Hiroshi Ishikawa

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Macular segmentation with optical coherence tomography
    Hiroshi Ishikawa
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, PA 15213, USA
    Invest Ophthalmol Vis Sci 46:2012-7. 2005
  2. pmc Retinal nerve fiber layer assessment using optical coherence tomography with active optic nerve head tracking
    Hiroshi Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 47:964-7. 2006
  3. pmc Anterior segment imaging: ultrasound biomicroscopy
    Hiroshi Ishikawa
    UPMC Eye Center and Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, Suite 816, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Ophthalmol Clin North Am 17:7-20. 2004
  4. pmc Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography
    Tarkan Mumcuoglu
    University of Pittsburgh Medical Center Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 115:782-789.e2. 2008
  5. pmc Evaluating objective and subjective quantitative parameters at the initial visit to predict future glaucomatous visual field progression
    Allison K Ungar
    UPMC Eye Center, Eye and Ear Institute, 203 Lothrop St, Pittsburgh, PA 15213, USA
    Ophthalmic Surg Lasers Imaging 43:416-24. 2012
  6. pmc Detection of glaucoma progression by population and individual derived variability criteria
    Lindsey S Folio
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Br J Ophthalmol 97:403-7. 2013
  7. pmc Assessing the relationship between central corneal thickness and retinal nerve fiber layer thickness in healthy subjects
    Tarkan Mumcuoglu
    UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 146:561-6. 2008
  8. pmc Variation in optical coherence tomography signal quality as an indicator of retinal nerve fibre layer segmentation error
    Lindsey S Folio
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Br J Ophthalmol 96:514-8. 2012
  9. ncbi request reprint Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage
    Gadi Wollstein
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 139:39-43. 2005
  10. pmc Automated assessment of the optic nerve head on stereo disc photographs
    Juan Xu
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 49:2512-7. 2008

Collaborators

Detail Information

Publications89

  1. pmc Macular segmentation with optical coherence tomography
    Hiroshi Ishikawa
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, PA 15213, USA
    Invest Ophthalmol Vis Sci 46:2012-7. 2005
    ..Dublin, CA) scan images and to test its performance in discriminating normal from glaucomatous eyes in comparison with conventional circumpapillary nerve fiber layer (cpNFL) thickness measurement...
  2. pmc Retinal nerve fiber layer assessment using optical coherence tomography with active optic nerve head tracking
    Hiroshi Ishikawa
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 47:964-7. 2006
    ..To develop an eye-motion-tracking optical coherence tomographic (OCT) method and assess its effect on image registration and nerve fiber layer (NFL) thickness measurement reproducibility...
  3. pmc Anterior segment imaging: ultrasound biomicroscopy
    Hiroshi Ishikawa
    UPMC Eye Center and Department of Ophthalmology, University of Pittsburgh School of Medicine, The Eye and Ear Institute, Suite 816, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Ophthalmol Clin North Am 17:7-20. 2004
    ....
  4. pmc Improved visualization of glaucomatous retinal damage using high-speed ultrahigh-resolution optical coherence tomography
    Tarkan Mumcuoglu
    University of Pittsburgh Medical Center Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 115:782-789.e2. 2008
    ..To test if improving optical coherence tomography (OCT) resolution and scanning speed improves the visualization of glaucomatous structural changes as compared with conventional OCT...
  5. pmc Evaluating objective and subjective quantitative parameters at the initial visit to predict future glaucomatous visual field progression
    Allison K Ungar
    UPMC Eye Center, Eye and Ear Institute, 203 Lothrop St, Pittsburgh, PA 15213, USA
    Ophthalmic Surg Lasers Imaging 43:416-24. 2012
    ..To evaluate the ability of structural assessment to predict glaucomatous visual field progression...
  6. pmc Detection of glaucoma progression by population and individual derived variability criteria
    Lindsey S Folio
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Br J Ophthalmol 97:403-7. 2013
    ..This study examined scanning laser polarimetry (SLP) population-derived versus individual-derived cut-off criteria for detecting progression...
  7. pmc Assessing the relationship between central corneal thickness and retinal nerve fiber layer thickness in healthy subjects
    Tarkan Mumcuoglu
    UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 146:561-6. 2008
    ....
  8. pmc Variation in optical coherence tomography signal quality as an indicator of retinal nerve fibre layer segmentation error
    Lindsey S Folio
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Br J Ophthalmol 96:514-8. 2012
    ..Signal quality can vary throughout a scan, contributing to local retinal nerve fibre layer segmentation errors (SegE). The purpose of this study was to develop an automated method, using local scan quality, to predict SegE...
  9. ncbi request reprint Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage
    Gadi Wollstein
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 139:39-43. 2005
    ..OCT enables posterior pole scanning of three regions: macula, peripapillary, and optic nerve head (ONH). This study compared the ability of each region to detect glaucomatous damage...
  10. pmc Automated assessment of the optic nerve head on stereo disc photographs
    Juan Xu
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 49:2512-7. 2008
    ..To develop automated software for optic nerve head (ONH) quantitative assessment from stereoscopic disc photographs and to evaluate its performance in comparison with human expert assessment...
  11. pmc Optical coherence tomography scan circle location and mean retinal nerve fiber layer measurement variability
    Michelle L Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 49:2315-21. 2008
    ..To investigate the effect on optical coherence tomography (OCT) retinal nerve fiber layer (RNFL) thickness measurements of varying the standard 3.4-mm-diameter circle location...
  12. pmc IOP elevation reduces Schlemm's canal cross-sectional area
    Larry Kagemann
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Invest Ophthalmol Vis Sci 55:1805-9. 2014
    ..The purpose of the present study was to determine the effect of acute IOP elevation on SC-CSA in living human eyes...
  13. pmc Retinal nerve fibre layer and visual function loss in glaucoma: the tipping point
    Gadi Wollstein
    Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Pittsburgh, PA 15213, USA
    Br J Ophthalmol 96:47-52. 2012
    ..To determine the retinal nerve fibre layer (RNFL) thickness at which visual field (VF) damage becomes detectable and associated with structural loss...
  14. pmc Glaucoma detection with matrix and standard achromatic perimetry
    Zvia Burgansky-Eliash
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Br J Ophthalmol 91:933-8. 2007
    ..Matrix perimetry is a new iteration of frequency-doubling technology (FDT) which uses a smaller target size in the standard achromatic perimetry presentation pattern...
  15. pmc Retinal nerve fiber layer thickness measurement comparability between time domain optical coherence tomography (OCT) and spectral domain OCT
    Jong S Kim
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, Swanson School of Engineering, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 51:896-902. 2010
    ..Spectral domain (SD)-OCT produces three-dimensional (3-D) data volumes. The purpose of this study was to create a robust technique that makes TD-OCT circular scan RNFL thickness measurements comparable with those from 3-D SD-OCT volumes...
  16. pmc Peripapillary schisis in glaucoma patients with narrow angles and increased intraocular pressure
    Malik Y Kahook
    UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 143:697-9. 2007
    ..To describe two cases of peripapillary retinal schisis in patients with glaucoma without evidence of optic nerve pits, pseudopits, or X-linked retinoschisis...
  17. pmc In vivo lamina cribrosa micro-architecture in healthy and glaucomatous eyes as assessed by optical coherence tomography
    Bo Wang
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Invest Ophthalmol Vis Sci 54:8270-4. 2013
    ..The lamina cribrosa (LC) is a prime location of glaucomatous damage. The purpose of this study was to compare LC 3-dimensional micro-architecture between healthy and glaucomatous eyes in vivo by using optical coherence tomography (OCT)...
  18. pmc Peripapillary nerve fiber layer thickness profile determined with high speed, ultrahigh resolution optical coherence tomography high-density scanning
    Michelle L Gabriele
    University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 48:3154-60. 2007
    ..To determine the retinal nerve fiber layer (RNFL) thickness profile in the peripapillary region of healthy eyes...
  19. pmc Effects of age on optical coherence tomography measurements of healthy retinal nerve fiber layer, macula, and optic nerve head
    Kyung Rim Sung
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Ophthalmology 116:1119-24. 2009
    ..To determine the effects of age on global and sectoral peripapillary retinal nerve fiber layer (RNFL), macular thicknesses, and optic nerve head (ONH) parameters in healthy subjects using optical coherence tomography (OCT)...
  20. pmc Three-dimensional optical coherence tomography (3D-OCT) image enhancement with segmentation-free contour modeling C-mode
    Hiroshi Ishikawa
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 50:1344-9. 2009
    ..To develop a semiautomated method to visualize structures of interest (SoIs) along their contour within three-dimensional, spectral domain optical coherence tomography (3D SD-OCT) data, without the need for segmentation...
  21. pmc Individual A-scan signal normalization between two spectral domain optical coherence tomography devices
    Chieh Li Chen
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 54:3463-71. 2013
    ..We developed a method to normalize optical coherence tomography (OCT) signal profiles from two spectral-domain (SD) OCT devices so that the comparability between devices increases...
  22. pmc High dynamic range imaging concept-based signal enhancement method reduced the optical coherence tomography measurement variability
    Hiroshi Ishikawa
    University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 54:836-41. 2013
    ..To develop and test a novel signal enhancement method for optical coherence tomography (OCT) images based on the high dynamic range (HDR) imaging concept...
  23. pmc Comparison of parameters from Heidelberg Retina Tomographs 2 and 3
    Michelle L Gabriele
    University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 115:673-7. 2008
    ....
  24. ncbi request reprint Optical coherence tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fields
    Gadi Wollstein
    UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 138:218-25. 2004
    ..To investigate the structure-function relationship between optical coherence tomography (OCT) macular retinal and peripapillary nerve fiber layer (NFL) thickness and automated visual field (VF) findings...
  25. pmc Characterisation of Schlemm's canal cross-sectional area
    Larry Kagemann
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Br J Ophthalmol 98:ii10-4. 2014
    ..To compare three methods of Schlemm's canal (SC) cross-sectional area (CSA) measurement...
  26. pmc Signal normalization reduces systematic measurement differences between spectral-domain optical coherence tomography devices
    Chieh Li Chen
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Invest Ophthalmol Vis Sci 54:7317-22. 2013
    ..To test the effect of a novel signal normalization method for reducing systematic optical coherence tomography (OCT) measurement differences among multiple spectral-domain (SD) OCT devices...
  27. pmc Automated volumetric evaluation of stereoscopic disc photography
    Juan Xu
    UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Opt Express 18:11347-59. 2010
    ....
  28. pmc Identification and assessment of Schlemm's canal by spectral-domain optical coherence tomography
    Larry Kagemann
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 51:4054-9. 2010
    ....
  29. pmc 3D visualization of aqueous humor outflow structures in-situ in humans
    Larry Kagemann
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Eye Res 93:308-15. 2011
    ..This approach may be useful as a model in future studies of human AH outflow...
  30. pmc Visualization of 3-D high speed ultrahigh resolution optical coherence tomographic data identifies structures visible in 2D frames
    Larry Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Opt Express 17:4208-20. 2009
    ..C-mode contour-corrected imaging of three dimensional structures provided the identification of previously unidentified structures visible in cross-sectional image slices...
  31. pmc Glaucoma discrimination of segmented cirrus spectral domain optical coherence tomography (SD-OCT) macular scans
    Jacek Kotowski
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Br J Ophthalmol 96:1420-5. 2012
    ..To evaluate the glaucoma discriminating ability of macular retinal layers as measured by spectral domain optical coherence tomography (SD-OCT)...
  32. pmc Alignment of 3-D optical coherence tomography scans to correct eye movement using a particle filtering
    Juan Xu
    Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    IEEE Trans Med Imaging 31:1337-45. 2012
    ..1% images were improved after x-alignment. The proposed algorithm is an efficient way to align 3-D OCT volume data and correct the eye movement without using references...
  33. pmc Comparison of retinal nerve fiber layer thickness measurement bias and imprecision across three spectral-domain optical coherence tomography devices
    Nancy M Buchser
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 53:3742-7. 2012
    ..We compared retinal nerve fiber layer (RNFL) bias and imprecision among three spectral-domain optical coherence tomographs (SD-OCT)...
  34. pmc Optical coherence tomography machine learning classifiers for glaucoma detection: a preliminary study
    Zvia Burgansky-Eliash
    UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, PA 15213, USA
    Invest Ophthalmol Vis Sci 46:4147-52. 2005
    ..The present study investigated whether the use of machine-learning classifiers improves optical coherence tomography (OCT) glaucoma detection...
  35. pmc Glaucoma detection with the Heidelberg retina tomograph 3
    Zvia Burgansky-Eliash
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 114:466-71. 2007
    ..To compare the ability of the Heidelberg retina tomograph version 3 (HRT 3) and HRT version 2 (HRT 2) to discriminate between healthy and glaucomatous eyes...
  36. pmc Reproducibility of in-vivo OCT measured three-dimensional human lamina cribrosa microarchitecture
    Bo Wang
    Department of Ophthalmology, University of Pittsburgh Medical Center UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pennsylvania, United States of America Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e95526. 2014
    ..To determine the reproducibility of automated segmentation of the three-dimensional (3D) lamina cribrosa (LC) microarchitecture scanned in-vivo using optical coherence tomography (OCT)...
  37. pmc Visualization of the conventional outflow pathway in the living human eye
    Larry Kagemann
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Ophthalmology 119:1563-8. 2012
    ..We sought to visualize the aqueous outflow system in 3 dimensions (3D) in living human eyes, and to investigate the use of commercially available spectral-domain optical coherence tomographic (SD-OCT) systems for this purpose...
  38. pmc Optic nerve crush mice followed longitudinally with spectral domain optical coherence tomography
    Michelle L Gabriele
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Invest Ophthalmol Vis Sci 52:2250-4. 2011
    ..To investigate the longitudinal effect of optic nerve crush injury in mice by measuring retinal thickness with spectral-domain optical coherence tomography (SD-OCT)...
  39. pmc Ultrahigh-resolution spectral domain optical coherence tomography imaging of the lamina cribrosa
    Larry Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh, Pennsylvania 15213, USA
    Ophthalmic Surg Lasers Imaging 39:S126-131. 2008
    ..The optical scan protocol for lamina cribrosa imaging appears to be a 3 x 3 mm 200 X 200 A-scan volume with the lamina cribrosa positioned near direct current...
  40. pmc In vivo corneal high-speed, ultra high-resolution optical coherence tomography
    Viki Christopoulos
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop St, Suite 827, Pittsburgh, PA 15213, USA
    Arch Ophthalmol 125:1027-35. 2007
    ..To introduce new corneal high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT) technology that improves the evaluation of complicated and uncomplicated cataract, corneal, and refractive surgical procedures...
  41. pmc Three dimensional optical coherence tomography imaging: advantages and advances
    Michelle L Gabriele
    Department of Ophthalmology, UPMC Eye Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Prog Retin Eye Res 29:556-79. 2010
    ..In addition, 3D-OCT offers the potential for preoperative surgical planning and intraoperative surgical guidance...
  42. ncbi request reprint Assessment of optic disc anatomy and nerve fiber layer thickness in ocular hypertensive subjects with normal short-wavelength automated perimetry
    Andrea Mistlberger
    Department of Ophthalmology, The New York Eye and Ear Infirmary, 310 East 14th Street, New York, NY 10003, USA
    Ophthalmology 109:1362-6. 2002
    ..To compare optic disc topography and nerve fiber layer thickness in ocular hypertensive eyes and normal subjects...
  43. pmc Comparison of optic disc margin identified by color disc photography and high-speed ultrahigh-resolution optical coherence tomography
    Anita Manassakorn
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Ophthalmol 126:58-64. 2008
    ..To determine the correspondence between optic disc margins evaluated using disc photography (DP) and optical coherence tomography (OCT)...
  44. pmc Spectral oximetry assessed with high-speed ultra-high-resolution optical coherence tomography
    Larry Kagemann
    University of Pittsburgh School of Medicine, Department of Ophthalmology, Ophthalmology and Visual Sciences Research Center, UPMC Eye Center, Eye and Ear Institute, Pittsburgh, Pennsylvania 15213, USA
    J Biomed Opt 12:041212. 2007
    ..0217) (mean+/-standard deviation). A difference between arterial and venous blood saturation was detected. This suggests that retinal oximetry may possibly be added as a metabolic measurement in structural imaging devices...
  45. pmc 3D OCT eye movement correction based on particle filtering
    Juan Xu
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Dept of Ophthalmology, University of Pittsburgh School of Medicine, PA, USA
    Conf Proc IEEE Eng Med Biol Soc 2010:53-6. 2010
    ..All the images were improved after z-alignment, while 81.1% images were improved after x-alignment. The proposed algorithm is an efficient way to align 3D OCT volume data and correct the eye movement without using references...
  46. pmc In vivo three-dimensional characterization of the healthy human lamina cribrosa with adaptive optics spectral-domain optical coherence tomography
    Zach Nadler
    Department of Ophthalmology, University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
    Invest Ophthalmol Vis Sci 55:6459-66. 2014
    ..To characterize the in vivo three-dimensional (3D) lamina cribrosa (LC) microarchitecture of healthy eyes using adaptive optics spectral-domain optical coherence tomography (AO-SDOCT)...
  47. pmc Three-dimensional spectral-domain optical coherence tomography data analysis for glaucoma detection
    Juan Xu
    University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    PLoS ONE 8:e55476. 2013
    ....
  48. pmc The optic nerve head as a robust biomechanical system
    Ian A Sigal
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Invest Ophthalmol Vis Sci 53:2658-67. 2012
    ..The authors also provide the first estimates of the typical mechanical response of the ONH to variations in IOP over a large population of ONHs...
  49. pmc Effect of corneal drying on optical coherence tomography
    Daniel M Stein
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 113:985-91. 2006
    ..To determine the effect of corneal drying on the outcome of optical coherence tomography (OCT)...
  50. pmc Retinal vessel segmentation on SLO image
    Juan Xu
    Department of Ophthalmology, University of Pittsburgh School of Medicine, PA, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:2258-61. 2008
    ..The algorithm showed substantial potential in various clinical applications. The use of this method can be also extended to medical image registration based on blood vessel location...
  51. pmc Decreased Lamina Cribrosa Beam Thickness and Pore Diameter Relative to Distance From the Central Retinal Vessel Trunk
    Bo Wang
    Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania, United States 2Department of Bioengineering, Swanson School of En
    Invest Ophthalmol Vis Sci 57:3088-92. 2016
    ..To investigate how the lamina cribrosa (LC) microstructure changes with distance from the central retinal vessel trunk (CRVT), and to determine how this change differs in glaucoma...
  52. pmc Gold nanorods as a contrast agent for Doppler optical coherence tomography
    Bo Wang
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 9:e90690. 2014
    ..To investigate gold nanorods (GNRs) as a contrast agent to enhance Doppler optical coherence tomography (OCT) imaging of the intrascleral aqueous humor outflow...
  53. pmc Morphometric analysis of aqueous humor outflow structures with spectral-domain optical coherence tomography
    Andrew W Francis
    Department of Ophthalmology, Boston University School of Medicine, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 53:5198-207. 2012
    ..To describe morphometric details of the human aqueous humor (AH) outflow microvasculature visualized with 360-degree virtual castings during active AH outflow in cadaver eyes and to compare these structures with corrosion casting studies...
  54. ncbi request reprint Detecting the inner and outer borders of the retinal nerve fiber layer using optical coherence tomography
    Hiroshi Ishikawa
    Department of Ophthalmology, The New York Medical College, Valhalla, USA
    Graefes Arch Clin Exp Ophthalmol 240:362-71. 2002
    ..The purpose of this study was to develop a new algorithm to detect the inner and outer borders of the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT)...
  55. ncbi request reprint Acute conformational changes in the optic nerve head with rapid intraocular pressure elevation: implications for LASIK surgery
    Scott Piette
    Department of Ophthalmology, The New York Eye and Ear Infirmary, New York 10003, USA
    Ophthalmic Surg Lasers Imaging 34:334-41. 2003
    ..To investigate the effects of acute intraocular pressure (IOP) elevation on optic disc morphology...
  56. pmc Repeated, noninvasive, high resolution spectral domain optical coherence tomography imaging of zebrafish embryos
    Larry Kagemann
    University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Mol Vis 14:2157-70. 2008
    ..To demonstrate a new imaging method for high resolution spectral domain optical coherence tomography (SD-OCT) for small animal developmental imaging...
  57. pmc Optical coherence tomography: history, current status, and laboratory work
    Michelle L Gabriele
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 52:2425-36. 2011
    ..This article reviews the history of OCT imaging of the eye, its current status, and the laboratory work that is driving the future of the technology...
  58. pmc Reproducibility of spectral-domain optical coherence tomography total retinal thickness measurements in mice
    Michelle L Gabriele
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Invest Ophthalmol Vis Sci 51:6519-23. 2010
    ..To test the reproducibility of spectral-domain optical coherence tomography (SD-OCT) total retinal thickness (TRT) measurements in mice...
  59. pmc Glaucoma Structural and Functional Progression in American and Korean Cohorts
    Tigran Kostanyan
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Ophthalmology 123:783-8. 2016
    ..To compare the rate of glaucoma structural and functional progression in American and Korean cohorts...
  60. pmc Histogram Matching Extends Acceptable Signal Strength Range on Optical Coherence Tomography Images
    Chieh Li Chen
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States 2Department of Bioengineering, Swanson School of En
    Invest Ophthalmol Vis Sci 56:3810-9. 2015
    ..We minimized the influence of image quality variability, as measured by signal strength (SS), on optical coherence tomography (OCT) thickness measurements using the histogram matching (HM) method...
  61. pmc Inflammatory response to intravitreal injection of gold nanorods
    Michelle Gabriele Sandrian
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Br J Ophthalmol 96:1522-9. 2012
    ..To evaluate the utility of gold nanorods (AuNRs) as a contrast agent for ocular optical coherence tomography (OCT)...
  62. pmc 3D optical coherence tomography super pixel with machine classifier analysis for glaucoma detection
    Juan Xu
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:3395-8. 2011
    ..855 and 0.707, respectively, p=0.031). This new method has the potential to improve early detection of glaucomatous structural damages...
  63. pmc Clinical use of OCT in assessing glaucoma progression
    Jacek Kotowski
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ophthalmic Surg Lasers Imaging 42:S6-S14. 2011
    ..This manuscript presents the capabilities of the OCT technology pertinent for detection of progressive glaucomatous damage and provides a review of the current knowledge on the device's clinical performance...
  64. pmc Validation of spectral domain optical coherence tomographic Doppler shifts using an in vitro flow model
    Larry Kagemann
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 50:702-6. 2009
    ..To validate velocity measurements produced by spectral domain optical coherence tomography (SD-OCT) in an in vitro laminar flow model...
  65. ncbi request reprint A new silicone eyecup for ultrasound biomicroscopy
    H Viet Tran
    Department of Ophthalmology, New York Eye and Ear Infirmary, 310 E 14th St, New York 10003, USA
    Ophthalmic Surg Lasers Imaging 34:73-5. 2003
    ..These findings indicate the silicone eyecup is a good alternative to the hard plastic eyecup and also is easier to use...
  66. pmc Persistence of Cloquet's canal in normal healthy eyes
    Larry Kagemann
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Ophthalmol 142:862-4. 2006
    ..Optic nerve head (ONH) structural imaging with state-of-the-art, high-speed, ultra-high-resolution optical coherence tomography (hsUHR-OCT)...
  67. pmc Comparison of visual field defects using matrix perimetry and standard achromatic perimetry
    Avni Patel
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Ophthalmology 114:480-7. 2007
    ..To compare visual field (VF) defects found by Swedish interactive thresholding Algorithm (SITA) perimetry and Matrix perimetry, a new VF device that utilizes frequency doubling technology in a 24-2 test pattern...
  68. pmc Optical coherence tomography and histologic measurements of nerve fiber layer thickness in normal and glaucomatous monkey eyes
    Joel S Schuman
    UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Sciences Research Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Invest Ophthalmol Vis Sci 48:3645-54. 2007
    ....
  69. doi request reprint Interocular symmetry in peripapillary retinal nerve fiber layer thickness measured with the Cirrus HD-OCT in healthy eyes
    Jean Claude Mwanza
    Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Am J Ophthalmol 151:514-21.e1. 2011
    ..To determine the cutoffs for the interocular difference in retinal nerve fiber layer (RNFL) thickness measured with Cirrus HD-OCT (Carl Zeiss Meditec, Inc) in normal eyes...
  70. ncbi request reprint Hypotonous malignant glaucoma: aqueous misdirection with low intraocular pressure
    Zvia Burgansky-Eliash
    UPMC Eye Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Ophthalmic Surg Lasers Imaging 39:155-9. 2008
    ..Intraocular pressure remained low in both cases. These cases demonstrate that hypotony and axial shallowing of the anterior chamber after trabeculectomy can result in a malignant glaucoma-like appearance...
  71. pmc Translation histogram based hierarchical algorithm for 3-d optic nerve head modeling
    Juan Xu
    Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:6752-5. 2007
    ..The algorithm indicates the potential usefulness for 3-D ONH modeling and evaluation...
  72. pmc Direct scanning of pathology specimens using spectral domain optical coherence tomography: a pilot study
    Jeffrey L Fine
    Department of Pathology, University of Pittsburgh School of Medicine, Magee Womens Hospital of UPMC, 300 Halket Street, Pittsburgh, PA 15213, USA
    Ophthalmic Surg Lasers Imaging 41:S58-64. 2010
    ..Spectral domain optical coherence tomography (SD-OCT) can be used to directly scan tissue blocks to produce three-dimensional histology images, potentially bypassing glass slide workflow...
  73. ncbi request reprint Ultrasound biomicroscopic assessment of zonular appearance in exfoliation syndrome
    Robert Ritch
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, USA
    Acta Ophthalmol Scand 85:495-9. 2007
    ..To assess zonular appearance using biomicroscopy (UBM) in exfoliation syndrome (XFS)...
  74. pmc Clinical application of ocular imaging
    Zach Nadler
    Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Optom Vis Sci 89:E543-53. 2012
    ..In this review, we are presenting the main commercially available devices for imaging of the posterior segment of the eye...
  75. ncbi request reprint Ultrasound biomicroscopy in uveitis-glaucoma-hyphema syndrome
    Scott Piette
    Department of Ophthalmology, New York Eye and Ear Infirmary, New York, New York 10003, USA
    Am J Ophthalmol 133:839-41. 2002
    ..To assess anterior segment anatomy in uveitis-glaucoma- hyphema syndrome...
  76. pmc Active retinal tracker for clinical optical coherence tomography systems
    Daniel X Hammer
    Physical Sciences Inc, 20 New England Business Center, Andover, Massachusetts 01810, USA
    J Biomed Opt 10:024038. 2005
    ..For example, tracking will enable very high density 3-D scans of the retina, which are susceptible to eye motion artifacts even for new high-speed systems...
  77. pmc Anterior segment imaging for glaucoma: OCT or UBM?
    Hiroshi Ishikawa
    Br J Ophthalmol 91:1420-1. 2007
  78. pmc Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma
    Gadi Wollstein
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Arch Ophthalmol 123:464-70. 2005
    ..To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry...
  79. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    ..A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated. The nerve fiber layer (NFL) thickness, macula thickness map, and optic nerve head (ONH) parameters in normal eyes were studied...
  80. pmc Ultrahigh-resolution optical coherence tomography in glaucoma
    Gadi Wollstein
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 112:229-37. 2005
    ..We investigated a new ultrahigh-resolution OCT (UHR-OCT) imaging system in glaucoma patients and compared the findings with those obtained by conventional-resolution OCT...
  81. ncbi request reprint Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma
    Takashi Okuyama
    Department of Surgery, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    Dis Colon Rectum 45:628-34. 2002
    ....
  82. ncbi request reprint Isolated oculomotor nerve palsy in Churg-Strauss syndrome
    Hiromasa Tsuda
    Division of Neurology, Nihon University, School of Medicine, Oyaguchikamicho, Tokyo
    Intern Med 44:638-40. 2005
    ..This is the first case of oculomotor nerve palsy due to midbrain infarction associated with Churg-Strauss syndrome...
  83. pmc Comparison of ultrahigh- and standard-resolution optical coherence tomography for imaging macular pathology
    Tony H Ko
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 112:1922.e1-15. 2005
    ....
  84. ncbi request reprint Predictive factors for preoperative serum levels of sialy Lewis(x), sialyl Lewis(a) and sialyl Tn antigens in gastric cancer patients
    Tohru Nakagoe
    First Department of Surgery, Nagasaki University School of Medicine, Japan
    Anticancer Res 22:451-8. 2002
    ..In addition, high serum CA19-9 levels may represent an independent predictor for lymph node metastasis...
  85. ncbi request reprint [Fisher syndrome with optic neuropathy]
    Noriko Koga
    Division of Ophthalmology, Department of Comprehensive Medical Sciences, Meikai University School of Dentistry 1 1 Keyakidai, Sakado, Saitama 350 0283, Japan
    Nippon Ganka Gakkai Zasshi 112:801-5. 2008
    ..Tonic pupil indicated disorder of the peripheral nervous system...
  86. ncbi request reprint Oxidative stress causes heart failure with impaired mitochondrial respiration
    Hidetoshi Nojiri
    Research Team for Molecular Biomarkers, Tokyo Metropolitan Institute of Gerontology, Itabashi ku, Tokyo 173 0015, Japan
    J Biol Chem 281:33789-801. 2006
    ..We here present a bona fide model for human cardiac failure with oxidative stress valuable for therapeutic interventions...
  87. ncbi request reprint The efficacy of latanoprost is independent of the width of the ciliary body face
    Robert Ritch
    Department of Ophthalmology and the Biostatistics and Epidemiology Service, The New York Eye and Ear Infirmary, New York, New York and The New York Medical College, Valhalla, New York 10003, USA
    J Glaucoma 11:239-43. 2002
    ..To assess the relation between the intraocular pressure-lowering efficacy of latanoprost 0.005% and the area of the ciliary body face exposed to the anterior chamber as assessed by ultrasound biomicroscopy...
  88. ncbi request reprint Budding as a useful prognostic marker in pT3 well- or moderately-differentiated rectal adenocarcinoma
    Takashi Okuyama
    Department of Surgery, Koshigaya Hospital, Dokkyo University School of Medicine, Minami Koshigaya, Koshigaya, Saitama, Japan
    J Surg Oncol 83:42-7. 2003
    ..We examined the prognostic significance of budding in patients with pT3 rectal carcinoma, particularly in comparison to other routine pathological findings...
  89. pmc Quantification of photoreceptor layer thickness in normal eyes using optical coherence tomography
    Annie Chan
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02111 1533, USA
    Retina 26:655-60. 2006
    ..Dublin, CA) and from the ultrahigh resolution OCT (UHR-OCT) prototype...