MICHELLE C JANELSINS

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age
    MICHELLE C JANELSINS
    Department of Surgery Cancer Control, University of Rochester, Rochester, NY, United States Electronic address
    Neurotoxicology 56:287-293. 2016
  2. pmc YOCAS©® Yoga Reduces Self-reported Memory Difficulty in Cancer Survivors in a Nationwide Randomized Clinical Trial: Investigating Relationships Between Memory and Sleep
    MICHELLE C JANELSINS
    University of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA
    Integr Cancer Ther 15:263-71. 2016
  3. pmc Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
    MICHELLE C JANELSINS
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neuroinflammation 2:23. 2005
  4. pmc Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Support Care Cancer 20:831-9. 2012
  5. pmc IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, New York 14642, USA
    Cancer Invest 28:544-53. 2010
  6. pmc An update on cancer- and chemotherapy-related cognitive dysfunction: current status
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Semin Oncol 38:431-8. 2011
  7. pmc Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, New York, NY 14642, USA
    Clin Breast Cancer 11:161-70. 2011
  8. pmc Bone health issues in breast cancer survivors: a Medicare Current Beneficiary Survey (MCBS) study
    Luke J Peppone
    Department of Surgery, University of Rochester, 601 Elmwood Ave, Box 704, Rochester, NY, 14642, USA
    Support Care Cancer 22:245-51. 2014
  9. pmc Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan
    Lisa K Sprod
    James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    J Cancer Surviv 6:146-54. 2012
  10. pmc Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial
    Luke J Peppone
    Department of Radiation Oncology, University of Rochester Medical Center, NY 14642, USA
    Clin Breast Cancer 10:224-9. 2010

Research Grants

  1. Modulating Disease in Alzheimer's Disease Models
    MICHELLE JANELSINS; Fiscal Year: 2007

Collaborators

Detail Information

Publications30

  1. pmc A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age
    MICHELLE C JANELSINS
    Department of Surgery Cancer Control, University of Rochester, Rochester, NY, United States Electronic address
    Neurotoxicology 56:287-293. 2016
    ..We utilized a delayed alternation paradigm similar to a delayed match to sample paradigm reported to be sensitive in human neurotoxicology research...
  2. pmc YOCAS©® Yoga Reduces Self-reported Memory Difficulty in Cancer Survivors in a Nationwide Randomized Clinical Trial: Investigating Relationships Between Memory and Sleep
    MICHELLE C JANELSINS
    University of Rochester Medical Center, Rochester, NY, USA Wilmot Cancer Institute, Rochester, NY, USA
    Integr Cancer Ther 15:263-71. 2016
    ..This study assessed the effects of YOCAS©® on memory and identified relationships between memory and sleep...
  3. pmc Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice
    MICHELLE C JANELSINS
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neuroinflammation 2:23. 2005
    ..The current study examines whether inflammatory processes are evident early in the disease process in the 3xTg-AD mouse model and if regional differences in inflammatory profiles exist...
  4. pmc Differential expression of cytokines in breast cancer patients receiving different chemotherapies: implications for cognitive impairment research
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Support Care Cancer 20:831-9. 2012
    ....
  5. pmc IGF-1 partially restores chemotherapy-induced reductions in neural cell proliferation in adult C57BL/6 mice
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, New York 14642, USA
    Cancer Invest 28:544-53. 2010
    ..Insulin-like growth factor 1, a molecule implicated in promoting neurogenesis, counteracted the effects of high doses of chemotherapy on neural cell proliferation...
  6. pmc An update on cancer- and chemotherapy-related cognitive dysfunction: current status
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Semin Oncol 38:431-8. 2011
    ..Mostly we focus is on cognitive effects of adjuvant chemotherapy for breast cancer; however, cognitive effects of chemotherapy on the elderly and brain tumor patients are also discussed...
  7. pmc Effects of Tai Chi Chuan on insulin and cytokine levels in a randomized controlled pilot study on breast cancer survivors
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester Medical Center, New York, NY 14642, USA
    Clin Breast Cancer 11:161-70. 2011
    ..Despite knowing the beneficial effects of conventional exercise interventions on these mediators, little is known about the physiologic effects of TCC on these pathways in breast cancer survivors...
  8. pmc Bone health issues in breast cancer survivors: a Medicare Current Beneficiary Survey (MCBS) study
    Luke J Peppone
    Department of Surgery, University of Rochester, 601 Elmwood Ave, Box 704, Rochester, NY, 14642, USA
    Support Care Cancer 22:245-51. 2014
    ....
  9. pmc Health-related quality of life and biomarkers in breast cancer survivors participating in tai chi chuan
    Lisa K Sprod
    James P Wilmot Cancer Center, University of Rochester, Rochester, NY 14642, USA
    J Cancer Surviv 6:146-54. 2012
    ..Breast cancer survivors experience diminished health-related quality of life (HRQOL). We report on the influence of tai chi chuan exercise (TCC) on HRQOL and explore associations between changes in HRQOL and biomarkers...
  10. pmc Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial
    Luke J Peppone
    Department of Radiation Oncology, University of Rochester Medical Center, NY 14642, USA
    Clin Breast Cancer 10:224-9. 2010
    ..This pilot study compared the influence of TCC with that of standard support therapy (ST; exercise control) on BL biomarkers among breast cancer survivors...
  11. pmc Triple-transgenic Alzheimer's disease mice exhibit region-specific abnormalities in brain myelination patterns prior to appearance of amyloid and tau pathology
    Maya K Desai
    Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Glia 57:54-65. 2009
    ....
  12. pmc Nausea and disturbed sleep as predictors of cancer-related fatigue in breast cancer patients: a multicenter NCORP study
    Anita R Peoples
    Department of Surgery, University of Rochester Medical Center, 265 Crittenden Blvd, CU 420658, Rochester, NY, 14642, USA
    Support Care Cancer . 2016
    ..The objectives of this study were to examine the prevalence, severity, and potential predictors for the early onset of CRF after chemotherapy cycle 1 in breast cancer patients...
  13. pmc The effect of YOCAS©® yoga for musculoskeletal symptoms among breast cancer survivors on hormonal therapy
    Luke J Peppone
    Department of Surgery, University of Rochester, Rochester, NY, USA
    Breast Cancer Res Treat 150:597-604. 2015
    ..Among breast cancer survivors on hormone therapy, the brief community-based YOCAS©® intervention significantly reduced general pain, muscle aches, and physical discomfort...
  14. pmc Exercise and Cancer Treatment Symptoms in 408 Newly Diagnosed Older Cancer Patients
    Lisa K Sprod
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York
    J Geriatr Oncol 3:90-97. 2012
    ..Exercise during these times is associated with less severe symptoms; further clinical research examining the efficacy of formal exercise interventions to reduce symptoms and improve SRH in older cancer patients is needed...
  15. pmc Prevalence, demographics, and psychological associations of sleep disruption in patients with cancer: University of Rochester Cancer Center-Community Clinical Oncology Program
    Oxana G Palesh
    Department of Radiation Oncology, Department of Psychiatry, University of Rochester Medical Center, James P Wilmot Cancer Center, 601 Elmwood Ave, Box 704, Rochester, New York, NY 14642, USA
    J Clin Oncol 28:292-8. 2010
    ..Sleep disruption is prevalent in patients with cancer and survivors, but the prevalence of insomnia, a distressing sleep disorder, in these populations has yet to be determined in large-scale studies...
  16. pmc The effect of cigarette smoking on cancer treatment-related side effects
    Luke J Peppone
    Department of Radiation Oncology, University of Rochester, Rochester, New York 14642, USA
    Oncologist 16:1784-92. 2011
    ..This study examines the influence of cigarette smoking on side effects among 947 cancer patients during and 6 months following treatment...
  17. pmc Exercise for the management of side effects and quality of life among cancer survivors
    Karen M Mustian
    University of Rochester School of Medicine and Dentistry, James P Wilmot Cancer Center, Department of Radiation Oncology, Rochester, NY, USA
    Curr Sports Med Rep 8:325-30. 2009
    ....
  18. pmc Interventions to Alleviate Symptoms Related to Breast Cancer Treatments and Areas of Needed Research
    MICHELLE C JANELSINS
    Department of Radiation Oncology, University of Rochester School of Medicine and Dentistry, James P Wilmot Cancer Center, USA
    J Cancer Sci Ther . 2011
    ..Additionally, clinical perspectives on symptom management and recommendations for areas of needed research are provided...
  19. pmc The association between partner support and psychological distress among prostate cancer survivors in a nationwide study
    Charles Kamen
    James P Wilmot Cancer Institute, University of Rochester Medical Center, 265 Crittenden Boulevard, Box 420658, Rochester, NY, 14642, USA
    J Cancer Surviv 9:492-9. 2015
    ..Support from a relationship partner can ameliorate psychological distress, but many studies treat relationship status as a dichotomous predictor without accounting for level of support provided by the partner...
  20. ncbi request reprint Cognitive Complaints in Survivors of Breast Cancer After Chemotherapy Compared With Age-Matched Controls: An Analysis From a Nationwide, Multicenter, Prospective Longitudinal Study
    MICHELLE C JANELSINS
    Michelle C Janelsins, Charles E Heckler, Luke J Peppone, Charles Kamen, Karen M Mustian, Supriya G Mohile, Allison Magnuson, Ian R Kleckner, Joseph J Guido, and Gary R Morrow, University of Rochester Medical Center, James P Wilmot Cancer Institute, Rochester Lora R Weiselberg, North Shore LIJ Health System National Cancer Institute Community Clinical Oncology Research Program NCORP, Lake Success Christine A Ambrosone, Roswell Park Cancer Institute, Buffalo Tim A Ahles, Memorial Sloan Kettering Cancer Center, New York, NY Kelley L Young, Kansas City Clinical Oncology Program, Kansas City, MO Alison K Conlin, Pacific Cancer Research Consortium NCORP, Seattle, WA and Jerry W Mitchell, Columbus NCORP, Columbus, OH
    J Clin Oncol . 2016
    ..5% v 13.6%). Conclusion Patients with breast cancer who were treated in community oncology clinics report substantially more cognitive difficulties up to 6 months after treatment with chemotherapy than do age-matched noncancer controls...
  21. doi request reprint Effects of cognitive behavioral therapy for insomnia and armodafinil on quality of life in cancer survivors: a randomized placebo-controlled trial
    Anita R Peoples
    Department of Surgery, University of Rochester Medical Center, 265 Crittenden Blvd, CU 420658, Rochester, NY, 14642 0658, USA
    J Cancer Surviv . 2017
    ..The present analysis examines the effects of CBT-I, with and without armodafinil, on QOL both directly and indirectly through improvements of insomnia...
  22. pmc The effect of various vitamin D supplementation regimens in breast cancer patients
    Luke J Peppone
    Department of Radiation Oncology, University of Rochester Medical Center, 601 Elmwood Ave, Box 704, Rochester, NY 14642, USA
    Breast Cancer Res Treat 127:171-7. 2011
    ..Clinicians should carefully consider vitamin D supplementation regimens when treating vitamin D deficiency/insufficiency in breast cancer patients...
  23. pmc Current pharmacotherapy for chemotherapy-induced nausea and vomiting in cancer patients
    MICHELLE C JANELSINS
    University of Rochester Medical Center, James P Wilmot Cancer Center, Department of Radiation Oncology, 265 Crittenden Blvd, Box 658, Rochester, NY 14642, USA
    Expert Opin Pharmacother 14:757-66. 2013
    ..Many cancer patients consider delaying future chemotherapy cycles and some contemplate stopping chemotherapy altogether because of their fear of experiencing further nausea and vomiting...
  24. pmc A Dyadic Exercise Intervention to Reduce Psychological Distress Among Lesbian, Gay, and Heterosexual Cancer Survivors
    Charles Kamen
    1 Department of Surgery, University of Rochester Medical Center, Rochester, New York
    LGBT Health . 2015
    ..Exercise and partner support are shown to reduce distress. However, exercise interventions haven't been delivered to lesbian and gay survivors with support by caregivers included...
  25. pmc Modafinil Moderates the Relationship Between Cancer-Related Fatigue and Depression in 541 Patients Receiving Chemotherapy
    Claire C Conley
    From the Department of Psychology, Ohio State University, Columbus, OH Cancer Control, Department of Surgery, University of Rochester Medical Center, Rochester, NY and Hematology Oncology Associates of Central New York, Syracuse, NY Dayton Community Clinical Oncology Program, Dayton, OH Wichita Community Clinical Oncology Program, Wichita, KS and Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA
    J Clin Psychopharmacol 36:82-5. 2016
    ..The primary aim is to elucidate factors that contributed to the effectiveness of modafinil in the parent trial...
  26. pmc Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice
    MICHELLE C JANELSINS
    Department of Microbiology and Immunology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, NY 14642, USA
    Am J Pathol 173:1768-82. 2008
    ..Results presented here suggest that chronic neuronal TNF-alpha expression promotes inflammation and, ultimately, neuronal cell death in this AD mouse model, advocating the development of TNF-alpha-specific agents to subvert AD...
  27. pmc The association between breast cancer prognostic indicators and serum 25-OH vitamin D levels
    Luke J Peppone
    Department of Radiation Oncology, University of Rochester Medical Center, Rochester, New York, NY, USA
    Ann Surg Oncol 19:2590-9. 2012
    ..The aim of this study is to examine 25-OH vitamin D levels between BC cases and controls and by prognostic indicators among BC cases...
  28. pmc Prevalence, mechanisms, and management of cancer-related cognitive impairment
    MICHELLE C JANELSINS
    Department of Surgery, Cancer Control, University of Rochester Medical Center, Rochester, New York, USA
    Int Rev Psychiatry 26:102-13. 2014
    ..This review highlights key research being conducted in these areas, both in patient populations and in animals, which will ultimately result in better understanding and effective treatments for CRCI...
  29. pmc Prevention of pegfilgrastim-induced bone pain: a phase III double-blind placebo-controlled randomized clinical trial of the university of rochester cancer center clinical community oncology program research base
    Jeffrey J Kirshner
    Hematology Oncology Associates of Central New York, Community Clinical Oncology Program, East Syracuse, NY, USA
    J Clin Oncol 30:1974-9. 2012
    ..Pegfilgrastim-induced bone pain is a significant clinical problem that may result in discontinuation of pegfilgrastim and lead to less effective chemotherapy dosing. Interventions for pegfilgrastim-induced bone pain are needed...
  30. pmc Chemotherapy-related cognitive impairment in older patients with cancer
    Kah Poh Loh
    James P Wilmot Cancer Institute, University of Rochester, United States Electronic address
    J Geriatr Oncol 7:270-80. 2016
    ..Although we focus on CRCI, we also discuss cognitive impairment related to cancer itself and other treatment modalities. We highlight several research priorities to improve the study of CRCI in older patients with cancer. ..

Research Grants1

  1. Modulating Disease in Alzheimer's Disease Models
    MICHELLE JANELSINS; Fiscal Year: 2007
    ..This work will give us major insight on the involvement of inflammation in the temporal and spatial progression of early AD pathogenic events and may potentially provide a new therapeutic target. ..