- The agrin/muscle-specific kinase pathway: new targets for autoimmune and genetic disorders at the neuromuscular junctionYohan Liyanage
Neurosciences Group, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Muscle Nerve 25:4-16. 2002..We then review the development of the NMJ, focusing on the important roles of nerve-derived agrin and MuSK in clustering of AChRs and other essential components of the NMJ...
- Molecular dissection of neuromuscular junction formationWerner Hoch
University of Houston, Science and Research Building 2, Houston, TX 77204 5001, USA
Trends Neurosci 26:335-7. 2003..Analysis of the imperfect postsynaptic specializations of these mice has provided new insights into the complex postsynaptic differentiation process...
- Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK)Smita Jha
Department of Biology and Biochemistry, University of Houston, TX 77204, USA
J Neuroimmunol 175:107-17. 2006..Myasthenic sera inhibited agrin-induced AChR aggregation in C2C12 myotubes. Conclusion: Anti-MuSK Abs induce MG, which might also result from blocking the agrin-signaling pathway...
- Antibodies in myasthenia gravis and related disordersAngela Vincent
Neurosciences Group, Department of Clinical Neurology, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom
Ann N Y Acad Sci 998:324-35. 2003..These antibodies are not found in AChR antibody-positive MG and are predominantly IgG4. MuSK antibody positivity appears to be associated with more severe bulbar disease that can be difficult to treat effectively...