Julian G Hurdle

Summary

Affiliation: University of Texas at Arlington
Country: USA

Publications

  1. pmc Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
    Julian G Hurdle
    Department of Biology, University of Texas at Arlington, Arlington, Texas 76019, USA
    Nat Rev Microbiol 9:62-75. 2011
  2. pmc The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection
    Xiaoqian Wu
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA
    Can J Microbiol 60:251-4. 2014
  3. pmc Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile
    Mohammed Zahidul Alam
    Department of Biology, University of Texas at Arlington, Arlington, Texas, USA
    Antimicrob Agents Chemother 59:5165-70. 2015
  4. pmc Screening for a diamond in the rough
    Xiaoqian Wu
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA
    Chem Biol 20:1091-2. 2013
  5. pmc The membrane as a target for controlling hypervirulent Clostridium difficile infections
    Xiaoqian Wu
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA
    J Antimicrob Chemother 68:806-15. 2013

Collaborators

  • Alex J O'Neill
  • Xiaoqian Wu
  • Mohammed Zahidul Alam
  • Carmela Mascio
  • Laurent Chesnel
  • Richard E Lee
  • Philip T Cherian

Detail Information

Publications5

  1. pmc Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
    Julian G Hurdle
    Department of Biology, University of Texas at Arlington, Arlington, Texas 76019, USA
    Nat Rev Microbiol 9:62-75. 2011
    ..Despite some drawbacks, membrane-active agents form an important new means of eradicating recalcitrant, non-growing bacteria...
  2. pmc The Clostridium difficile proline racemase is not essential for early logarithmic growth and infection
    Xiaoqian Wu
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA
    Can J Microbiol 60:251-4. 2014
    ..difficile infection. These findings indicate that PrdF as well as other enzymes encoded by the proline reductase operon are all nonessential and are unsuitable targets for anti-C. difficile drug discovery. ..
  3. pmc Mode of action and bactericidal properties of surotomycin against growing and nongrowing Clostridium difficile
    Mohammed Zahidul Alam
    Department of Biology, University of Texas at Arlington, Arlington, Texas, USA
    Antimicrob Agents Chemother 59:5165-70. 2015
    ..These observations are consistent with surotomycin acting as a membrane-active antibiotic, exhibiting rapid bactericidal activities against growing and nongrowing C. difficile. ..
  4. pmc Screening for a diamond in the rough
    Xiaoqian Wu
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA
    Chem Biol 20:1091-2. 2013
    ....
  5. pmc The membrane as a target for controlling hypervirulent Clostridium difficile infections
    Xiaoqian Wu
    Department of Biology, University of Texas at Arlington, Arlington, TX 76019, USA
    J Antimicrob Chemother 68:806-15. 2013
    ..We investigated whether disrupting the functions of the clostridial membrane is an approach to control C. difficile infections by promptly removing growing and non-growing cells...