Thomas K Hunt

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Copper-induced vascular endothelial growth factor expression and wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 282:H1821-7. 2002
  2. ncbi request reprint Oxygen: at the foundation of wound healing--introduction
    Thomas K Hunt
    World J Surg 28:291-3. 2004
  3. ncbi request reprint Regulatory role of lactate in wound repair
    Q Perveen Ghani
    UCSF, Wound Healing Laboratory, San Francisco, California 94143 0522, USA
    Methods Enzymol 381:565-75. 2004
  4. ncbi request reprint Hyperoxia improves microvascular perfusion in a murine wound model
    Ahmad Y Sheikh
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Wound Repair Regen 13:303-8. 2005
  5. pmc Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
    Thomas K Hunt
    Wound Healing Laboratory, University of California San Francisco, San Francisco, California 94143 0522, USA
    Antioxid Redox Signal 9:1115-24. 2007
  6. doi request reprint Lactate, with oxygen, incites angiogenesis
    Thomas K Hunt
    Department of Surgery, University of California Medical Center, San Francisco, CA 94143, USA
    Adv Exp Med Biol 614:73-80. 2008
  7. ncbi request reprint Lactate stimulates endothelial cell migration
    Stefan Beckert
    Department of Surgery, University of California, San Francisco, California, USA, and Department of General Surgery, University Hospital Tubingen, Germany
    Wound Repair Regen 14:321-4. 2006
  8. ncbi request reprint Hyperoxia and angiogenesis
    Harriet W Hopf
    Wound Healing Research Laboratory, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    Wound Repair Regen 13:558-64. 2005
  9. ncbi request reprint Using physiology to improve surgical wound outcomes
    Christiane Ueno
    University of California, San Francisco, Wound Healing Laboratory, Departments of Anesthesia and Perioperative Care and Surgery, San Francisco, Calif 94143 0648, USA
    Plast Reconstr Surg 117:59S-71S. 2006
  10. ncbi request reprint Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing
    Odilo Trabold
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Wound Repair Regen 11:504-9. 2003

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Copper-induced vascular endothelial growth factor expression and wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Department of Surgery, 512 Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    Am J Physiol Heart Circ Physiol 282:H1821-7. 2002
    ..Copper-sensitive pathways regulate key mediators of wound healing such as angiogenesis and extracellular matrix remodeling. Copper-based therapeutics represents a feasible approach to promote dermal wound healing...
  2. ncbi request reprint Oxygen: at the foundation of wound healing--introduction
    Thomas K Hunt
    World J Surg 28:291-3. 2004
    ..A historical and evolutionary perspective on the role of oxygen in wound healing--from the classical physiology of oxygen in the wound to the refined concept of redox signaling--is presented...
  3. ncbi request reprint Regulatory role of lactate in wound repair
    Q Perveen Ghani
    UCSF, Wound Healing Laboratory, San Francisco, California 94143 0522, USA
    Methods Enzymol 381:565-75. 2004
  4. ncbi request reprint Hyperoxia improves microvascular perfusion in a murine wound model
    Ahmad Y Sheikh
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Wound Repair Regen 13:303-8. 2005
    ..05). Laser Doppler imaging was able to detect and quantify the increase in wound bed perfusion resulting from intermittent HBO treatments and shows promise as a noninvasive measure of angiogenesis and wound healing...
  5. pmc Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
    Thomas K Hunt
    Wound Healing Laboratory, University of California San Francisco, San Francisco, California 94143 0522, USA
    Antioxid Redox Signal 9:1115-24. 2007
    ..Accumulated lactate, therefore, appears to convey the impression of "metabolic need" for vascularization, even in well-oxygenated and pH-neutral conditions. Lactate and oxygen together stimulate angiogenesis and matrix deposition...
  6. doi request reprint Lactate, with oxygen, incites angiogenesis
    Thomas K Hunt
    Department of Surgery, University of California Medical Center, San Francisco, CA 94143, USA
    Adv Exp Med Biol 614:73-80. 2008
    ..This paper, a mini-review, is occasioned by new data showing increased presence of VEGF and angiogenesis in an oxygenated site by adding a slow-release source of lactate into Matrigel and implanting the Matrigel subcutaneously in mice...
  7. ncbi request reprint Lactate stimulates endothelial cell migration
    Stefan Beckert
    Department of Surgery, University of California, San Francisco, California, USA, and Department of General Surgery, University Hospital Tubingen, Germany
    Wound Repair Regen 14:321-4. 2006
    ..Lactate enhances VEGF production in endothelial cells, although lactate, itself, is not a chemoattractant. We conclude that the lactate-mediated increase in cellular migration is regulated by VEGF...
  8. ncbi request reprint Hyperoxia and angiogenesis
    Harriet W Hopf
    Wound Healing Research Laboratory, Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143, USA
    Wound Repair Regen 13:558-64. 2005
    ..We conclude that angiogenesis is proportional to ambient pO(2) over a wide range. This confirms the clinical impression that angiogenesis requires oxygen. Intermittent oxygen exposure can satisfy the need for oxygen in ischemic tissue...
  9. ncbi request reprint Using physiology to improve surgical wound outcomes
    Christiane Ueno
    University of California, San Francisco, Wound Healing Laboratory, Departments of Anesthesia and Perioperative Care and Surgery, San Francisco, Calif 94143 0648, USA
    Plast Reconstr Surg 117:59S-71S. 2006
    ..This article reviews how knowledge of and attention to physiology can improve quality of care in both acute and chronic wounds...
  10. ncbi request reprint Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing
    Odilo Trabold
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Wound Repair Regen 11:504-9. 2003
    ..The data are consistent with ADP-ribosylation effects and oxidant signaling. (WOUND REP REG 2003;11:504-509)..
  11. ncbi request reprint IGF-I-induced VEGF expression in HUVEC involves phosphorylation and inhibition of poly(ADP-ribose)polymerase
    Stefan Beckert
    Department of Surgery, School of Medicine, University of California, San Francisco, 94123, USA
    Biochem Biophys Res Commun 341:67-72. 2006
    ..The IGF-I-mediated phosphorylation and inhibition of PARP represent a novel mechanism of VEGF protein expression...
  12. ncbi request reprint Role of ADP-ribosylation in wound repair. The contributions of Thomas K. Hunt, MD
    Q Perveen Ghani
    Department of Preventive and Restorative Dental Sciences, University of California, San Francisco, California 94143, USA
    Wound Repair Regen 11:439-44. 2003
    ..Down-regulation of the ubiquitous protein modification reaction called ADP-ribosylation turned out to be a basic signal behind the role of lactate in wound healing...
  13. ncbi request reprint Development of subcutaneous wound oxygen measurement in humans: contributions of Thomas K Hunt, MD
    Harriet W Hopf
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143 0648, USA
    Wound Repair Regen 11:424-30. 2003
    ..All these observations required tissue oxygen measurement, and, in particular, translation of basic scientific observations to clinical research required a method of measuring wound oxygen tension in humans...
  14. ncbi request reprint Measuring oxygen in wounds
    Harriet W Hopf
    Department of Surgery, UCSF, Wound Healing Laboratory, San Francisco, California 94143 0522, USA
    Methods Enzymol 381:539-64. 2004
  15. doi request reprint The role of oxygen during fracture healing
    Chuanyong Lu
    Department of Orthopaedic Surgery, Orthopaedic Trauma Institute, San Francisco General Hospital, University of California at San Francisco, 1001 Potrero Ave, San Francisco, CA 94110, USA
    Bone 52:220-9. 2013
    ..In conclusion, our results indicate that environmental oxygen levels affect tissue vascularization and fracture healing, and that providing oxygen when fractures are accompanied by ischemia may be beneficial...
  16. ncbi request reprint Methods of measuring oxygen in wounds
    Harriet W Hopf
    Department of Anesthesia and Perioperative Care, Department of Surgery, University of California, San Francisco, CA, USA
    Methods Mol Med 78:389-416. 2003
  17. ncbi request reprint Accuracy of a polarographic electrode at high oxygen concentrations
    Mark D Rollins
    Bioengineering Graduate Group, University of California, San Francisco, CA, USA
    Adv Exp Med Biol 510:169-73. 2003
  18. pmc Lactate stimulates vasculogenic stem cells via the thioredoxin system and engages an autocrine activation loop involving hypoxia-inducible factor 1
    Tatyana N Milovanova
    Institute for Environmental Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6068, USA
    Mol Cell Biol 28:6248-61. 2008
    ..Oxidative stress from lactate metabolism by SPCs accelerated further SPC recruitment and differentiation through Trx1-mediated elevations in HIF-1 levels and the subsequent synthesis of HIF-1-dependent growth factors...
  19. ncbi request reprint Noninvasive assessment of wound-healing angiogenesis with contrast-enhanced MRI
    Thomas H Helbich
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California, San Francisco 94143 0628, USA
    Acad Radiol 9:S145-7. 2002
  20. ncbi request reprint Oxidant-induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing
    Chandan K Sen
    Laboratory of Molecular Medicine, Dorothy M Davis Heart and Lung Research Institute, Department of Surgery Center for Minimally Invasive Surgery, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 277:33284-90. 2002
    ..Taken together, the results of this study indicate that wound healing is subject to redox control...
  21. pmc Dermal wound healing is subject to redox control
    Sashwati Roy
    Laboratory of Molecular Medicine, Department of Surgery, Comprehensive Wound Center, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Mol Ther 13:211-20. 2006
    ..Taken together, this work presents the first in vivo evidence indicating that strategies to influence the redox environment of the wound site may have a bearing on healing outcomes...
  22. ncbi request reprint Oxygen: from the benefits of inducing VEGF expression to managing the risk of hyperbaric stress
    Viren Patel
    Laboratory of Molecular Medicine, Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Antioxid Redox Signal 7:1377-87. 2005
    ..This is of special concern for people with inadequate intake of dietary antioxidants. Nutritional antioxidant supplementation may offset HBO-induced oxidative stress...
  23. ncbi request reprint Comparison of inflammatory and systemic sources of growth factors in acute and chronic human wounds
    Silvia Wagner
    Department of General Surgery, University Hospital Tubingen, Germany
    Wound Repair Regen 11:253-60. 2003
    ..If blood IGF-I is low, wound levels are lower. This data suggests that healing impairment due to IGF-I deficiency can be readily detected and is, at least in part, easily and safely correctable...
  24. ncbi request reprint On squeezing blood out of turnips
    Thomas K Hunt
    Int J Low Extrem Wounds 4:130-1. 2005
  25. ncbi request reprint Significance of oxygen therapeutics
    Gayle M Gordillo
    Wound Repair Regen 11:393; author reply 393. 2003
  26. ncbi request reprint Correlation of a simple direct measurement of muscle pO(2) to a clinical ischemia index and histology in a rat model of chronic severe hindlimb ischemia
    Robert Paek
    Division of Vascular Surgery, Department of Surgery, University of California San Francisco, USA
    J Vasc Surg 36:172-9. 2002
    ..Our aim was to develop a model of clinically relevant severe limb ischemia and correlate a simple direct measurement of muscle pO(2) to a clinical ischemia index, muscle mass, and capillary density...
  27. ncbi request reprint Age-dependency of insulin-like growth factors, insulin-like growth factor-binding proteins, and acid labile subunit in plasma and wounds of surgical patients
    Corinna Wicke
    Department of Surgery, Pediatric Endocrinology Section of the Children s Hospital, and BG Trauma Center, University of Tubingen, Tubingen, Germany
    Wound Repair Regen 10:360-5. 2002
    ..The current data adds to accumulating evidence that a decline in the IGF system in aged patients contributes to the healing deficits observed in the elderly...
  28. ncbi request reprint Perflubron emulsion increases subcutaneous tissue oxygen tension in rats
    Noah A Rosen
    Department of Surgery, Boston University Medical Center, Boston, Massachusetts, USA
    Wound Repair Regen 14:55-60. 2006
    ..0 vol%. These findings agree with those results analytically predicted based on the oxygen solubility of the perflubron emulsion...
  29. ncbi request reprint Supplemental oxygen and risk of surgical site infection
    Harriet W Hopf
    JAMA 291:1956; author reply 1958-9. 2004
  30. ncbi request reprint Stimulation of fibroblast proliferation by lactate-mediated oxidants
    Silvia Wagner
    Department of General Surgery, University Hospital Tubingen, Medical Research Center ZMF, Waldhoernlestrasse 22, 72072 Tubingen, Germany
    Wound Repair Regen 12:368-73. 2004
    ..The antioxidants catalase and mannitol abolish the inhibitory effect of high lactate. We conclude from these results that increased proliferation of cultured human fibroblasts by exogenous lactate is mediated by oxidant production...