Inna Hughes

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses
    Belen Hurle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Evol Biol 11:23. 2011
  2. pmc Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members
    Inna Hughes
    Department of Developmental Biology, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Evol Biol 8:41. 2008
  3. pmc Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Rm 3902 South Building Campus Box 8103, Washington University in St Louis, School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res 1091:58-74. 2006
  4. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
  5. pmc Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:12023-8. 2007
  6. pmc Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 276:391-402. 2004
  7. pmc The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function
    Hongtao Wang
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:1523-38. 2010

Collaborators

Detail Information

Publications7

  1. pmc Lineage-specific evolution of the vertebrate Otopetrin gene family revealed by comparative genomic analyses
    Belen Hurle
    Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Evol Biol 11:23. 2011
    ....
  2. pmc Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members
    Inna Hughes
    Department of Developmental Biology, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Evol Biol 8:41. 2008
    ..Vertebrate Otop1 and its paralogues Otop2 and Otop3 define a new gene family with homology to the invertebrate Domain of Unknown Function 270 genes (DUF270; pfam03189)...
  3. pmc Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Rm 3902 South Building Campus Box 8103, Washington University in St Louis, School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res 1091:58-74. 2006
    ....
  4. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
    ..These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear...
  5. pmc Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:12023-8. 2007
    ..In a physiologic setting, these activities could direct the formation and growth of otoconia and regulate other biomineralization processes...
  6. pmc Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 276:391-402. 2004
    ..These studies demonstrate that Otop1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith...
  7. pmc The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function
    Hongtao Wang
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:1523-38. 2010
    ..Thus, changes in GDNF expression can create a wide variety of alterations in ENS structure and function and may in part contribute to human motility disorders...