Hal M Hoffman

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies
    Hal M Hoffman
    Division of Rheumatology and Allergy Immunology, University of California at San Diego, La Jolla, CA 92093 0635, USA
    Arthritis Rheum 58:2443-52. 2008
  2. pmc Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    Lancet 364:1779-85. 2004
  3. pmc An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury
    Alana A Shigeoka
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:6277-85. 2010
  4. pmc Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia
    Sanna Rosengren
    Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 119:991-6. 2007
  5. pmc NLRP3 inflammasome activation is required for fibrosis development in NAFLD
    Alexander Wree
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0715, La Jolla, CA, 92037 0715, USA
    J Mol Med (Berl) 92:1069-82. 2014
  6. doi request reprint Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study
    Hal M Hoffman
    University of California San Diego, La Jolla, USA
    Clin Ther 34:2091-103. 2012
  7. pmc Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models
    Matthew D McGeough
    Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 189:2707-11. 2012
  8. doi request reprint Recurrent febrile syndromes: what a rheumatologist needs to know
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093, USA
    Nat Rev Rheumatol 5:249-56. 2009
  9. pmc Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis
    Lori Broderick
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr MC 0635, La Jolla, CA 92093, USA
    J Clin Immunol 33:162-71. 2013
  10. pmc ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6
    Marina Miller
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 109:16648-53. 2012

Collaborators

Detail Information

Publications44

  1. doi request reprint Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies
    Hal M Hoffman
    Division of Rheumatology and Allergy Immunology, University of California at San Diego, La Jolla, CA 92093 0635, USA
    Arthritis Rheum 58:2443-52. 2008
    ....
  2. pmc Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    Lancet 364:1779-85. 2004
    ..The genetic basis of this disease has been elucidated. Cryopyrin, the protein that is altered in FCAS, is one of the adaptor proteins that activate caspase 1, resulting in release of interleukin 1...
  3. pmc An inflammasome-independent role for epithelial-expressed Nlrp3 in renal ischemia-reperfusion injury
    Alana A Shigeoka
    Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 185:6277-85. 2010
    ..We conclude that Nlrp3 contributes to renal IRI by a direct effect on renal tubular epithelium and that this effect is independent of inflammasome-induced proinflammatory cytokine production...
  4. pmc Monocytes from familial cold autoinflammatory syndrome patients are activated by mild hypothermia
    Sanna Rosengren
    Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 119:991-6. 2007
    ..CIAS1, the gene that codes for cryopyrin, is mutated in FCAS. Treatment with anakinra (IL-1 receptor antagonist) prevents symptoms, indicating a crucial role for IL-1 in this disease...
  5. pmc NLRP3 inflammasome activation is required for fibrosis development in NAFLD
    Alexander Wree
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0715, La Jolla, CA, 92037 0715, USA
    J Mol Med (Berl) 92:1069-82. 2014
    ..Patients with severe NAFLD exhibit increased levels of NLRP3 inflammasome components and levels of pro-IL1β mRNA correlate with the expression of COL1A1...
  6. doi request reprint Long-term efficacy and safety profile of rilonacept in the treatment of cryopryin-associated periodic syndromes: results of a 72-week open-label extension study
    Hal M Hoffman
    University of California San Diego, La Jolla, USA
    Clin Ther 34:2091-103. 2012
    ..The interleukin-1 inhibitor rilonacept has been shown to be well-tolerated and effective in preventing CAPS symptoms in 2 pivotal studies...
  7. pmc Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models
    Matthew D McGeough
    Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA
    J Immunol 189:2707-11. 2012
    ..Taken together, our results indicate that IL-6 is a reliable marker of inflammation, with no direct role in inflammasome-mediated disease...
  8. doi request reprint Recurrent febrile syndromes: what a rheumatologist needs to know
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093, USA
    Nat Rev Rheumatol 5:249-56. 2009
    ..NSAIDs, colchicine and corticosteroids have roles in the treatment of some of these disorders, but biologic drugs that target interleukin-1beta are emerging as consistently effective therapies...
  9. pmc Mutations of complement factor I and potential mechanisms of neuroinflammation in acute hemorrhagic leukoencephalitis
    Lori Broderick
    Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California San Diego, 9500 Gilman Dr MC 0635, La Jolla, CA 92093, USA
    J Clin Immunol 33:162-71. 2013
    ....
  10. pmc ORMDL3 is an inducible lung epithelial gene regulating metalloproteases, chemokines, OAS, and ATF6
    Marina Miller
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 109:16648-53. 2012
    ..These studies provide evidence of the inducible nature of ORMDL3 ER expression in particular in bronchial epithelial cells and suggest an ER UPR pathway through which ORMDL3 may be linked to asthma...
  11. ncbi request reprint MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3
    Qilin Pan
    Department of Immunology, The Scripps Research Institute, La Jolla, California, USA
    J Leukoc Biol 82:177-83. 2007
    ..Together, our data provide a new understanding of this important pathway of IL-1beta production and allow for further studies of the role of these proteins within the broader context of inflammatory disease...
  12. pmc Identification of EpCAM as the gene for congenital tufting enteropathy
    Mamata Sivagnanam
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California San Diego, La Jolla, California, USA
    Gastroenterology 135:429-37. 2008
    ..The pathogenesis and genetics of this disorder are not well understood. The objective of this study was to identify the gene responsible for CTE...
  13. ncbi request reprint Successful treatment of renal amyloidosis due to familial cold autoinflammatory syndrome using an interleukin 1 receptor antagonist
    Brian D Thornton
    Division of Nephrology, University of California Davis Medical Center, La Jolla, CA, USA
    Am J Kidney Dis 49:477-81. 2007
    ..Use of specific anticytokine therapy may be a new paradigm in the treatment of patients with renal amyloidosis caused by systemic inflammatory diseases...
  14. ncbi request reprint Cryopyrin-associated periodic syndromes: development of a patient-reported outcomes instrument to assess the pattern and severity of clinical disease activity
    Hal M Hoffman
    University of California at San Diego, La Jolla, CA 92093 0635, USA
    Curr Med Res Opin 24:2531-43. 2008
    ..Development of an instrument for characterization of symptom patterns and severity in patients with cryopyrin-associated periodic syndromes (CAPS)...
  15. ncbi request reprint Hereditary immunologic disorders caused by pyrin and cryopyrin
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego Medical School, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Curr Allergy Asthma Rep 7:323-30. 2007
    ..These advances have also resulted in direct improvement in diagnosis and therapy for autoinflammatory disorders such as the cryopyrinopathies and familial Mediterranean fever and have implications for more common inflammatory diseases...
  16. pmc Recurrent fever syndromes in patients after recovery from Kawasaki syndrome
    Lori Broderick
    Department of Pediatrics, University of California San Diego and Rady Children s Hospital, San Diego, California, USA
    Pediatrics 127:e489-93. 2011
    ..We propose that these 2 syndromes exist within a family of febrile disorders related to innate immune dysregulation...
  17. pmc NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms
    Chao Qu
    Division of Bone and Mineral Diseases and Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri, USA and Division of Allergy, Immunology, and Rheumatology, University of California, San Diego, La Jolla, California, USA
    FASEB J 29:1269-79. 2015
    ..Thus, NLRP3 inflammasome activation is not restricted to the production of proinflammatory mediators but also leads to cytokine-autonomous responses...
  18. pmc Familial atypical cold urticaria: description of a new hereditary disease
    Chhavi Gandhi
    Division of Rheumatology, Allergy, and Immunology, University of California, San Diego, La Jolla, CA, USA
    J Allergy Clin Immunol 124:1245-50. 2009
    ..We describe 3 unrelated families (A, B, and C) with lifelong atypical cold urticaria distinguished from ACU and familial cold autoinflammatory syndrome...
  19. pmc Inflammasome and IL-1beta-mediated disorders
    Hal M Hoffman
    Division of Allergy and Immunology, University of California at San Diego and Rady Children s Hospital of San Diego, La Jolla, CA 92093, USA
    Curr Allergy Asthma Rep 10:229-35. 2010
    ..However, many other diseases are likely to be mediated by the inflammasome and interleukin-1beta, providing additional targets in the future...
  20. pmc Therapy of autoinflammatory syndromes
    Hal M Hoffman
    Department of Pediatrics and Medicine, Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0635, USA
    J Allergy Clin Immunol 124:1129-38; quiz 1139-40. 2009
    ..This article reviews the general approach to the therapy of autoinflammatory diseases, focusing on current approved therapies and novel approaches that might be used in the future...
  21. ncbi request reprint Rilonacept for the treatment of cryopyrin-associated periodic syndromes (CAPS)
    Hal M Hoffman
    University of California at San Diego, Division of Rheumatology and Allergy Immunology, Mail Code 0635, 9500 Gilman Drive, La Jolla, CA 92093 0635, USA
    Expert Opin Biol Ther 9:519-31. 2009
    ..Until recently, there was no effective treatment for CAPS, but identification of the genetic basis of CAPS highlighted the pathogenic role of IL-1beta...
  22. pmc Definition of IFN-γ-related pathways critical for chemically-induced systemic autoimmunity
    K Michael Pollard
    Department of Molecular and Experimental Medicine, MEM125, Scripps Research Institute, La Jolla, CA 92037, USA
    J Autoimmun 39:323-31. 2012
    ..These findings have implications for the therapeutic targeting of IFN-γ pathways in systemic autoimmunity...
  23. pmc Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production
    Jose M Gonzalez-Navajas
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 207:2799-807. 2010
    ..Our data identifies a new molecular pathway by which IL-1 signaling attenuates TLR9-mediated proinflammatory responses...
  24. pmc Structural, expression, and evolutionary analysis of mouse CIAS1
    Justin P Anderson
    Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Gene 338:25-34. 2004
    ..We also detected significant expression in mouse eye and skin tissue, which is consistent with symptoms observed in human Cryopyrin-associated diseases...
  25. pmc NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria
    Zhenyu Zhong
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA Department of Pathology, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Cell 164:896-910. 2016
    ....
  26. doi request reprint The role of the inflammasome in patients with autoinflammatory diseases
    Hal M Hoffman
    Division of Pediatric Allergy, Immunology, and Rheumatology, University of California at San Diego, and Rady Children s Hospital of San Diego, La Jolla, Calif Electronic address
    J Allergy Clin Immunol 138:3-14. 2016
    ..This review will focus on understanding the molecular basis of inflammasomes, recognizing the distinguishing features of the classic autoinflammatory disorders, and appreciating the treatment modalities available. ..
  27. pmc A group A Streptococcus ADP-ribosyltransferase toxin stimulates a protective interleukin 1β-dependent macrophage immune response
    Ann E Lin
    Department of Pediatrics, University of California, San Diego, La Jolla, California, USA
    MBio 6:e00133. 2015
    ..Thus, SpyA triggers caspase-1-dependent inflammatory cell death in macrophages, revealing a toxin-triggered IL-1β-dependent innate immune response pathway critical in defense against invasive bacterial infection...
  28. pmc The inflammasome adaptor ASC contributes to multiple innate immune processes in the resolution of otitis media
    Arwa Kurabi
    School of Medicine, Department of Surgery, Division of Otolaryngology, University of California San Diego, La Jolla, CA, USA
    Innate Immun 21:203-14. 2015
    ..These data demonstrate an important role for the inflammasome and cytokine processing in the course and resolution of OM. ..
  29. doi request reprint From NAFLD to NASH to cirrhosis-new insights into disease mechanisms
    Alexander Wree
    Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037 0715, USA
    Nat Rev Gastroenterol Hepatol 10:627-36. 2013
    ..These studies bring new insight into this complex disorder and have led to the development of novel therapeutic and diagnostic strategies that might enable a personalized approach in the management of this disease. ..
  30. ncbi request reprint Fine structure mapping of CIAS1: identification of an ancestral haplotype and a common FCAS mutation, L353P
    Hal M Hoffman
    Division of Rheumatology, Allergy, and Immunology, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0635, USA
    Hum Genet 112:209-16. 2003
    ..We also report a comprehensive list of intragenic single nucleotide polymorphisms. The data provided here will assist others researching the 1q44 region and will aid clinicians in the diagnosis of FCAS...
  31. pmc Autoinflammation: translating mechanism to therapy
    Taylor A Doherty
    Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0635, USA
    J Leukoc Biol 90:37-47. 2011
    ..Here, we review current treatment strategies of autoinflammatory diseases with a focus on IL-1 antagonism...
  32. pmc Staphylococcus aureus golden pigment impairs neutrophil killing and promotes virulence through its antioxidant activity
    George Y Liu
    Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, USA
    J Exp Med 202:209-15. 2005
    ..Blocking S. aureus carotenogenesis increases oxidant sensitivity and decreases whole-blood survival, suggesting a novel target for antibiotic therapy...
  33. ncbi request reprint The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
    Ralph Knoll
    Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
    Cell 111:943-55. 2002
    ..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure...
  34. pmc The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model
    Ivona Aksentijevich
    Genetics and Genomics Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892 1820, USA
    Arthritis Rheum 56:1273-85. 2007
    ..This study was undertaken to investigate the structural effect of disease-causing mutations on cryopyrin, in order to gain better understanding of the impact of disease-associated mutations on protein function...
  35. ncbi request reprint A large kindred with familial cold autoinflammatory syndrome
    Reid F Johnstone
    Allergy Immunology Section, Department of Pediatrics, Medical College of Georgia, Augusta, Georgia, USA
    Ann Allergy Asthma Immunol 90:233-7. 2003
    ..Recently, mutations responsible for FCAS were identified in a novel gene (CIAS1), making it possible to confirm the diagnosis in most patients...
  36. ncbi request reprint The spectrum of acquired and familial cold-induced urticaria/urticaria-like syndromes
    Alan A Wanderer
    University of Colorado Health Sciences Center, Denver, USA
    Immunol Allergy Clin North Am 24:259-86, vii. 2004
    ..FCAS has become an important investigative syndrome, as it represents a reproducible in vivo model of chronic inflammation...
  37. pmc Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC
    Stephen B Willingham
    Lineberger Comprehensive Cancer Center, Curriculum in Genetics and Molecular Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Host Microbe 2:147-59. 2007
    ..While similar proteins mediate pathogen-induced cell death in plants, this report identifies cryopyrin as an important host regulator of programmed pathogen-induced necrosis in animals, a process we term pyronecrosis...
  38. ncbi request reprint CATERPILLERs, pyrin and hereditary immunological disorders
    Jenny P Y Ting
    Department of Microbiology Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599, USA
    Nat Rev Immunol 6:183-95. 2006
    ..Most importantly, they are genetically linked to several human immunological disorders...
  39. ncbi request reprint A severe case of chronic infantile neurologic, cutaneous, articular syndrome treated with biologic agents
    Tomoyo Matsubara
    Department of Pediatrics, Yamaguchi University School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Arthritis Rheum 54:2314-20. 2006
    ..Pathologic examination of autopsy specimens was also performed. This case illustrates the continued difficulty in management of patients with CINCA syndrome and the complexity of the inflammatory pathways in this disorder...
  40. ncbi request reprint Anakinra prevents symptoms of familial cold autoinflammatory syndrome and Raynaud's disease
    Samy K Metyas
    Division of Rheumatology, University of Southern California, Los Angeles, California 90033, USA
    J Rheumatol 33:2085-7. 2006
    ..Our report supports increasing evidence that anakinra plays an important role in the treatment of select chronic inflammatory diseases...
  41. ncbi request reprint Response to IL-1-receptor antagonist in a child with familial cold autoinflammatory syndrome
    Turlough Bolger
    Department of Dermatology, Our Lady s Children s Hospital, Crumlin, Dublin, Ireland
    Pediatr Dermatol 24:85-9. 2007
    ....
  42. ncbi request reprint IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients
    Jeffrey H Stack
    Vertex Pharmaceuticals, San Diego, CA 92121, USA
    J Immunol 175:2630-4. 2005
    ..These results further link mutations in cryopyrin with abnormal caspase-1 activation, and support the clinical testing of caspase-1 inhibitors such as VX-765 in autoinflammatory disorders...
  43. ncbi request reprint Genomic-based therapy: targeting interleukin-1 for autoinflammatory diseases
    Hal M Hoffman
    Arthritis Rheum 50:345-9. 2004
  44. doi request reprint The infevers autoinflammatory mutation online registry: update with new genes and functions
    Florian Milhavet
    Institut de Genetique Humaine, CNRS UPR1142, Montpellier, France
    Hum Mutat 29:803-8. 2008
    ....