Richard E Honkanen

Summary

Affiliation: University of South Alabama
Country: USA

Publications

  1. pmc Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
    D A Dean
    Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA
    BMC Cell Biol 2:6. 2001
  2. ncbi request reprint Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?
    R E Honkanen
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Curr Med Chem 9:2055-75. 2002
  3. pmc Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death
    Benjamin Theobald
    Department of Biochemistry and Molecular Biology, MSB 2362, University of South Alabama, Mobile, AL 36688, USA
    Mol Cancer Res 11:845-55. 2013
  4. pmc Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer
    Teresa Golden
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Biochim Biophys Acta 1782:259-70. 2008
  5. pmc Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors
    Mark R Swingle
    Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, USA
    J Pharmacol Exp Ther 331:45-53. 2009
  6. pmc Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1)
    Lauren Amable
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 286:40413-22. 2011
  7. ncbi request reprint Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice
    Teresa Golden
    Department of Biochemistry and Molecular Biology, MSB 2362, 307 University Blvd, University of South Alabama, Mobile, Alabama 36688 USA
    Cancer Lett 215:95-100. 2004
  8. ncbi request reprint Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade
    Guofei Zhou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 279:46595-605. 2004
  9. pmc Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse
    Mark Swingle
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, USA
    Methods Mol Biol 365:23-38. 2007
  10. ncbi request reprint Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5
    Mark R Swingle
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 279:33992-9. 2004

Collaborators

  • Teresa Golden
  • Henrik Ortsäter
  • Yanping Liu
  • Alexey I Nesvizhskii
  • Lalita A Shevde
  • Rajeev S Samant
  • Guofei Zhou
  • Ewa M Ciszak
  • Ake Sjoholm
  • Scott E Wolkenberg
  • Anne Claude Gingras
  • Mark R Swingle
  • Lauren Amable
  • Mikael Lehtihet
  • Kathy Bonness
  • Nicholas M Dean
  • Li Ni
  • Brian G Lawhorn
  • Gudrun Urban
  • Dale L Boger
  • Benjamin Theobald
  • Suzanne B Buck
  • Xiulan Yang
  • Arun Bhardwaj
  • Dana V Skarra
  • Mark Swingle
  • G Urban
  • Ileana V Aragon
  • Alla Musiyenko
  • Joel F Andrews
  • Xizhong Huang
  • I V Aragon
  • D A Dean
  • N M Dean
  • Jason W Largen
  • Renaud Tissier
  • Fangdi Hu
  • Eddie Reed
  • Hyungwon Choi
  • Xi Ming Yang
  • Lin Cui
  • Ajay P Singh
  • Peyman Soltani
  • Michael Mullin
  • James M Downey
  • Sanjeev K Srivastava
  • Seema Singh
  • Marilyn Goudreault
  • Michael V Cohen
  • Nina Grankvist
  • Kimberly L Fischer
  • Pukar Ratti
  • Christopher P Burke
  • Austin C Bourgeois
  • Mark S Swingle
  • Carla Maria Gauss
  • David A Colby
  • Solomon Ofori-Acquah
  • Sobhana B Boga
  • Beth Rutland
  • X Huang
  • Lex Cowsert
  • Scott R Cooper
  • Kathy M Bonness
  • Inkyu Hwang
  • C M Gauss
  • Christophe Hardouin
  • Danielle R Soenen
  • Satoshi Ichikawa
  • M Swingle
  • S Rusconi
  • J G Scammell
  • M Bueno
  • B Miller

Detail Information

Publications28

  1. pmc Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttling
    D A Dean
    Division of Pulmonary and Critical Care Medicine, Northwestern University, Chicago, IL 60611, USA
    BMC Cell Biol 2:6. 2001
    ....
  2. ncbi request reprint Regulators of serine/threonine protein phosphatases at the dawn of a clinical era?
    R E Honkanen
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Curr Med Chem 9:2055-75. 2002
    ....
  3. pmc Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death
    Benjamin Theobald
    Department of Biochemistry and Molecular Biology, MSB 2362, University of South Alabama, Mobile, AL 36688, USA
    Mol Cancer Res 11:845-55. 2013
    ..This effect was not observed following the suppression of PP1C, PP2AC, or PP5C. These data clarify PP4C as a fostriecin-sensitive phosphatase and demonstrate that the suppression of PP4C triggers mitotic slippage/apoptosis...
  4. pmc Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer
    Teresa Golden
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Biochim Biophys Acta 1782:259-70. 2008
    ..Together, these studies indicate that elevated levels of PP5 protein occur in human breast cancer and suggest that PP5 over-expression may aid tumor progression...
  5. pmc Structure-activity relationship studies of fostriecin, cytostatin, and key analogs, with PP1, PP2A, PP5, and( beta12-beta13)-chimeras (PP1/PP2A and PP5/PP2A), provide further insight into the inhibitory actions of fostriecin family inhibitors
    Mark R Swingle
    Department of Biochemistry and Molecular Biology, University of South Alabama College of Medicine, Mobile, USA
    J Pharmacol Exp Ther 331:45-53. 2009
    ..When considered together with previous data, these studies suggest that, despite the high structural conservation of the catalytic site in PP1, PP2A and PP5, the development of highly selective catalytic inhibitors should be feasible...
  6. pmc Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1)
    Lauren Amable
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 286:40413-22. 2011
    ..A comparable role for PP5 in the regulation of Chk1 phosphorylation was also observed in human cells...
  7. ncbi request reprint Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice
    Teresa Golden
    Department of Biochemistry and Molecular Biology, MSB 2362, 307 University Blvd, University of South Alabama, Mobile, Alabama 36688 USA
    Cancer Lett 215:95-100. 2004
    ..In the xenograph model a modest two fold increase in PP5 protein levels significantly enhanced the growth rate of estrogen-dependent tumors, suggesting PP5 plays a positive role in tumor development...
  8. ncbi request reprint Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade
    Guofei Zhou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 279:46595-605. 2004
    ..Together, these studies indicate that PP5 plays an important role in the survival of cells in a low oxygen environment by suppressing a hypoxia-induced ASK-1/MKK4/JNK signaling cascade that promotes an apoptotic response...
  9. pmc Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse
    Mark Swingle
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, USA
    Methods Mol Biol 365:23-38. 2007
    ....
  10. ncbi request reprint Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5
    Mark R Swingle
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 279:33992-9. 2004
    ..Resolution of the entire C terminus revealed a novel subdomain, and the structure of the PP5c should also aid development of type-specific inhibitors...
  11. pmc Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2Aalpha
    Kathy Bonness
    Department of Biochemistry and Molecular Biology, University of South Alabama, MSB 2362, Mobile, AL 36688, USA
    Mol Cancer Ther 5:2727-36. 2006
    ....
  12. pmc Protein phosphatases in pancreatic islets
    Henrik Ortsäter
    Biovation Park TelgeSödertälje, SwedenResearch UnitSödertälje Hospital, SE 152 86 Södertälje, SwedenDegenerative Disease ProgramSanford Burnham Medical Research Institute, Del E Webb Neuroscience, Aging and Stem Cell Research Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USADepartment of Biochemistry and Molecular BiologyCollege of Medicine, University of South Alabama, Mobile, Alabama 36688, USADepartment of Internal MedicineSödertälje Hospital, Sodertalje, SwedenBiovation Park TelgeSödertälje, SwedenResearch UnitSödertälje Hospital, SE 152 86 Södertälje, SwedenDegenerative Disease ProgramSanford Burnham Medical Research Institute, Del E Webb Neuroscience, Aging and Stem Cell Research Center, 10901 North Torrey Pines Road, La Jolla, California 92037, USADepartment of Biochemistry and Molecular BiologyCollege of Medicine, University of South Alabama, Mobile, Alabama 36688, USADepartment of Internal MedicineSödertälje Hospital, Sodertalje, Sweden
    J Endocrinol 221:R121-44. 2014
    ..Herein, we review extant data implicating serine/threonine and tyrosine phosphatases in various aspects of healthy and diabetic islet biology, ranging from control of hormonal stimulus-secretion coupling to mitogenesis and apoptosis. ..
  13. pmc High yield expression of serine/threonine protein phosphatase type 5, and a fluorescent assay suitable for use in the detection of catalytic inhibitors
    Li Ni
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA
    Assay Drug Dev Technol 5:645-53. 2007
    ....
  14. ncbi request reprint Regulating the expression of protein phosphatase type 5
    Teresa A Golden
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    Methods Enzymol 366:372-90. 2003
  15. ncbi request reprint Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression
    Gudrun Urban
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 278:9747-53. 2003
    ....
  16. pmc Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications
    Arun Bhardwaj
    Department of Oncologic Sciences Mitchell Cancer Institute, University of South Alabama 1660 Springhill Avenue, Mobile, AL 36604, USA
    Mol Cancer Ther 10:720-31. 2011
    ..Altogether, our findings suggest that modulation of PP2A activity may represent an alternative therapeutic approach for the treatment of advanced androgen-independent prostate cancer...
  17. pmc Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5
    Dana V Skarra
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Proteomics 11:1508-16. 2011
    ....
  18. pmc Cardioprotection by mild hypothermia during ischemia involves preservation of ERK activity
    Xiulan Yang
    Department of Physiology, University of South Alabama College of Medicine, Mobile, 36688, USA
    Basic Res Cardiol 106:421-30. 2011
    ..Hence, mild hypothermia preserves ERK and MEK activity during ischemia which somehow protects the heart. While a PPase inhibitor mimicked cooling's protection, a direct effect of cooling on PP2A could not be demonstrated...
  19. ncbi request reprint Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively
    G Urban
    Departments of Biochemistry and Molecular Biology and Pharmacology and Comparative Medicine, University of South Alabama, Mobile, Alabama 36688, USA
    J Biol Chem 276:27638-46. 2001
    ....
  20. pmc Development and validation of a robust and sensitive assay for the discovery of selective inhibitors for serine/threonine protein phosphatases PP1α (PPP1C) and PP5 (PPP5C)
    Mark R Swingle
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile, Alabama
    Assay Drug Dev Technol 12:481-96. 2014
    ..93; representative PP1Cα assay data: Z'=0.90) fluorescent phosphatase assay that can be used to simultaneously screen chemical libraries and natural product extracts for the presence of catalytic inhibitors of PP1 and PP5...
  21. ncbi request reprint Molecular cloning, expression, and characterization of a novel human serine/threonine protein phosphatase, PP7, that is homologous to Drosophila retinal degeneration C gene product (rdgC)
    X Huang
    Department of Biochemistry and Molecular Biology, College of Medicine, University of South Alabama, Mobile 36688, USA
    J Biol Chem 273:1462-8. 1998
    ..PP7 is not affected by calmodulin and is insensitive to inhibition by okadaic acid, microcystin-LR, calyculin A, and cantharidin...
  22. pmc Total synthesis and evaluation of cytostatin, its C10-C11 diastereomers, and additional key analogues: impact on PP2A inhibition
    Brian G Lawhorn
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Am Chem Soc 128:16720-32. 2006
    ....
  23. ncbi request reprint Fundamental role of the fostriecin unsaturated lactone and implications for selective protein phosphatase inhibition
    Suzanne B Buck
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    J Am Chem Soc 125:15694-5. 2003
    ..This 200-fold increase in PP2A inhibition attributable to the unsaturated lactone potentially may be due to reversible C269 alkylation within the PP beta12-beta13 active site loop accounting for PP2A/4 potency and selectivity...
  24. ncbi request reprint Glucose metabolites inhibit protein phosphatases and directly promote insulin exocytosis in pancreatic beta-cells
    Ake Sjoholm
    Department of Internal Medicine, Karolinska Institutet, Stockholm South Hospital, SE 118 83 Stockholm, Sweden
    Endocrinology 143:4592-8. 2002
    ..Thus, an increase in phosphorylation state, through inhibition of protein dephosphorylation by metabolic intermediates, may be a novel regulatory mechanism linking glucose sensing to insulin exocytosis in the beta-cell...
  25. pmc The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer
    Teresa Golden
    Department of Biological Sciences, Southeastern Oklahoma State University, Durant, OK 74701, USA
    Cancer Metastasis Rev 27:169-78. 2008
    ....
  26. ncbi request reprint Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells
    Mikael Lehtihet
    Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital, SE 118 83 Stockholm, Sweden
    Biochem Biophys Res Commun 328:601-7. 2005
    ..Thus, an increase in phosphorylation state, through inhibition of protein dephosphorylation by glucose-derived L-glutamate, may be a novel regulatory mechanism linking glucose sensing to sustained insulin exocytosis...
  27. ncbi request reprint Inositol hexakisphosphate and sulfonylureas regulate beta-cell protein phosphatases
    Mikael Lehtihet
    Karolinska Institutet, Department of Internal Medicine, Stockholm South Hospital, SE 118 83 Stockholm, Sweden
    Biochem Biophys Res Commun 316:893-7. 2004
    ....
  28. ncbi request reprint Use of antisense oligonucleotides: advantages, controls, and cardiovascular tissue
    Teresa Golden
    Department of Biochemistry Molecular Biology, University of South Alabama, Mobile, AL 36688, USA
    Microcirculation 9:51-64. 2002
    ..This review highlights some of the advances made in the field of antisense research, placing an emphasis on uses and proper controls...