Mark R Hutchinson

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    ScientificWorldJournal 7:98-111. 2007
  2. ncbi request reprint Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Adelaide, South Australia, 5005, Australia
    Int Immunopharmacol 5:1713-22. 2005
  3. pmc Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia
    Mark R Hutchinson
    Department of Psychology, The Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1248-56. 2008
  4. pmc The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release
    Sondra T Bland
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:492-7. 2009
  5. pmc Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
  6. pmc Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains
    Liang Liu
    Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia
    Brain Behav Immun 25:1223-32. 2011
  7. pmc Evidence that opioids may have toll-like receptor 4 and MD-2 effects
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:83-95. 2010
  8. pmc Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice
    Yue Wu
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, South Australia, Australia
    Br J Pharmacol 165:1319-29. 2012
  9. pmc (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats
    Susannah S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, 80309 0345, USA
    J Pain 13:498-506. 2012
  10. pmc Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:240-50. 2009

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    ScientificWorldJournal 7:98-111. 2007
    ....
  2. ncbi request reprint Characterisation of the in vitro modulation of splenocyte proliferation by non-4,5-epoxymorphinan opioids
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Adelaide, South Australia, 5005, Australia
    Int Immunopharmacol 5:1713-22. 2005
    ..These data support the non-classical opioid nature of direct opioid modulation of splenocyte proliferation...
  3. pmc Minocycline suppresses morphine-induced respiratory depression, suppresses morphine-induced reward, and enhances systemic morphine-induced analgesia
    Mark R Hutchinson
    Department of Psychology, The Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1248-56. 2008
    ....
  4. pmc The glial activation inhibitor AV411 reduces morphine-induced nucleus accumbens dopamine release
    Sondra T Bland
    Department of Psychology and Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:492-7. 2009
    ..These results indicate that glial activation contributes to the effects of morphine on NAc DA, which is associated with somatic signs of precipitated withdrawal...
  5. pmc Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 22:1178-89. 2008
    ..These data implicate multiple opioid-induced spinal proinflammatory cytokines in opposing both acute and chronic opioid analgesia, and provide a novel mechanism for the opposition of acute opioid analgesia...
  6. pmc Naloxone-precipitated morphine withdrawal behavior and brain IL-1β expression: comparison of different mouse strains
    Liang Liu
    Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia 5005, Australia
    Brain Behav Immun 25:1223-32. 2011
    ..Moreover, this study demonstrated the advantages of utilizing multiple mouse strains and indicates that appropriate choice of mouse strains could enhance future research outcomes...
  7. pmc Evidence that opioids may have toll-like receptor 4 and MD-2 effects
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 24:83-95. 2010
    ..These data provide evidence that select opioids may non-stereoselectively influence TLR4 signaling and have behavioral consequences resulting, in part, via TLR4 signaling...
  8. pmc Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice
    Yue Wu
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, South Australia, Australia
    Br J Pharmacol 165:1319-29. 2012
    ..The aim of the current study was to determine whether TLR4-MyD88-dependent signalling is involved in the acute behavioural actions of alcohol and if alcohol can activate TLR4-downstream MAPK and NF-κB pathways...
  9. pmc (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats
    Susannah S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, 80309 0345, USA
    J Pain 13:498-506. 2012
    ..Additional, they provide further support for the TLR4 inhibitor (+)-naloxone as a novel candidate for the treatment of neuropathic pain...
  10. pmc Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 23:240-50. 2009
    ..Hence, suppression of glial proinflammatory responses can significantly reduce opioid withdrawal, while improving analgesia...
  11. pmc Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain
    Susannah S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 30:24-32. 2013
    ....
  12. doi request reprint Harnessing pain heterogeneity and RNA transcriptome to identify blood-based pain biomarkers: a novel correlational study design and bioinformatics approach in a graded chronic constriction injury model
    Peter M Grace
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    J Neurochem 122:976-94. 2012
    ..Future studies may demonstrate the predictive ability of these biomarker genes across other models and additional variables...
  13. doi request reprint Low-dose endotoxin potentiates capsaicin-induced pain in man: evidence for a pain neuroimmune connection
    Mark R Hutchinson
    Discipline of Physiology, School of Medical Sciences, University of Adelaide, Australia
    Brain Behav Immun 30:3-11. 2013
    ..Additionally, the simplicity of the model makes it suitable as a test-bed for novel immune-targeted pain therapeutics...
  14. pmc Morphine activates neuroinflammation in a manner parallel to endotoxin
    Xiaohui Wang
    Department of Chemistry and Biochemistry, Center for Neuroscience, and Biofrontiers Institute, University of Colorado at Boulder, Boulder, CO 80309, USA
    Proc Natl Acad Sci U S A 109:6325-30. 2012
    ..These results provide an exciting, nonconventional avenue to improving the clinical efficacy of opioids...
  15. doi request reprint Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment
    Yue Wu
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, SA, Australia
    Brain Behav Immun 25:S155-64. 2011
    ..Collectively these data suggest that alcohol is capable of rapid modification of proinflammatory immune signaling in the brain and this contributes significantly to the pharmacology of alcohol...
  16. doi request reprint Pathological pain and the neuroimmune interface
    Peter M Grace
    1 Department of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado Boulder, Boulder 80309 0345, USA 2 School of Medical Sciences, University of Adelaide, Adelaide 5005, Australia
    Nat Rev Immunol 14:217-31. 2014
    ..Given the prevalence of chronic pain and the incomplete efficacy of current drugs--which focus on suppressing aberrant neuronal activity--new strategies to manipulate neuroimmune pain transmission hold considerable promise...
  17. pmc Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)
    Mark R Hutchinson
    Department of Psychology and the Center for Neuroscience, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Eur J Neurosci 28:20-9. 2008
    ..Thus, these data suggest that (+)-opioid antagonists such as (+)-naloxone may be useful clinically to suppress glial activation, yet (-)-opioid agonists suppress pain...
  18. doi request reprint Adoptive transfer of peripheral immune cells potentiates allodynia in a graded chronic constriction injury model of neuropathic pain
    Peter M Grace
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide 5005, Australia
    Brain Behav Immun 25:503-13. 2011
    ..001), confirming that infiltrating immune cells are not passive bystanders, but actively contribute to nociceptive hypersensitivity in the lumbar spinal cord...
  19. pmc Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling
    Frances Corrigan
    Discipline of Anatomy and Pathology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Brain Behav Immun 45:245-52. 2015
    ....
  20. pmc Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
    Mark R Hutchinson
    Discipline of Pharmacology, School of Medical Science, University of Adelaide, South Australia, Australia, 5005
    Pharmacol Rev 63:772-810. 2011
    ..Novel pharmacological targets for future drug development are discussed in the hope that disease-modifying chronic pain treatments arising from the appreciation of opioid-induced central immune signaling may become practical...
  21. doi request reprint A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity
    Peter M Grace
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    J Neurosci Methods 193:47-53. 2010
    ..05, r(2)>0.9). DLF glial activation may represent a contributor to contralateral pain. Our novel graded model has a dynamic range, allowing sensitive detection of interactions and subtle influences on neuropathic pain processing...
  22. pmc The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia
    Linda R Watkins
    Department of Psychology and Neuroscience and The Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado USA
    Trends Pharmacol Sci 30:581-91. 2009
    ..Excitingly, with newly-established clinical trials of two glial modulators for treating neuropathic pain and improving the utility of opioids, translation from rats-to-humans now begins with the promise of improved clinical pain control...
  23. ncbi request reprint (S)-(+)-methadone is more immunosuppressive than the potent analgesic (R)-(--)-methadone
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Level 5, Medical School North, Frome Road, 5005, Adelaide, Australia
    Int Immunopharmacol 4:1525-30. 2004
    ..Moreover, the dose at which immune suppression occurred could be achieved clinically...
  24. ncbi request reprint Relationship between 4,5-epoxymorphinan structure and in vitro modulation of cell proliferation
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Frome Road, Adelaide 5005, South Australia, Australia
    Eur J Pharmacol 494:251-62. 2004
    ..A structure-effect relationship was developed and significant evidence for non-classical opioid receptor function on immune cells was concluded...
  25. pmc "Listening" and "talking" to neurons: implications of immune activation for pain control and increasing the efficacy of opioids
    Linda R Watkins
    Department of Psychology and Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res Rev 56:148-69. 2007
    ..Such changes in neuronal function would be expected to occur wherever immune-derived substances come in close contact with neurons...
  26. pmc Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain
    Lisa C Loram
    Department of Psychology and Center for Neurosciences, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    J Neurosci 29:14015-25. 2009
    ..Activation of A(2A)Rs after intrathecal administration may be a novel, therapeutic approach for the treatment of neuropathic pain by increasing IL-10 in the immunocompetent cells of the CNS...
  27. pmc Norman Cousins Lecture. Glia as the "bad guys": implications for improving clinical pain control and the clinical utility of opioids
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, Muenzinger D 244, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Behav Immun 21:131-46. 2007
    ....
  28. doi request reprint Glial Attenuation With Ibudilast in the Treatment of Medication Overuse Headache: A Double-Blind, Randomized, Placebo-Controlled Pilot Trial of Efficacy and Safety
    Jacinta L Johnson
    Discipline of Pharmacology, University of Adelaide, Adelaide, Australia
    Headache 55:1192-208. 2015
    ..We therefore hypothesized ibudilast would reduce headache burden and opioid analgesic requirements in patients with opioid overuse headache...
  29. pmc Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain
    Susannah S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA Electronic address
    Brain Behav Immun 44:128-36. 2015
    ....
  30. pmc TLR 2 and 4 responsiveness from isolated peripheral blood mononuclear cells from rats and humans as potential chronic pain biomarkers
    Yuen H Kwok
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 8:e77799. 2013
    ..Here we have used a human-to-rat and rat-to-human approach to further investigate whether peripheral blood immune responses to TLR agonists might be suitable for development as possible systems biomarkers of chronic pain in humans...
  31. doi request reprint The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro
    Yibai Li
    Discipline of Pharmacology, The University of Adelaide, South Australia, Australia
    Drug Metab Dispos 41:1264-72. 2013
    ..05). These results indicate a major role of CYP2B6 in ketamine N-demethylation in vitro and a significant impact of the CYP2B6*6 allele on enzyme-ketamine binding and catalytic activity...
  32. pmc CYP2D6 and CYP3A4 involvement in the primary oxidative metabolism of hydrocodone by human liver microsomes
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, Australia, 5005
    Br J Clin Pharmacol 57:287-97. 2004
    ....
  33. doi request reprint Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain
    Peter M Grace
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, SA 5005, Australia
    Brain Behav Immun 25:1322-32. 2011
    ....
  34. ncbi request reprint The effects of a single exposure to uncontrollable stress on the subsequent conditioned place preference responses to oxycodone, cocaine, and ethanol in rats
    Andre Der-Avakian
    Department of Psychology and Center for Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309 0345, USA
    Psychopharmacology (Berl) 191:909-17. 2007
    ..However, this persistent, trans-situational enhancement did not occur to amphetamine CPP...
  35. pmc Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions
    Catherine Joce
    Department of Chemistry and Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA
    Bioorg Med Chem Lett 20:5411-3. 2010
    ....
  36. pmc The cortical innate immune response increases local neuronal excitability leading to seizures
    Krista M Rodgers
    Department of Psychology and Neuroscience, University of Colorado, UCB 345, Boulder, CO 80309, USA
    Brain 132:2478-86. 2009
    ....
  37. ncbi request reprint Glia: novel counter-regulators of opioid analgesia
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Trends Neurosci 28:661-9. 2005
    ..New data suggest that glia also release neuroexcitatory substances in response to morphine, thereby opposing its effects. Controlling glial activation could therefore increase the clinical utility of analgesic drugs...
  38. doi request reprint Irinotecan-Induced Gastrointestinal Dysfunction and Pain Are Mediated by Common TLR4-Dependent Mechanisms
    Hannah R Wardill
    Discipline of Anatomy and Pathology, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, South Australia, Australia
    Mol Cancer Ther 15:1376-86. 2016
    ..Mol Cancer Ther; 15(6); 1376-86. ©2016 AACR. ..
  39. doi request reprint Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia
    Susannah S Lewis
    Department of Psychology and Neuroscience, University of Colorado, Boulder, USA
    Brain Behav Immun . 2016
    ....
  40. ncbi request reprint Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4
    RYAN BACHTELL
    Department of Psychology and Neuroscience, and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309 0345, USA
    CNS Neurol Disord Drug Targets 14:692-9. 2015
    ..Taken together, multiple lines of evidence converge to raise TLR4 as a promising therapeutic target for drug abuse. ..
  41. doi request reprint Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment
    Jacinta L Johnson
    Discipline of Pharmacology, University of Adelaide, Australia
    Cephalalgia 33:52-64. 2013
    ..Despite the prevalence and clinical impact of MOH, the pathophysiology behind this disorder remains unclear and specific mechanism-based treatment options are lacking...
  42. pmc The effects of pregabalin and the glial attenuator minocycline on the response to intradermal capsaicin in patients with unilateral sciatica
    Nicole M Sumracki
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    PLoS ONE 7:e38525. 2012
    ..No studies have investigated whether this pain model can screen for novel anti-neuropathic agents in patients with pre-existing neuropathic pain syndromes...
  43. doi request reprint Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence
    Janet K Coller
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, South Australia 5005, Australia
    Pharmacol Ther 134:219-45. 2012
    ....
  44. pmc CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects
    Yibai Li
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    Br J Clin Pharmacol 80:276-84. 2015
    ..Our aims were to examine the impact of the CYP2B6*6 allele on ketamine plasma clearance and on adverse effects in chronic pain patients...
  45. pmc Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth
    Peck Yin Chin
    Robinson Research Institute and Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia
    Sci Rep 6:36112. 2016
    ..Further studies are warranted to investigate the utility of small molecule inhibition of TLR-driven inflammation as a component of strategies for fetal protection and delaying preterm birth in the clinical setting...
  46. doi request reprint Novel imaging tools for investigating the role of immune signalling in the brain
    Jonathan Henry W Jacobsen
    School of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia ARC Centre of Excellence for Nanoscale BioPhotonics, Australia
    Brain Behav Immun 58:40-47. 2016
    ..Therefore, this review aims to convey emerging novel and complementary imaging technologies in a form accessible to medical scientists engaging in neuroimmune research...
  47. ncbi request reprint Ethnicity-dependent influence of innate immune genetic markers on morphine PCA requirements and adverse effects in postoperative pain
    Andrew A Somogyi
    aDiscipline of Pharmacology, School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia bDepartment of Clinical Pharmacology, Royal Adelaide Hospital, Adelaide, South Australia, Australia cKK Research Centre, KK Women s and Children s Hospital, Singapore dDepartment of Women s Anesthesia, KK Women s and Children s Hospital, Singapore ePaediatrics Academic Clinical Programme, Singhealth Duke NUS Graduate Medical School, Singapore fDiscipline of Physiology, School of Medicine, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia gAustralian Research Council Centre of Excellence for Nanoscale BioPhotonics, University of Adelaide, Adelaide, South Australia, Australia
    Pain 157:2458-2466. 2016
    ..0007) but not in the Malay or Indian cohorts. Innate immune genetics may contribute to variability in postsurgical opioid requirements in an ethnicity-dependent manner...
  48. pmc Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury
    Amanda Ellis
    University of Colorado Boulder, Department of Psychology and Neuroscience, Center for Neuroscience, Boulder, CO, USA
    Brain Behav Immun 58:348-356. 2016
    ..TLR4 initiates this phenomenon and, as such, may be potential therapeutic targets for preventing the deleterious effects of administering opioids after traumatic injury...
  49. doi request reprint Reduced response to the thermal grill illusion in chronic pain patients
    Nicole M Sumracki
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Pain Med 15:647-60. 2014
    ..The objective of this study was to investigate whether the response to the thermal grill illusion was tolerable in patients with chronic pain and whether the response differed between patients with chronic pain and pain-free volunteers...
  50. pmc Increased responsiveness of peripheral blood mononuclear cells to in vitro TLR 2, 4 and 7 ligand stimulation in chronic pain patients
    Yuen H Kwok
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 7:e44232. 2012
    ..These data demonstrate that PBMCs from chronic pain sufferers were more responsive to TLR agonists compared with controls, suggesting peripheral cells may have the potential to become a source of biomarkers for chronic pain...
  51. doi request reprint Exploring neuroinflammation as a potential avenue to improve the clinical efficacy of opioids
    Jacob Thomas
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    Expert Rev Neurother 12:1311-24. 2012
    ..This review will examine the nonclassic actions of opioids specifically appreciating the actions of the released immune products...
  52. doi request reprint Association of IL-1B genetic polymorphisms with an increased risk of opioid and alcohol dependence
    Liang Liu
    Discipline of Pharmacology, School of Medical Sciences, Faculty of Health Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Pharmacogenet Genomics 19:869-76. 2009
    ..To confirm a previous study, we also examined the association between the IL-1B genetic polymorphism and alcohol dependence...
  53. ncbi request reprint In vitro opioid induced proliferation of peripheral blood immune cells correlates with in vivo cold pressor pain tolerance in humans: a biological marker of pain tolerance
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, Level 5, Medical School North, University of Adelaide, Frome Rd, Adelaide, SA 5005, Australia
    Pain 110:751-5. 2004
    ..92, P < 0.0001). These pilot data provide evidence of a novel objective biological marker of pain tolerance in humans, which also links the immune and opioid systems with basal pain tolerance...
  54. pmc Portable optical fiber probe for in vivo brain temperature measurements
    Stefan Musolino
    ARC Centre of Excellence for Nanoscale BioPhotonics and Institute for Photonics and Advanced Sensing, Adelaide, SA 5005, Australia School of Medicine, The University of Adelaide, Adelaide, SA 5005, Australia
    Biomed Opt Express 7:3069-77. 2016
    ..This probe can be interrogated using a portable optical measurement setup, allowing for measurements to be performed outside of standard optical laboratories. ..
  55. doi request reprint Inflammatory mediators in mastitis and lactation insufficiency
    Wendy V Ingman
    Discipline of Surgery, School of Medicine, The Queen Elizabeth Hospital, University of Adelaide, Woodville, Australia
    J Mammary Gland Biol Neoplasia 19:161-7. 2014
    ....
  56. pmc Toll-like receptors in chronic pain
    Lauren Nicotra
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, South Australia, 5005, Australia
    Exp Neurol 234:316-29. 2012
    ..The influence possible sex differences in Toll-like receptor signaling have for female pain and the recognition of small molecule xenobiotics by Toll-like receptors will also be reviewed...
  57. ncbi request reprint Diacetylmorphine degradation to 6-monoacetylmorphine and morphine in cell culture: implications for in vitro studies
    Mark R Hutchinson
    Department of Clinical and Experimental Pharmacology, The University of Adelaide, Level 5, Medical School North, Frome Road, Adelaide, South Australia 5005, Australia
    Eur J Pharmacol 453:27-32. 2002
    ..The study highlights the limitations of conclusions made in previous studies which have not recognised diacetylmorphine instability...
  58. pmc A peptide antagonist of the TLR4-MD2 interaction
    Peter F Slivka
    Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Chembiochem 10:645-9. 2009
    ..We herein report a chemical biology approach by using a rationally designed peptide inhibitor to disrupt the TLR4-MD2 association, thereby blocking TLR4 signaling...
  59. doi request reprint A new metabotropic glutamate receptor agonist with in vivo anti-allodynic activity
    Nathan J Stanley
    Discipline of Chemistry, The University of Adelaide, Adelaide, Australia
    Bioorg Med Chem 18:6089-98. 2010
    ..In vitro binding assays at metabotropic glutamate receptors revealed selective activity. In vivo testing in a rodent model of neuropathic pain indicated one amino acid significantly and dose-dependently decreased mechanical allodynia...
  60. doi request reprint Chemotherapy-induced gut toxicity and pain: involvement of TLRs
    Rachel J Gibson
    Discipline of Anatomy and Pathology, School of Medicine, University of Adelaide, North Terrace, Adelaide, 5005, South Australia, Australia
    Support Care Cancer 24:2251-8. 2016
    ..This study examined the interaction between chemotherapy-induced gut toxicity and pain and related these to gut TLR and glial fibrillary acidic protein (GFAP) expression...
  61. doi request reprint Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy
    Jonathan Henry W Jacobsen
    Discipline of Physiology, School of Medicine, University of Adelaide, Adelaide, SA 5005, Australia ARC Centre for Nanoscale BioPhotonics, University of Adelaide, Adelaide, SA 5005, Australia
    Curr Opin Pharmacol 26:131-7. 2016
    ..The idea of receptor heteromerisation and receptor mosaics will be introduced to explain cross talk between the receptors and signalling molecules implicated in neuroimmune signalling pathways. ..
  62. doi request reprint Immune priming and experimental glaucoma: the effect of prior systemic lipopolysaccharide challenge on tissue outcomes after optic nerve injury
    Daniel S Narayan
    Ophthalmic Research Laboratories, South Australian Institute of Ophthalmology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia Department of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia
    Clin Experiment Ophthalmol 42:539-54. 2014
    ..The aim of the current work was to investigate whether microglial priming with lipopolysaccharide would exacerbate optic nerve injury in rats following experimental glaucoma...
  63. doi request reprint Toll-like receptor 4 regulates lipopolysaccharide-induced inflammation and lactation insufficiency in a mouse model of mastitis
    Danielle J Glynn
    School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, South Australia, Australia
    Biol Reprod 90:91. 2014
    ....
  64. doi request reprint Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction
    Jonathan Henry W Jacobsen
    Discipline of Pharmacology, School of Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia
    Int Rev Neurobiol 118:129-63. 2014
    ..As such, the aim of this chapter is to review and integrate the neuronal and central immune signaling perspective of addiction. ..
  65. pmc Why is neuroimmunopharmacology crucial for the future of addiction research?
    Mark R Hutchinson
    Discipline of Physiology, School of Medical Sciences, University of Adelaide, Level 5, Medical School South, Frome Rd, Adelaide, South Australia 5005, Australia Electronic address
    Neuropharmacology 76:218-27. 2014
    ..Such discoveries will point us in the direction such that one day soon we might successfully intervene to successfully treat drug addiction. This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  66. doi request reprint Role of microglia and toll-like receptor 4 in the pathophysiology of delirium
    Ryan Jalleh
    Discipline of Physiology, School of Medical Sciences, University of Adelaide, Adelaide, Australia
    Med Hypotheses 79:735-9. 2012
    ..We hypothesize that these drugs could be a novel pharmacotherapy that could significantly improve the outcome of post-operative delirious patients...
  67. ncbi request reprint Quantification of the O- and N-demethylated metabolites of hydrocodone and oxycodone in human liver microsomes using liquid chromatography with ultraviolet absorbance detection
    Andrew Menelaou
    Department of Clinical and Experimental Pharmacology, University of Adelaide, Australia
    J Chromatogr B Analyt Technol Biomed Life Sci 785:81-8. 2003
    ..These methods provide good precision, accuracy and sensitivity for use in in vitro kinetic studies investigating the oxidative metabolism of hydrocodone and oxycodone in human liver microsomes...
  68. ncbi request reprint Ibudilast (AV-411). A new class therapeutic candidate for neuropathic pain and opioid withdrawal syndromes
    Annemarie Ledeboer
    Avigen, Inc, Department of Preclinical Development, Alameda, CA 94502, USA
    Expert Opin Investig Drugs 16:935-50. 2007
    ..Thus ibudilast may improve opioid efficacy and is a promising therapeutic candidate for neuropathic pain, with a novel mechanism of action...