David B Hoyt

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint A twelve-year analysis of disease and provider complications on an organized level I trauma service: as good as it gets?
    David B Hoyt
    Division of Trauma, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 54:26-36; discussion 36-7. 2003
  2. ncbi request reprint The predictive value of field versus arrival Glasgow Coma Scale score and TRISS calculations in moderate-to-severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, California 92103 8676, USA
    J Trauma 60:985-90. 2006
  3. ncbi request reprint The impact of safety belt use on liver injuries in motor vehicle crashes: the importance of motor vehicle safety systems
    Troy Lisa Holbrook
    Division of Trauma, Department of Surgery, University of California, San Diego, California 92103 8896, USA
    J Trauma 63:300-6. 2007
  4. doi request reprint Air medical response to traumatic brain injury: a computer learning algorithm analysis
    Daniel P Davis
    Divisions of Trauma, University of California, San Diego, California, USA
    J Trauma 64:889-97. 2008
  5. ncbi request reprint Head-injured patients who "talk and die": the San Diego perspective
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, CA 92103 8676, USA
    J Trauma 62:277-81. 2007
  6. ncbi request reprint LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression
    Raul Coimbra
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, 200 W Arbor Drive, San Diego, CA 92103 8896, USA
    J Trauma 60:115-25. 2006
  7. ncbi request reprint Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation
    Jessica Deree
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California School of Medicine, CA, USA
    J Trauma 62:818-27; discussion 827-8. 2007
  8. pmc Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury
    Wolfgang G Junger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School and Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria Defence Research and Development Canada, Toronto Research Centre and Departments of Surgery and Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada and American College of Surgeons, Department of Surgery, University of California, Irvine, California
    Shock 40:366-74. 2013
  9. ncbi request reprint The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
    J Trauma 57:1-8; discussion 8-10. 2004
  10. ncbi request reprint Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 59:575-82. 2005

Detail Information

Publications82

  1. ncbi request reprint A twelve-year analysis of disease and provider complications on an organized level I trauma service: as good as it gets?
    David B Hoyt
    Division of Trauma, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 54:26-36; discussion 36-7. 2003
    ..The annual incidence of complications in a trauma population has been previously reported but the frequency change over time in a single institution is not well studied...
  2. ncbi request reprint The predictive value of field versus arrival Glasgow Coma Scale score and TRISS calculations in moderate-to-severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, California 92103 8676, USA
    J Trauma 60:985-90. 2006
    ..This study explores the predictive value of field GCS (fGCS) and arrival GCS (aGCS) as well as TRISS calculations using field (fTRISS) and arrival (aTRISS) data in patients with moderate-to-severe traumatic brain injury (TBI)...
  3. ncbi request reprint The impact of safety belt use on liver injuries in motor vehicle crashes: the importance of motor vehicle safety systems
    Troy Lisa Holbrook
    Division of Trauma, Department of Surgery, University of California, San Diego, California 92103 8896, USA
    J Trauma 63:300-6. 2007
    ..In the unstable patient, early detection of LI based on clinical suspicion will improve acute trauma care and outcomes. The specific objectives of this analysis are to identify crash scene and occupant risk factors for LI from MVC...
  4. doi request reprint Air medical response to traumatic brain injury: a computer learning algorithm analysis
    Daniel P Davis
    Divisions of Trauma, University of California, San Diego, California, USA
    J Trauma 64:889-97. 2008
    ..Learning algorithms, such as artificial neural networks (ANN), support vector machines (SVM), and decision trees, can identify relationships between data set variables but are not empirically useful for hypothesis testing...
  5. ncbi request reprint Head-injured patients who "talk and die": the San Diego perspective
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, CA 92103 8676, USA
    J Trauma 62:277-81. 2007
    ..This study uses a large, comprehensive database to explore risk factors for head-injured patients who deteriorate after their initial presentation...
  6. ncbi request reprint LPS-induced acute lung injury is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression
    Raul Coimbra
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, 200 W Arbor Drive, San Diego, CA 92103 8896, USA
    J Trauma 60:115-25. 2006
    ..We postulated that PTX treatment in acute endotoxemia downregulates the inflammatory response and may decrease lung injury...
  7. ncbi request reprint Hypertonic saline and pentoxifylline attenuates gut injury after hemorrhagic shock: the kinder, gentler resuscitation
    Jessica Deree
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California School of Medicine, CA, USA
    J Trauma 62:818-27; discussion 827-8. 2007
    ....
  8. pmc Prehospital hypertonic saline resuscitation attenuates the activation and promotes apoptosis of neutrophils in patients with severe traumatic brain injury
    Wolfgang G Junger
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School and Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria Defence Research and Development Canada, Toronto Research Centre and Departments of Surgery and Critical Care Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada and American College of Surgeons, Department of Surgery, University of California, Irvine, California
    Shock 40:366-74. 2013
    ..Since hypertonic fluids can inhibit PMN activation, we studied whether hypertonic fluid resuscitation can reduce excessive PMN activation in TBI patients...
  9. ncbi request reprint The impact of hypoxia and hyperventilation on outcome after paramedic rapid sequence intubation of severely head-injured patients
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
    J Trauma 57:1-8; discussion 8-10. 2004
    ..An increase in mortality has been documented in association with paramedic rapid sequence intubation (RSI) of severely head-injured patients. This analysis explores the impact of hypoxia and hyperventilation on outcome...
  10. ncbi request reprint Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    J Trauma 59:575-82. 2005
    ..In addition, we investigated the effects of PTX on nuclear factor (NK)-kappaB activation using lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells (PBMCs) as a model...
  11. ncbi request reprint Recovery at one year following isolated traumatic brain injury: a Western Trauma Association prospective multicenter trial
    David H Livingston
    Department of Surgery, New Jersey Trauma Center, UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    J Trauma 59:1298-304; discussion 1304. 2005
    ..The purpose of this study was to further investigate the effect of age on outcome at 1 year in all patients surviving isolated TBI...
  12. ncbi request reprint HSPTX protects against hemorrhagic shock resuscitation-induced tissue injury: an attractive alternative to Ringer's lactate
    Raul Coimbra
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of California San Diego School of Medicine, 200 W Arbor Drive, San Diego, CA 92103, USA
    J Trauma 60:41-51. 2006
    ..Herein, we hypothesized that HSPTX decreases end-organ injury when compared with RL in an animal model of hemorrhagic shock...
  13. ncbi request reprint Role of hypertonic saline and pentoxifylline on neutrophil activation and tumor necrosis factor-alpha synthesis: a novel resuscitation strategy
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, CA 92103 8896, USA
    J Trauma 59:257-64; discussion 264-5. 2005
    ....
  14. ncbi request reprint The ability of paramedics to predict aspiration in patients undergoing prehospital rapid sequence intubation
    Tyler F Vadeboncoeur
    Department of Emergency Medicine, University of California San Diego UCSD Medical Center, San Diego, California 92103 8676, USA
    J Emerg Med 30:131-6. 2006
    ..The vast majority of aspiration events seem to occur before the arrival of prehospital personnel. Alteration in consciousness from TBI may carry a higher risk of aspiration than with other causes, such as alcohol intoxication...
  15. ncbi request reprint Hypertonic saline and pentoxifylline reduces hemorrhagic shock resuscitation-induced pulmonary inflammation through attenuation of neutrophil degranulation and proinflammatory mediator synthesis
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California School of Medicine, San Diego, CA, USA
    J Trauma 62:104-11. 2007
    ..Because the neutrophil plays a major role in postshock inflammation, we hypothesized that HSPTX reduces pulmonary inflammation after resuscitation in comparison to RL...
  16. ncbi request reprint Pentoxifylline attenuates stored blood-induced inflammation: A new perspective on an old problem
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA, USA
    Surgery 140:186-91. 2006
    ..Its supernatant fraction has been proven to activate neutrophils. We hypothesized that pentoxifylline (PTX) would attenuate stored blood-induced neutrophil activation and pro-inflammatory mediator production...
  17. ncbi request reprint Hypotensive patients with blunt abdominal trauma: performance of screening US
    Navid Farahmand
    Departments of Radiology and Surgery and General Clinical Research Center, University of California at San Diego, 200 W Arbor Drive, San Diego, CA 92103 8756, USA
    Radiology 235:436-43. 2005
    ..To determine retrospectively the accuracy of screening ultrasonography (US) in patients with hypotension (systolic blood pressure <or= 90 mm Hg) after blunt abdominal trauma...
  18. doi request reprint Risk factors for traumatic injury findings on thoracic computed tomography among patients with blunt trauma having a normal chest radiograph
    Meghann L Kaiser
    Department of Surgery, University of California, Irvine, 333 City Blvd W, The City Tower, Orange, CA 92868, USA
    Arch Surg 146:459-63. 2011
    ..We sought to identify risk factors that might predict acute traumatic injury findings on thoracic computed tomography (TCT) among patients having a normal initial chest radiograph (CR)...
  19. ncbi request reprint The impact of aeromedical response to patients with moderate to severe traumatic brain injury
    Daniel P Davis
    The UC San Diego Emergency Medicine, San Diego, CA 92103 8676, USA
    Ann Emerg Med 46:115-22. 2005
    ..Here we explore the impact of aeromedical response in patients with moderate to severe traumatic brain injury...
  20. ncbi request reprint The impact of prehospital endotracheal intubation on outcome in moderate to severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, School of Medicine, University of California, San Diego, 92103 8676, USA
    J Trauma 58:933-9. 2005
    ..Although early intubation to prevent the mortality that accompanies hypoxia is considered the standard of care for severe traumatic brain injury (TBI), the efficacy of this approach remains unproven...
  21. doi request reprint Asphyxia: a rare cause of death for motor vehicle crash occupants
    Carol Conroy
    Department of Surgery, University of California, San Diego, San Diego, California, USA
    Am J Forensic Med Pathol 29:14-8. 2008
    ..This study suggests classifying the mechanism of asphyxia for these fatalities may be a challenge to forensic pathologists who seldom see these rare deaths...
  22. doi request reprint The influence of damage distribution on serious brain injury in occupants in frontal motor vehicle crashes
    Raul Coimbra
    Department of Surgery, County of San Diego Emergency Medical Services, University of California San Diego, 6255 Mission Gorge Road, San Diego, CA 92120, USA
    Accid Anal Prev 40:1569-75. 2008
    ..It also illustrates how studying "real world" crashes may provide useful information on occupant injuries under impact circumstances not currently covered by crash testing...
  23. ncbi request reprint Traumatic brain injury outcomes in pre- and post- menopausal females versus age-matched males
    Daniel P Davis
    Department of Emergency Medicine, UC San Diego, San Diego, California 92103 8676, USA
    J Neurotrauma 23:140-8. 2006
    ..The identical pattern of improved outcomes in post-menopausal but not pre-menopausal females versus age-matched males was observed. These data suggest that endogenous female sex hormone production is not neuroprotective...
  24. ncbi request reprint Patient factors and operating room resuscitation predict mortality in traumatic abdominal aortic injury: a 20-year analysis
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego, San Diego, CA, USA
    J Vasc Surg 45:493-7. 2007
    ..The purposes of this study were to identify primary predictors of mortality and to examine the impact of a well-established operating room resuscitation protocol on survival in patients with traumatic aortic injury...
  25. doi request reprint Postinjury depression is a serious complication in adolescents after major trauma: injury severity and injury-event factors predict depression and long-term quality of life deficits
    Peggy P Han
    San Diego State University, San Diego, California, USA
    J Trauma 70:923-30. 2011
    ..Specific objectives of this report are to identify risk factors for depression onset and the impact of depression on quality of life (QoL) outcomes...
  26. ncbi request reprint The association between field Glasgow Coma Scale score and outcome in patients undergoing paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego UCSD, San Diego, California 92103 8676, USA
    J Emerg Med 29:391-7. 2005
    ..Other factors should be considered to screen TBI patients for prehospital RSI...
  27. ncbi request reprint Hypertonic saline resuscitation: efficacy may require early treatment in severely injured patients
    Naoyuki Hashiguchi
    University of California San Diego School of Medicine, San Diego, California 92103 8236, USA
    J Trauma 62:299-306. 2007
    ..Hypertonic saline (HS) resuscitation prevents PMN activation in vitro and in animal models. Here, we studied how clinical parameters and timing requirements influence the efficacy of HS in suppressing PMN activation...
  28. doi request reprint Risk factors for venous thromboembolism in critically ill trauma patients who cannot receive chemical prophylaxis
    Darren Malinoski
    Department of Surgery, Cedars Sinai Medical Center, USA
    Injury 44:80-5. 2013
    ....
  29. ncbi request reprint Ventilation patterns in patients with severe traumatic brain injury following paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, CA, USA
    Neurocrit Care 2:165-71. 2005
    ..This analysis explores ventilation patterns in a cohort of trial patients undergoing end-tidal CO2 (ETCO2) monitoring...
  30. ncbi request reprint Motor vehicle-related cardiac and aortic injuries differ from other thoracic injuries
    Carol Conroy
    Department of Surgery, University of California, San Diego, California 92103 8896, USA
    J Trauma 62:1462-7. 2007
    ..The purpose of this study was to identify potential risk factors for motor vehicle-related cardiac and thoracic aortic (HTA) injury using the Crash Injury Research Engineering Network (CIREN) database...
  31. doi request reprint The impact of select chronic diseases on outcomes after trauma: a study from the National Trauma Data Bank
    Madhukar S Patel
    Department of Surgery, University of California, Irvine, Orange, USA
    J Am Coll Surg 212:96-104. 2011
    ....
  32. doi request reprint Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice
    David B Hoyt
    Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
    J Trauma 65:755-64; discussion 764-5. 2008
    ..Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly...
  33. ncbi request reprint Neutrophil degranulation and the effects of phosphodiesterase inhibition
    Jessica Deree
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, CA, USA
    J Surg Res 133:22-8. 2006
    ..We hypothesized that PTX down-regulates neutrophil activation by decreasing the surface expression of both CD35 and CD66b, two markers of neutrophil degranulation...
  34. pmc Out-of-hospital hypertonic resuscitation following severe traumatic brain injury: a randomized controlled trial
    Eileen M Bulger
    Department of Surgery, University of Washington, Seattle, USA
    JAMA 304:1455-64. 2010
    ..Hypertonic fluids restore cerebral perfusion with reduced cerebral edema and modulate inflammatory response to reduce subsequent neuronal injury and thus have potential benefit in resuscitation of patients with traumatic brain injury (TBI)...
  35. ncbi request reprint Blunt abdominal trauma: clinical value of negative screening US scans
    Claude B Sirlin
    Department of Radiology, University of California, San Diego Medical Center, 200 W Arbor Dr, MC 8756, San Diego, CA 92103 8756, USA
    Radiology 230:661-8. 2004
    ..To assess clinical and surgical outcomes in patients with blunt abdominal trauma and negative screening ultrasonographic (US) scans...
  36. ncbi request reprint Upper extremity fracture patterns following motor vehicle crashes differ for drivers and passengers
    Carol Conroy
    Department of Surgery, University of California, San Diego, CA 92120, United States
    Injury 38:350-7. 2007
    ..The purpose of this study was to compare upper extremity injury in drivers and passengers using the Crash Injury Research Engineering Network (CIREN) database...
  37. ncbi request reprint Does sexual dimorphism influence outcome of traumatic brain injury patients? The answer is no!
    Raul Coimbra
    Department of Surgery, University of California San Diego, USA
    J Trauma 54:689-700. 2003
    ....
  38. ncbi request reprint LPS-stimulated PMN activation and proinflammatory mediator synthesis is downregulated by phosphodiesterase inhibition: role of pentoxifylline
    Raul Coimbra
    Division of Trauma, Department of Surgery, University of California San Diego School of Medicine, San Diego, California, USA
    J Trauma 57:1157-63. 2004
    ..We hypothesized that LPS-induced TNF-alpha synthesis and subsequent PMN beta2-integrin expression and oxidative burst are downregulated by concomitant treatment with the non-specific phosphodiesterase inhibitor pentoxifylline (PTX)...
  39. ncbi request reprint A follow-up analysis of factors associated with head-injury mortality after paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, Division of Trauma, University of California San Diego, CA92103 8946, USA
    J Trauma 59:486-90. 2005
    ..Here we explore factors affecting outcome in the entire cohort of patients undergoing paramedic RSI to confirm previous findings. This also represents a synthesis of findings from previous analyses..
  40. ncbi request reprint Nonspecific phosphodiesterase inhibition attenuates liver injury in acute endotoxemia
    Raul Coimbra
    Division of Trauma and Surgical Critical Care, Department of Surgery, University of California San Diego School of Medicine, San Diego, California 92103 8896, USA
    Surg Infect (Larchmt) 6:73-85. 2005
    ..We hypothesized that PTX would preserve liver architecture and function after intravenous lipopolysaccharide (LPS) injection...
  41. ncbi request reprint The use of quantitative end-tidal capnometry to avoid inadvertent severe hyperventilation in patients with head injury after paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, CA 92103 8676, USA
    J Trauma 56:808-14. 2004
    ..This study aimed to determine whether field end-tidal carbon dioxide CO2 (ETCO2) monitoring decreases inadvertent severe hyperventilation after paramedic rapid sequence intubation...
  42. ncbi request reprint Physiologic response to hemorrhagic shock depends on rate and means of hemorrhage
    David A Z Frankel
    University of California, San Diego, California, USA
    J Surg Res 143:276-80. 2007
    ..Our hypothesis was that rapid bleeding followed by slower bleeding using a fixed total volume would result in a greater physiologic insult...
  43. ncbi request reprint The epidemiology of serious and fatal injury in San Diego County over an 11-year period
    Bruce M Potenza
    Department of Surgery, University of California, San Diego, 92103 8896, USA
    J Trauma 56:68-75. 2004
    ..Analysis of the mechanism and severity of injury over time may permit a more focused planning of acute care and trauma prevention programs...
  44. ncbi request reprint Trauma in adolescents causes long-term marked deficits in quality of life: adolescent children do not recover preinjury quality of life or function up to two years postinjury compared to national norms
    Troy Lisa Holbrook
    Division of Trauma, Department of Surgery, University of California, CA, USA
    J Trauma 62:577-83; discussion 583. 2007
    ..The objectives of the present report are to describe long-term QoL outcomes and compare posttrauma QoL to national norms for QoL in uninjured adolescents from the National Health Interview Survey (NHIS)...
  45. ncbi request reprint Reversal of anticoagulation in trauma: a North-American survey on clinical practices among trauma surgeons
    Raul Coimbra
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego School of Medicine, CA 92103 8896, USA
    J Trauma 59:375-82. 2005
    ..Recent studies addressing reversal of anticoagulation in trauma have reported conflicting results. We hypothesized that current clinical practice is variable throughout North America...
  46. doi request reprint Human polymerized hemoglobin for the treatment of hemorrhagic shock when blood is unavailable: the USA multicenter trial
    Ernest E Moore
    Department of Surgery, Denver Health Medical Center, University of Colorado, Denver, CO, USA
    J Am Coll Surg 208:1-13. 2009
    ..This multicenter phase III trial was the first US study to assess survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injury...
  47. ncbi request reprint The Combitube as a salvage airway device for paramedic rapid sequence intubation
    Daniel P Davis
    Department of Emergency Medicine, University of California San Diego, San Diego, CA 92103 8676, USA
    Ann Emerg Med 42:697-704. 2003
    ..Here we describe our experience with the Combitube (esophageal-tracheal twin-lumen airway device) as a salvage airway device for paramedic rapid sequence intubation...
  48. doi request reprint The U.S. trauma surgeon's current scope of practice: can we deliver acute care surgery?
    C Clay Cothren
    Department of Surgery, Denver Health Medical Center and the University of Colorado School of Medicine, Denver, Colorado, USA
    J Trauma 64:955-65; discussion 965-8. 2008
    ..The purpose of this study is to determine the practice patterns of trauma surgeons at major trauma centers throughout the United States...
  49. ncbi request reprint Screening ultrasound in blunt abdominal trauma
    Michele A Brown
    Department of Radiology, UCSD Medical Center, San Diego, CA 92103, USA
    J Intensive Care Med 18:253-60. 2003
    ..Successful use of abdominal ultrasound in the setting of trauma can be maximized with adequate sonographer training, appreciation of technical limitations, and adherence to an appropriate trauma ultrasound protocol...
  50. doi request reprint Injury patterns in frontal crashes: the association between knee-thigh-hip (KTH) and serious intra-abdominal injury
    Jeanne Lee
    Department of Surgery, School of Medicine, University of California at San Diego, San Diego, CA, USA
    Accid Anal Prev 42:50-5. 2010
    ..These results may be useful to motor vehicle manufacturers and others who design and test motor vehicle safety systems...
  51. ncbi request reprint Phosphodiesterase inhibition attenuates stored blood-induced neutrophil activation: a novel adjunct to blood transfusion
    Rohan N Lall
    Division of Trauma, University of California San Diego, San Diego, CA 92103 8896, USA
    J Am Coll Surg 202:10-7. 2006
    ..We hypothesized that adding PTX to PRBCs would attenuate blood transfusion-induced neutrophil activation...
  52. ncbi request reprint The safety and efficacy of prehospital needle and tube thoracostomy by aeromedical personnel
    Daniel P Davis
    Department of Emergency Medicine, UCSD, San Diego, CA 92103, USA
    Prehosp Emerg Care 9:191-7. 2005
    ..Aeromedical crews routinely use needle thoracostomy (NT) and tube thoracostomy (TT) to treat major trauma victims (MTVs) with potential tension pneumothorax; however, the efficacy of prehospital NT and TT is unclear...
  53. ncbi request reprint High rates of acute stress disorder impact quality-of-life outcomes in injured adolescents: mechanism and gender predict acute stress disorder risk
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California 92103 8896, USA
    J Trauma 59:1126-30. 2005
    ..The specific objectives of the present report are to examine ASD rates and the association of ASD with QoL outcomes in injured adolescents...
  54. ncbi request reprint Urgent and emergent thoracotomy for penetrating chest trauma
    Riyad Karmy-Jones
    Department of Surgery, Box 359796, 325 Ninth Avenue, Harborview Medical Center, Seattle, WA 98104, USA
    J Trauma 56:664-8; discussion 668-9. 2004
    ..Although the major factor in outcome is presenting physiology, the site of the TCY may influence survival, with the operating room offering a superior environment to the emergency room...
  55. ncbi request reprint The effect of age on functional outcome in mild traumatic brain injury: 6-month report of a prospective multicenter trial
    Anne C Mosenthal
    Department of Surgery, New Jersey Trauma Center, University of Medicine and Dentistry of New Jersey New Jersey, Medical School, Newark, New Jersey, USA
    J Trauma 56:1042-8. 2004
    ..We hypothesized that surviving elderly patients would also have decreased functional outcome, and this study examined the functional outcome of patients with isolated TBI at discharge and at 6 months posthospitalization...
  56. ncbi request reprint Fatal positional asphyxia associated with rollover crashes
    Carol Conroy
    Department of Surgery, University of California, San Diego, California, USA
    Am J Forensic Med Pathol 28:330-2. 2007
    ..Although this is a rare cause of motor vehicle related death, our results suggest that these are potentially preventable deaths...
  57. doi request reprint Inhibition of intraluminal pancreatic enzymes with nafamostat mesilate improves clinical outcomes after hemorrhagic shock in swine
    Hubert D Kim
    Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
    J Trauma 68:1078-83. 2010
    ..The objective of this study was to determine whether enteroclysis with NM would improve the clinical outcomes in swine after hemorrhagic shock and intestinal hypoperfusion...
  58. ncbi request reprint The impact of major trauma: quality-of-life outcomes are worse in women than in men, independent of mechanism and injury severity
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California San Diego, San Diego, California 92103 8896, USA
    J Trauma 56:284-90. 2004
    ....
  59. ncbi request reprint Female gender does not protect blunt trauma patients from complications and mortality
    Joseph F Rappold
    Department of Surgery, Division of Trauma, Critical Care, and Burns, University of California San Diego, 92103, USA
    J Trauma 53:436-41; discussion 441. 2002
    ....
  60. ncbi request reprint Incidence of transient hypoxia and pulse rate reactivity during paramedic rapid sequence intubation
    James V Dunford
    Department of Emergency Medicine, University of California San Diego, USA
    Ann Emerg Med 42:721-8. 2003
    ..We determine the incidence of desaturation and pulse rate reactivity during paramedic rapid sequence intubation of patients with severe head injuries (Glasgow Coma Scale score <or=8)...
  61. ncbi request reprint Long-term posttraumatic stress disorder persists after major trauma in adolescents: new data on risk factors and functional outcome
    Troy L Holbrook
    Department of Family and Preventive Medicine, University of California, San Diego, San Diego, California, USA
    J Trauma 58:764-9; discussion 769-71. 2005
    ..The specific objectives of the present report are to describe long-term PTSD and to identify risk factors for long-term PTSD and the impact of PTSD on QoL...
  62. pmc Prehospital Resuscitation of Traumatic Hemorrhagic Shock with Hypertonic Solutions Worsens Hypocoagulation and Hyperfibrinolysis
    Matthew J Delano
    Department of Surgery, Division of Acute Care Surgery, University of Michigan, Ann Arbor, Michigan American College of Surgeons, Department of Surgery, University of California, Irvine, California Department of Surgery and Critical Care Medicine, St Michael s Hospital, and Defence Research and Development Canada Toronto, University of Toronto, Toronto, Ontario, Canada Department of Surgery, Harborview Medical Center, University of Washington, Seattle, Washington Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts Brain Injury Laboratory, Cara Phelan Centre for Trauma Research Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada and US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas
    Shock 44:25-31. 2015
    ....
  63. pmc Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock
    Frank A DeLano
    Department of Bioengineering, The Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Sci Transl Med 5:169ra11. 2013
    ....
  64. ncbi request reprint Hypertonic resuscitation after severe injury: is it of benefit?
    Eileen M Bulger
    Department of Surgery, Harborview Medical Center, University of Washington, Box 359796, 325 9th Avenue, Seattle, WA 98104, USA
    Adv Surg 46:73-85. 2012
    ..Assessment of long-term neurologic outcome in this patient population remains the gold standard in determining benefit...
  65. doi request reprint Hypertonic resuscitation: design and implementation of a prehospital intervention trial
    Karen J Brasel
    Department of Surgery, Division of Trauma Critical Care, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Am Coll Surg 206:220-32. 2008
    ..Trauma is the leading cause of death among North Americans between the ages of 1 and 44 years. Resuscitation with hypertonic saline (7.5%) solutions can reduce mortality in hypotensive and brain-injured patients...
  66. pmc Severe traumatic injury: regional variation in incidence and outcome
    Joseph P Minei
    Division of Burn, Trauma and Critical Care, Department of Surgery, UT Southwestern Medical Center, Dallas, TX 75390 9158, USA
    Ann Surg 252:149-57. 2010
    ..The objective of this study was to determine whether the incidence and outcome associated with severe traumatic injury differs across geographic regions of North America...
  67. ncbi request reprint Rollover crashes: predicting serious injury based on occupant, vehicle, and crash characteristics
    Carol Conroy
    University of California, Department of Surgery, San Diego, USA
    Accid Anal Prev 38:835-42. 2006
    ..This also requires improvement in data collection systems documenting these types of crashes...
  68. doi request reprint Standard prophylactic enoxaparin dosing leads to inadequate anti-Xa levels and increased deep venous thrombosis rates in critically ill trauma and surgical patients
    Darren Malinoski
    Department of Surgery, University of California, Irvine Medical Center, Orange, California 92868, USA
    J Trauma 68:874-80. 2010
    ..We hypothesized that low Anti-Xa levels would be found in critically ill trauma and surgical patients and that low levels would be associated with higher rates of DVT...
  69. ncbi request reprint An assessment of the potential for reducing future combat deaths through medical technologies and training
    Christopher G Blood
    Naval Health Research Center, San Diego, CA 92186 5122, USA
    J Trauma 53:1160-5. 2002
    ....
  70. ncbi request reprint National survey of trauma surgeons' use of alcohol screening and brief intervention
    Carol R Schermer
    Department of Surgery, 1 University of New Mexico, Albuquerque, NM 817131, USA
    J Trauma 55:849-56. 2003
    ....
  71. ncbi request reprint Are we the problem? Overcoming obstacles to implementing intervention programs
    David B Hoyt
    Department of Surgery, Division of Trauma, University of California, San Diego, CA 92103 8896, USA
    J Trauma 59:S135-6; discussion S146-66. 2005
    ..Although many obstacles have inhibited progress and made implementing preventive interventions a difficult task, economic constraints are among the biggest challenges to implementing intervention programs as part of routine trauma care...
  72. ncbi request reprint Surgical resident and attending physician attitudes toward glucose control in the surgical patient
    Todd W Costantini
    Department of Surgery, University of California, San Diego Medical Center, San Diego, California, USA
    Am Surg 74:993-6. 2008
    ..This study reveals an important knowledge deficit among surgical resident and attending physicians. Focused education on glycemic control in the perioperative patient should be a mandatory component of surgical training...
  73. ncbi request reprint Effect of the Uniform Accident and Sickness Policy Provision Law on alcohol screening and intervention in trauma centers
    Larry M Gentilello
    Department of Surgery, The University of Texas Southwestern Medical School, Dallas, Texas 75390 9158, USA
    J Trauma 59:624-31. 2005
    ....
  74. ncbi request reprint Trauma systems
    David B Hoyt
    Department of Surgery, University of California, Irvine School of Medicine, City Tower, 333 City Boulevard West, 700, Orange, CA 92868, USA
    Surg Clin North Am 87:21-35, v-vi. 2007
    ..Disaster preparedness also is an important function of trauma systems, and using an established trauma system network facilitates the care of victims of natural disasters or terrorist attacks...
  75. ncbi request reprint Pharmacotherapy to prevent PTSD: Results from a randomized controlled proof-of-concept trial in physically injured patients
    Murray B Stein
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    J Trauma Stress 20:923-32. 2007
    ..Implications are discussed for future pharmacological prevention studies in survivors of acute traumatic injury...
  76. ncbi request reprint Nonoperative management reduces the overall mortality of grades 3 and 4 blunt liver injuries
    Raul Coimbra
    Division of Trauma, Critical Care, and Burns, Department of Surgery, University of California San Diego, San Diego, California 92103 8896, USA
    Int Surg 91:251-7. 2006
    ..Six patients failed NON-OP management (22.2%). The mortality rate in the NON-OP group was 0%. NON-OP was associated with a 23.5% reduction in mortality. Unnecessary OP management of grades 3 and 4 liver injuries should be discouraged...
  77. ncbi request reprint The effect of paramedic rapid sequence intubation on outcome in patients with severe traumatic brain injury
    Daniel P Davis
    Department of Emergency Medicine, UC San Diego, CA 92103 8676, USA
    J Trauma 54:444-53. 2003
    ..To evaluate the effect of paramedic rapid sequence intubation (RSI) on outcome in patients with severe traumatic brain injury...
  78. ncbi request reprint National inventory of hospital trauma centers
    Ellen J MacKenzie
    Johns Hopkins Bloomberg School of Public Health, Center for Injury Research and Policy, Baltimore, MD 21205, USA
    JAMA 289:1515-22. 2003
    ..The last full accounting of the number and distribution of trauma centers identified 471 trauma centers in the United States in 1991...
  79. ncbi request reprint Early ventilation and outcome in patients with moderate to severe traumatic brain injury
    Daniel P Davis
    UC San Diego, Department of Emergency Medicine, USA
    Crit Care Med 34:1202-8. 2006
    ..This analysis explores the impact of early ventilation on outcome in moderate to severe traumatic brain injury...
  80. doi request reprint The coagulopathy of trauma: a review of mechanisms
    John R Hess
    Department of Pathology, University of Maryland Medical Center, Baltimore, Maryland 21201, USA
    J Trauma 65:748-54. 2008
    ..Coagulopathy associated with severe injury complicates the control of bleeding and is associated with increased morbidity and mortality in trauma patients. The causes and mechanisms are multiple and yet to be clearly defined...
  81. ncbi request reprint Air medical transport of severely head-injured patients undergoing paramedic rapid sequence intubation
    Jennifer C Poste
    Air Med J 23:36-40. 2004
    ..This analysis explores the impact of air medical transport of trial patients on outcome...
  82. ncbi request reprint When will it be clear?
    David B Hoyt
    Crit Care Med 32:1608-9. 2004