Richard D Irons

Summary

Affiliation: University of Colorado Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint Prevalence of MDS subtypes in Shanghai, China: a comparison of the World Health Organization and French American British classifications
    Richard D Irons
    Sino US Joint Clinical and Molecular Laboratory, Fudan University, Shanghai, China
    Leuk Res 30:769-75. 2006
  2. ncbi request reprint Comparative toxicity of dithiocarbamates and butadiene metabolites in human lymphoid and bone marrow cells
    R D Irons
    University of Colorado Health Sciences Center, 4200 East 9th Avenue, C238, Denver, CO 80262, USA
    Chem Biol Interact 135:615-25. 2001
  3. ncbi request reprint Chronic exposure to benzene results in a unique form of dysplasia
    Richard D Irons
    Sino US Joint Clinical and Molecular Laboratory, Fudan University, Shanghai 200032, China
    Leuk Res 29:1371-80. 2005
  4. ncbi request reprint The effects of benzene and other leukaemogenic agents on haematopoietic stem and progenitor cell differentiation
    R D Irons
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Eur J Haematol Suppl 60:119-24. 1996
  5. pmc The process of leukemogenesis
    R D Irons
    School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Environ Health Perspect 104:1239-46. 1996
  6. pmc Dithiocarbamates and viral IL-10 collaborate in the immortalization and evasion of immune response in EBV-infected human B lymphocytes
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences and Department of Pathology, Fudan University, Shanghai, China
    Chem Biol Interact 172:81-92. 2008
  7. ncbi request reprint Comparative toxicity of known and putative metabolites of 1, 3-butadiene in human CD34(+) bone marrow cells
    R D Irons
    The Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, 80262, Denver, CO, USA
    Toxicology 150:99-106. 2000
  8. doi request reprint Integrating WHO 2001-2008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): a case-case analysis of benzene exposure
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Chem Biol Interact 184:30-8. 2010
  9. doi request reprint A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China
    Sherilyn A Gross
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong an Road, 200032, Shanghai, China
    Int J Hematol 88:165-73. 2008
  10. doi request reprint Prospective analysis of clinical and cytogenetic features of 435 cases of MDS diagnosed using the WHO (2001) classification: a prognostic scoring system for predicting survival in RCMD
    Xiao Qin Wang
    Fudan Cinpathogen Clinical and Molecular Research Center CMRC, Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Int J Hematol 90:361-9. 2009

Research Grants

  1. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Prevalence of MDS subtypes in Shanghai, China: a comparison of the World Health Organization and French American British classifications
    Richard D Irons
    Sino US Joint Clinical and Molecular Laboratory, Fudan University, Shanghai, China
    Leuk Res 30:769-75. 2006
    ....
  2. ncbi request reprint Comparative toxicity of dithiocarbamates and butadiene metabolites in human lymphoid and bone marrow cells
    R D Irons
    University of Colorado Health Sciences Center, 4200 East 9th Avenue, C238, Denver, CO 80262, USA
    Chem Biol Interact 135:615-25. 2001
    ..These results are consistent with the pattern of DTC toxicity previously observed in clinical and molecular studies...
  3. ncbi request reprint Chronic exposure to benzene results in a unique form of dysplasia
    Richard D Irons
    Sino US Joint Clinical and Molecular Laboratory, Fudan University, Shanghai 200032, China
    Leuk Res 29:1371-80. 2005
    ..No clonal cytogenetic abnormalities were observed. These results suggest that autoimmune-mediated bone marrow injury is an early or predisposing event in the pathogenesis of benzene-induced persistent hematopoietic disease...
  4. ncbi request reprint The effects of benzene and other leukaemogenic agents on haematopoietic stem and progenitor cell differentiation
    R D Irons
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Eur J Haematol Suppl 60:119-24. 1996
    ....
  5. pmc The process of leukemogenesis
    R D Irons
    School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Environ Health Perspect 104:1239-46. 1996
    ....
  6. pmc Dithiocarbamates and viral IL-10 collaborate in the immortalization and evasion of immune response in EBV-infected human B lymphocytes
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences and Department of Pathology, Fudan University, Shanghai, China
    Chem Biol Interact 172:81-92. 2008
    ....
  7. ncbi request reprint Comparative toxicity of known and putative metabolites of 1, 3-butadiene in human CD34(+) bone marrow cells
    R D Irons
    The Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, 80262, Denver, CO, USA
    Toxicology 150:99-106. 2000
    ..Further interpretation of these findings requires a better understanding of the metabolism of BD in humans...
  8. doi request reprint Integrating WHO 2001-2008 criteria for the diagnosis of Myelodysplastic Syndrome (MDS): a case-case analysis of benzene exposure
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Chem Biol Interact 184:30-8. 2010
    ....
  9. doi request reprint A prospective study of 728 cases of non-Hodgkin lymphoma from a single laboratory in Shanghai, China
    Sherilyn A Gross
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, 130 Dong an Road, 200032, Shanghai, China
    Int J Hematol 88:165-73. 2008
    ..Precursor T lymphoblastic leukemia/lymphoma, anaplastic large T cell lymphoma, aggressive NK cell leukemia, angioimmunoblastic T cell lymphoma and peripheral T cell lymphoma were prominent subtypes of T cell NHL...
  10. doi request reprint Prospective analysis of clinical and cytogenetic features of 435 cases of MDS diagnosed using the WHO (2001) classification: a prognostic scoring system for predicting survival in RCMD
    Xiao Qin Wang
    Fudan Cinpathogen Clinical and Molecular Research Center CMRC, Institute of Biomedical Sciences, Fudan University, Shanghai, China
    Int J Hematol 90:361-9. 2009
    ..Multivariate analysis demonstrated that a scoring system based on age (> or =60 years), ANC (<1.0 x 10(9)/L), Hb (<90 g/L), number of cytopenias and complex karyotype is a more useful predictor of survival in RCMD...
  11. doi request reprint Characterization of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) in Shanghai, China: molecular and cytogenetic characteristics, IgV gene restriction and hypermutation patterns
    Richard D Irons
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Leuk Res 33:1599-603. 2009
    ..IgV(H) gene mutation status was a significant predictor of initial survival in CLL/SLL. However, an influence of karyotype on prognosis was not observed...
  12. doi request reprint Adult precursor B lymphoblastic leukemia in Shanghai, China: characterization of phenotype, cytogenetics and outcome for 137 consecutive cases
    Liming Bao
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Int J Hematol 89:431-7. 2009
    ..These findings suggest significant geographic heterogeneity in precursor B-cell ALL which may be of both etiological and therapeutic significance...
  13. ncbi request reprint Aggressive natural killer cell leukemia: report of a Chinese series and review of the literature
    John Ryder
    Sino US Joint Clinical and Molecular Laboratory, Departement of Pathology, Fudan University, Shanghai, China
    Int J Hematol 85:18-25. 2007
    ..Because of its aggressive course, rapid and accurate diagnosis of ANKL is essential for a better understanding of the etiology, pathogenesis, and treatment of the disease...
  14. ncbi request reprint The TNF-alpha 238A polymorphism is associated with susceptibility to persistent bone marrow dysplasia following chronic exposure to benzene
    Ling Lv
    International Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Leuk Res 31:1479-85. 2007
    ..These findings are consistent with a role for inflammation in the development of BID and suggest that cell-specific alterations in TNF-alpha expression may promote clonal selection in the evolution of neoplastic hematopoietic disease...
  15. doi request reprint A hospital-based case control study of aplastic anemia in Shanghai, China
    Sherilyn A Gross
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Chem Biol Interact 184:165-73. 2010
    ....
  16. doi request reprint Acute myeloid leukemia following exposure to benzene more closely resembles de novo than therapy related-disease
    Richard D Irons
    Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China
    Genes Chromosomes Cancer 52:887-94. 2013
    ..These findings are important for further understanding the biological basis of AML, particularly in environmental and occupational settings...
  17. ncbi request reprint [Cytogenetic and interphase FISH studies in the diagnosis of malignant lymphomas]
    Xi Chun Hu
    Department of Medical Oncology, Fudan University Cancer Hospital, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 29:45-8. 2007
    ..To evaluate the role of cytogenetic study and interphase FISH analysis in differential diagnosis of patients with clinical and/or cytological diagnosis as lymphoma or "suspicious for lymphoma"...
  18. doi request reprint A case-control study of chronic myelomonocytic leukemia (CMML) in Shanghai, China: evaluation of risk factors for CMML, with special focus on benzene
    Sherilyn A Gross
    Fudan Cinpathogen Clinical and Molecular Research Center, Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Arch Environ Occup Health 67:206-18. 2012
    ..These results do not support an increased risk for developing CMML associated with historical exposures to benzene...
  19. ncbi request reprint Hydroquinone modulates the GM-CSF signaling pathway in TF-1 cells
    J H Zheng
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Leukemia 18:1296-304. 2004
    ..These results suggest that HQ stimulates proliferation via activation of ERK/AP-1 and is at least partially mediated via the production of GM-CSF...
  20. ncbi request reprint PU.1 phosphorylation correlates with hydroquinone-induced alterations in myeloid differentiation and cytokine-dependent clonogenic response in human CD34(+) hematopoietic progenitor cells
    S A Gross
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Biol Toxicol 22:229-41. 2006
    ..These results suggest that HQ induces a dysregulation in the external signals modulating PU.1 protein phosphorylation and this dysregulation may be an early event in the generation of benzene-induced AML...
  21. pmc Chemical suppression of a subpopulation of primitive hematopoietic progenitor cells: 1,3-butadiene produces a hematopoietic defect similar to steel or white spotted mutations in mice
    D B Colagiovanni
    Molecular Toxicology and Environmental Health Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262
    Proc Natl Acad Sci U S A 90:2803-6. 1993
    ....
  22. doi request reprint Cytogenetics in benzene-associated myelodysplastic syndromes and acute myeloid leukemia: new insights into a disease continuum
    Richard D Irons
    Department of Hematology, Huashan Hospital, Fudan University, Shanghai, China Anshutz Medical Center, University of Colorado, Aurora, Colorado Cinpathogen, Inc, Boulder, Colorado
    Ann N Y Acad Sci 1310:84-8. 2014
    ..Understanding alterations of homeostatic regulation in the BM niche is important for validation of models of leukemogenesis, monitoring at-risk populations, and development of novel treatment and prevention strategies. ..
  23. ncbi request reprint Benzene exposure in the shoemaking industry in China, a literature survey, 1978-2004
    Laiming Wang
    Fudan University School of Public Health, Shanghai, China
    Regul Toxicol Pharmacol 46:149-56. 2006
    ....
  24. pmc Impact of benzene metabolites on differentiation of bone marrow progenitor cells
    R D Irons
    School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Environ Health Perspect 104:1247-50. 1996
    ..These findings suggest that an early step in chemical leukemogenesis may involve transient alterations in the regulation of cytokine response to GM-CSF...
  25. ncbi request reprint Characterization and phenotypic analysis of differentiating CD34+ human bone marrow cells in liquid culture
    S Gross
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Eur J Haematol 59:318-26. 1997
    ....
  26. ncbi request reprint Dithiocarbamates inhibit hematopoiesis via a copper-dependent mechanism
    D W Pyatt
    Molecular Toxicology and Environmental Health Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, 80262, USA
    Biochem Biophys Res Commun 274:513-8. 2000
    ..These data support a role for copper in DTC-induced hematotoxicity...
  27. ncbi request reprint Dithiocarbamates as potential confounders in butadiene epidemiology
    R D Irons
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, Department of Pathology, University of Colorado Health Sciences Center, Denver 80262, USA
    Carcinogenesis 19:539-42. 1998
    ..Based on these findings additional studies on the epidemiology, carcinogenesis and molecular biology of dithiocarbamates are clearly warranted...
  28. ncbi request reprint Benzene metabolites antagonize etoposide-stabilized cleavable complexes of DNA topoisomerase IIalpha
    R K Baker
    Molecular Toxicology and Environmental Health Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA
    Blood 98:830-3. 2001
    ..It is therefore unlikely that benzene-induced acute myelogenous leukemia stems from events invoked for leukemogenic topo II cleavable complex-stabilizing antitumor agents. (Blood. 2001;98:830-833)..
  29. ncbi request reprint Inhibition of NF-kappaB by hydroquinone sensitizes human bone marrow progenitor cells to TNF-alpha-induced apoptosis
    Patrick J Kerzic
    Molecular Toxicology and Environmental Health Sciences Program, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Box C238, Denver 80262, USA
    Toxicology 187:127-37. 2003
    ..These effects may play a role in the suppression of hematopoiesis seen in some benzene exposed individuals...
  30. doi request reprint Analysis of hydroquinone and catechol in peripheral blood of benzene-exposed workers
    P J Kerzic
    Fudan Cinpathogen Clinical and Molecular Research Center, Shanghai, China
    Chem Biol Interact 184:182-8. 2010
    ..01-78.8 mg/m(3)). This method demonstrates the feasibility of analyzing benzene metabolites in human blood, and should allow for further investigation of the health effects of benzene and its metabolites...
  31. ncbi request reprint Peroxidase activity in murine and human hematopoietic progenitor cells: potential relevance to benzene-induced toxicity
    D G Schattenberg
    Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262
    Mol Pharmacol 46:346-51. 1994
    ..These data may have relevance for studies of hematopoietic cell differentiation and for the examination of mechanisms underlying cell-specific toxicity in bone marrow...
  32. ncbi request reprint Dimethyldithiocarbamate inhibits in vitro activation of primary human CD4+ T lymphocytes
    D W Pyatt
    Molecular Toxicology and Environmental Health Sciences, School of Pharmacy, University of Colorado Health Sciences Center, Denver 80262, USA
    Toxicology 128:83-90. 1998
    ..These data demonstrate that DMDTC is a potent immunosuppressive compound in vitro...
  33. ncbi request reprint Prospective study of 174 de novo acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and FLT3 mutations
    Liming Bao
    Division of Human Genetics, Cincinnati Children s Hospital Medical Center, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, USA
    Eur J Haematol 77:35-45. 2006
    ..Both mutations were associated with leukocytosis. Our study also suggests that the FLT3 mutations are biomarkers independent of cytogenetic characteristics...

Research Grants1

  1. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..