Affiliation: University of North Carolina at Charlotte
- Cardiac responses to 24 hrs hyperoxia in Bmp2 and Bmp4 heterozygous miceR Howden
Laboratory of Systems Physiology, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte NC 28223, USA
Inhal Toxicol 25:509-16. 2013..Therefore, understanding susceptibility to hyperoxia exposure is clinically important. Bone morphogenetic proteins (BMPs) 2 and 4 are involved in cardiac development and may influence responses to hyperoxia...
- The influence of Nrf2 on cardiac responses to environmental stressorsReuben Howden
Laboratory of Systems Physiology, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, NC, USA
Oxid Med Cell Longev 2013:901239. 2013..01). Results demonstrate that Nrf2 deletion increases susceptibility to change in HR and HRV responses to environmental stressors and suggest potential therapeutic strategies to prevent cardiovascular alterations...
- Genetic and environmental influences on gas exchangeReuben Howden
University of North Carolina at Charlotte, Charlotte, North Carolina, USA
Compr Physiol 2:2595-614. 2012..Under these conditions, common genetic mechanisms, and their interaction with environment, help to maintain, or are detrimental to, gas exchange...
- Cardiac physiologic and genetic predictors of hyperoxia-induced acute lung injury in miceReuben Howden
Department of Kinesiology, University of North Carolina at Charlotte, 28223, USA
Am J Respir Cell Mol Biol 46:470-8. 2012..Understanding the genetic mechanisms of these responses may have significant diagnostic clinical value...
- Nrf2 and cardiovascular defenseReuben Howden
Laboratory of Systems Physiology, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
Oxid Med Cell Longev 2013:104308. 2013..Further studies on the cellular environments related to cardiovascular diseases that influence Nrf2 pathways are required before Nrf2 can be considered a therapeutic target for the treatment of cardiovascular diseases...
- Genetic susceptibility to ozone-induced lung inflammation in animal models of asthmaGillian S Backus-Hazzard
Toxicology Curriculum, University of North Carolina, Chapel Hill, North Carolina, USA
Curr Opin Allergy Clin Immunol 4:349-53. 2004..This review describes the advances that have been made in understanding mechanisms of genetic susceptibility to ozone-induced inflammation, and the interaction between ozone and allergen exposure in mice and a non-human primate model...