M Nedim Ince
Affiliation: University of Iowa
- Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulationM Nedim Ince
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
J Immunol 176:726-9. 2006..Thus, during helminth infection, LPS challenge induces mucosal T cells to make TGFbeta through a TLR4-dependent process without promoting synthesis of proinflammatory cytokines...
- Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulationM Nedim Ince
Department of Internal Medicine, University of Iowa, Iowa City, USA
Eur J Immunol 39:1870-8. 2009..Thus, T cell TGF-beta signaling is essential for helminthic stimulation of mucosal IL-10 production, helminthic modulation of intestinal IFN-gamma generation and H. polygyrus-mediated suppression of chronic colitis...
- Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 productionDavid E Elliott
Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
J Immunol 181:2414-9. 2008..Ab-mediated blockade of IL-17 improves colitis in IL-10-deficient mice. Thus, helminth-associated inhibition of IL-17 production is most likely an important mechanism mediating protection from inappropriate intestinal inflammation...
- Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestineTommy Setiawan
Division of Gastroenterology 4611 JCP, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
Infect Immun 75:4655-63. 2007..IL-10 is particularly important for limiting the Th1 response. The T-cell origin of these cytokines demonstrates mucosal regulatory T-cell induction...
- Immunologic and molecular mechanisms in inflammatory bowel diseaseM Nedim Ince
Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, Carver College of Medicine, 4611 JCP, 200 Hawkins Drive, Iowa City, IA 52242, USA
Surg Clin North Am 87:681-96. 2007..Biologic agents that block inflammatory cytokines (anti-TNFalpha antibodies) have been used successfully to treat IBD. Recent advances have also identified mucosal regulatory pathways...