Steven P Hodak

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Information for clinicians: commercially available molecular diagnosis testing in the evaluation of thyroid nodule fine-needle aspiration specimens
    Steven P Hodak
    Department of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Thyroid 23:131-4. 2013
  2. pmc Suspicious ultrasound characteristics predict BRAF V600E-positive papillary thyroid carcinoma
    Adam S Kabaker
    Department of Surgery, University of Pittsburgh, 3471 Fifth Ave, Pittsburgh, PA 15213, USA
    Thyroid 22:585-9. 2012
  3. doi request reprint RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers
    Nikhil Gupta
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 98:E914-22. 2013
  4. doi request reprint Intraoperative pathologic examination in the era of molecular testing for differentiated thyroid cancer
    Kelly L McCoy
    Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Am Coll Surg 215:546-54. 2012
  5. doi request reprint Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer
    Gina M Howell
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 18:3566-71. 2011
  6. doi request reprint Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients
    Linwah Yip
    Department of Surgery, Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, PA Department of Pathology, University of Pittsburgh, Pittsburgh, PA Department of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA
    Ann Surg 262:519-25; discussion 524-5. 2015
  7. pmc PAX8/PPARγ rearrangement in thyroid nodules predicts follicular-pattern carcinomas, in particular the encapsulated follicular variant of papillary carcinoma
    Michaele J Armstrong
    1 Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Thyroid 24:1369-74. 2014
  8. doi request reprint Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation
    Linwah Yip
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Surgery 146:1215-23. 2009
  9. doi request reprint BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer
    Gina M Howell
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Surg Oncol 20:47-52. 2013
  10. doi request reprint BRAF mutation detection in indeterminate thyroid cytology specimens: underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma
    N Paul Ohori
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Cancer Cytopathol 121:197-205. 2013

Collaborators

Detail Information

Publications19

  1. doi request reprint Information for clinicians: commercially available molecular diagnosis testing in the evaluation of thyroid nodule fine-needle aspiration specimens
    Steven P Hodak
    Department of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Thyroid 23:131-4. 2013
    ..Until evidence-based recommendations are available, determining whether or not the limited data available support the use of these methods should be considered on a case-by-case basis...
  2. pmc Suspicious ultrasound characteristics predict BRAF V600E-positive papillary thyroid carcinoma
    Adam S Kabaker
    Department of Surgery, University of Pittsburgh, 3471 Fifth Ave, Pittsburgh, PA 15213, USA
    Thyroid 22:585-9. 2012
    ..The aim of this blinded cohort study was to determine whether these specific US characteristics can also reliably detect the more aggressive variants of PTC that are often associated with the BRAF(V600E) mutation...
  3. doi request reprint RAS mutations in thyroid FNA specimens are highly predictive of predominantly low-risk follicular-pattern cancers
    Nikhil Gupta
    Division of Endocrinology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 98:E914-22. 2013
    ..RAS mutations are common in thyroid tumors and confer a high risk of cancer when detected in fine-needle aspiration (FNA) specimens. Specific characteristics of RAS-positive thyroid cancers are not well described...
  4. doi request reprint Intraoperative pathologic examination in the era of molecular testing for differentiated thyroid cancer
    Kelly L McCoy
    Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Am Coll Surg 215:546-54. 2012
    ..We hypothesized that preoperative MT obviates the need for routine IOPE during lobectomy...
  5. doi request reprint Both BRAF V600E mutation and older age (≥ 65 years) are associated with recurrent papillary thyroid cancer
    Gina M Howell
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Ann Surg Oncol 18:3566-71. 2011
    ..This study was designed to examine the aggressive features of BRAF-positive papillary thyroid cancer (PTC) and association with age...
  6. doi request reprint Tumor genotype determines phenotype and disease-related outcomes in thyroid cancer: a study of 1510 patients
    Linwah Yip
    Department of Surgery, Division of Endocrine Surgery, University of Pittsburgh, Pittsburgh, PA Department of Pathology, University of Pittsburgh, Pittsburgh, PA Department of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, PA Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA
    Ann Surg 262:519-25; discussion 524-5. 2015
    ..To correlate thyroid cancer genotype with histology and outcomes...
  7. pmc PAX8/PPARγ rearrangement in thyroid nodules predicts follicular-pattern carcinomas, in particular the encapsulated follicular variant of papillary carcinoma
    Michaele J Armstrong
    1 Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
    Thyroid 24:1369-74. 2014
    ..The diagnostic and phenotypic features of thyroid nodules positive for PAX8/PPARγ on preoperative examination are not well understood...
  8. doi request reprint Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation
    Linwah Yip
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Surgery 146:1215-23. 2009
    ..It is not known whether pre-operative identification of BRAF mutations in cytologic specimens should alter surgical management...
  9. doi request reprint BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer
    Gina M Howell
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Ann Surg Oncol 20:47-52. 2013
    ..This study was designed to examine whether available preoperative clinical parameters, including B-type Raf kinase (BRAF) V600E mutation status, can identify patients at risk for central compartment lymph node metastasis (CLNM)...
  10. doi request reprint BRAF mutation detection in indeterminate thyroid cytology specimens: underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma
    N Paul Ohori
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Cancer Cytopathol 121:197-205. 2013
    ..However, indeterminate thyroid cytology cases are inevitable and understanding the significance of the BRAF mutation within the context of the Bethesda System for Reporting Thyroid Cytopathology would be valuable...
  11. pmc Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples
    Yuri E Nikiforov
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 96:3390-7. 2011
    ..Fine-needle aspiration (FNA) cytology provides a definitive diagnosis of benign or malignant disease in many cases, whereas about 25% of nodules are indeterminate, hindering most appropriate management...
  12. pmc A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma
    Leo A Niemeier
    Department of Pathology and Laboratory Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer 118:2069-77. 2012
    ..The objective of the study was to evaluate whether the combination of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation and specific histopathologic features allows risk stratification of TPMC...
  13. doi request reprint Thyroid nodules (≥4 cm): can ultrasound and cytology reliably exclude cancer?
    Laura I Wharry
    Department of Surgery, University of Pittsburgh School of Medicine, Suite 101 3471 Fifth Avenue, Pittsburgh, PA, 15213, USA
    World J Surg 38:614-21. 2014
    ....
  14. doi request reprint Thyroid paragangliomas are locally aggressive
    Michaele J Armstrong
    Division of Endocrine Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Thyroid 22:88-93. 2012
    ..Thyroid paraganglioma (TP) is a very rare neoplasm that can be misdiagnosed. We evaluated the clinical and pathologic characteristics of three patients with TP...
  15. doi request reprint Contribution of molecular testing to thyroid fine-needle aspiration cytology of "follicular lesion of undetermined significance/atypia of undetermined significance"
    N Paul Ohori
    Department of Pathology, University of Pittsburgh Medical Center Presbyterian, Pittsburgh, Pennsylvania 15213, USA
    Cancer Cytopathol 118:17-23. 2010
    ..The use of ancillary molecular studies has not been widely explored for this diagnosis...
  16. pmc RAS mutations in thyroid cancer
    Gina M Howell
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Oncologist 18:926-32. 2013
    ..This review summarizes the current literature surrounding RAS and discusses its potential as a diagnostic and prognostic indicator in the management of thyroid cancer. ..
  17. pmc Identification of the transforming STRN-ALK fusion as a potential therapeutic target in the aggressive forms of thyroid cancer
    Lindsey M Kelly
    Department of Pathology and Laboratory Medicine, Department of Pharmacology and Chemical Biology, Department of Otolaryngology, Department of Surgery, Division of Endocrine Surgery, and Department of Medicine, Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Proc Natl Acad Sci U S A 111:4233-8. 2014
    ..Our data demonstrate that STRN-ALK fusion occurs in a subset of patients with highly aggressive types of thyroid cancer and provide initial evidence suggesting that it may represent a therapeutic target for these patients. ..
  18. pmc Cost impact of molecular testing for indeterminate thyroid nodule fine-needle aspiration biopsies
    Linwah Yip
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Endocrinol Metab 97:1905-12. 2012
    ..We hypothesized that FNA molecular testing of two indeterminate categories (follicular lesion of undetermined significance and follicular/Hürthle cell neoplasm) can be cost saving...
  19. doi request reprint Thyrotoxicosis
    Stuart C Seigel
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Med Clin North Am 96:175-201. 2012
    ..In addition to the diagnosis, clinical presentation, and treatment of the various causes of hyperthyroidism, a section on functional imaging and appropriate laboratory testing is included...