Sung Cheng Huang

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Investigation of a new input function validation approach for dynamic mouse microPET studies
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, USA
    Mol Imaging Biol 6:34-46. 2004
  2. pmc An internet-based "kinetic imaging system" (KIS) for MicroPET
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California in Los Angeles, CA 90095, USA
    Mol Imaging Biol 7:330-41. 2005
  3. ncbi request reprint Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
    Kooresh Shoghi-Jadid
    Division of Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 10:24-35. 2002
  4. ncbi request reprint Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
  5. ncbi request reprint 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease
    Eric D Agdeppa
    Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:404-17. 2003
  6. pmc Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Rm B2 085E CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 37:575-88. 2010
  7. ncbi request reprint Imaging beta-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization
    Kooresh Shoghi-Jadid
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1766, USA
    Nucl Med Biol 32:337-51. 2005
  8. ncbi request reprint Selective metabolic reduction in gray matter acutely following human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 21:149-61. 2004
  9. pmc Movement correction method for human brain PET images: application to quantitative analysis of dynamic 18F-FDDNP scans
    Mirwais Wardak
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6948, USA
    J Nucl Med 51:210-8. 2010
  10. ncbi request reprint Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 44:1709-16. 2003

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Investigation of a new input function validation approach for dynamic mouse microPET studies
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, USA
    Mol Imaging Biol 6:34-46. 2004
    ..We introduced the theoretical basis and used computer simulations to show the capability of a new approach that requires only a small number of blood samples per mouse but uses multiple animals...
  2. pmc An internet-based "kinetic imaging system" (KIS) for MicroPET
    Sung Cheng Huang
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California in Los Angeles, CA 90095, USA
    Mol Imaging Biol 7:330-41. 2005
    ..KIS is designed for biology/pharmaceutical scientists to make learning and applying tracer kinetics fun and easy...
  3. ncbi request reprint Localization of neurofibrillary tangles and beta-amyloid plaques in the brains of living patients with Alzheimer disease
    Kooresh Shoghi-Jadid
    Division of Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA, USA
    Am J Geriatr Psychiatry 10:24-35. 2002
    ..0007). This noninvasive technique for monitoring AP and NFT development is expected to facilitate diagnostic assessment of patients with AD and assist in response-monitoring during experimental treatments...
  4. ncbi request reprint Acute changes in regional cerebral (18)F-FDG kinetics in patients with traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6948, USA
    J Nucl Med 45:775-83. 2004
    ..The purpose of this study was to characterize contusional, pericontusional, and remote regions of TBI by estimating glucose transporter and hexokinase activities on the basis of (18)F-FDG kinetic modeling...
  5. ncbi request reprint 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease
    Eric D Agdeppa
    Department of Molecular and Medical Pharmacology, Laboratory of Structural Biology and Molecular Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:404-17. 2003
    ..Therefore it is anticipated that a new vision for prevention, early diagnosis and treatment of Alzheimer's disease would be rapidly developing...
  6. pmc Quantitative analysis of [18F]FDDNP PET using subcortical white matter as reference region
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Rm B2 085E CHS, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Eur J Nucl Med Mol Imaging 37:575-88. 2010
    ..Subcortical white matter is known to be relatively unaffected by amyloid deposition in Alzheimer's disease (AD). We investigated the use of subcortical white matter as a reference region to quantify [(18)F]FDDNP binding in the human brain...
  7. ncbi request reprint Imaging beta-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization
    Kooresh Shoghi-Jadid
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1766, USA
    Nucl Med Biol 32:337-51. 2005
    ....
  8. ncbi request reprint Selective metabolic reduction in gray matter acutely following human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA Brain Injury Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 21:149-61. 2004
    ..There was a selective CMRglc reduction in cortical GM following TBI. The pathophysiological basis for the reduction in GM-to-WM CMRglc ratio seen on FDG-PET imaging following TBI remains to be determined...
  9. pmc Movement correction method for human brain PET images: application to quantitative analysis of dynamic 18F-FDDNP scans
    Mirwais Wardak
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 6948, USA
    J Nucl Med 51:210-8. 2010
    ....
  10. ncbi request reprint Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 44:1709-16. 2003
    ..Therefore, thalamic and brain stem CMRglc may have a closer correlation than does the cerebral cortex with depth of coma after TBI...
  11. ncbi request reprint 18F-fluorothymidine kinetics of malignant brain tumors
    Christiaan Schiepers
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, AR 144 CHS 10833 Le Conte Avenue, Los Angeles, CA 90095 6942, USA
    Eur J Nucl Med Mol Imaging 34:1003-11. 2007
    ..18F-labeled deoxy-fluorothymidine (FLT), a marker of cellular proliferation, has been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were investigated...
  12. ncbi request reprint Visualizing pathology deposits in the living brain of patients with Alzheimer's disease
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Methods Enzymol 412:144-60. 2006
    ..In contrast, control subjects have uniformly low levels of [F-18]FDDNP binding in all areas, which is comparable to that of cerebellum...
  13. pmc Serotonin 1A receptors in the living brain of Alzheimer's disease patients
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 103:702-7. 2006
    ....
  14. pmc Discriminant analysis of ¹⁸F-fluorothymidine kinetic parameters to predict survival in patients with recurrent high-grade glioma
    Mirwais Wardak
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Clin Cancer Res 17:6553-62. 2011
    ....
  15. doi request reprint Kinetics of 3'-deoxy-3'-18F-fluorothymidine during treatment monitoring of recurrent high-grade glioma
    Christiaan Schiepers
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 6942, USA
    J Nucl Med 51:720-7. 2010
    ..3'-Deoxy-3'-(18)F-fluorothymidine ((18)F-FLT) is used as a biomarker of cell proliferation. We investigated the kinetics of (18)F-FLT during treatment of malignant glioma with bevacizumab and irinotecan...
  16. pmc Postmortem 3-D brain hemisphere cortical tau and amyloid-β pathology mapping and quantification as a validation method of neuropathology imaging
    Lojze M Smid
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:261-74. 2013
    ..This work offers a mapping brain model applicable to all imaging probes for verification of imaging results with Aβ and/or tau neuropathology brain distribution using immunohistochemistry, fluorescence microscopy, and autoradiography...
  17. ncbi request reprint Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, UCLA DOE Center for Molecular Medicine, Los Angeles, CA 90095, USA
    Mol Imaging Biol 5:32-41. 2003
    ....
  18. ncbi request reprint Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury after human traumatic brain injury
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095 6901, USA
    Neurosurgery 55:1306-15; discussio 1316-7. 2004
    ..The objective was to determine the nature, extent, and degree of metabolic abnormalities in subcortical brain regions remote from hemorrhagic lesions...
  19. ncbi request reprint In vivo brain imaging of tangle burden in humans
    Gary W Small
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA, USA
    J Mol Neurosci 19:323-7. 2002
    ....
  20. pmc Regional distribution of SGLT activity in rat brain in vivo
    Amy S Yu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Cell Physiol 304:C240-7. 2013
    ..The expression of SGLTs in the brain raises questions about the potential effects of SGLT inhibitors under development for the treatment of diabetes...
  21. pmc Comparative evaluation of Logan and relative-equilibrium graphical methods for parametric imaging of dynamic [18F]FDDNP PET determinations
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroimage 60:241-51. 2012
    ..In this work, we have characterized a relative-equilibrium-based (RE) graphical method against the Logan analysis for parametric imaging and region-of-interest (ROI) analysis...
  22. doi request reprint PET of brain prion protein amyloid in Gerstmann-Sträussler-Scheinker disease
    Vladimir Kepe
    David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 6948, USA
    Brain Pathol 20:419-30. 2010
    ....
  23. doi request reprint Tight glycemic control increases metabolic distress in traumatic brain injury: a randomized controlled within-subjects trial
    Paul Vespa
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Crit Care Med 40:1923-9. 2012
    ..To determine the effects of tight glycemic control on brain metabolism after traumatic brain injury using brain positron emission tomography and microdialysis...
  24. ncbi request reprint Perceived loss of memory ability and cerebral metabolic decline in persons with the apolipoprotein E-IV genetic risk for Alzheimer disease
    Linda Ercoli
    Department of Psychiatry, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 90024, USA
    Arch Gen Psychiatry 63:442-8. 2006
    ..Concerns about age-related memory loss are greater in persons who have the apolipoprotein E-IV (APOE4) genetic risk for Alzheimer disease, but the correlation between the degree of concerns and future cerebral metabolic decline is unknown...
  25. ncbi request reprint In vivo quantitation of glucose metabolism in mice using small-animal PET and a microfluidic device
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 6948, USA
    J Nucl Med 48:837-45. 2007
    ..Difficulties associated with the conventional blood-sampling procedure need to be overcome to facilitate the full use of this technique in mice...
  26. pmc Blood flow, flow reserve, and glucose utilization in viable and nonviable myocardium in patients with ischemic cardiomyopathy
    Xiaoli Zhang
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095 6948, USA
    Eur J Nucl Med Mol Imaging 40:532-41. 2013
    ..The aim of the study was to determine whether glucose uptake in viable myocardium of ischemic cardiomyopathy patients depends on rest myocardial blood flow (MBF) and the residual myocardial flow reserve (MFR)...
  27. ncbi request reprint Exploring a mathematical model for the kinetics of beta-amyloid molecular imaging probes through a critical analysis of plaque pathology
    Kooresh Shoghi-Jadid
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 8:151-62. 2006
    ..The bias may be partially overcome through evaluation in conjunction with other measures of AD progression including cerebral glucose metabolism rate, neuronal cell loss, and activated inflammatory presence...
  28. pmc Noninvasive measurement of cardiovascular function in mice with high-temporal-resolution small-animal PET
    Michael C Kreissl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California, USA
    J Nucl Med 47:974-80. 2006
    ..The aim of this study was to explore the feasibility of determining parameters of cardiovascular function in mice noninvasively by high-temporal-resolution imaging with a dedicated small-animal PET system...
  29. ncbi request reprint A semi-automated workflow solution for multimodal neuroimaging: application to patients with traumatic brain injury
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Brain Inform 3:1-15. 2016
    ..The proposed workflow solution is applied to dynamic PET scanning with 15O-water (0-10 min) and 18F-FDDNP (0-6 min) for measuring cerebral blood flow in patients with TBI...
  30. pmc First-Pass Angiography in Mice Using FDG-PET: A Simple Method of Deriving the Cardiovascular Transit Time Without the Need of Region-of-Interest Drawing
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 USA
    IEEE Trans Nucl Sci 52:1311-1315. 2005
    ..20; r = 0.76). We expect that this fast and robust method is applicable to the pathophysiology of cardiovascular diseases using small animal models such as rats and mice...
  31. pmc A semi-automated workflow solution for multimodal neuroimaging: application to patients with traumatic brain injury
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA USA
    Brain Inform 3:1-15. 2016
    ..The proposed workflow solution is applied to dynamic PET scanning with 15O-water (0-10 min) and 18F-FDDNP (0-6 min) for measuring cerebral blood flow in patients with TBI...
  32. pmc Estimation of the 18F-FDG input function in mice by use of dynamic small-animal PET and minimal blood sample data
    Gregory Z Ferl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 6948, USA
    J Nucl Med 48:2037-45. 2007
    ..We sought to develop a method for plasma time-activity curve estimation based on a model of tracer kinetics in blood, muscle, and liver...
  33. ncbi request reprint Accuracy of a method using short inhalation of (15)O-O(2) for measuring cerebral oxygen extraction fraction with PET in healthy humans
    Naoya Hattori
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Nucl Med 45:765-70. 2004
    ..The purpose of this study was to test the accuracy of the short-inhalation technique for estimating OEF in healthy human volunteers...
  34. ncbi request reprint 18F-FDOPA kinetics in brain tumors
    Christiaan Schiepers
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    J Nucl Med 48:1651-61. 2007
    ..Evaluation of tumor recurrence in neurooncology is another application. Here, the kinetics of (18)F-FDOPA in brain tumors were investigated...
  35. pmc Redefining the pericontusional penumbra following traumatic brain injury: evidence of deteriorating metabolic derangements based on positron emission tomography
    Hsiao Ming Wu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 7039, USA
    J Neurotrauma 30:352-60. 2013
    ..68) with time after injury. A large proportion (%area: 22-76%) of pericontusional hypodense GM tissue had CMRO2 values less than 35 μmol/100 g/min, with this percentage increased with time after injury...
  36. pmc Influence of dietary state and insulin on myocardial, skeletal muscle and brain [F]-fluorodeoxyglucose kinetics in mice
    Michael C Kreissl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    EJNMMI Res 1:8. 2011
    ..We evaluated the effect of insulin stimulation and dietary changes on myocardial, skeletal muscle and brain [(18)F]-fluorodeoxyglucose (FDG) kinetics and uptake in vivo in intact mice...
  37. pmc Prediction of cognitive decline based on hemispheric cortical surface maps of FDDNP PET
    Hillary D Protas
    Department of Biomathematics, David Geffen School of Medicine at UCLA, CA 90095, USA
    Neuroimage 61:749-60. 2012
    ....
  38. doi request reprint Phase I, first-in-human study of BMS747158, a novel 18F-labeled tracer for myocardial perfusion PET: dosimetry, biodistribution, safety, and imaging characteristics after a single injection at rest
    Jamshid Maddahi
    Department of Molecular and Medical Pharmacology Nuclear Medicine, David Geffen School of Medicine at University of California, Los Angeles, California 90095 7064, USA
    J Nucl Med 52:1490-8. 2011
    ....
  39. pmc Amyloid-β positron emission tomography imaging probes: a critical review
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, CA 90095, USA
    J Alzheimers Dis 36:613-31. 2013
    ....
  40. pmc PET imaging of neuropathology in tauopathies: progressive supranuclear palsy
    Vladimir Kepe
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 6948, USA
    J Alzheimers Dis 36:145-53. 2013
    ..In this work, we evaluate in vivo [18F]FDDNP labeling of brain neuropathology, primarily tau fibrillar aggregates, in patients with progressive supranuclear palsy (PSP), a human tauopathy usually lacking amyloid-β deposits...
  41. ncbi request reprint Semiautomated analysis of small-animal PET data
    Adam L Kesner
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6942, USA
    J Nucl Med 47:1181-6. 2006
    ..The objective of the work reported here was to develop and test automated methods to calculate biodistribution of PET tracers using small-animal PET images...
  42. pmc [F-18]FDDNP microPET imaging correlates with brain Aβ burden in a transgenic rat model of Alzheimer disease: effects of aging, in vivo blockade, and anti-Aβ antibody treatment
    Edmond Teng
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurobiol Dis 43:565-75. 2011
    ..These results corroborate previous analyses of [F-18]FDDNP PET imaging in clinical populations...
  43. pmc Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis
    Tomo o Ishikawa
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    Mol Oncol 4:119-25. 2010
    ....
  44. pmc Functional expression of SGLTs in rat brain
    Amy S Yu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, Universityof California Los Angeles, California 90095 1751, USA
    Am J Physiol Cell Physiol 299:C1277-84. 2010
    ..4-FDG PET imaging also established that this BBB-permeable SGLT tracer now offers a functional imaging approach in humans to assess regulation of SGLT activity in health and disease...
  45. doi request reprint 1-11C-acetate kinetics of prostate cancer
    Christiaan Schiepers
    Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 6942, USA
    J Nucl Med 49:206-15. 2008
    ..1-(11)C-Labeled acetate, a substrate for the citric acid cycle, is superior. The kinetics of prostate tumors were investigated...
  46. pmc Effects of administration route, dietary condition, and blood glucose level on kinetics and uptake of 18F-FDG in mice
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Nucl Med 52:800-7. 2011
    ..The effects of dietary condition and blood glucose level on the kinetics and uptake of (18)F-FDG in mice were systematically investigated using intraperitoneal and tail-vein injection...
  47. pmc Depression and anxiety symptoms are associated with cerebral FDDNP-PET binding in middle-aged and older nondemented adults
    Helen Lavretsky
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095 9668, USA
    Am J Geriatr Psychiatry 17:493-502. 2009
    ....
  48. pmc ¹⁸F-FLT    and ¹⁸F-FDOPA PET kinetics in recurrent brain tumors
    Mirwais Wardak
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Los Angeles, CA, 90095 6948, USA
    Eur J Nucl Med Mol Imaging 41:1199-209. 2014
    ....
  49. pmc Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study
    Paul Vespa
    1David Geffen School of Medicine at UCLA, UCLA Medical Center, University of California, Los Angeles, 90095, USA
    J Cereb Blood Flow Metab 25:763-74. 2005
    ..001), but not with OEF or CvO(2). Traumatic brain injury leads to a state of persistent metabolic crisis as reflected by abnormal cerebral microdialysis LPR that is not related to ischemia...
  50. ncbi request reprint Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression
    Sanjaya Saxena
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 300 UCLA Medical Plaza, Room 2229, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 59:250-61. 2002
    ....
  51. pmc Automated VOI Analysis in FDDNP PET Using Structural Warping: Validation through Classification of Alzheimer's Disease Patients
    Moses Q Wilks
    Department of Biomathematics, David Geffen School of Medicine at UCLA, Box 951766, Los Angeles, CA 90095, USA
    Int J Alzheimers Dis 2012:512069. 2012
    ..This suggests that this automated method can remove variance in measurements of PET data and can facilitate accurate, high-throughput image analysis...
  52. doi request reprint Dissecting molecular mechanisms in the living brain of dementia patients
    Jorge R Barrio
    Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    Acc Chem Res 42:842-50. 2009
    ....
  53. ncbi request reprint Inverse consistent mapping in 3D deformable image registration: its construction and statistical properties
    Alex Leow
    Rm 4238, 710 Westwood Plaza, Loni, UCLA School of Medicine, USA
    Inf Process Med Imaging 19:493-503. 2005
    ..Statistically significant differences were detected between consistent versus inconsistent matching when permutation tests were performed on the resulting deformation maps...
  54. pmc Revisiting the physiological roles of SGLTs and GLUTs using positron emission tomography in mice
    Monica Sala-Rabanal
    The Department of Physiology and the Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA
    J Physiol 594:4425-38. 2016
    ..This work provides further support for the use of SGLT imaging in the investigation of the role of SGLT transporters in human physiology and diseases such as diabetes and cancer...
  55. pmc Improved derivation of input function in dynamic mouse [18F]FDG PET using bladder radioactivity kinetics
    Koon Pong Wong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Mol Imaging Biol 15:486-96. 2013
    ....
  56. pmc Titration of variant HSV1-tk gene expression to determine the sensitivity of 18F-FHBG PET imaging in a prostate tumor
    Mai Johnson
    Department of Molecular, Cellular and Integrative Physiology, UCLA, Los Angeles, CA, USA
    J Nucl Med 50:757-64. 2009
    ..Addressing this question could determine the sensitivity of vector-mediated sr39tk PET in cancer-targeting strategies...
  57. pmc Quantification of cerebral glucose metabolic rate in mice using 18F-FDG and small-animal PET
    Amy S Yu
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 6948, USA
    J Nucl Med 50:966-73. 2009
    ..The feasibility of using the image-derived liver time-activity curve as a surrogate input function in various quantification methods was also evaluated...
  58. pmc Derivation of a compartmental model for quantifying 64Cu-DOTA-RGD kinetics in tumor-bearing mice
    Gregory Z Ferl
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, California 90095 6948, USA
    J Nucl Med 50:250-8. 2009
    ..To better understand the PET signal obtained with radiolabeled RGD peptides, we have constructed a compartmental model that can describe the time-activity curves in tumors after an intravenous injection...
  59. pmc Improved modeling of in vivo kinetics of slowly diffusing radiotracers for tumor imaging
    Moses Q Wilks
    Department of Biomathematics, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, California and Department of Molecular and Medical Pharmacology, David Geffen School of Medicine the University of California Los Angeles, Los Angeles, California
    J Nucl Med 55:1539-44. 2014
    ..In this work, we investigate the effects of subvoxel spatial heterogeneity on measured time-activity curves in PET imaging and the effects of ignoring diffusion limitation on parameter estimates from kinetic modeling...
  60. pmc A semi-automated technique determining the liver standardized uptake value reference for tumor delineation in FDG PET-CT
    Kenji Hirata
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 9:e105682. 2014
    ..We propose a semi-automated algorithm to objectively determine liver standardized uptake value (SUV), which is used as a threshold for tumor delineation...
  61. pmc Unexpected expression pattern for glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) in mouse tissues revealed by positron emission tomography scanning
    Tove Olafsen
    Department of Molecular and Medical Pharmacology, California NanoSystems Institute, Los Angeles, California 90095, USA
    J Biol Chem 285:39239-48. 2010
    ..In support of this concept, lung LPL levels were significantly lower in Gpihbp1(-/-) mice than in Gpihbp1(+/+) mice. In addition, Lpl(-/-) mice expressing human LPL exclusively in muscle contained high levels of human LPL in the lung...
  62. ncbi request reprint Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small-animal positron emission tomograph
    Takashi Kudo
    Crump Institute for Molecular Imaging, Laboratory of Structural Biology and Molecular Medicine and Department of Molecular and Medical Pharmacology, UCLA School of Medicine, University of California at Los Angeles, 90095 1735, USA
    Circulation 106:118-23. 2002
    ..We explored the feasibility of measuring regional tracer activity concentrations and flow defects in myocardium of rats with a high spatial resolution small-animal PET system (microPET)...
  63. ncbi request reprint Improved parametric image generation using spatial-temporal analysis of dynamic PET studies
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Neuroimage 15:697-707. 2002
    ..NLRRSC provided a reliable estimate of glucose metabolite uptake rate with a comparable image quality compared to Patlak analysis. In conclusion, NLRRSC is a reliable and robust parametric imaging algorithm for dynamic PET studies...
  64. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
  65. ncbi request reprint A least-squares error minimization approach in the determination of ferric ion diffusion coefficient of Fricke-infused dosimeter gels
    Y J Tseng
    Institute of Biomedical Engineering, University Systems of Taiwan National Yang Ming University, Pei Tou, Taipei, Taiwan, Republic of China
    Med Phys 32:1017-23. 2005
    ....