Jonathan Himmelfarb

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Uremic toxicity, oxidative stress, and hemodialysis as renal replacement therapy
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Semin Dial 22:636-43. 2009
  2. doi request reprint Acute kidney injury in the elderly: problems and prospects
    Jonathan Himmelfarb
    Kidney Research Institute, Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98104, USA
    Semin Nephrol 29:658-64. 2009
  3. doi request reprint Creating research infrastructure and functionality to address chronic kidney disease: the Kidney Research Institute
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Semin Nephrol 29:457-66. 2009
  4. pmc Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
    Etienne Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego San Diego, 200 West Arbor Drive, MC 8342, San Diego, CA 92103, USA
    Crit Care 14:R82. 2010
  5. pmc Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease
    Halil O Ikizler
    University of Vermont College of Medicine, Burlington, Vermont Kidney Research Institute, University of Washington, Seattle, Washington
    J Ren Nutr 26:93-102. 2016
  6. pmc Comparison of methods for estimating glomerular filtration rate in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 25:102-7. 2010
  7. pmc Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA
    Intensive Care Med 37:241-8. 2011
  8. pmc Association of Vascular Access Type with Mortality, Hospitalization, and Transfer to In-Center Hemodialysis in Patients Undergoing Home Hemodialysis
    Matthew B Rivara
    Department of Medicine, Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington
    Clin J Am Soc Nephrol 11:298-307. 2016
  9. ncbi request reprint Timing of initiation of dialysis in critically ill patients with acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, USA
    Clin J Am Soc Nephrol 1:915-9. 2006
  10. ncbi request reprint Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients
    M Luisa Trirogoff
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Clin Nutr 86:1642-8. 2007

Research Grants

  1. NUTRITION AND METABOLISM IN ACUTE RENAL FAILURE
    Jonathan Himmelfarb; Fiscal Year: 2001

Detail Information

Publications84

  1. doi request reprint Uremic toxicity, oxidative stress, and hemodialysis as renal replacement therapy
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Kidney Research Institute, University of Washington, Seattle, Washington 98104 2499, USA
    Semin Dial 22:636-43. 2009
    ....
  2. doi request reprint Acute kidney injury in the elderly: problems and prospects
    Jonathan Himmelfarb
    Kidney Research Institute, Department of Medicine, Division of Nephrology, University of Washington, Seattle, WA 98104, USA
    Semin Nephrol 29:658-64. 2009
    ..The increasing prevalence and extended clinical consequences of AKI in the elderly are of great concern from a clinical and public health perspective...
  3. doi request reprint Creating research infrastructure and functionality to address chronic kidney disease: the Kidney Research Institute
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
    Semin Nephrol 29:457-66. 2009
    ....
  4. pmc Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
    Etienne Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego San Diego, 200 West Arbor Drive, MC 8342, San Diego, CA 92103, USA
    Crit Care 14:R82. 2010
    ..We evaluated the effect of fluid accumulation on sCr to estimate severity of AKI...
  5. pmc Dietary Acid Load is Associated With Serum Bicarbonate but not Insulin Sensitivity in Chronic Kidney Disease
    Halil O Ikizler
    University of Vermont College of Medicine, Burlington, Vermont Kidney Research Institute, University of Washington, Seattle, Washington
    J Ren Nutr 26:93-102. 2016
    ..We examined associations between dietary acid load, serum bicarbonate, and insulin sensitivity in CKD...
  6. pmc Comparison of methods for estimating glomerular filtration rate in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 25:102-7. 2010
    ....
  7. pmc Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA
    Intensive Care Med 37:241-8. 2011
    ..This study examined the incidence of, and outcomes associated with, sepsis developing after AKI...
  8. pmc Association of Vascular Access Type with Mortality, Hospitalization, and Transfer to In-Center Hemodialysis in Patients Undergoing Home Hemodialysis
    Matthew B Rivara
    Department of Medicine, Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington
    Clin J Am Soc Nephrol 11:298-307. 2016
    ..However, it is unclear whether a similar difference in risk by vascular access type is present in patients undergoing home HD...
  9. ncbi request reprint Timing of initiation of dialysis in critically ill patients with acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, USA
    Clin J Am Soc Nephrol 1:915-9. 2006
    ..Although the results could reflect residual confounding by severity of illness, they provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill patients with severe AKI...
  10. ncbi request reprint Body mass index and fat mass are the primary correlates of insulin resistance in nondiabetic stage 3-4 chronic kidney disease patients
    M Luisa Trirogoff
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Clin Nutr 86:1642-8. 2007
    ..Insulin resistance has been noted in patients with chronic kidney disease (CKD). The determinants of insulin resistance have not been well-studied in CKD patients...
  11. pmc Racial and Ethnic Disparities in Use of and Outcomes with Home Dialysis in the United States
    Rajnish Mehrotra
    Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington
    J Am Soc Nephrol 27:2123-34. 2016
    ..Disparities in kidney transplantation evident for blacks and Hispanics undergoing home dialysis are similar to those with in-center HD. Future studies should identify modifiable causes for these disparities. ..
  12. pmc Provision of antioxidant therapy in hemodialysis (PATH): a randomized clinical trial
    Jonathan Himmelfarb
    Department of Medicine, Division of Nephrology, University of Washington, Seattle, Washington
    J Am Soc Nephrol 25:623-33. 2014
    ..In conclusion, the administration of mixed tocopherols and ALA was generally safe and well tolerated, but did not influence biomarkers of inflammation and oxidative stress or the erythropoietic response...
  13. pmc Association between physical performance and all-cause mortality in CKD
    Baback Roshanravan
    Division of Nephrology, Department of Medicine, University of Washington Kidney Research Institute, Box 359606, 325 9th Avenue, Seattle, WA 98104, USA
    J Am Soc Nephrol 24:822-30. 2013
    ..In summary, impaired physical performance of the lower extremities is common in CKD and strongly associates with all-cause mortality...
  14. pmc The serum 24,25-dihydroxyvitamin D concentration, a marker of vitamin D catabolism, is reduced in chronic kidney disease
    Cortney R Bosworth
    Department of Medicine, Division of Nephrology and Kidney Research Institute, University of Washington, Seattle, WA 98104, USA
    Kidney Int 82:693-700. 2012
    ..Thus, chronic kidney disease is a state of stagnant vitamin D metabolism characterized by decreases in both 1,25(OH)(2)D production and vitamin D catabolism...
  15. pmc Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease
    Luis F Ramos
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    J Ren Nutr 21:211-8. 2011
    ..The purpose of this study was to investigate whether a combination of mixed tocopherols and alpha lipoic acid (ALA) would alter biomarkers of oxidative stress and inflammation in subjects with stage 3 to 4 CKD...
  16. pmc Decreased pulse pressure during hemodialysis is associated with improved 6-month outcomes
    Jula K Inrig
    Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 8523, USA
    Kidney Int 76:1098-107. 2009
    ..Our study found that in prevalent dialysis subjects, a decrease in pulse pressure during dialysis was associated with improved outcomes. Further study is needed to identify how to control pulse pressure to improve outcomes...
  17. doi request reprint Effect of Coenzyme Q10 on Biomarkers of Oxidative Stress and Cardiac Function in Hemodialysis Patients: The CoQ10 Biomarker Trial
    Matthew B Rivara
    Kidney Research Institute, Seattle, WA Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA
    Am J Kidney Dis . 2016
    ..Identifying therapies that reduce oxidative stress has the potential to improve cardiovascular outcomes in patients undergoing maintenance dialysis...
  18. pmc Extended-hours hemodialysis is associated with lower mortality risk in patients with end-stage renal disease
    Matthew B Rivara
    Kidney Research Institute, Division of Nephrology, University of Washington, Seattle, Washington, USA Electronic address
    Kidney Int 90:1312-1320. 2016
    ..Adequately powered randomized clinical trials comparing extended-hours to conventional hemodialysis are required to confirm these findings...
  19. pmc Effluent volume in continuous renal replacement therapy overestimates the delivered dose of dialysis
    Rolando Claure-Del Granado
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA
    Clin J Am Soc Nephrol 6:467-75. 2011
    ..Because filter fouling can reduce the efficacy of solute clearance, the actual delivered dose may be substantially lower than the observed effluent rate...
  20. pmc Evaluation and initial management of acute kidney injury
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 3:962-7. 2008
    ....
  21. doi request reprint Determinants of plasma adiponectin levels in nondiabetic subjects with moderate to severe chronic kidney disease
    Luis F Ramos
    Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2372, USA
    J Ren Nutr 19:197-203. 2009
    ..Our objective was to determine factors associated with adiponectin levels in subjects with stage III to IV chronic kidney disease (CKD)...
  22. ncbi request reprint Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress
    Lara B Pupim
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:2371-9. 2004
    ..To our knowledge, no prospective studies have examined how initiation of maintenance hemodialysis (MHD) affects biomarkers of inflammation and oxidative stress status...
  23. pmc Association of markers of endothelial dysregulation Ang1 and Ang2 with acute kidney injury in critically ill patients
    Cassianne Robinson-Cohen
    Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, 325 9th Ave, Box 359606, Seattle, WA, 98104, USA
    Crit Care 20:207. 2016
    ..The role of endothelial dysregulation with acute kidney injury (AKI) in critically ill patients is unclear...
  24. ncbi request reprint Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232 2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  25. pmc Kidney disease and increased mortality risk in type 2 diabetes
    Maryam Afkarian
    Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98014, USA
    J Am Soc Nephrol 24:302-8. 2013
    ..2%-29.6%) when further adjusted. We observed similar patterns for cardiovascular and noncardiovascular mortality. In conclusion, those with kidney disease predominantly account for the increased mortality observed in type 2 diabetes...
  26. pmc A prospective study of frailty in nephrology-referred patients with CKD
    Baback Roshanravan
    Department of Medicine, Division of Nephrology, University of Washington Kidney Research Institute, 325 9th Ave, Seattle, WA 98104, USA
    Am J Kidney Dis 60:912-21. 2012
    ..However, there are limited data describing the prevalence or consequences of frailty in middle-aged patients with chronic kidney disease (CKD)...
  27. ncbi request reprint Survival by dialysis modality in critically ill patients with acute kidney injury
    Kerry C Cho
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94118, USA
    J Am Soc Nephrol 17:3132-8. 2006
    ..Larger, prospective, randomized clinical trials to compare CRRT and IHD in severe AKI are needed...
  28. ncbi request reprint Effect of renal transplantation on biomarkers of inflammation and oxidative stress in end-stage renal disease patients
    Edith M Simmons
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN, USA
    Transplantation 79:914-9. 2005
    ..Because maintenance hemodialysis is ineffective in controlling these factors, we hypothesized that restoration of kidney function by transplantation would be required to improve uremic inflammation and oxidative stress...
  29. doi request reprint Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 76:422-7. 2009
    ..Whether the fluid overload was the result of a more severe renal failure or it contributed to its cause will require clinical trials in which the role of fluid administration to such patients is directly tested...
  30. pmc Physical activity and metabolic health in chronic kidney disease: a cross-sectional study
    Wilson Bowlby
    University of Washington School of Medicine, Seattle, WA, USA
    BMC Nephrol 17:187. 2016
    ..Physical activity may reduce these risks by improving metabolic health. We tested associations of physical activity with central components of metabolic health among people with moderate-severe non-diabetic CKD...
  31. pmc Diabetes, Kidney Disease, and Cardiovascular Outcomes in the Jackson Heart Study
    Maryam Afkarian
    Kidney Research Institute and Division of Nephrology, University of Washington, Seattle, Washington
    Clin J Am Soc Nephrol 11:1384-91. 2016
    ..Diabetes and CKD, risk factors for cardiovascular mortality in the general population, are common among blacks. We sought to assess their contribution to cardiovascular disease and mortality in blacks...
  32. pmc Characteristics and performance of minority-serving dialysis facilities
    Yoshio N Hall
    Kidney Research Institute, University of Washington, Seattle, WA
    Health Serv Res 49:971-91. 2014
    ..To examine the structure, processes, and outcomes of American dialysis facilities that predominantly treat racial-ethnic minority patients...
  33. pmc Estimated GFR and circulating 24,25-dihydroxyvitamin D3 concentration: a participant-level analysis of 5 cohort studies and clinical trials
    Ian H De Boer
    Division of Nephrology, Department of Medicine, Seattle, WA Kidney Research Institute, Department of Medicine, Seattle, WA Department of Epidemiology, University of Washington, Seattle, WA Electronic address
    Am J Kidney Dis 64:187-97. 2014
    ..We tested associations of estimated GFR (eGFR) with the circulating concentration of 24,25-dihydroxyvitamin D3 (24,25[OH]2D3), the most abundant product of 25(OH)D3 catabolism, across populations with a wide range of GFRs...
  34. pmc Assessment of physical activity in chronic kidney disease
    Cassianne Robinson-Cohen
    Department of Epidemiology, University of Washington, Seattle, USA
    J Ren Nutr 23:123-31. 2013
    ..Physical inactivity plays an important role in the development of kidney disease and its complications; however, the validity of standard tools for measuring physical activity (PA) is not well understood...
  35. pmc Use of aspirin associates with longer primary patency of hemodialysis grafts
    Bradley S Dixon
    Division of Nephrology, University of Iowa College of Medicine, E 300D GH, 200 Hawkins Drive, Iowa City, IA 52242 1081, USA
    J Am Soc Nephrol 22:773-81. 2011
    ..In conclusion, use of aspirin associates with a trend toward longer primary unassisted patency of newly placed hemodialysis grafts similar to that observed for ERDP/ASA...
  36. doi request reprint Tipping the redox balance of oxidative stress in fibrogenic pathways in chronic kidney disease
    Daryl M Okamura
    Seattle Children s Research Institute, Department of Pediatrics, University of Washington, Seattle, WA, USA
    Pediatr Nephrol 24:2309-19. 2009
    ..We also review the data linking the pathogenesis of oxidative stress, inflammation, and the progressive loss of kidney function in chronic kidney disease...
  37. pmc Risk Factors for Rapid Kidney Function Decline Among African Americans: The Jackson Heart Study (JHS)
    Bessie A Young
    Center of Innovation, Veterans Affairs Puget Sound Health Care System, Seattle, WA Hospital and Specialty Medicine, Veterans Affairs Puget Sound Health Care System, Seattle, WA Kidney Research Institute and Division of Nephrology, University of Washington, Seattle, WA Electronic address
    Am J Kidney Dis 68:229-39. 2016
    ..Greater understanding of potentially modifiable risk factors for early kidney function loss may help reduce the burden of kidney failure in this high-risk population...
  38. pmc Markers of kidney disease and risk of subclinical and clinical heart failure in African Americans: the Jackson Heart Study
    Nisha Bansal
    Kidney Research Institute, Division of Nephrology, University of Washington, 908 Jefferson Street, 3rd Floor, Seattle, WA, USA
    Nephrol Dial Transplant 31:2057-2064. 2016
    ..We also examined whether the association of markers of kidney disease with HF was attenuated with adjustment for echocardiographic measures...
  39. pmc Urine matrix metalloproteinase-7 and risk of kidney disease progression and mortality in type 2 diabetes
    Maryam Afkarian
    Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA Electronic address
    J Diabetes Complications 29:1024-31. 2015
    ..We asked if this increase is associated with subsequent progression to end-stage renal disease (ESRD) or death...
  40. pmc Uncorrected and Albumin-Corrected Calcium, Phosphorus, and Mortality in Patients Undergoing Maintenance Dialysis
    Matthew B Rivara
    Kidney Research Institute, University of Washington, Seattle, Washington
    J Am Soc Nephrol 26:1671-81. 2015
    ..Additional studies are needed to investigate whether control of hypercalcemia and hyperphosphatemia in patients undergoing dialysis results in improved clinical outcomes. ..
  41. pmc Creatinine clearance, walking speed, and muscle atrophy: a cohort study
    Baback Roshanravan
    Division of Nephrology, Department of Medicine, University of Washington Kidney Research Institute, Seattle, WA Electronic address
    Am J Kidney Dis 65:737-47. 2015
    ..These processes may lead to loss of skeletal muscle and reduced physical performance. Associations of kidney function with muscle composition and longitudinal measures of physical performance are unknown...
  42. doi request reprint Adverse effects of systemic glucose absorption with peritoneal dialysis: how good is the evidence?
    Rajnish Mehrotra
    Kidney Research Institute, University of Washington, Seattle, Washington, USA
    Curr Opin Nephrol Hypertens 22:663-8. 2013
    ..In this review, we examine the evidence linking this obligatory absorption with adverse systemic effects...
  43. pmc Association of major depression and mortality in Stage 5 diabetic chronic kidney disease
    Bessie A Young
    Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98101, USA
    Gen Hosp Psychiatry 32:119-24. 2010
    ..Depression is the most common psychiatric disorder in patients with chronic kidney disease (CKD). We sought to determine the association of major depression with mortality among diabetic patients with late stage CKD...
  44. pmc Association of FMO3 Variants and Trimethylamine N-Oxide Concentration, Disease Progression, and Mortality in CKD Patients
    Cassianne Robinson-Cohen
    Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, 98195, United States of America
    PLoS ONE 11:e0161074. 2016
    ..Understanding the contribution of genetic variation of FMO3 to disease progression and all-cause mortality can guide recommendations for diet modification or pharmacotherapy in CKD patients at increased risk of adverse outcomes. ..
  45. doi request reprint Initiation of dialysis should be timely: neither early nor late
    Rajnish Mehrotra
    Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, Washington
    Semin Dial 26:644-9. 2013
    ..volume overload, refractory hyperkalemia). Finally, there is a compelling need to reexamine the symptoms that could be attributed to uremia and clearly improve upon initiation of dialysis to better guide clinical decision-making. ..
  46. doi request reprint Prevention and treatment of protein energy wasting in chronic kidney disease patients: a consensus statement by the International Society of Renal Nutrition and Metabolism
    T Alp Ikizler
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Kidney Int 84:1096-107. 2013
    ....
  47. pmc Paricalcitol does not improve glucose metabolism in patients with stage 3-4 chronic kidney disease
    Ian H De Boer
    Division of Nephrology and Kidney Research Institute, Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    Kidney Int 83:323-30. 2013
    ..Thus, despite substantial effects on vitamin D metabolism, paricalcitol did not improve glucose metabolism in nondiabetic patients with stage 3-4 chronic kidney disease...
  48. pmc Homelessness and CKD: a cohort study
    Yoshio N Hall
    Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Clin J Am Soc Nephrol 7:1094-102. 2012
    ..This study examined the associations between homelessness and clinical outcomes of CKD among adults from the urban healthcare safety net...
  49. pmc Tubular expression of KIM-1 does not predict delayed function after transplantation
    Bernd Schroppel
    Division of Nephrology, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Am Soc Nephrol 21:536-42. 2010
    ..Our findings are consistent with a role for KIM-1 as an early indicator of tubular injury but do not support tissue KIM-1 measurement before transplantation to identify kidneys at risk for DGF...
  50. ncbi request reprint Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..Understanding the changing spectrum of ARF will be necessary to facilitate quality improvement efforts and to design successful interventional trials...
  51. ncbi request reprint Are biomarkers useful for assessing cardiovascular risk in patients with chronic kidney disease?
    Clifford Rubin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Curr Opin Nephrol Hypertens 16:506-11. 2007
    ..This review will summarize these studies and critically assess the utility of cardiovascular risk biomarkers for clinical practice...
  52. doi request reprint Oxidative stress in hemodialysis
    Jonathan Himmelfarb
    Department of Medicine, Division of Nephrology and Renal Transplantation, Maine Medical Center, Portland, Maine 04102, USA
    Contrib Nephrol 161:132-7. 2008
    ..The pathophysiology of increased oxidative stress in uremia is multifactorial, but the retention of oxidized solute by the loss of kidney function is probably a major contributor...
  53. doi request reprint Prediction, progression, and outcomes of chronic kidney disease in older adults
    Sharon Anderson
    Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA
    J Am Soc Nephrol 20:1199-209. 2009
    ..Answers to emerging research questions will support the integration of geriatrics and nephrology and thus improve care for older patients at risk for chronic kidney disease...
  54. ncbi request reprint Hemodialysis acutely improves hepatic CYP3A4 metabolic activity
    Thomas D Nolin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Am Soc Nephrol 17:2363-7. 2006
    ..50, P = 0.012), but not to several middle molecules. This is the first study in humans characterizing uremia as a state in which hepatic CYP3A4 activity is acutely improved by hemodialysis...
  55. pmc Risk prediction to inform surveillance of chronic kidney disease in the US Healthcare Safety Net: a cohort study
    Yuxiang Xie
    Kidney Research Institute, Department of Medicine, University of Washington, Seattle, WA, USA
    BMC Nephrol 17:57. 2016
    ..We sought to leverage EHR data for predicting risk of progressing from CKD to end-stage renal disease (ESRD) to help inform surveillance of CKD among vulnerable patients from the healthcare safety-net...
  56. pmc Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California, San Francisco, San Francisco, CA, United States of America
    PLoS ONE 11:e0164832. 2016
    ..Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood...
  57. pmc Biomarkers of Endothelial Activation Are Associated with Poor Outcome in Critical Illness
    Carmen Mikacenic
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 10:e0141251. 2015
    ..In this study, we determined if biomarkers of endothelial activation and inflammation exhibit independent associations with poor outcomes in SIRS...
  58. pmc Association of plasma F2-isoprostanes and isofurans concentrations with erythropoiesis-stimulating agent resistance in maintenance hemodialysis patients
    Matthew B Rivara
    Division of Nephrology, Department of Medicine, University of Washington, Box 359606, 325 9th Ave, Seattle, WA, 98104, USA
    BMC Nephrol 16:79. 2015
    ..This study assessed the association of plasma markers of oxidative stress and inflammation with ESA resistance in patients undergoing maintenance HD...
  59. pmc Rapid and sensitive analysis of reduced and oxidized coenzyme Q10 in human plasma by ultra performance liquid chromatography-tandem mass spectrometry and application to studies in healthy human subjects
    Adam J Claessens
    Pharmacokinetics Laboratory, Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA, USA
    Ann Clin Biochem 53:265-73. 2016
    ..Ex vivo oxidation of ubiquinol-10 to ubiquinone-10 during sample collection, processing and analysis may obfuscate the in vivo ratio...
  60. pmc Coenzyme Q10 dose-escalation study in hemodialysis patients: safety, tolerability, and effect on oxidative stress
    Catherine K Yeung
    Department of Pharmacy, University of Washington School of Pharmacy, Box 357630, Seattle, WA, 98195, USA
    BMC Nephrol 16:183. 2015
    ..There are no studies evaluating the safety, tolerability and efficacy of varying doses of CoQ10 in chronic hemodialysis patients, a population subject to increased oxidative stress...
  61. pmc A pilot randomized crossover trial assessing the safety and short-term effects of pomegranate supplementation in hemodialysis patients
    Matthew B Rivara
    Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington Kidney Research Institute, Seattle, Washington Electronic address
    J Ren Nutr 25:40-9. 2015
    ..The secondary aim was to assess the effect of pomegranate supplementation on oxidative stress, systemic inflammation, monocyte function, and blood pressure...
  62. pmc Advances in understanding ischemic acute kidney injury
    Raj Munshi
    Department of Pediatrics, Division of Nephrology, University of Washington and Seattle Children s Hospital, Seattle, WA, USA
    BMC Med 9:11. 2011
    ..On the basis of recent breakthroughs in understanding the pathophysiology of ischemic AKI, therapies that can treat or even prevent ischemic AKI may become a reality in the near future...
  63. ncbi request reprint Hemodialysis complications
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, ME 04102, USA
    Am J Kidney Dis 45:1122-31. 2005
  64. ncbi request reprint Chronic kidney disease and the public health: gaps in evidence from interventional trials
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall St, Portland, ME 04102, USA
    JAMA 297:2630-3. 2007
  65. pmc Predictors of treatment with dialysis modalities in observational studies for comparative effectiveness research
    Sooraj Kuttykrishnan
    Kidney Research Institute, Division of Nephrology, University of Washington, Seattle, WA, USA
    Nephrol Dial Transplant 30:1208-17. 2015
    ..Given the importance of ensuring internal and external validity, the goal of this study was to identify potential sources of bias in observational studies that compare outcomes with different dialysis modalities...
  66. pmc Evaluating risk of ESRD in the urban poor
    Marlena Maziarz
    Kidney Research Institute, Department of Medicine, Department of Biostatistics, and
    J Am Soc Nephrol 26:1434-42. 2015
    ..Applying risk prediction using a population health approach may improve CKD surveillance and management of vulnerable groups by directing resources to a small subpopulation at highest risk for progressing to ESRD. ..
  67. pmc MCP-1 gene activation marks acute kidney injury
    Raj Munshi
    Seattle Children s Hospital Medical Center, Seattle, Washington, USA
    J Am Soc Nephrol 22:165-75. 2011
    ..In conclusion, these data suggest that MCP-1 has potential as a biomarker of AKI and provide "proof of concept" that urinary histone assessments provide mechanistic insight among patients with kidney disease...
  68. pmc Regional differences in dialysis care and mortality among American Indians and Alaska Natives
    Yoshio N Hall
    Kidney Research Institute, University of Washington, 325 9th Avenue, Box 359606, Seattle, WA 98104, USA
    J Am Soc Nephrol 22:2287-95. 2011
    ..Our findings suggest that an area-based approach examining the care structure of relatively few dialysis facilities may delineate determinants of these differences and improve the quality of care to many AIAN communities...
  69. ncbi request reprint Perioperative topical bovine thrombin exposure is not associated with hemodialysis graft thrombosis
    Mark D Vannorsdall
    Division of Nephrology, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 64:690-6. 2003
    ..We conclude that perioperative topical bovine thrombin exposure is not associated with subsequent graft thrombosis...
  70. ncbi request reprint The elephant in uremia: oxidant stress as a unifying concept of cardiovascular disease in uremia
    Jonathan Himmelfarb
    Division of Nephrology, Department of Medicine, Maine Medical Center, Portland, Maine 04102, USA
    Kidney Int 62:1524-38. 2002
    ..Anti-oxidative therapeutic strategies for patients with uremia are in their very early stages; nonetheless, early studies demonstrate the potential for significant efficacy in reducing cardiovascular complications...
  71. ncbi request reprint End-stage renal disease measures of quality
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, Maine 04102, USA
    Annu Rev Med 58:387-99. 2007
    ..The feasibility, value, pitfalls, and appropriate quality metrics in a "payment-for-quality" program for dialysis care are currently under vigorous discussion...
  72. pmc Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress
    Thomas D Nolin
    Division of Nephrology and Transplantation, Department of Medicine, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 852:554-61. 2007
    ..This assay is well suited for high-throughput quantitative determination of aminothiols in clinical studies, and is currently being used to support investigations of oxidative stress in patients with chronic kidney disease...
  73. pmc Relationship between interdialytic weight gain and blood pressure among prevalent hemodialysis patients
    Jula K Inrig
    Department of Medicine, Duke University Medical Center, Durham, NC 27705, USA
    Am J Kidney Dis 50:108-18, 118.e1-4. 2007
    ..This study seeks to define the relationship between IDWG and BP in prevalent hemodialysis subjects...
  74. ncbi request reprint Dialysis at a crossroads: reverse engineering renal replacement therapy
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Clin J Am Soc Nephrol 1:896-902. 2006
  75. doi request reprint Technology Insight: biomarker development in acute kidney injury--what can we anticipate?
    Bruce A Molitoris
    Division of Nephrology, Department of Medicine and the Indiana Center for Biologic Microscopy, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 4:154-65. 2008
    ..Great strides forward are being made in breaking down important barriers to the successful prevention and treatment of this devastating disorder...
  76. pmc HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injury
    Ali Cm Johnson
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Clin J Am Soc Nephrol 6:2108-13. 2011
    ..This study tested whether these two processes culminate in increased urinary pellet cholesterol content, and whether the latter has potential AKI biomarker utility...
  77. pmc Temporal trends in the prevalence of diabetic kidney disease in the United States
    Ian H De Boer
    Kidney Research Institute and Division of Nephrology, Department of Medicine, University of Washington, Seattle, WA 98104, USA
    JAMA 305:2532-9. 2011
    ..Over time, the prevalence of diabetic kidney disease (DKD) may increase due to the expanding size of the diabetes population or decrease due to the implementation of diabetes therapies...
  78. doi request reprint Safety of low volume iodinated contrast administration for arteriovenous fistula intervention in chronic kidney disease stage 4 or 5 utilizing a bicarbonate prophylaxis strategy
    Elizabeth Eisenhart
    Division of Nephrology, Maine Medical Center, Portland, Maine 04102, USA
    Semin Dial 23:638-42. 2010
    ..Fistulography alone, or with angioplasty, utilizing a low volume of iodinated contrast and sodium bicarbonate solution for prophylaxis, appears to be safe in the CKD stages 4 and 5 population...
  79. pmc Dialysis therapies: a National Dialogue
    Rajnish Mehrotra
    Kidney Research Institute, Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington, Ohio State University, Columbus, Ohio, University Health Network, Toronto, Ontario, Canada, University of California, San Francisco, California, Oregon Health and Science University, Portland, Oregon, Emory University, Atlanta, Georgia, National Institute of Diabetes, Digestive, and Kidney Disease, National Institutes of Health, Bethesda, Maryland
    Clin J Am Soc Nephrol 9:812-4. 2014
    ..Together, these research objectives provide a path forward for improving patient-centered outcomes in ESRD. ..
  80. doi request reprint Dialysis in 2012: Could longer and more frequent haemodialysis improve outcomes?
    Rajnish Mehrotra
    Harborview Medical Center and Kidney Research Institute, Division of Nephrology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    Nat Rev Nephrol 9:74-5. 2013
    ....
  81. ncbi request reprint Cost, quality, and value: the changing political economy of dialysis care
    Jonathan Himmelfarb
    Maine Medical Center, Division of Nephrology, Portland, ME 04102, USA
    J Am Soc Nephrol 18:2021-7. 2007
  82. ncbi request reprint Sepsis and the kidney
    Jennifer Klenzak
    Division of Nephrology, Maine Medical Center, 22 Bramhall Street, Portland, ME 04102, USA
    Crit Care Clin 21:211-22. 2005
    ..Experimental therapies to improve outcomes in sepsis-associated ARF include the provision of plasmapheresis and adsorption therapies, and the recent development and deployment of a renal tubule assist device...
  83. ncbi request reprint Urea space and total body water measurements by stable isotopes in patients with acute renal failure
    T Alp Ikizler
    Vanderbilt University Medical Center, Division of Nephrology, Nashville, Tennessee 37232 2372, USA
    Kidney Int 65:725-32. 2004
    ..However, these estimates of Vurea and TBW have not been validated by isotopic methods, considered as reference measurement standards...
  84. ncbi request reprint Urea volume of distribution exceeds total body water in patients with acute renal failure
    Jonathan Himmelfarb
    Division of Nephrology, Maine Medical Center, Portland, Maine, USA
    Kidney Int 61:317-23. 2002
    ..While Vurea has been shown to be substantially the same as total body water (TBW) in other patient populations, this relationship has not been adequately studied in detail in ARF patients...

Research Grants1

  1. NUTRITION AND METABOLISM IN ACUTE RENAL FAILURE
    Jonathan Himmelfarb; Fiscal Year: 2001
    ..The feasibility of implementing an optimized nutritional regimen and measuring the effects on nutritional and metabolic parameters will also be performed. ..