Molly A Hughes

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
    Matthew A Crawford
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    PLoS Pathog 6:e1001199. 2010
  2. ncbi request reprint Amebic liver abscess
    M A Hughes
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Infect Dis Clin North Am 14:565-82, viii. 2000
  3. pmc MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, P O Box 800513, Charlottesville, VA 22908, USA
    Infect Immun 73:7535-40. 2005
  4. pmc The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908 0466, USA
    J Leukoc Biol 86:1111-8. 2009
  5. ncbi request reprint Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 127:113-20. 2003
  6. pmc Escherichia coli Pyruvate Dehydrogenase Complex Is an Important Component of CXCL10-Mediated Antimicrobial Activity
    Kirsten M Schutte
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA
    Infect Immun 84:320-8. 2015
  7. pmc Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:17159-64. 2011
  8. pmc Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Infect Immun 77:1664-78. 2009
  9. pmc Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis
    Stacy J Park
    Department of Microbiology, University of Virginia, Charlottesville, 22908, USA
    J Immunol 182:4306-12. 2009
  10. pmc CXCL10 Acts as a Bifunctional Antimicrobial Molecule against Bacillus anthracis
    Katie R Margulieux
    Division of Infectious Diseases, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    MBio 7:. 2016

Research Grants

Collaborators

Detail Information

Publications12

  1. pmc Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
    Matthew A Crawford
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    PLoS Pathog 6:e1001199. 2010
    ..anthracis infection, as well as infections caused by pathogenic and potentially, multi-drug resistant bacteria including other spore-forming organisms...
  2. ncbi request reprint Amebic liver abscess
    M A Hughes
    Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Infect Dis Clin North Am 14:565-82, viii. 2000
    ..This article reviews epidemiologic features, pathophysiology, clinical features, diagnostic tests, imaging studies, treatment of amebic liver abscess, and prevention measures...
  3. pmc MyD88-dependent signaling contributes to protection following Bacillus anthracis spore challenge of mice: implications for Toll-like receptor signaling
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, P O Box 800513, Charlottesville, VA 22908, USA
    Infect Immun 73:7535-40. 2005
    ..We conclude that, although recognition of B. anthracis occurs via TLR2, additional MyD88-dependent pathways contribute to the host innate immune response to anthrax infection...
  4. pmc The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908 0466, USA
    J Leukoc Biol 86:1111-8. 2009
    ..In this review, we present data supporting the critical role these cells play in the pathogenesis of pulmonary fibrosis...
  5. ncbi request reprint Identification of Entamoeba histolytica thiol-specific antioxidant as a GalNAc lectin-associated protein
    Molly A Hughes
    Department of Internal Medicine, Division of Infectious Diseases, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Mol Biochem Parasitol 127:113-20. 2003
    ..Recruitment of TSA by the GalNAc lectin suggests a novel mechanism of parasite defense against reactive oxygen intermediates generated by host peripheral mononuclear cells...
  6. pmc Escherichia coli Pyruvate Dehydrogenase Complex Is an Important Component of CXCL10-Mediated Antimicrobial Activity
    Kirsten M Schutte
    Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, Virginia, USA
    Infect Immun 84:320-8. 2015
    ..To our knowledge, this is the first description of PDHc as a key bacterial component involved in the antibacterial effect of a chemokine. ..
  7. pmc Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:17159-64. 2011
    ....
  8. pmc Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Infect Immun 77:1664-78. 2009
    ..anthracis infection as well as infections caused by other spore-forming organisms...
  9. pmc Early NK cell-derived IFN-{gamma} is essential to host defense in neutropenic invasive aspergillosis
    Stacy J Park
    Department of Microbiology, University of Virginia, Charlottesville, 22908, USA
    J Immunol 182:4306-12. 2009
    ..Taken together, these data indicate that NK cells are the main source of early IFN-gamma in the lungs in neutropenic invasive aspergillosis, and this is an important mechanism in the defense against this infection...
  10. pmc CXCL10 Acts as a Bifunctional Antimicrobial Molecule against Bacillus anthracis
    Katie R Margulieux
    Division of Infectious Diseases, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    MBio 7:. 2016
    ..The FtsE/X-independent mechanism involves membrane depolarization by CXCL10, likely because of its ╬▒-helix. These findings present a new paradigm for understanding mechanisms by which CXCL10 and related chemokines kill bacteria...
  11. pmc Genome Sequences of Multidrug-Resistant, Colistin-Susceptible and -Resistant Klebsiella pneumoniae Clinical Isolates from Pakistan
    Matthew A Crawford
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Genome Announc 4:. 2016
    ..Here, we report the complete genome sequences of 10 MDR, colistin-susceptible and -resistant K. pneumoniae clinical isolates obtained in Pakistan between 2010 and 2013...
  12. ncbi request reprint Identification and characterization of an Entamoeba histolytica upstream regulatory element 3 sequence-specific DNA-binding protein containing EF-hand motifs
    C A Gilchrist
    Departments of Internal Medicine, Microbiology, and Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 276:11838-43. 2001
    ..Characterization of URE3-BP should provide insight into transcription regulation and virulence control in this parasite...

Research Grants2

  1. Identification of E. histolytica virulence factors
    Molly Hughes; Fiscal Year: 2004
    ..Successful completion of these studies will yield a fundamental understanding of amebic proteins that interact with the E. histolytica GalNAc lectin and their role in pathogenicity. ..
  2. Studies on Macrophage Resistance to Anthrax Lethal Toxin
    Molly Hughes; Fiscal Year: 2004
    ..Successful completion of these studies will yield a fundamental understanding of mechanisms of macrophage resistance to LT. ..