Ziwei Huang

Summary

Affiliation: University of Illinois
Country: USA

Publications

  1. ncbi request reprint Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor
    Jing An
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 279:19133-40. 2004
  2. ncbi request reprint Structure, function and modulation of chemokine receptors: members of the g-protein-coupled receptor superfamily
    Ziwei Huang
    Department of Biochemistry, School of Molecular and Cellular Biology, University of Illinois at Urbana Champaign, 61801, USA
    Mini Rev Med Chem 2:373-83. 2002
  3. pmc A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochemistry 51:7078-86. 2012
  4. pmc Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine
    Dongxiang Liu
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Virol 81:11489-98. 2007
  5. ncbi request reprint Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand
    Chang Zhi Dong
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Med Chem 48:7923-4. 2005
  6. pmc Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1α probed by a novel synthetically and modularly modified-chemokine analog
    Chang Zhi Dong
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Exp Biol Med (Maywood) 236:1413-9. 2011
  7. ncbi request reprint SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development
    Santosh Kumar
    Department of Biochemistry, University of Illinois at Urbana Champaign, 61801, USA
    Chem Biol 13:69-79. 2006
  8. pmc Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues
    Chang Zhi Dong
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochemistry 51:5951-7. 2012
  9. ncbi request reprint Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 282:7154-63. 2007
  10. ncbi request reprint Crystal structure of chemically synthesized vMIP-II
    Ying Li
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Proteins 67:243-6. 2007

Collaborators

  • Jing An
  • Santosh Kumar
  • Joseph G Sodroski
  • Jun Wang
  • Ying Li
  • Bin Yang
  • Yan Xu
  • M Kaul
  • Stuart Lipton
  • D D Richman
  • Guy Salvesen
  • M Milella
  • Marcin Drag
  • J C Reed
  • Dongxiang Liu
  • Chang Zhi Dong
  • Won Tak Choi
  • Shaomin Tian
  • Navid Madani
  • Youli Wang
  • Rong Cao
  • Xiaofeng Han
  • Jian Yuan
  • Dayong Zhai
  • Sutapa Ghosh
  • Zhihong Zeng
  • Mayuko Mori
  • Muhammad Z Khan
  • James Pesavento
  • Naiming Zhou
  • Hirohito Yamaguchi
  • Srinivas Duggineni
  • Arnold C Satterthwait
  • Chaofang Jin
  • MI YOUN LIM
  • Luke A Pallansch
  • Caroline R Lefebure
  • Yi Gui Gao
  • Scott Wilson
  • I M Krishna Kumar
  • Sameer P Kawatkar
  • Julie D Russell
  • Adam Chervin
  • Mark Munsell
  • Ismael J Samudio
  • Elihu Estey
  • Michael Andreeff
  • Marina Konopleva
  • Aihua Nie
  • Renato Brandimarti
  • Alessandro Fatatis
  • Olimpia Meucci
  • Jeegar P Patel
  • Nha Huynh
  • Jiansong Luo
  • Xuejun Fan
  • Xiaobing Han
  • Hong Gang Wang
  • Kapil N Bhalla
  • Michael W Lee
  • Megumi Hiraoka
  • Zhaowen Luo
  • Mark Cayabyab
  • Shanthi R Paranawithana
  • Hideko Kaji

Detail Information

Publications26

  1. ncbi request reprint Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor
    Jing An
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 279:19133-40. 2004
    ..The involvement of endoplasmic reticulum and mitochondrial signals suggests both organelles are crucial for HA14-1-induced apoptosis...
  2. ncbi request reprint Structure, function and modulation of chemokine receptors: members of the g-protein-coupled receptor superfamily
    Ziwei Huang
    Department of Biochemistry, School of Molecular and Cellular Biology, University of Illinois at Urbana Champaign, 61801, USA
    Mini Rev Med Chem 2:373-83. 2002
    ..These studies demonstrate a paradigm for exploring and controlling membrane protein-protein interactions...
  3. pmc A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochemistry 51:7078-86. 2012
    ..The development of this bivalent ligand provides a tool for further probing the functions of CXCR4 dimerization and studying CXCR4 heterodimerization with other receptors...
  4. pmc Crystal structure and structural mechanism of a novel anti-human immunodeficiency virus and D-amino acid-containing chemokine
    Dongxiang Liu
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Virol 81:11489-98. 2007
    ....
  5. ncbi request reprint Different stereochemical requirements for CXCR4 binding and signaling functions as revealed by an anti-HIV, D-amino acid-containing SMM-chemokine ligand
    Chang Zhi Dong
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Med Chem 48:7923-4. 2005
    ....
  6. pmc Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1α probed by a novel synthetically and modularly modified-chemokine analog
    Chang Zhi Dong
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Exp Biol Med (Maywood) 236:1413-9. 2011
    ....
  7. ncbi request reprint SMM-chemokines: a class of unnatural synthetic molecules as chemical probes of chemokine receptor biology and leads for therapeutic development
    Santosh Kumar
    Department of Biochemistry, University of Illinois at Urbana Champaign, 61801, USA
    Chem Biol 13:69-79. 2006
    ..These results support the concept of SMM-chemokines for studying and controlling the function of other chemokine receptors...
  8. pmc Critical role in CXCR4 signaling and internalization of the polypeptide main chain in the amino terminus of SDF-1α probed by novel N-methylated synthetically and modularly modified chemokine analogues
    Chang Zhi Dong
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochemistry 51:5951-7. 2012
    ....
  9. ncbi request reprint Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 282:7154-63. 2007
    ....
  10. ncbi request reprint Crystal structure of chemically synthesized vMIP-II
    Ying Li
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Proteins 67:243-6. 2007
  11. ncbi request reprint Oligomerization of BH4-truncated Bcl-x(L) in solution
    Youli Wang
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 361:1006-11. 2007
    ..NDelta61-Bcl-x(L)-CDelta21 also loses its heterodimerization capability with the BH3 peptide derived from Bak. This newly acquired property might be linked to its ability to induce apoptosis in cells...
  12. ncbi request reprint Design and synthesis of novel chemokine analogs derived from vMIP-II
    Jun Wang
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Protein Pept Lett 13:499-501. 2006
    ..This demonstrates the feasibility of using this synthetic method to generate de novo designed protein ligand molecules to study the biology and pharmacology of chemokine receptors...
  13. ncbi request reprint The chemical biology of apoptosis. Exploring protein-protein interactions and the life and death of cells with small molecules
    Ziwei Huang
    Departments of Biochemistry and Chemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801
    Chem Biol 9:1059-72. 2002
    ..The review of these studies highlights the opportunity and challenge in this emerging area of chemical and chemical biological research...
  14. ncbi request reprint Synthesis and helical structure of lactam bridged BH3 peptides derived from pro-apoptotic Bcl-2 family proteins
    Bin Yang
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Bioorg Med Chem Lett 14:1403-6. 2004
    ..Furthermore, the synthetic method for lactam bridge incorporation reported here may find application in studies of other helical structures and development of helix mimics...
  15. pmc Unique ligand binding sites on CXCR4 probed by a chemical biology approach: implications for the design of selective human immunodeficiency virus type 1 inhibitors
    Won Tak Choi
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Virol 79:15398-404. 2005
    ....
  16. pmc Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains
    Shaomin Tian
    Departments of Biochemistry, University of Illnois at Urbana Champaign, 61801, USA
    J Virol 79:12667-73. 2005
    ..Taken together, our first detailed characterization of the different functional roles of CXCR4 TM domains may suggest a mechanistic basis for the discovery of new selective anti-HIV agents...
  17. ncbi request reprint A chemical strategy to promote helical peptide-protein interactions involved in apoptosis
    Dongxiang Liu
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Bioorg Med Chem Lett 15:4467-9. 2005
    ..This finding may point to a new strategy for studying and mimicking helical peptide-protein interactions involved in apoptosis...
  18. ncbi request reprint NMR structures of anti-HIV D-peptides derived from the N-terminus of viral chemokine vMIP-II
    Mayuko Mori
    Department of Biochemistry, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Biochem Biophys Res Commun 335:651-8. 2005
    ..The NMR structures of the d-peptides provide a structural basis to understand their mechanism of action and design new peptidomimetic analogs to further explore the structure-activity relationship of d-peptide ligand binding to CXCR4...
  19. pmc Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1
    Dayong Zhai
    Burnham Institute for Medical Research, 10901 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Biol Chem 283:9580-6. 2008
    ..Altogether, the findings reveal striking distinctions in the behaviors of Bcl-B and Mcl-1 relative to the other anti-apoptotic Bcl-2 family members, where Bcl-B and Mcl-1 display reciprocal abilities to bind and neutralize Bax and Bak...
  20. ncbi request reprint Synergistic induction of apoptosis by simultaneous disruption of the Bcl-2 and MEK/MAPK pathways in acute myelogenous leukemia
    Michele Milella
    Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Blood 99:3461-4. 2002
    ..These findings show that the Bcl-2 and MAPK pathways are relevant molecular targets in AML and that their concurrent inhibition could be developed into a new therapeutic strategy for this disease...
  21. ncbi request reprint Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells
    Hirohito Yamaguchi
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 62:466-71. 2002
    ..The enhanced cytotoxicity of EpoB by blocking Bcl-2 at mitochondria implies a potential application of the combination of EpoB and Bcl-2 antagonists in the treatment of human breast cancer...
  22. ncbi request reprint Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Marcin Drag
    Apoptosis and Cell Death Research Program, Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Biochem J 409:461-9. 2008
    ..We also show that SENP6 and 7 have an unexpected specificity that distinguishes them from other members of the family, implying that, in contrast to previous predictions, their natural substrate(s) may not be SUMO conjugates...
  23. ncbi request reprint Structure-based virtual screening of chemical libraries for drug discovery
    Sutapa Ghosh
    The Burnham Institute for Medical Research, La Jolla, CA 92037, USA
    Curr Opin Chem Biol 10:194-202. 2006
    ....
  24. ncbi request reprint Exploring the stereochemistry of CXCR4-peptide recognition and inhibiting HIV-1 entry with D-peptides derived from chemokines
    Naiming Zhou
    Kimmel Cancer Center and the Department of Biochemistry, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 277:17476-85. 2002
    ..Further studies to understand the mechanism of this unusual feature of the CXCR4 binding surface might aid the development of novel CXCR4-binding molecules like the d-peptides that have high affinity and stability...
  25. pmc Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis
    Muhammad Z Khan
    Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania 19102, USA
    AIDS Res Hum Retroviruses 20:1063-71. 2004
    ..These findings have important implications for our understanding of CXCR4-mediated responses in the CNS, as well as the role of this coreceptor in HIV neuropathogenesis...
  26. ncbi request reprint Inhibition of CXCR4 with the novel RCP168 peptide overcomes stroma-mediated chemoresistance in chronic and acute leukemias
    Zhihong Zeng
    Department of Blood and Marrow Transplantation, Section of Molecular Hematology and Therapy, Unit 448, 1515 Holcombe Boulevard, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 5:3113-21. 2006
    ..Disruption of these interactions by the peptide CXCR4 inhibitor RCP168 represents a novel strategy for targeting leukemic cells within the bone marrow microenvironment...