Daniel N Holena

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Lead-Time Bias and Interhospital Transfer after Injury: Trauma Center Admission Vital Signs Underpredict Mortality in Transferred Trauma Patients
    Daniel N Holena
    Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA The Penn Injury Science Center at the University of Pennsylvania, Philadelphia PA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Electronic address
    J Am Coll Surg . 2016
  2. pmc Failure to rescue in trauma: Coming to terms with the second term
    Daniel N Holena
    Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States The Leonard Davis Institute, Wharton School of Business at the University of Pennsylvania, Philadelphia, PA, United States Electronic address
    Injury 47:77-82. 2016
  3. pmc The association of early transfusion with acute lung injury in patients with severe injury
    Daniel N Holena
    Division of Traumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Trauma Acute Care Surg 73:825-31. 2012
  4. doi request reprint Transfer status: a risk factor for mortality in patients with necrotizing fasciitis
    Daniel N Holena
    Department of Surgery, Division of Traumatology, Surgical Critical Care, and Emergency Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Surgery 150:363-70. 2011
  5. pmc African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients
    Michael G S Shashaty
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:496-504. 2012
  6. ncbi request reprint Interhospital transfer: an independent risk factor for mortality in the surgical intensive care unit
    Katherine R Arthur
    Department of Surgery, Weill Cornell School of Medicine, New York, New York, USA
    Am Surg 79:909-13. 2013
  7. pmc Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients*
    Michael G S Shashaty
    1Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 3Division of Traumatology, Surgical Critical Care, and Emergency Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 4Drexel University School of Public Health, Philadelphia, PA 5Renal, Electrolyte, and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 6Cardiovascular Medicine Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 7Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 8Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:1619-28. 2014
  8. pmc There's no place like home: boarding surgical ICU patients in other ICUs and the effect of distances from the home unit
    Jose L Pascual
    From the Division of Traumatology, Surgical Critical Care and Emergency Surgery J L P, N W B, D N H, M D, S R A, N D M, C S, C W S, P M R, and Department of Anesthesia and Critical Care B A K, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania and University of Virginia Medical Center M R, Charlottesville, Virginia
    J Trauma Acute Care Surg 76:1096-102. 2014
  9. doi request reprint Teaching status: the impact on emergency and elective surgical care in the US
    Daniel N Holena
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Surg 253:1017-23. 2011
  10. pmc Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients
    Michael G S Shashaty
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Division of Traumatology, Surgical Critical Care, and Emergency Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Resuscitation Science, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Renal, Electrolyte, and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Shock 46:139-43. 2016

Collaborators

Detail Information

Publications31

  1. pmc Lead-Time Bias and Interhospital Transfer after Injury: Trauma Center Admission Vital Signs Underpredict Mortality in Transferred Trauma Patients
    Daniel N Holena
    Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA The Penn Injury Science Center at the University of Pennsylvania, Philadelphia PA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Electronic address
    J Am Coll Surg . 2016
    ..We sought determine the impact of using vital signs on arrival at the referring center vs. on arrival at the trauma center in mortality prediction models for transferred trauma patients...
  2. pmc Failure to rescue in trauma: Coming to terms with the second term
    Daniel N Holena
    Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States The Leonard Davis Institute, Wharton School of Business at the University of Pennsylvania, Philadelphia, PA, United States Electronic address
    Injury 47:77-82. 2016
    ..We hypothesised that use of high quality data would result precedence rates in higher than those derived from national datasets, and we further sought to characterise the nature of those deaths not preceded by major complications...
  3. pmc The association of early transfusion with acute lung injury in patients with severe injury
    Daniel N Holena
    Division of Traumatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Trauma Acute Care Surg 73:825-31. 2012
    ..We hypothesized that the relationship between PRBC delivery and ALI risk varies through time after injury...
  4. doi request reprint Transfer status: a risk factor for mortality in patients with necrotizing fasciitis
    Daniel N Holena
    Department of Surgery, Division of Traumatology, Surgical Critical Care, and Emergency Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Surgery 150:363-70. 2011
    ..We hypothesized that mortality would be higher in patients undergoing surgical debridement for necrotizing fasciitis after IT compared to Emergency Department (ED) admission...
  5. pmc African American race, obesity, and blood product transfusion are risk factors for acute kidney injury in critically ill trauma patients
    Michael G S Shashaty
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Crit Care 27:496-504. 2012
    ..Acute kidney injury (AKI) is a common source of morbidity after trauma. We sought to determine novel risk factors for AKI, by Acute Kidney Injury Network (AKIN) criteria, in critically ill trauma patients...
  6. ncbi request reprint Interhospital transfer: an independent risk factor for mortality in the surgical intensive care unit
    Katherine R Arthur
    Department of Surgery, Weill Cornell School of Medicine, New York, New York, USA
    Am Surg 79:909-13. 2013
    ..Interhospital transfer is an independent risk factor for mortality in the SICU population; this risk is unevenly distributed through service lines. Further efforts to determine the cause of this association are warranted...
  7. pmc Computed tomography-defined abdominal adiposity is associated with acute kidney injury in critically ill trauma patients*
    Michael G S Shashaty
    1Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 2Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 3Division of Traumatology, Surgical Critical Care, and Emergency Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 4Drexel University School of Public Health, Philadelphia, PA 5Renal, Electrolyte, and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 6Cardiovascular Medicine Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 7Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 8Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:1619-28. 2014
    ..Since body mass index is nonspecific, reflecting lean, fluid, and adipose mass, we evaluated the use of CT to determine if abdominal adiposity underlies the body mass index-acute kidney injury association...
  8. pmc There's no place like home: boarding surgical ICU patients in other ICUs and the effect of distances from the home unit
    Jose L Pascual
    From the Division of Traumatology, Surgical Critical Care and Emergency Surgery J L P, N W B, D N H, M D, S R A, N D M, C S, C W S, P M R, and Department of Anesthesia and Critical Care B A K, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania and University of Virginia Medical Center M R, Charlottesville, Virginia
    J Trauma Acute Care Surg 76:1096-102. 2014
    ..We hypothesized that surgical ICU patients experience more complications when boarding in an overflow ICU and that the frequency of these complications are greatest in boarders farthest from the home unit (HU)...
  9. doi request reprint Teaching status: the impact on emergency and elective surgical care in the US
    Daniel N Holena
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Ann Surg 253:1017-23. 2011
    ..To examine the relation between hospital teaching status and surgical outcomes for both emergency and elective general surgery cases using a national database...
  10. pmc Plasma Levels of Receptor Interacting Protein Kinase-3 (RIP3), an Essential Mediator of Necroptosis, are Associated with Acute Kidney Injury in Critically Ill Trauma Patients
    Michael G S Shashaty
    Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Translational Lung Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Division of Traumatology, Surgical Critical Care, and Emergency Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Resuscitation Science, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Renal, Electrolyte, and Hypertension Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Shock 46:139-43. 2016
    ..The importance of necroptosis in human AKI is unknown. We hypothesized that plasma RIP3 concentrations would be associated with acute kidney injury (AKI) after severe trauma...
  11. doi request reprint Penetrating trauma in urban women: patterns of injury and violence
    Christina L Jacovides
    Division of Traumatology, Surgical Critical Care and Emergency Surgery, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Surg Res 184:592-8. 2013
    ..We hypothesized that the nature of penetrating injury differs significantly by gender and that these injuries in women are associated with important psychosocial and environmental factors...
  12. doi request reprint Hyperbaric oxygen therapy in necrotizing soft tissue infections
    Paul R Massey
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Surg Res 177:146-51. 2012
    ..Despite this, the efficacy of HBO remains unclear. We hypothesized that HBO would have no effect on mortality or amputation rates...
  13. doi request reprint Arteriography for Lower Gastrointestinal Hemorrhage: Role of Preceding Abdominal Computed Tomographic Angiogram in Diagnosis and Localization
    Christina L Jacovides
    Division of Traumatology, Surgical Critical Care, and Emergency Surgery, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia
    JAMA Surg 150:650-6. 2015
    ..Optimizing the nature and sequence of diagnostic imaging when managing lower gastrointestinal hemorrhage may reduce subsequent morbidity and mortality...
  14. doi request reprint Failure-to-rescue after injury is associated with preventability: The results of mortality panel review of failure-to-rescue cases in trauma
    Lindsay E Kuo
    Department of Surgery, Center for Surgery and Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Electronic address
    Surgery . 2016
    ..We sought to evaluate the relationship between preventability and failure-to-rescue in trauma...
  15. doi request reprint Practitioner perceptions of trauma video review
    Leah Davis
    Department of Nursing, Hospital of the University of Pennsylvania, Philadelphia, USA
    J Trauma Nurs 20:150-4. 2013
    ..We examined perceptions of educational value and anxiety associated with being reviewed in TVR...
  16. doi request reprint Severity-adjusted mortality in trauma patients transported by police
    Roger A Band
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA Electronic address
    Ann Emerg Med 63:608-614.e3. 2014
    ..We examine the association between mode of out-of-hospital transport (police department versus emergency medical services [EMS]) and mortality among patients with penetrating trauma in Philadelphia...
  17. doi request reprint Characteristics and outcomes of injured patients presenting by private vehicle in a state trauma system
    Nicholas J Johnson
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Emerg Med 31:275-81. 2013
    ..We sought to describe the characteristics and outcomes of injured patients transported by PV in a state trauma system compared to patients transported by EMS...
  18. doi request reprint Is a Colectomy Always Just a Colectomy? Additional Procedures as a Proxy for Operative Complexity
    Kristina D Simmons
    Center for Surgery and Health Economics, Department of Surgery, University of Pennsylvania, Philadelphia, PA
    J Am Coll Surg 221:862-70.e1-2. 2015
    ..We hypothesized that analyzing same-day procedures (SDPs) would provide a useful step toward including operative complexity in risk adjustment...
  19. pmc Mineralocorticoid deficiency in hemorrhagic shock
    Nikolai S Tolstoy
    Penn State Hershey College of Medicine, Hershey, Pennsylvania, USA
    J Surg Res 180:232-7. 2013
    ..We also hypothesized that MD in these patients would be associated with increased length of stay, hypotension, fluid requirements, and acute kidney injury (AKI)...
  20. doi request reprint Racial disparity in analgesic treatment for ED patients with abdominal or back pain
    Angela M Mills
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Emerg Med 29:752-6. 2011
    ..Research on how race affects access to analgesia in the emergency department (ED) has yielded conflicting results. We assessed whether patient race affects analgesia administration for patients presenting with back or abdominal pain...
  21. ncbi request reprint Handoffs in the Intensive Care Unit: Are Off Hours a Vulnerable Time?
    Beth R Hochman
    University of Pennsylvania Perelman School of Medicine, Philadelphia, PA
    Am J Med Qual . 2015
    ..Specific handoff protocols merit evaluation and training to ensure consistent practices in different ICU models and at different times...
  22. doi request reprint Telemedicine coverage for post-operative ICU patients
    Tara Ann Collins
    1 Department of Advanced Practice, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania
    J Telemed Telecare 23:360-364. 2017
    ..The specific patient populations for which this approach is most appropriate merits further investigation...
  23. pmc Disparities in access to trauma care in the United States: A population-based analysis
    Brendan G Carr
    Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States Electronic address
    Injury . 2017
    ..The extent to which disparities in access to trauma care exist in the US is unknown. Our objective was to describe geographic, demographic, and socioeconomic disparities in access to trauma care in the United States...
  24. doi request reprint Perceptions of Family Participation in Intensive Care Unit Rounds and Telemedicine: A Qualitative Assessment
    Elisabeth A Stelson
    Elisabeth A Stelson is manager of community programs and evaluation at Lutheran Settlement House, Philadelphia, Pennsylvania Kate E Golden is a clinical research coordinator, Mixed Methods Research Lab, Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia Brendan G Carr is vice dean, Department of Emergency Medicine, Jefferson University School of Medicine, Philadelphia Niels Martin is medical director of the surgical intensive care unit and assistant professor of surgery, Division of Traumatology, Surgical Critical Care and Emergency Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia Therese S Richmond is the Andrea B Laporte Professor and associate dean for research and innovation, University of Pennsylvania School of Nursing, Philadelphia M Kit Delgado is an assistant professor of emergency medicine and epidemiology, Department of Emergency Medicine, a senior scholar at the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, and a senior fellow at The Leonard Davis Institute, Wharton School of Business at the University of Pennsylvania Daniel N Holena is an assistant professor, Division of Traumatology, Surgical Critical Care and Emergency Surgery and a senior scholar, the Leonard Davis Institute, Wharton School of Business, University of Pennsylvania
    Am J Crit Care 25:440-7. 2016
    ..Family-centered rounds involve purposeful interactions between patients' families and care providers to refocus the delivery of care on patients' needs...
  25. doi request reprint Short simulation training improves objective skills in established advanced practitioners managing emergencies on the ward and surgical intensive care unit
    Jose L Pascual
    Division of Traumatology, Surgical Critical Care and Emergency Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Trauma 71:330-7; discussion 337-8. 2011
    ..We hypothesized that human patient simulator-based training would improve surgical ICU APs' skills at managing medical crises...
  26. doi request reprint Wind, water, wound, walk--do the data deliver the dictum?
    Elizabeth M Sonnenberg
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Department of Surgery, Center for Surgery and Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    J Surg Educ 72:164-9. 2015
    ..To evaluate the teaching dictum "wind, water, wound, walk" in the modern surgical environment...
  27. doi request reprint Therapeutic hypothermia for treatment of intractable intracranial hypertension after liver transplantation
    Daniel N Holena
    Department of Trauma and Surgical Critical Care, Hospital of the University of Pennsylvania, Philadelphia, USA
    Am J Crit Care 21:72-5. 2012
    ..Normalization of intracranial pressure was rapid. Findings on neurological examination improved and the patient was discharged from the hospital with no neurological impairment...
  28. doi request reprint Enoxaparin ameliorates post-traumatic brain injury edema and neurologic recovery, reducing cerebral leukocyte endothelial interactions and vessel permeability in vivo
    Shengjie Li
    From the Division of Traumatology, Surgical Critical Care and Emergency Surgery S L, J A M, R E, K K, D S, D N H, S R A, J L P, Department of Surgery, and Department of Neurosurgery K D B, D H S, J L P, Center for Brain Injuryand Repair, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania and Tianjin Neurological Institute S L, V E J, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China
    J Trauma Acute Care Surg 79:78-84. 2015
    ..We hypothesized that enoxaparin (ENX) after TBI blunts in vivo leukocyte (LEU) mobilization to injured brain and cerebral edema, while improving neurologic recovery without increasing the size of the cerebral hemorrhagic contusion...
  29. doi request reprint A risk prediction model for mortality in the moribund general surgical patient
    Lindsay E Kuo
    Department of Surgery, University of Pennsylvania, Philadelphia, PA Electronic address
    J Crit Care 30:310-4. 2015
    ..Surgeons struggle to counsel families on the role of surgery and likelihood of survival in the moribund patient. We sought to develop a risk prediction model for postoperative inpatient death for the moribund surgical candidate...
  30. doi request reprint The simulated ward: ideal for training clinical clerks in an era of patient safety
    Elizabeth A Mollo
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Surg Res 177:e1-6. 2012
    ..We report the feasibility of and clinical clerk opinions regarding a novel simulated floor management course to teach patient care concepts required on the surgical wards...
  31. pmc Analgesia for older adults with abdominal or back pain in emergency department
    Angela M Mills
    University of Pennsylvania, Department of Emergency Medicine, Philadelphia, PA
    West J Emerg Med 12:43-50. 2011
    ..To determine the association between age and analgesia for emergency department (ED) patients with abdominal or back pain...