Alan F Hofmann

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The continuing importance of bile acids in liver and intestinal disease
    A F Hofmann
    Department of Medicine, University of California, San Diego, La Jolla 92093 0813, USA
    Arch Intern Med 159:2647-58. 1999
  2. doi request reprint Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics
    A F Hofmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
    Cell Mol Life Sci 65:2461-83. 2008
  3. ncbi request reprint Novel biotransformation and physiological properties of norursodeoxycholic acid in humans
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, 92093, USA
    Hepatology 42:1391-8. 2005
  4. pmc How bile acids confer gut mucosal protection against bacteria
    Alan F Hofmann
    Department of Medicine, Division of Gastroenterology, University of California at San Diego, La Jolla, CA 92093 0813, USA
    Proc Natl Acad Sci U S A 103:4333-4. 2006
  5. ncbi request reprint The enterohepatic circulation of bile acids in mammals: form and functions
    Alan F Hofmann
    Division of Gastroenterology Department of Medicine, University of California, San Diego La Jolla, California 92093 0063, USA
    Front Biosci (Landmark Ed) 14:2584-98. 2009
  6. pmc Increased deoxycholic acid absorption and gall stones in acromegalic patients treated with octreotide: more evidence for a connection between slow transit constipation and gall stones
    A F Hofmann
    Department of Medicine, MC 0813, University of California, San Diego, La Jolla, CA 92093 0813, USA
    Gut 54:575-8. 2005
  7. doi request reprint Bile acids: trying to understand their chemistry and biology with the hope of helping patients
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA 92093 0063, USA
    Hepatology 49:1403-18. 2009
  8. pmc Bile salts of vertebrates: structural variation and possible evolutionary significance
    Alan F Hofmann
    Department of Medicine, University of California, San Diego, San Diego, CA 92093 0063, USA
    J Lipid Res 51:226-46. 2010
  9. pmc Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry
    A F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego 92093 0813, USA
    Gut 52:1239-41. 2003
  10. doi request reprint Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    J Pediatr Gastroenterol Nutr 47:598-606. 2008

Research Grants

Collaborators

Detail Information

Publications53

  1. ncbi request reprint The continuing importance of bile acids in liver and intestinal disease
    A F Hofmann
    Department of Medicine, University of California, San Diego, La Jolla 92093 0813, USA
    Arch Intern Med 159:2647-58. 1999
    ..A knowledge of bile acid physiology and the perturbations of bile acid metabolism in liver and digestive disease should be useful for the internist...
  2. doi request reprint Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics
    A F Hofmann
    Department of Medicine, University of California, San Diego, La Jolla, California 92093 0063, USA
    Cell Mol Life Sci 65:2461-83. 2008
    ..Bile acids are used therapeutically to correct deficiency states, to decrease the cholesterol saturation of bile, or to decrease the cytotoxicity of retained bile acids in cholestatic liver disease...
  3. ncbi request reprint Novel biotransformation and physiological properties of norursodeoxycholic acid in humans
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, 92093, USA
    Hepatology 42:1391-8. 2005
    ..NorUDCA ingestion induces a bicarbonate-rich hypercholeresis and evokes less phospholipid and cholesterol secretion into bile than UDCA. Molecules that undergo cholehepatic shunting should be powerful choleretics in humans...
  4. pmc How bile acids confer gut mucosal protection against bacteria
    Alan F Hofmann
    Department of Medicine, Division of Gastroenterology, University of California at San Diego, La Jolla, CA 92093 0813, USA
    Proc Natl Acad Sci U S A 103:4333-4. 2006
  5. ncbi request reprint The enterohepatic circulation of bile acids in mammals: form and functions
    Alan F Hofmann
    Division of Gastroenterology Department of Medicine, University of California, San Diego La Jolla, California 92093 0063, USA
    Front Biosci (Landmark Ed) 14:2584-98. 2009
    ..Methods for characterizing the enterohepatic circulation are summarized. Bile acids have numerous physiological functions in the liver, biliary tract, and intestine resulting from their signaling and physicochemical properties...
  6. pmc Increased deoxycholic acid absorption and gall stones in acromegalic patients treated with octreotide: more evidence for a connection between slow transit constipation and gall stones
    A F Hofmann
    Department of Medicine, MC 0813, University of California, San Diego, La Jolla, CA 92093 0813, USA
    Gut 54:575-8. 2005
  7. doi request reprint Bile acids: trying to understand their chemistry and biology with the hope of helping patients
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, CA 92093 0063, USA
    Hepatology 49:1403-18. 2009
    ..Finally, principles of therapy with bile acid agonists and antagonists are given. Advances in understanding bile acid biology and chemistry have helped to improve the lives of patients with hepatobiliary or digestive disease...
  8. pmc Bile salts of vertebrates: structural variation and possible evolutionary significance
    Alan F Hofmann
    Department of Medicine, University of California, San Diego, San Diego, CA 92093 0063, USA
    J Lipid Res 51:226-46. 2010
    ..Bile salt composition is a biochemical trait providing clues to evolutionary relationships, complementing anatomical and genetic analyses...
  9. pmc Inappropriate ileal conservation of bile acids in cholestatic liver disease: homeostasis gone awry
    A F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego 92093 0813, USA
    Gut 52:1239-41. 2003
  10. doi request reprint Altered bile acid metabolism in childhood functional constipation: inactivation of secretory bile acids by sulfation in a subset of patients
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    J Pediatr Gastroenterol Nutr 47:598-606. 2008
    ..To test this possibility, fecal bile acid composition was determined in children with functional constipation and in nonconstipated control children...
  11. doi request reprint Biliary bile acids in birds of the Cotingidae family: taurine-conjugated (24R,25R)-3α,7α,24-trihydroxy-5β-cholestan-27-oic acid and two epimers (25R and 25S) of 3α,7α-dihydroxy-5β-cholestan-27-oic acid
    Lee R Hagey
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    Steroids 76:1126-35. 2011
    ....
  12. pmc Major biliary bile acids of the medaka (Oryzias latipes): 25R- and 25S-epimers of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoic acid
    Lee R Hagey
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    Zoolog Sci 27:565-73. 2010
    ..The medaka is the first fish species identified as having C(27) biliary bile acids as dominant among its major bile salts...
  13. ncbi request reprint Human cecal bile acids: concentration and spectrum
    James P Hamilton
    Division of Gastroenterology and Hepatology, Department of Medicine, Veterans Affairs Maryland Health Care System and University of Maryland School of Medicine, 22 S Greene Street, Baltimore, MD 21201, USA
    Am J Physiol Gastrointest Liver Physiol 293:G256-63. 2007
    ..In the human cecum, deconjugation and dehydroxylation of bile acids are nearly complete, resulting in most bile acids being in unconjugated form at submicellar and subsecretory concentrations...
  14. pmc Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites
    Lee R Hagey
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    BMC Evol Biol 10:133. 2010
    ..We greatly extend prior surveys of bile salt diversity in both reptiles and mammals, including analysis of 8,000 year old human coprolites and coprolites from the extinct Shasta ground sloth (Nothrotherium shastense)...
  15. doi request reprint A novel varanic acid epimer--(24R,25S)-3α,7α,12α,24-tetrahydroxy-5β-cholestan-27-oic acid--is a major biliary bile acid in two varanid lizards and the Gila monster
    Lee R Hagey
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 063, USA
    Steroids 77:1510-21. 2012
    ..The structure was established by mass spectroscopy and by (1)H and (13)C nuclear magnetic spectroscopy, as well as by synthesis of the compound...
  16. pmc Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway
    Lee R Hagey
    Department of Medicine, University of California San Diego, MC 0063, La Jolla, California 92093, USA
    Physiol Biochem Zool 83:308-21. 2010
    ..Analysis of the evolution of bile salt synthetic pathways provides a rich model system for the molecular evolution of a complex biochemical pathway in vertebrates...
  17. ncbi request reprint A novel primary bile acid in the Shoebill stork and herons and its phylogenetic significance
    L R Hagey
    Zoological Society of San Diego, San Diego, CA 92112, USA
    J Lipid Res 43:685-90. 2002
    ..The presence of this biochemical trait in the Shoebill stork and certain herons suggests that these birds are closely related...
  18. ncbi request reprint Bile acid-induced secretion in polarized monolayers of T84 colonic epithelial cells: Structure-activity relationships
    Stephen J Keely
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, California, USA
    Am J Physiol Gastrointest Liver Physiol 292:G290-7. 2007
    ..These studies indicate marked structural specificity for bile acid-induced chloride secretion and show that modification of bile acid structure by colonic bacteria modulates the secretory properties of these endogenous secretagogues...
  19. ncbi request reprint Physicochemical and physiological properties of 5alpha-cyprinol sulfate, the toxic bile salt of cyprinid fish
    T Goto
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, CA 92093 0813, USA
    J Lipid Res 44:1643-51. 2003
    ..These studies indicate that 5alpha-cyprinol sulfate is an excellent digestive detergent and suggest that a micellar phase is present during digestion in cyprinid fish...
  20. pmc A new, major C27 biliary bile acid in the red-winged tinamou (Rhynchotus rufescens):25R-1beta, 3alpha,7alpha-trihydroxy-5beta-cholestan-27-oic acid
    Lee R Hagey
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0063, USA
    J Lipid Res 50:651-7. 2009
    ..Although C27 bile acids with a 1beta-hydroxyl group have been identified as trace bile acids in the alligator, this is the first report of a major biliary C27 bile acid possessing a 1beta-hydroxyl group...
  21. ncbi request reprint Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, California, USA
    Drug Metab Rev 36:703-22. 2004
    ..Lithocholic acid is a rare example of a toxic endobiotic; a variety of mechanisms have evolved to solve the problem of efficient detoxification...
  22. pmc Key discoveries in bile acid chemistry and biology and their clinical applications: history of the last eight decades
    Alan F Hofmann
    Department of Medicine, University of California, San Diego, San Diego, CA
    J Lipid Res 55:1553-95. 2014
    ..The rise and decline of dissolution of cholesterol gallstones by the ingestion of 3,7-dihydroxy bile acids is chronicled. Scientists from throughout the world have contributed to these achievements. ..
  23. ncbi request reprint Accurate enzymatic measurement of fecal bile acids in patients with malabsorption
    Jack L Porter
    Department of Medicine, Baylor University Medical Center, Dallas, Texas 75246, USA
    J Lab Clin Med 141:411-8. 2003
    ..95), both in normal subjects and in patients with malabsorption syndromes...
  24. doi request reprint Herbert Falk: a vital force in the renaissance of bile acid research and bile acid therapy
    Alan F Hofmann
    Department of Medicine, University of California San Diego, La Jolla, Calif, USA
    Dig Dis 29:23-36. 2011
    ..We must all be grateful to Herbert Falk's vision in establishing the Falk Foundation that has so generously sponsored these meetings. We also express our gratitude to his widow, Ursula Falk, who continues this worthy tradition...
  25. ncbi request reprint Cholestatic liver disease: pathophysiology and therapeutic options
    Alan F Hofmann
    Division of Gastroenterology, Department of Medicine, University of California, San Diego, CA 92093, USA
    Liver 22:14-9. 2002
    ..Extracorporeal dialysis against albumin offers promise of a realistic albeit partial simulation of hepatic excretory function...
  26. ncbi request reprint Biliary secretion and excretion in health and disease: current concepts
    Alan F Hofmann
    Division of Gastroenterology Department of Medicine University of California, San Diego California 92093 0813, USA
    Ann Hepatol 6:15-27. 2007
    ..A synthetic bile acid, norUDCA is absorbed by the biliary ductules after secretion and cures the peribiliary fibrosis occurring in the MDR2-/- mouse which lacks biliary phospholipid...
  27. ncbi request reprint Inhibition of bile acid transport across Na+/taurocholate cotransporting polypeptide (SLC10A1) and bile salt export pump (ABCB 11)-coexpressing LLC-PK1 cells by cholestasis-inducing drugs
    Sachiko Mita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Drug Metab Dispos 34:1575-81. 2006
    ..Our study suggests that such coexpressing cells can provide a useful system for the identification of inhibitors of these two transport systems, including potential drug candidates...
  28. ncbi request reprint Methotrexate (MTX) plus ursodeoxycholic acid (UDCA) in the treatment of primary biliary cirrhosis
    Burton Combes
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9151, USA
    Hepatology 42:1184-93. 2005
    ..In conclusion, methotrexate when added to UDCA for a median period of 7.6 years had no effect on the course of PBC treated with UDCA alone...
  29. ncbi request reprint A phylogenetic survey of biliary lipids in vertebrates
    Antonio Moschetta
    Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Lipid Res 46:2221-32. 2005
    ..Mammals have a higher phospholipid and cholesterol to bile salt ratio, with the dominant phospholipid being PC...
  30. ncbi request reprint Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats
    Vicente Lorenzo-Zúñiga
    Departments of Gastroenterology, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
    Hepatology 37:551-7. 2003
    ..Oral conjugated bile acids may be useful in preventing bacterial translocation, endotoxemia, and spontaneous bacterial perotonitis in cirrhotic patients...
  31. ncbi request reprint Chemical synthesis of the 3-sulfooxy-7-N-acetylglucosaminyl-24-amidated conjugates of 3beta,7beta-dihydroxy-5-cholen-24-oic acid, and related compounds: unusual, major metabolites of bile acid in a patient with Niemann-Pick disease type C1
    Takashi Iida
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Setagaya, Sakurajousui, Tokyo 156 8550, Japan
    Steroids 71:18-29. 2006
    ..The structures of the multi-conjugated bile acids were characterized by liquid chromatography-mass spectrometry with an electrospray ionization probe under the positive and negative ionization modes...
  32. ncbi request reprint Helicobacter and cholesterol gallstones: do findings in the mouse apply to man?
    Alan F Hofmann
    Gastroenterology 128:1126-9. 2005
  33. ncbi request reprint Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump
    Sachiko Mita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Gastrointest Liver Physiol 288:G159-67. 2005
    ..This double-expressing system can be used as a model to clarify vectorial transport of bile salts across hepatocytes under physiological conditions...
  34. ncbi request reprint Substrate specificity of human ABCC4 (MRP4)-mediated cotransport of bile acids and reduced glutathione
    Maria Rius
    Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
    Am J Physiol Gastrointest Liver Physiol 290:G640-9. 2006
    ..In cholestatic conditions, ABCC4 may become a key pathway for efflux of bile acids from hepatocytes into blood...
  35. ncbi request reprint Gallstone disease: physicochemical research sheds new light on an old disease and points the way to medical therapy
    Alan F Hofmann
    J Hepatol 41:195-200. 2004
  36. ncbi request reprint Chemical synthesis of (22E)-3 alpha,6 beta,7 beta-trihydroxy-5 beta-chol-22-en-24-oic acid and its taurine and glycine conjugates: a major bile acid in the rat
    Genta Kakiyama
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajousui, Setagaya, Tokyo 156 8550, Japan
    J Lipid Res 45:567-73. 2004
    ....
  37. ncbi request reprint The effect of extracorporeal albumin dialysis on plasma phospholipid fatty acids in patients with end-stage liver disease
    Nina Zeh
    School of Medicine, University of Rostock, Germany
    Liver Int 23:34-8. 2003
    ..ECAD causes a transient increase in PLFA toward normal levels and also increases the proportion of n3 and n6 FA...
  38. ncbi request reprint Potential bile acid metabolites. 25. Synthesis and chemical properties of stereoisomeric 3alpha,7alpha,16- and 3alpha,7alpha,15-trihydroxy-5beta-cholan-24-oic acids
    Takashi Iida
    College of Humanities and Sciences, Nihon University, Japan
    Chem Pharm Bull (Tokyo) 50:1327-34. 2002
    ..A facile formation of the corresponding epsilon-lactones between the side chain carboxyl group at C-24 and the 16alpha- (or 16beta-) hydroxyl group in bile acids is also clarified...
  39. pmc Human CYP7A1 deficiency: progress and enigmas
    Anne Beigneux
    Gladstone Institute of Cardiovascular Disease, Cardiovascular Research Institute, University of California San Francisco, 365 Vermont Street, San Francisco, CA 94103, USA
    J Clin Invest 110:29-31. 2002
  40. ncbi request reprint Nasobiliary drainage for cholestatic pruritus
    Alan F Hofmann
    Hepatology 43:1170-1. 2006
  41. ncbi request reprint Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep
    Hisamitsu Hayashi
    Department of Molecular Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochim Biophys Acta 1738:54-62. 2005
    ..TLC-S, which is present in human bile but not rodent bile, is more avidly transported by hBSEP compared with rBsep...
  42. pmc Evolution of the bile salt nuclear receptor FXR in vertebrates
    Erica J Reschly
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Lipid Res 49:1577-87. 2008
    ..Our observations present an integrated picture of the coevolution of bile salt structure and of the binding pocket of their target nuclear receptor FXR...
  43. ncbi request reprint Identification of a novel bile acid in swans, tree ducks, and geese: 3alpha,7alpha,15alpha-trihydroxy-5beta-cholan-24-oic acid
    Genta Kakiyama
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajousui, Setagaya, Tokyo 156 8550, Japan
    J Lipid Res 47:1551-8. 2006
    ..3alpha,7alpha,15alpha-Trihydroxy-5beta-cholan-24-oic acid is a new primary bile acid that is present in the biliary bile acids of swans, tree ducks, and geese and may be termed 15alpha-hydroxy-chenodeoxycholic acid...
  44. ncbi request reprint Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8)
    Kazuya Maeda
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Mol Pharm 3:70-7. 2006
    ..These results provide an explanation for the efficient hepatic clearance of UDCA and its conjugates in patients receiving UDCA therapy...
  45. ncbi request reprint Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit
    Ephraim Sehayek
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY, USA
    J Lipid Res 47:2020-7. 2006
    ..In this intercross, Cyp8b1, a strong candidate, does not appear to be responsible...
  46. ncbi request reprint Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport
    Coen C Paulusma
    Amsterdam Liver Center, Department of Experimental Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 44:195-204. 2006
    ..The loss of phospholipid asymmetry may subsequently impair bile salt transport and cause cholestasis...
  47. pmc Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor
    Xianghai Chen
    Faculty of Pharmacy, University of Toronto, 19 Russell Street, Toronto, Ontario M5S 2S2, Canada
    Mol Pharmacol 69:1913-23. 2006
    ..Human ABST mRNA and promoter activity were also increased in Caco-2 cells treated with 1,25(OH)(2)D(3), suggesting a physiological role of VDR in human ileal bile acid homeostasis...
  48. ncbi request reprint Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep
    Sachiko Mita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Gastrointest Liver Physiol 290:G550-6. 2006
    ..In conclusion, the substrate specificity of human and rat NTCP and BSEP appear to be very similar at least for monovalent bile salts under physiological conditions...
  49. ncbi request reprint Why bile acid glucuronidation is a minor pathway for conjugation of endogenous bile acids in man
    Alan F Hofmann
    Hepatology 45:1083-4; author reply 1084-5. 2007
  50. ncbi request reprint 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    Peter Fickert
    Department of Medicine, Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Medical University Graz, Austria
    Gastroenterology 130:465-81. 2006
    ..Experiments were performed to test in such mice the therapeutic effects of 24-norUrsodeoxycholic acid, a C(23) homologue of ursodeoxycholic acid with 1 fewer methylene group in its side chain...
  51. ncbi request reprint Enhancement of dietary protein digestion by conjugated bile acids
    Jonathan Gass
    Department of Chemical Engineering, Stanford University, Stanford, California, USA
    Gastroenterology 133:16-23. 2007
    ..Conjugated bile acids promote absorption of dietary lipids by solubilizing them in mixed micelles. Bile acids are not considered to facilitate the digestion of other nutrients...
  52. doi request reprint Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies
    Hiroyuki Sato
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique INSERM ULP, Illkirch, France
    J Med Chem 51:1831-41. 2008
    ....
  53. ncbi request reprint Transport of the sulfated, amidated bile acid, sulfolithocholyltaurine, into rat hepatocytes is mediated by Oatp1 and Oatp2
    Ling Jie Meng
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Hepatology 35:1031-40. 2002
    ....

Research Grants1

  1. DEFECTIVE BILE ACID SYNTHESIS IN CHILDHOOD CONSTIPATION
    ALAN HOFMANN; Fiscal Year: 2005
    ..Results of this study should lead to clinical trials that test the efficacy of oral primary bile acids for constipation caused by defective bile acid biosynthesis. ..