Genomes and Genes
Wen Chi Hsueh
Affiliation: University of California
- Diabetes risk assessment in Mexicans and Mexican Americans: effects of parental history of diabetes are modified by adiposity levelHector E Velasco Mondragon
Morgan State University, Baltimore, Maryland, USA
Diabetes Care 33:2260-5. 2010..Whether this relationship is affected by other known risk factors, specifically obesity, remains unclear, possibly due to a relative paucity of lean diabetic patients...
- A genome-wide linkage scan of insulin level derived traits: the Amish Family Diabetes StudyWen Chi Hsueh
Department of Medicine, School of Medicine, University of California, San Francisco, California, USA
Diabetes 56:2643-8. 2007..The goal of our study was to identify chromosomal regions that are likely to harbor genetic determinants of these traits...
- Replication and extension of association between common genetic variants in SIM1 and human adiposityMichael M Swarbrick
Diabetes Center and Department of Medicine, University of California, San Francisco, California, USA
Obesity (Silver Spring) 19:2394-403. 2011..In white males, rs4072568 in ARNT2 was also associated with BMI (P = 9 × 10(-4)) and % body fat (P = 0.001). Our findings implicate heritable defects of the SIM1-ARNT2 axis in the predisposition to human obesity...
- A common variant in the telomerase RNA component is associated with short telomere lengthOmer T Njajou
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 5:e13048. 2010....
- Variation in the lamin A/C gene: associations with metabolic syndromeNanette I Steinle
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Arterioscler Thromb Vasc Biol 24:1708-13. 2004..To determine whether polymorphisms in LMNA influence susceptibility to metabolic syndrome and its constituent components...
- Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition StudyOmer T Njajou
University of California, San Francisco, CA 94143 0794, USA
Diabetes Metab Res Rev 25:733-9. 2009..We examined the relationship between oxLDL, and T2D- and obesity-related traits in a bi-racial sample of 2985 subjects at baseline and after 7 years of follow-up...
- The association of cataract with leukocyte telomere length in older adults: defining a new marker of agingJason L Sanders
Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pennsylvania, USA
J Gerontol A Biol Sci Med Sci 66:639-45. 2011..47, 95% confidence interval 0.22-1.02) after adjustment. Lens transparency might be associated with longer LTL in community-dwelling older adults and should be investigated further as a possible biomarker of aging...
- Telomere length is paternally inherited and is associated with parental lifespanOmer T Njajou
Department of Medicine and Institute of Human Genetics, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 104:12135-9. 2007..Our data, which are based on one of the largest family studies of human TL, support a link between TL and aging and lifespan and suggest a strong genetic influence, possibly via an imprinting mechanism, on TL regulation...
- The genetics of human longevityWarren S Browner
California Pacific Medical Center Research Institute, San Francisco, California 94115, USA
Am J Med 117:851-60. 2004..Despite the challenges in study design and analysis that face investigators in this area, the identification of genetic pathways that regulate longevity may suggest potential targets for therapy...
- Cumulative inflammatory load is associated with short leukocyte telomere length in the Health, Aging and Body Composition StudyAoife O'Donovan
Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e19687. 2011..However, in spite of the proposed causal links between inflammatory activity and LTL, there is little clinical evidence in support of their covariation and interaction...
- Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition StudyDonglei Hu
Department of Medicine, University of California at San Francisco, San Francisco, California, USA
J Am Geriatr Soc 57:1213-8. 2009..To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults...
- Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC StudyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California, San Francisco, CA 94143, USA
Neurobiol Aging 32:2055-60. 2011..There was a borderline statistically significant interaction for telomere length and APOE e4 on 3MS change score (p=0.06). Thus, telomere length may serve as a biomarker for cognitive aging...
- Habitual sleep/wake patterns in the Old Order Amish: heritability and association with non-genetic factorsDaniel S Evans
Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
Sleep 34:661-9. 2011..We sought to evaluate the contribution of genetic and non-genetic factors on habitual sleep/wake patterns in a community-dwelling agrarian population using a physical activity monitoring device, the Actical...
- Leukocyte Telomere Length Is Not Associated With BMD, Osteoporosis, or Fracture in Older Adults: Results From the Health, Aging and Body Composition StudyJason L Sanders
Medical Scientist Training Program, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Bone Miner Res 24:1531-6. 2009..TL is not associated with BMD, osteoporosis, or fracture in older men or women in this sample...
- Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition studyChristina L Wassel Fyr
Department of Epidemiology, University of Minnesota, Minneapolis, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 1015, USA
Hum Genet 121:615-24. 2007..The association with adiponectin became stronger after adjustment for adiposity. These novel findings suggest that admixture mapping may identify genetic factors influencing the levels of IL-6 SR, CRP, IL-2 SR, and adiponectin...
- Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regionsDaniel S Evans
California Pacific Medical Center Research Institute, San Francisco, California, United States of America
PLoS ONE 9:e96805. 2014..The identification of a putative insulator in this region could help to explain the challenges faced in this study and others to link SNPs associated with adiposity to altered MC4R expression. ..
- Association between telomere length, specific causes of death, and years of healthy life in health, aging, and body composition, a population-based cohort studyOmer T Njajou
Departments of Medicine and Institute for Human Genetics, 513 Parnassus Street, HSE 672, University of California, San Francisco, San Francisco, CA 94143 0794, USA
J Gerontol A Biol Sci Med Sci 64:860-4. 2009..TL, however, was positively associated with more YHL (beta = 0.08 +/- 0.04, p = .03). Findings suggest that TL may not be a strong biomarker of survival in older individuals, but it may be an informative biomarker of healthy aging...
- Direct determination of haplotypes from single DNA moleculesMing Xiao
Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Nat Methods 6:199-201. 2009..We demonstrate the utility of this technology by accurately determining the haplotypes consisting of up to 16 single-nucleotide polymorphisms in genomic regions up to 50 kilobases...
- TOR signaling never gets old: aging, longevity and TORC1 activityDaniel S Evans
Department of Medicine, University of California, San Francisco, United States
Ageing Res Rev 10:225-37. 2011..We discuss the potential impact of manipulating TOR activity for human health and lifespan...
- Association of common genetic variation in the insulin/IGF1 signaling pathway with human longevityLudmila Pawlikowska
Department of Anesthesia and Perioperative Care, University of California, San Francisco, USA
Aging Cell 8:460-72. 2009..35, 95%CI = 1.15-1.57, adjusted P = 0.0093). These results demonstrate that common variants in several genes in the insulin/IGF1 pathway are associated with human lifespan...
- Familial aggregation of nutrient intake and physical activity: results from the San Antonio Family Heart StudyBraxton D Mitchell
Department of Medicine, University of Maryland School of Medicine, Baltimore 21201, USA
Ann Epidemiol 13:128-35. 2003..To evaluate the extent to which levels of physical activity and nutrient intake aggregate in families, and secondarily, to assess the repeatability of these behavioral measures over a 5-year period...
- Lack of support for the association between GAD2 polymorphisms and severe human obesityMichael M Swarbrick
Diabetes Center, University of California, San Francisco, California, USA
PLoS Biol 3:e315. 2005....
- Genome-wide and fine-mapping linkage studies of type 2 diabetes and glucose traits in the Old Order Amish: evidence for a new diabetes locus on chromosome 14q11 and confirmation of a locus on chromosome 1q21-q24Wen Chi Hsueh
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas, USA
Diabetes 52:550-7. 2003..07, P = 0.000085 for HbA(1c) and LOD = 1.50 for glucose 0). In conclusion, our findings provide evidence that type 2 diabetes susceptibility genes reside on chromosomes 1, 14, and 18...
- The genetics of obesity in Mexican Americans: the evidence from genome scanning efforts in the San Antonio family heart studyAnthony G Comuzzie
Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245, USA
Hum Biol 75:635-46. 2003..Here, we summarize the latest results from our ongoing efforts to identify obesity genes in the San Antonio Family Heart Study...
- A genome-wide scan of serum lipid levels in the Old Order AmishToni I Pollin
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
Atherosclerosis 173:89-96. 2004....
- Family history of type 2 diabetes is associated with increased carotid artery intimal-medial thickness in Mexican AmericansW H Linda Kao
Department of Epidemiology, Bloomberg School of Public Health, John s Hopkins University, Baltimore, Maryland, USA
Diabetes Care 28:1882-9. 2005..To evaluate whether the joint risk of diabetes and atherosclerosis tracked within families, we assessed the correlation between a family history of diabetes and intimal-medial thickness (IMT) of the common carotid artery (CCA)...
- Meta-analysis of genome-wide linkage studies of quantitative lipid traits in families ascertained for type 2 diabetesAlka Malhotra
Diabetes and Obesity Research Unit, Genetic Basis of Human Disease, Translational Genomics Research Institute, 445 N 5th Street, Phoenix, AZ 85004, USA
Diabetes 56:890-6. 2007....
- Meta-analysis of 23 type 2 diabetes linkage studies from the International Type 2 Diabetes Linkage Analysis ConsortiumWeihua Guan
Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
Hum Hered 66:35-49. 2008..The International Type 2 Diabetes Linkage Analysis Consortium was formed to localize type 2 diabetes predisposing variants based on 23 autosomal linkage scans...
- Eating behavior in the Old Order Amish: heritability analysis and a genome-wide linkage analysisNanette I Steinle
University of Maryland School of Medicine, Baltimore 21201, USA
Am J Clin Nutr 75:1098-106. 2002..Eating behavior and thus dietary intake affect the development of obesity-related diseases such as diabetes, hypertension, and hyperlipidemia...
- Diurnal Preference in Amish FamiliesWen Chi Hsueh; Fiscal Year: 2007..This proposed family study in a genetically homogeneous founder population with an "old-fashioned" life style provides a unique opportunity to study diurnal preference in a large and free-living human population. ..
- Genetic Epidemiology of Telomere Length in the AmishWen Chi Hsueh; Fiscal Year: 2008..Such knowledge may also aid in the development of regenerative medicine, cultured tissue transplantation, and stem cell therapeutics. ..