Affiliation: University of Washington
- Signaling pathways mediating anti-apoptotic action of neurotrophinsM Hetman
Department of Environmental Health, University of Washington, Seattle, WA 98195 7234, USA
Acta Neurobiol Exp (Wars) 60:531-45. 2000..In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death...
- Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neuronsJ E Cavanaugh
Departments of Environmental Health and Pharmacology, University of Washington, Seattle, Washington 98195-7234, USA
J Neurosci 21:434-43. 2001..Furthermore, ERK5 is the first MAP kinase identified whose activity is stimulated by neurotrophins but not by neuronal activity...
- Taxol induces apoptosis in cortical neurons by a mechanism independent of Bcl-2 phosphorylationX A Figueroa-Masot
Departments of Environmental Health and Pharmacology, Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, Washington 98195-7234, USA
J Neurosci 21:4657-67. 2001..These data suggest that taxol induces apoptosis in neurons by a mechanism quite distinct from that of non-neuronal cell lines and emphasize the importance of elucidating apoptotic mechanisms specific for neurons in the CNS...
- p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neuronsS Ghatan
Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195 6470, USA
J Cell Biol 150:335-47. 2000..These results demonstrate that p38 MAP kinase activity plays a critical role in NO-mediated cell death in neurons by stimulating Bax translocation to the mitochondria, thereby activating the cell death pathway...
- Neuroprotection by brain-derived neurotrophic factor is mediated by extracellular signal-regulated kinase and phosphatidylinositol 3-kinaseM Hetman
Toxicology Program, Department of Environmental Health, the Graduate Program in Neurobiology and Behavior, The Graduate Program in Molecular and Cell Biology, University of Washington, Seattle, Washington 98195 7234, USA
J Biol Chem 274:22569-80. 1999..Furthermore, the relative contribution of the ERK and PI 3-kinase pathways to neuronal survival may depend on the type of cellular injury...