprint Schizophrenia: new pathological insights and therapies
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Annu Rev Med 58:49-61. 2007
    ..This review provides an update on developments in research on the neuropathology of schizophrenia and discusses recent advances in antipsychotic treatment and the potential impact on long-term outcomes...
  5. ncbi request reprint Apoptosis in schizophrenia: pathophysiologic and therapeutic considerations
    L Fredrik Jarskog
    Department of Psychiatry, Schizophrenia Research Center, University of North Carolina, Chapel Hill 27599 7160, USA
    Curr Opin Psychiatry 19:307-12. 2006
    ..This paper will review studies of apoptotic regulatory proteins, DNA fragmentation, and gene microarrays to highlight the potential role of apoptosis in the pathophysiology and treatment of schizophrenia...
  6. ncbi request reprint Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    Neuropsychopharmacology 32:95-102. 2007
    ..Although the association between antipsychotic treatment and increased pro-apoptotic caspase-3 is intriguing, further study is needed to understand its potential effects...
  7. pmc microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    Diana O Perkins
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599, USA
    Genome Biol 8:R27. 2007
    ..They have been implicated in the etiology of a variety of complex diseases, including Tourette's syndrome, Fragile x syndrome, and several types of cancer...
  8. ncbi request reprint Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal-fetal unit of the rat
    John H Gilmore
    Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 138:49-55. 2003
    ..Abnormal expression of neurotrophic factors represents a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders...
  9. ncbi request reprint Maternal poly I:C exposure during pregnancy regulates TNF alpha, BDNF, and NGF expression in neonatal brain and the maternal-fetal unit of the rat
    John H Gilmore
    UNC Schizophrenia Research Center, Department of Psychiatry, CB 7160, University of North Carolina, Chapel Hill, NC 27599 7160, USA
    J Neuroimmunol 159:106-12. 2005
    ..Changes in TNFalpha, BDNF, and NGF after maternal exposure to poly I:C represent a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders...
  10. pmc Developmental regulation of the NMDA receptor subunits, NR3A and NR1, in human prefrontal cortex
    Maile A Henson
    Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC 27705, USA
    Cereb Cortex 18:2560-73. 2008
    ..These data provide insights into NMDAR functions in the developing CNS and will contribute to designing pharmacotherapies for neurological disorders...
  11. ncbi request reprint Neuroprotection in schizophrenia
    L Fredrik Jarskog
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, USA
    J Clin Psychiatry 67:e09. 2006
    ....
  12. doi request reprint Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex
    Kayvon Salimi
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Synapse 62:273-82. 2008
    ....
  13. pmc Pro-apoptotic Par-4 and dopamine D2 receptor in temporal cortex in schizophrenia, bipolar disorder and major depression
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Schizophr Res 118:292-9. 2010
    ..Changes in the Par-4/D2DR signaling pathway represent a novel mechanism that may link apoptotic and dopamine signaling pathways in major depression and schizophrenia...
  14. doi request reprint Schizophrenia: when clozapine fails
    Seiya Miyamoto
    aDepartment of Neuropsychiatry, St Marianna University School of Medicine, Kawasaki, Japan bNorth Carolina Psychiatric Research Center, Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA cDepartment of Psychiatry and Psychotherapy, Medical University Innsbruck, Innsbruck, Austria
    Curr Opin Psychiatry 28:243-8. 2015
    ..This article reviews the recent evidence for therapeutic strategies for patients with treatment-resistant schizophrenia (TRS) not responding to or only partially responding to clozapine...
  15. pmc Intranasal oxytocin blocks alcohol withdrawal in human subjects
    Cort A Pedersen
    Department of Psychiatry, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
    Alcohol Clin Exp Res 37:484-9. 2013
    ..Numerous recent studies in human subjects indicate that OT administered by the intranasal route penetrates into and exerts effects within the brain...
  16. doi request reprint Antipsychotic drugs for first-episode schizophrenia: a comparative review
    Kayvon Salimi
    Department of Psychiatry, University of North Carolina at Chapel Hill, USA
    CNS Drugs 23:837-55. 2009
    ..However, metabolic concerns associated with many atypical agents along with limited benefits in cognition and negative symptom domains highlight the persistent therapeutic needs of these patients...
  17. pmc Deficits in adult prefrontal cortex neurons and behavior following early post-natal NMDA antagonist treatment
    Leon G Coleman
    Curriculum in Neurobiology, Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7178, United States
    Pharmacol Biochem Behav 93:322-30. 2009
    ..These findings indicate that early brain insults affecting glutamatergic neurotransmission lead to persistent brain pathology that could contribute to impulsivity and cognitive dysfunction...
  18. ncbi request reprint Secretin in a patient with treatment-resistant schizophrenia and prominent autistic features
    Sayed S Alamy
    Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7160, USA
    Schizophr Res 66:183-6. 2004
    ..The case illustrates the potential role of secretin as a novel adjunctive treatment strategy in schizophrenic patients with autistic features...
  19. ncbi request reprint Apoptotic mechanisms and the synaptic pathology of schizophrenia
    Leisa A Glantz
    Department of Psychiatry, University of North Carolina Chapel Hill, CB 7160, Chapel Hill, NC 27599 7160, USA
    Schizophr Res 81:47-63. 2006
    ..This paper will review converging lines of data that implicate synaptic deficits in the pathophysiology of schizophrenia and propose an underlying role for apoptotic dysregulation...

Research Grants1

  1. Bcl-2 Family Protein and Apoptosis in Schizophrenia
    LARS JARSKOG; Fiscal Year: 2005
    ..Stereological neuronal cell counting and measurement of somal size will also be assessed. Finally, young adult rats will receive typical and atypical antipsychotics to assess their effect on the apoptotic regulatory proteins. ..