M Nedim Ince

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi request reprint Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation
    M Nedim Ince
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 176:726-9. 2006
  2. pmc Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation
    M Nedim Ince
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Eur J Immunol 39:1870-8. 2009
  3. pmc Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
    David E Elliott
    Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    J Immunol 181:2414-9. 2008
  4. pmc Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine
    Tommy Setiawan
    Division of Gastroenterology 4611 JCP, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Infect Immun 75:4655-63. 2007
  5. pmc Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice
    Yue Li
    Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242
    J Immunol 194:1011-20. 2015
  6. pmc Graft Versus Host Disease After Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management
    Arvind R Murali
    1 Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA 2 Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 3 Department of Pediatrics, Division of Blood and Bone Marrow Transplantation, University of Minnesota, Minneapolis, MN 4 Department of Internal Medicine, Division of Hematology and Oncology, Bone Marrow Transplant, University of Iowa Hospitals and Clinics, Iowa City, IA
    Transplantation 100:2661-2670. 2016
  7. pmc Understanding Luminal Microorganisms and Their Potential Effectiveness in Treating Intestinal Inflammation
    M Nedim Ince
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Medical Center, University of Minnesota, Minneapolis, Minnesota Division of Infectious Diseases, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa and Department of Veterinary Microbiology, Iowa State University, Ames, Iowa
    Inflamm Bowel Dis 22:194-201. 2016
  8. ncbi request reprint Immunologic and molecular mechanisms in inflammatory bowel disease
    M Nedim Ince
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, Carver College of Medicine, 4611 JCP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Surg Clin North Am 87:681-96. 2007

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Heligmosomoides polygyrus induces TLR4 on murine mucosal T cells that produce TGFbeta after lipopolysaccharide stimulation
    M Nedim Ince
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA
    J Immunol 176:726-9. 2006
    ..Thus, during helminth infection, LPS challenge induces mucosal T cells to make TGFbeta through a TLR4-dependent process without promoting synthesis of proinflammatory cytokines...
  2. pmc Role of T cell TGF-beta signaling in intestinal cytokine responses and helminthic immune modulation
    M Nedim Ince
    Department of Internal Medicine, University of Iowa, Iowa City, USA
    Eur J Immunol 39:1870-8. 2009
    ..Thus, T cell TGF-beta signaling is essential for helminthic stimulation of mucosal IL-10 production, helminthic modulation of intestinal IFN-gamma generation and H. polygyrus-mediated suppression of chronic colitis...
  3. pmc Colonization with Heligmosomoides polygyrus suppresses mucosal IL-17 production
    David E Elliott
    Department of Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    J Immunol 181:2414-9. 2008
    ..Ab-mediated blockade of IL-17 improves colitis in IL-10-deficient mice. Thus, helminth-associated inhibition of IL-17 production is most likely an important mechanism mediating protection from inappropriate intestinal inflammation...
  4. pmc Heligmosomoides polygyrus promotes regulatory T-cell cytokine production in the murine normal distal intestine
    Tommy Setiawan
    Division of Gastroenterology 4611 JCP, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242 1009, USA
    Infect Immun 75:4655-63. 2007
    ..IL-10 is particularly important for limiting the Th1 response. The T-cell origin of these cytokines demonstrates mucosal regulatory T-cell induction...
  5. pmc Intestinal helminths regulate lethal acute graft-versus-host disease and preserve the graft-versus-tumor effect in mice
    Yue Li
    Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242
    J Immunol 194:1011-20. 2015
    ..These results suggest that helminths suppress acute GVHD using Tregs and TGF-β-dependent pathways in mice. Helminthic regulation of GVHD and GVT through intestinal immune conditioning may improve the outcome of BMT. ..
  6. pmc Graft Versus Host Disease After Liver Transplantation in Adults: A Case series, Review of Literature, and an Approach to Management
    Arvind R Murali
    1 Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Iowa Hospitals and Clinics, Iowa City, IA 2 Department of Surgery, Division of Transplantation and Hepatobiliary Surgery, University of Iowa Hospitals and Clinics, Iowa City, IA 3 Department of Pediatrics, Division of Blood and Bone Marrow Transplantation, University of Minnesota, Minneapolis, MN 4 Department of Internal Medicine, Division of Hematology and Oncology, Bone Marrow Transplant, University of Iowa Hospitals and Clinics, Iowa City, IA
    Transplantation 100:2661-2670. 2016
    ..Graft-versus-host-disease (GVHD) after liver transplantation (LT) is a deadly complication with very limited data on risk factors, diagnosis and management. We report a case series and a comprehensive review of the literature...
  7. pmc Understanding Luminal Microorganisms and Their Potential Effectiveness in Treating Intestinal Inflammation
    M Nedim Ince
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Medical Center, University of Minnesota, Minneapolis, Minnesota Division of Infectious Diseases, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa Division of Hematology, Oncology and Bone Marrow Transplantation, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa and Department of Veterinary Microbiology, Iowa State University, Ames, Iowa
    Inflamm Bowel Dis 22:194-201. 2016
    ..Restoring microbiota through intestinal delivery of bacterial strains, helminths, fecal microbiota transplantation, or stool substitutes have the potential to improve and correct aberrant immune reactivity in various disorders. ..
  8. ncbi request reprint Immunologic and molecular mechanisms in inflammatory bowel disease
    M Nedim Ince
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa, Carver College of Medicine, 4611 JCP, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Surg Clin North Am 87:681-96. 2007
    ..Biologic agents that block inflammatory cytokines (anti-TNFalpha antibodies) have been used successfully to treat IBD. Recent advances have also identified mucosal regulatory pathways...