Ines Hellmann

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals
    Ines Hellmann
    Departments of Integrative Biology and Statistics, University of California, Berkeley, California 94720, USA
    Genome Res 18:1020-9. 2008
  2. pmc Population genetic inference from genomic sequence variation
    John E Pool
    Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Genome Res 20:291-300. 2010
  3. ncbi request reprint Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Science 309:1850-4. 2005
  4. pmc Why do human diversity levels vary at a megabase scale?
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 15:1222-31. 2005
  5. pmc A neutral explanation for the correlation of diversity with recombination rates in humans
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:1527-35. 2003
  6. pmc Selection on human genes as revealed by comparisons to chimpanzee cDNA
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:831-7. 2003
  7. pmc Regional patterns of gene expression in human and chimpanzee brains
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 14:1462-73. 2004
  8. pmc A neutral model of transcriptome evolution
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E132. 2004
  9. ncbi request reprint Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    Michael Weber
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Genet 39:457-66. 2007
  10. pmc Recent and ongoing selection in the human genome
    Rasmus Nielsen
    Center for Comparative Genomics, University of Copenhagen, Universitetsparken 15, 2100 Kbh Ø, Denmark
    Nat Rev Genet 8:857-68. 2007

Detail Information

Publications10

  1. pmc Population genetic analysis of shotgun assemblies of genomic sequences from multiple individuals
    Ines Hellmann
    Departments of Integrative Biology and Statistics, University of California, Berkeley, California 94720, USA
    Genome Res 18:1020-9. 2008
    ..Finally, we identify a number of genomic regions with increased or reduced diversity compared with the local level of human-chimpanzee divergence and the local recombination rate...
  2. pmc Population genetic inference from genomic sequence variation
    John E Pool
    Department of Integrative Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Genome Res 20:291-300. 2010
    ..Here, we assess the challenges to analyzing whole-genome sequence polymorphism data, and we discuss the potential of these data to yield new insights concerning population history and the genomic prevalence of natural selection...
  3. ncbi request reprint Parallel patterns of evolution in the genomes and transcriptomes of humans and chimpanzees
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Science 309:1850-4. 2005
    ....
  4. pmc Why do human diversity levels vary at a megabase scale?
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 15:1222-31. 2005
    ..Because there are indications that recombination rates may have changed rapidly during human evolution, we favor the latter explanation...
  5. pmc A neutral explanation for the correlation of diversity with recombination rates in humans
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:1527-35. 2003
    ..Consistent with this hypothesis, diversity levels no longer increase significantly with recombination rates after correction for divergence to chimpanzee...
  6. pmc Selection on human genes as revealed by comparisons to chimpanzee cDNA
    Ines Hellmann
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:831-7. 2003
    ..This indicates that positive selection may have had a considerable influence on 5'UTRs. The dinucleotide CG (CpG) also exhibits a different substitution pattern within 5'UTRs as compared with other parts of the genome...
  7. pmc Regional patterns of gene expression in human and chimpanzee brains
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 14:1462-73. 2004
    ..Furthermore, genes that show an elevated expression level in humans are statistically significantly enriched in regions that are recently duplicated in humans...
  8. pmc A neutral model of transcriptome evolution
    Philipp Khaitovich
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    PLoS Biol 2:E132. 2004
    ..Furthermore, it may be possible to apply a molecular clock based on expression differences to infer the evolutionary history of tissues...
  9. ncbi request reprint Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
    Michael Weber
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nat Genet 39:457-66. 2007
    ..Moreover, we observe that inactive unmethylated CpG island promoters show elevated levels of dimethylation of Lys4 of histone H3, suggesting that this chromatin mark may protect DNA from methylation...
  10. pmc Recent and ongoing selection in the human genome
    Rasmus Nielsen
    Center for Comparative Genomics, University of Copenhagen, Universitetsparken 15, 2100 Kbh Ø, Denmark
    Nat Rev Genet 8:857-68. 2007
    ..Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings...