Carl K Hoh

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Sentinel lymph node mapping of breast cancer via intradermal administration of Lymphoseek
    Anne M Wallace
    Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 34:849-53. 2007
  2. pmc Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor
    Jason K Sicklick
    Division of Surgical Oncology and Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA 92093 0987, USA
    J Transl Med 12:41. 2014
  3. ncbi request reprint Clinical use of FDG PET
    Carl K Hoh
    Department of Radiology, UCSD Medical Center, San Diego, CA 92103 8758, USA
    Nucl Med Biol 34:737-42. 2007
  4. ncbi request reprint Preclinical studies of [(99m)Tc]DTPA-mannosyl-dextran
    Carl K Hoh
    Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 30:457-64. 2003
  5. ncbi request reprint Sentinel lymph node mapping of the colon and stomach using lymphoseek in a pig model
    Scott J Ellner
    Department of Surgery, University of California, San Diego Comprehensive Cancer Center, La Jolla, USA
    Ann Surg Oncol 11:674-81. 2004
  6. pmc Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a "2-day" protocol
    Anne M Wallace
    Department of Surgery, University of California, San Diego, CA 92103, USA Moores UCSD Cancer Center, University of California, La Jolla, CA 92093, USA
    Nucl Med Biol 36:687-92. 2009
  7. ncbi request reprint Dose-dependent biodistribution of [(99m)Tc]DTPA-mannosyl-dextran for breast cancer sentinel lymph node mapping
    Scott J Ellner
    Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 30:805-10. 2003
  8. pmc Optimization via specific fluorescence brightness of a receptor-targeted probe for optical imaging and positron emission tomography of sentinel lymph nodes
    Zhengtao Qin
    University of California, San Diego, Department of Chemistry, La Jolla, California 92093, USA
    J Biomed Opt 18:101315. 2013
  9. pmc Comparative evaluation of [(99m)tc]tilmanocept for sentinel lymph node mapping in breast cancer patients: results of two phase 3 trials
    Anne M Wallace
    Divisions of Surgical Oncology and Plastic Surgery, UCSD Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA
    Ann Surg Oncol 20:2590-9. 2013
  10. ncbi request reprint Lymphoseek: a molecular imaging agent for melanoma sentinel lymph node mapping
    Anne M Wallace
    Department of Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, California 92103, USA
    Ann Surg Oncol 14:913-21. 2007

Research Grants

Collaborators

Detail Information

Publications37

  1. pmc Sentinel lymph node mapping of breast cancer via intradermal administration of Lymphoseek
    Anne M Wallace
    Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 34:849-53. 2007
    ..7 h for fTcSC. The mean SLN uptake of Lymphoseek (1.1+/-.5%) and fTcSC (2.5+/-4.9%) was statistically equivalent (P=.28). When an intra dermal injection was employed, Lymphoseek demonstrated faster injection site clearance than fTcSC...
  2. pmc Generation of orthotopic patient-derived xenografts from gastrointestinal stromal tumor
    Jason K Sicklick
    Division of Surgical Oncology and Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, Mail Code 0987, La Jolla, CA 92093 0987, USA
    J Transl Med 12:41. 2014
    ..We hypothesized that it was feasible to develop orthotopic patient-derived xenografts (PDXs) from resected GIST that could recapitulate the genetic heterogeneity and biology of the human disease...
  3. ncbi request reprint Clinical use of FDG PET
    Carl K Hoh
    Department of Radiology, UCSD Medical Center, San Diego, CA 92103 8758, USA
    Nucl Med Biol 34:737-42. 2007
    ..and applied to the various clinical applications of FDG to understand this difference: (a) Are there competing tests? (b) Is there a cost-effective role in the clinical management? (c) Is the interpretation of the imaging study easy?..
  4. ncbi request reprint Preclinical studies of [(99m)Tc]DTPA-mannosyl-dextran
    Carl K Hoh
    Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 30:457-64. 2003
    ..15 mGy/MBq and the effective dose was 1.06 x 10(-2) mSv/MBq. This preclinical study demonstrates that [(99m)Tc]DTPA-mannosyl-dextran has no toxicities and has an acceptable biodistribution and radiation dose...
  5. ncbi request reprint Sentinel lymph node mapping of the colon and stomach using lymphoseek in a pig model
    Scott J Ellner
    Department of Surgery, University of California, San Diego Comprehensive Cancer Center, La Jolla, USA
    Ann Surg Oncol 11:674-81. 2004
    ..Lymphoseek is a radiopharmaceutical designed for sentinel lymph node (SLN) mapping. The purpose of this study was to compare Lymphoseek colon and gastric pharmacokinetics with filtered [(99m)Tc]sulfur colloid (fTcSC)...
  6. pmc Sentinel lymph node accumulation of Lymphoseek and Tc-99m-sulfur colloid using a "2-day" protocol
    Anne M Wallace
    Department of Surgery, University of California, San Diego, CA 92103, USA Moores UCSD Cancer Center, University of California, La Jolla, CA 92093, USA
    Nucl Med Biol 36:687-92. 2009
    ..5+/-3.1%) was statistically equivalent (P=.213). When an intradermal injection is employed, Lymphoseek demonstrated faster injection site clearance than unfiltered [(99m)Tc]sulfur colloid and persistent SLN accumulation for at least 24 h...
  7. ncbi request reprint Dose-dependent biodistribution of [(99m)Tc]DTPA-mannosyl-dextran for breast cancer sentinel lymph node mapping
    Scott J Ellner
    Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 30:805-10. 2003
    ..Radiation absorbed doses did not differ among the three dose levels, but were lower than filtered [(99m)Tc]sulfur colloid...
  8. pmc Optimization via specific fluorescence brightness of a receptor-targeted probe for optical imaging and positron emission tomography of sentinel lymph nodes
    Zhengtao Qin
    University of California, San Diego, Department of Chemistry, La Jolla, California 92093, USA
    J Biomed Opt 18:101315. 2013
    ..These studies demonstrated the feasibility of 800CW-tilmanocept for multimodal SLN mapping via fluorescence and PET-computed tomography imaging...
  9. pmc Comparative evaluation of [(99m)tc]tilmanocept for sentinel lymph node mapping in breast cancer patients: results of two phase 3 trials
    Anne M Wallace
    Divisions of Surgical Oncology and Plastic Surgery, UCSD Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA
    Ann Surg Oncol 20:2590-9. 2013
    ..99m)Tc]Tilmanocept is a novel receptor-targeted radiopharmaceutical evaluated in 2 open-label, nonrandomized, within-patient, phase 3 trials designed to assess the lymphatic mapping performance...
  10. ncbi request reprint Lymphoseek: a molecular imaging agent for melanoma sentinel lymph node mapping
    Anne M Wallace
    Department of Surgery, University of California, San Diego, 200 West Arbor Drive, San Diego, California 92103, USA
    Ann Surg Oncol 14:913-21. 2007
    ..We conducted a phase I clinical trial in which Lymphoseek was compared with filtered [(99m)Tc]sulfur colloid (fTcSC) for melanoma sentinel lymph node detection...
  11. ncbi request reprint A preclinical study of prostate sentinel lymph node mapping with [99mTC]diethylenetetramine pentaacetic acid-mannosyl-dextran
    Carol E Salem
    Division of Urology, University of California San Diego, La Jolla, California, USA
    J Urol 175:744-8. 2006
    ..Lymphoseek is a new radiopharmaceutical specifically designed for SLN mapping. It shows rapid and sustained SLN uptake...
  12. ncbi request reprint Minimally invasive sentinel lymph node mapping of the pig colon with Lymphoseek
    Anne M Wallace
    Department of Surgery, Moores UCSD Cancer Center, University of California, San Diego, La Jolla, Calif, USA
    Surgery 139:217-23. 2006
    ....
  13. doi request reprint Prospective study of functional bone marrow-sparing intensity modulated radiation therapy with concurrent chemotherapy for pelvic malignancies
    Yun Liang
    Department of Radiation Oncology, and Center for Advanced Radiotherapy Technologies, University of California, San Diego, La Jolla, California 92093, USA
    Int J Radiat Oncol Biol Phys 85:406-14. 2013
    ....
  14. doi request reprint Preoperative sentinel lymph node mapping of the prostate using PET/CT fusion imaging and Ga-68-labeled tilmanocept in an animal model
    Sean P Stroup
    Division of Urology, Department of Surgery, UCSD Moores Cancer Center, University of California, San Diego, CA, USA
    Clin Exp Metastasis 29:673-80. 2012
    ..Gallium-68-labaled tilmanocept was highly specific for sentinel nodes. Image-guided tumor resection and lymphadenectomy may become a promising future application in urologic oncology and warrants further investigation...
  15. ncbi request reprint Whole-body radiation dosimetry of 2-[18F]Fluoro-A-85380 in human PET imaging studies
    Sebastian L Obrzut
    Department of Radiology, Division of Nuclear Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Nucl Med Biol 32:869-74. 2005
    ..184 rad/mCi) and the kidneys (0.0470 mGy/MBq, 0.174 rad/mCi). The mean effective dose equivalent is estimated to be 0.0278 mSv/MBq (0.103 rem/mCi), indicating that radiation dosimetry associated with 2-[18F]FA is within acceptable limits...
  16. ncbi request reprint Detection of gastric and colonic sentinel nodes through endoscopic administration of 99mTc-DTPA-mannosyl-dextran in pigs
    Jeanette Mendez
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, California 92103, USA
    J Nucl Med 44:1677-81. 2003
    ..99m)Tc-Diethylenetriaminepentaacetic acid (DTPA)-mannosyl-dextran is a new radiotracer labeled with (99m)Tc and composed of multiple units of mannose attached to the polymeric backbone, dextran...
  17. pmc Robotic-assisted fluorescence sentinel lymph node mapping using multimodal image guidance in an animal model
    Michael A Liss
    Department of Urology, UC San Diego Health System, San Diego, CA UCSD Moores Cancer Center, La Jolla, CA
    Urology 84:982.e9-14. 2014
    ..To investigate positron emission tomography/computed tomography (PET/CT) preoperative imaging and intraoperative detection of a fluorescent-labeled receptor-targeted radiopharmaceutical in a prostate cancer animal model...
  18. ncbi request reprint Cy5.5-DTPA-galactosyl-dextran: a fluorescent probe for in vivo measurement of receptor biochemistry
    David R Vera
    Department of Radiology, University of California, San Diego, La Jolla, 92093, USA
    Nucl Med Biol 32:687-93. 2005
    ..5-DTPA-dextran. This study demonstrated the feasibility of optically labeling a receptor-binding diagnostic probe and imaging in the TD with sufficient sensitivity and temporal resolution for pharmacokinetic analysis...
  19. ncbi request reprint Breast imaging: a surgeon's prospective
    Anne M Wallace
    Moores UCSD Cancer Center, University of California, San Diego, La Jolla, 92093, USA
    Nucl Med Biol 32:781-92. 2005
    ..In addition, molecular imaging will enable rapid translation between basic science and medical practice...
  20. ncbi request reprint Lymphoseek: a molecular radiopharmaceutical for sentinel node detection
    Anne M Wallace
    Department of Surgery, University of California, San Diego Comprehensive Cancer Center, USA
    Ann Surg Oncol 10:531-8. 2003
    ..We conducted a phase I clinical trial in which Lymphoseek was compared with filtered [(99m)Tc]sulfur colloid (fTcSC) for sentinel node detection in patients with breast cancer...
  21. doi request reprint Single photon emission computed tomography in chronic thromboembolic pulmonary hypertension
    Xavier Soler
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, UCSD Medical Center, San Diego, California 92103 8377, USA
    Respirology 16:131-7. 2011
    ..We conducted this study to test the hypothesis that SPECT lung perfusion scans are more accurate than planar scans for determining the location and extent of perfusion defects in patients with CTEPH...
  22. pmc Comparison of Post-injection Site Pain Between Technetium Sulfur Colloid and Technetium Tilmanocept in Breast Cancer Patients Undergoing Sentinel Lymph Node Biopsy
    Jonathan T Unkart
    Department of Surgery, University of California, San Diego, La Jolla, CA, 92093, USA
    Ann Surg Oncol 22:S559-65. 2015
    ..No prior studies have examined injection pain associated with Technetium-99m Tilmanocept (TcTM)...
  23. doi request reprint A tri-modal molecular imaging agent for sentinel lymph node mapping
    Zhengtao Qin
    Department of Chemistry, University of California, San Diego, La Jolla, California Moores UCSD Cancer Center, University of California, San Diego, La Jolla, California Department of Radiology, University of California, San Diego, La Jolla, California UCSD In Vivo Cancer and Molecular Imaging Center, University of California, San Diego, La Jolla, California
    Nucl Med Biol 42:917-22. 2015
    ..We report an "instant kit" method to radiolabel fluorescent-tilmanocept with (68)Ga and (99m)Tc for tri-modal molecular imaging of sentinel lymph nodes (SLNs)...
  24. doi request reprint Correlation between radiation dose to ¹⁸F-FDG-PET defined active bone marrow subregions and acute hematologic toxicity in cervical cancer patients treated with chemoradiotherapy
    Brent S Rose
    Department of Radiation Oncology and Center for Advanced Radiotherapy Technologies, Rebecca and John Moores Comprehensive Cancer Center, University of California, San Diego, La Jolla, CA, USA
    Int J Radiat Oncol Biol Phys 83:1185-91. 2012
    ....
  25. doi request reprint The role of positron emission tomography following radiosurgical treatment of malignant lung lesions
    Beant Singh Gill
    Department of Radiation Oncology, University of California, San Diego, La Jolla, CA 92093 0843, USA
    Nucl Med Commun 33:607-12. 2012
    ..To establish response patterns in PET following stereotactic body radiotherapy (SBRT) of malignant lung lesions...
  26. pmc Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease
    David S Karow
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
    Radiology 256:932-42. 2010
    ..To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD...
  27. doi request reprint Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models
    Bernd Schnabl
    Department of Medicine, University of California, San Diego, La Jolla, CA
    Nucl Med Biol 43:179-87. 2016
    ....
  28. pmc Comparison of [(99m)Tc]tilmanocept and filtered [(99m)Tc]sulfur colloid for identification of SLNs in breast cancer patients
    Jennifer L Baker
    Department of Surgery, University of California, San Diego, La Jolla, CA, 92093, USA
    Ann Surg Oncol 22:40-5. 2015
    ..We evaluated technical outcomes of SLN biopsy in breast cancer patients mapped with TcTM + vital blue dye (VBD) versus filtered [(99m)Tc]sulfur colloid (fTcSC) + VBD...
  29. doi request reprint Glucose corrected standardized uptake value (SUVgluc) in the evaluation of brain lesions with 18F-FDG PET
    Asae Nozawa
    Department of Radiology, UC San Diego, La Jolla, CA, USA
    Eur J Nucl Med Mol Imaging 40:997-1004. 2013
    ....
  30. doi request reprint Portal shunt scintigraphy (PSS) in the evaluation of patients suspected of hereditary hemorrhagic telangiectasia
    Asae Nozawa
    Department of Radiology, University of California, San Diego, San Diego, CA, USA
    Clin Nucl Med 38:741-3. 2013
    ..In this study, we applied noninvasive portal shunt scintigraphy to determine the portal shunt index for their evaluation. We present a case of the patient with a high PSI value and another case with a normal PSI value (<10%). ..
  31. doi request reprint Prognostic value of post-Yttrium 90 radioembolization therapy 18F-fluorodeoxyglucose positron emission tomography in patients with liver tumors
    Sebastian Obrzut
    University of California, San Diego, Radiology, San Diego, CA, USA
    Clin Imaging 42:43-49. 2016
    ..This study assessed the benefit of post-therapy 18F-FDG PET/CT versus CT alone in identifying malignant liver tumor progression following radioembolization with Y-90 microspheres...
  32. pmc [(18)F]Fluoro-2-deoxy-2-d-glucose versus 3'-deoxy-3'-[(18)F]fluorothymidine for defining hematopoietically active pelvic bone marrow in gynecologic patients
    Jeffrey C Wyss
    Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, United States
    Radiother Oncol 118:72-8. 2016
    ....
  33. doi request reprint Pilot study comparing SPECT perfusion scintigraphy with CT pulmonary angiography in chronic thromboembolic pulmonary hypertension
    Xavier Soler
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California, San Diego, California, USA
    Respirology 17:180-4. 2012
    ..The purpose of this study is to compare SPECT with CTPA for detecting segmental pulmonary artery obstruction in CTEPH...
  34. doi request reprint Utility of fluorodeoxyglucose-positron emission tomography in the identification of new lesions in lung cancer patients for the assessment of therapy response
    Sebastian Obrzut
    Department of Radiology, University of California San Diego, La Jolla, California, USA
    Nucl Med Commun 31:1008-15. 2010
    ....
  35. ncbi request reprint Molecular targeting of the lymphovascular system for imaging and therapy
    Heiko Schoder
    Department of Radiology Nuclear Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Metastasis Rev 25:185-201. 2006
    ..We also review the current status of sentinel lymph node mapping with radiocolloids and the application of molecular targeting for the development of a radiopharmaceutical specifically designed for sentinel lymph node mapping...
  36. ncbi request reprint 18F-fluorothymidine kinetics of malignant brain tumors
    Christiaan Schiepers
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, AR 144 CHS 10833 Le Conte Avenue, Los Angeles, CA 90095 6942, USA
    Eur J Nucl Med Mol Imaging 34:1003-11. 2007
    ..18F-labeled deoxy-fluorothymidine (FLT), a marker of cellular proliferation, has been used in PET tumor imaging. Here, the FLT kinetics of malignant brain tumors were investigated...
  37. doi request reprint 1-11C-acetate kinetics of prostate cancer
    Christiaan Schiepers
    Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California 90095 6942, USA
    J Nucl Med 49:206-15. 2008
    ..1-(11)C-Labeled acetate, a substrate for the citric acid cycle, is superior. The kinetics of prostate tumors were investigated...

Research Grants1

  1. A New Radiotracer for Sentinel Node Mapping of Colon Cancer
    Carl Hoh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..