H David Humes

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc A biomimetic membrane device that modulates the excessive inflammatory response to sepsis
    Feng Ding
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 6:e18584. 2011
  2. doi request reprint The bioartificial kidney: current status and future promise
    H David Humes
    Innovative BioTherapies, Inc, 650 Avis Dr, Suite 300, Ann Arbor, MI, 48108, USA
    Pediatr Nephrol 29:343-51. 2014
  3. doi request reprint A selective cytopheretic inhibitory device to treat the immunological dysregulation of acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Blood Purif 29:183-90. 2010
  4. ncbi request reprint Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells
    H David Humes
    Department of Medicine, VA Medical Center, and University of Michigan, Ann Arbor, MI 48109 0644, USA
    Am J Kidney Dis 39:1078-87. 2002
  5. ncbi request reprint Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0726, USA
    Crit Care Med 31:2421-8. 2003
  6. ncbi request reprint Renal cell therapy in the treatment of patients with acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0726, USA
    Blood Purif 22:60-72. 2004
  7. pmc Cell-based approaches for the treatment of systemic inflammation
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Nephrol Dial Transplant 28:296-302. 2013
  8. doi request reprint Selective cytopheretic inhibitory device with regional citrate anticoagulation and portable sorbent dialysis
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Artif Organs 37:203-10. 2013
  9. pmc Renal cell therapy and beyond
    Joon Ho Song
    Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Semin Dial 22:603-9. 2009
  10. pmc Stem cell technology for the treatment of acute and chronic renal failure
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI 48108, USA
    Transl Res 156:161-8. 2010

Detail Information

Publications27

  1. pmc A biomimetic membrane device that modulates the excessive inflammatory response to sepsis
    Feng Ding
    Division of Nephrology, Huashan Hospital, Fudan University, Shanghai, China
    PLoS ONE 6:e18584. 2011
    ..The incorporation of the SCD along an extracorporeal blood circuit coupled with regional anticoagulation with citrate to lower blood ionized calcium was devised to modulate leukocyte activation in sepsis...
  2. doi request reprint The bioartificial kidney: current status and future promise
    H David Humes
    Innovative BioTherapies, Inc, 650 Avis Dr, Suite 300, Ann Arbor, MI, 48108, USA
    Pediatr Nephrol 29:343-51. 2014
    ....
  3. doi request reprint A selective cytopheretic inhibitory device to treat the immunological dysregulation of acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Mich, USA
    Blood Purif 29:183-90. 2010
    ..Evolving evidence suggests that the kidney, and specifically renal epithelial cells, plays an important role in the immunological response of leukocytes under disease states...
  4. ncbi request reprint Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells
    H David Humes
    Department of Medicine, VA Medical Center, and University of Michigan, Ann Arbor, MI 48109 0644, USA
    Am J Kidney Dis 39:1078-87. 2002
    ..With these results, clinical evaluation of this device in the treatment of severely ill patients with acute renal failure in an intensive care unit has been initiated...
  5. ncbi request reprint Cell therapy with a tissue-engineered kidney reduces the multiple-organ consequences of septic shock
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109 0726, USA
    Crit Care Med 31:2421-8. 2003
    ....
  6. ncbi request reprint Renal cell therapy in the treatment of patients with acute and chronic renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0726, USA
    Blood Purif 22:60-72. 2004
    ..Clinical trials in patients suffering from either ARF or ESRD are currently ongoing to evaluate the influence of the RAD on the inflammatory response in these groups of patients...
  7. pmc Cell-based approaches for the treatment of systemic inflammation
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Nephrol Dial Transplant 28:296-302. 2013
    ..Both of these unconventional strategies have shown early clinical efficacy in pilot clinical trials and may transform the therapeutic approach to organ failure disorders...
  8. doi request reprint Selective cytopheretic inhibitory device with regional citrate anticoagulation and portable sorbent dialysis
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Artif Organs 37:203-10. 2013
    ....
  9. pmc Renal cell therapy and beyond
    Joon Ho Song
    Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Semin Dial 22:603-9. 2009
    ..Both devices may become comprehensive treatments, replacing full renal function and correcting inflammatory imbalance in patients with acute and chronic renal disorders...
  10. pmc Stem cell technology for the treatment of acute and chronic renal failure
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI 48108, USA
    Transl Res 156:161-8. 2010
    ..In this review, current stem cell technologies including adult stem cells, embryonic stem cells and induced pluripotent stem cells will be discussed as cell sources for the treatment of acute and chronic renal failure...
  11. ncbi request reprint The future of renal support: high-flux dialysis to bioartificial kidneys
    Khajohn Tiranathanagul
    Department of Internal Medicine, University of Michigan Medical School, 4520 MSRB I, Box 0651, 1150 West Medical Center Drive, Ann Arbor, MI 48109, USA
    Crit Care Clin 21:379-94. 2005
    ....
  12. ncbi request reprint Advances in cell therapy for renal failure
    H David Humes
    Research and Development Division, Nephros Therapeutics Inc and Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0726, USA
    Transpl Immunol 12:219-27. 2004
    ..This review will focus on our group's use of human stem/progenitor cells in the treatment of acute and chronic renal failure as extensions to current successful renal substitution processes of hemodialysis and hemofiltration...
  13. doi request reprint The bioartificial kidney and bioengineered membranes in acute kidney injury
    Feng Ding
    Department of Internal Medicine, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Nephron Exp Nephrol 109:e118-22. 2008
    ..New developments in this translational research area will improve the unmet medical needs of patients with renal failure...
  14. ncbi request reprint Bioartificial kidney ameliorates gram-negative bacteria-induced septic shock in uremic animals
    William H Fissell
    Departments of Medicine, Veterans Administration Medical Center and The University of Michigan, Ann Arbor, Michigan, USA
    J Am Soc Nephrol 14:454-61. 2003
    ..These results demonstrate that the addition of cell therapy to hemofiltration in an acutely uremic animal model with septic shock ameliorates cardiovascular dysfunction, alters systemic cytokine balance, and improves survival time...
  15. pmc Stem cells: the next therapeutic frontier
    H David Humes
    Department of Internal Medicine, University of Michigan Medical School, 4520 MSRB I, Box 0651, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0726, USA
    Trans Am Clin Climatol Assoc 116:167-83; discussion 183-4. 2005
    ..This review will focus on our group's use of human stem/progenitor cells in the treatment of acute and chronic renal failure as extensions to the current successful renal substitution processes of hemodialysis and hemofiltration...
  16. doi request reprint The effect of the selective cytopheretic device on acute kidney injury outcomes in the intensive care unit: a multicenter pilot study
    James A Tumlin
    Department of Medicine, College of Medicine, University of Tennessee, Chattanooga, TN Department of Medicine, George Washington University, Washington, DC Department of Medicine, University of Alabama, Birmingham, AL Department of Medicine, University of California, San Diego, CA Department of Medicine, Mayo Clinic, Rochester, MN Department of Medicine, University of Texas, Houston, TX Department of Medicine, Cytopherx, Inc, Ann Arbor, MI Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI Department of Medicine, University of Michigan, Ann Arbor, MI
    Semin Dial 26:616-23. 2013
    ..The SCD warrants further study in scientifically sound, pivotal trial to demonstrate reasonable assurance of safety and effectiveness...
  17. ncbi request reprint Rare incorporation of bone marrow-derived cells into kidney after folic acid-induced injury
    Mark S Szczypka
    Research Division, Nephros Therapeutics Inc, Ann Arbor, Michigan, USA
    Stem Cells 23:44-54. 2005
    ..These results suggest that BMDCs may incorporate into glomeruli as specialized glomerular mesangial cells; however, BMDCs rarely contribute to the repair of renal tubules in uninjured or FA-treated mouse kidneys...
  18. ncbi request reprint Bioartificial kidney in the treatment of acute renal failure associated with sepsis
    Khajohn Tiranathanagul
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Nephrology (Carlton) 11:285-91. 2006
    ..The results to date of large animal studies and recent Phase I/II and Phase II clinical trials show that such a device replaces multiple kidney functions and modifies the sepsis condition to improve survival in ARF...
  19. ncbi request reprint Kidney epithelial cells
    Peter L Smith
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Methods Enzymol 419:194-207. 2006
    ....
  20. ncbi request reprint Bioartificial kidney alters cytokine response and hemodynamics in endotoxin-challenged uremic animals
    William H Fissell
    Department of Medicine, VA Medical Center and The University of Michigan, Ann Arbor, MI 48109, USA
    Blood Purif 20:55-60. 2002
    ....
  21. pmc Cell-based strategies for the treatment of kidney dysfunction: a review
    Christopher J Pino
    Innovative BioTherapies, Inc, Ann Arbor, MI 48108, USA
    Blood Purif 34:117-23. 2012
    ..In this review, both cell therapy and cell processing approaches will be discussed in the context of acute kidney injury and chronic renal disease...
  22. ncbi request reprint Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure
    H David Humes
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Kidney Int 66:1578-88. 2004
    ..An FDA-approved Phase I/II clinical trial on 10 patients has been completed, and demonstrated that this experimental treatment can be delivered safely for up to 24 hours...
  23. pmc Bioartificial Renal Epithelial Cell System (BRECS): A Compact, Cryopreservable Extracorporeal Renal Replacement Device
    Deborah A Buffington
    Innovative BioTherapies, Inc, Ann Arbor, MI, USA
    Cell Med 4:33-43. 2012
    ..This technology could be extended to administer other cell-based therapies where metabolic, regulatory, or secretion functions can be leveraged in an immunoisolated extracorporeal circuit...
  24. ncbi request reprint Differentiated growth of human renal tubule cells on thin-film and nanostructured materials
    William H Fissell
    Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI, USA
    ASAIO J 52:221-7. 2006
    ....
  25. ncbi request reprint Stem cell approaches for the treatment of renal failure
    James C Brodie
    Division of Nephrology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Pharmacol Rev 57:299-313. 2005
    ..Immunoisolation of heterologous cells by encapsulation creates opportunities for their safe use as a component of implanted or ex vivo devices...
  26. doi request reprint Substitution-free hemodiafiltration
    Kyungsoo Lee
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA
    ASAIO J 58:514-21. 2012
    ..In this article, substitution-free HDF strategies are reviewed in detail, with specific attention to technical aspects of the methodology, in vivo and in vitro efficacies, and applicability to clinical use...
  27. ncbi request reprint BKV and SV40 infection of human kidney tubular epithelial cells in vitro
    Jonathan Low
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Virology 323:182-8. 2004
    ..It was observed that the related polyomavirus SV40 is incapable of infecting human kidney epithelium except in the presence of the GM1 ganglioside, recently reported to be an SV40 receptor...