Kevin Haynes

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc Temporal and within practice variability in the health improvement network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 20:948-55. 2011
  2. doi request reprint Cancer incidence in The Health Improvement Network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:730-6. 2009
  3. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
  4. pmc Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative period
    Kevin Haynes
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Med Inform Assoc 18:164-8. 2011
  5. ncbi request reprint Declining public health burden of digoxin toxicity from 1991 to 2004
    K Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 84:90-4. 2008
  6. ncbi request reprint Inter-rater reliability of a classification system for hospital adverse drug event reports
    K Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 83:485-8. 2008
  7. doi request reprint Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
  8. pmc Risk of Acute Liver Failure in Patients With Drug-Induced Liver Injury: Evaluation of Hy's Law and a New Prognostic Model
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Clin Gastroenterol Hepatol 13:2360-8. 2015
  9. doi request reprint Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia Electronic address
    Am J Med 129:283-91.e5. 2016
  10. pmc Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 22:861-72. 2013

Collaborators

Detail Information

Publications66

  1. pmc Temporal and within practice variability in the health improvement network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 20:948-55. 2011
    ..However, little is known about the consistency within practices across observation years and among practices within a given year, in THIN or other large medical record databases...
  2. doi request reprint Cancer incidence in The Health Improvement Network
    Kevin Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:730-6. 2009
    ..This study assessed whether the recorded incidence of cancer among patients in The Health Improvement Network (THIN) database is comparable to that expected in the UK based on national cancer registry data...
  3. doi request reprint Increased risk of digoxin toxicity following hospitalization
    Kevin Haynes
    Program for the Reduction in Medication Errors, Department of Biostatistics and Epidemiology and School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:28-35. 2009
    ..The objective of the study was to identify health care system factors that affect the risk of digoxin toxicity for older adults on digoxin...
  4. pmc Effectiveness of an information technology intervention to improve prophylactic antibacterial use in the postoperative period
    Kevin Haynes
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, and Center for Education and Research on Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Med Inform Assoc 18:164-8. 2011
    ..Electronic order sets have shown promise as a means of integrating guideline information with electronic order entry systems and facilitating safer, more effective care...
  5. ncbi request reprint Declining public health burden of digoxin toxicity from 1991 to 2004
    K Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 84:90-4. 2008
    ..The public health burden of digoxin toxicity declined dramatically from 1991 to 2004 in the United Kingdom and the United States...
  6. ncbi request reprint Inter-rater reliability of a classification system for hospital adverse drug event reports
    K Haynes
    Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Clin Pharmacol Ther 83:485-8. 2008
    ..Agreement on specific processes associated with ADEs ranged from poor to moderate, which limits the ability to target accurately processes to improve drug utilization...
  7. doi request reprint Diagnostic E-codes for commonly used, narrow therapeutic index medications poorly predict adverse drug events
    Charles E Leonard
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6021, USA
    J Clin Epidemiol 61:561-71. 2008
    ..We sought to examine the validity of specific hospital discharge codes in identifying drug toxicity precipitating hospitalization, among elderly users of high-risk medications...
  8. pmc Risk of Acute Liver Failure in Patients With Drug-Induced Liver Injury: Evaluation of Hy's Law and a New Prognostic Model
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Clin Gastroenterol Hepatol 13:2360-8. 2015
    ..We compared its performance with that of Hy's Law, which predicts severity of DILI based on levels of alanine aminotransferase or aspartate aminotransferase and total bilirubin, and validated the model in a separate sample...
  9. doi request reprint Oral Azole Antifungal Medications and Risk of Acute Liver Injury, Overall and by Chronic Liver Disease Status
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia Electronic address
    Am J Med 129:283-91.e5. 2016
    ..We evaluated incidence rates of acute liver injury associated with oral azole antifungals...
  10. pmc Validity of diagnostic codes to identify cases of severe acute liver injury in the US Food and Drug Administration's Mini-Sentinel Distributed Database
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 22:861-72. 2013
    ....
  11. pmc Patient reported receipt of medication instructions for warfarin is associated with reduced risk of serious bleeding events
    Joshua P Metlay
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Gen Intern Med 23:1589-94. 2008
    ..Adverse drug events are an important cause of preventable hospitalizations...
  12. pmc Validity of diagnostic codes and laboratory tests of liver dysfunction to identify acute liver failure events
    Vincent Lo Re
    Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 24:676-83. 2015
    ..We examined positive predictive values (PPVs) of hospital ICD-9 diagnoses and laboratory tests of liver dysfunction for identifying ALF within a large, community-based integrated care organization...
  13. pmc Five-year malignancy incidence in patients with chronic pruritus: a population-based cohort study aimed at limiting unnecessary screening practices
    Nicole Fett
    Philadelphia Department of Veterans Affairs Medical Center, Philadelphia, Pennsylvania Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania Electronic address
    J Am Acad Dermatol 70:651-8. 2014
    ..The incidence of malignancy in patients with chronic pruritus and nondiseased skin is unknown...
  14. pmc Risk of moderate to advanced kidney disease in patients with psoriasis: population based cohort study
    Joy Wan
    Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    BMJ 347:f5961. 2013
    ..To determine the risk of chronic kidney disease in patients with psoriasis...
  15. pmc Risk of mortality in patients with psoriatic arthritis, rheumatoid arthritis and psoriasis: a longitudinal cohort study
    Alexis Ogdie
    Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 73:149-53. 2014
    ..The objective of this study was to examine the risk of mortality in patients with PsA compared with matched controls, patients with psoriasis and those with rheumatoid arthritis (RA)...
  16. doi request reprint Safety of saxagliptin: rationale for and design of a series of postmarketing observational studies
    Vincent Lo Re
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 21:1202-15. 2012
    ..To describe the design and rationale of a series of postmarketing studies to examine the safety of saxagliptin, an oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus, in real-world settings...
  17. pmc Validity of The Health Improvement Network (THIN) for epidemiologic studies of hepatitis C virus infection
    Vincent Lo Re
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, PA 19104 6021, USA
    Pharmacoepidemiol Drug Saf 18:807-14. 2009
    ..We determined the accuracy of HCV diagnostic codes within The Health Improvement Network (THIN), an electronic database containing medical record data from general medical practices in the United Kingdom...
  18. pmc Antibiotic Exposure, Infection, and the Development of Pediatric Psoriasis: A Nested Case-Control Study
    Daniel B Horton
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia2Division of Rheumatology, Nemours A I duPont Hospital for Children, Thomas Jefferson University, Wilmington, Delaware3Rutgers Biomed
    JAMA Dermatol 152:191-9. 2016
    ..Antibiotics disrupt human microbiota and have been associated with several pediatric autoimmune diseases. Psoriasis activity has been linked to group A streptococcal and viral infections...
  19. pmc Population-representative incidence of drug-induced acute liver failure based on an analysis of an integrated health care system
    David S Goldberg
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Leonard Davis Institute of Health Economics, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Gastroenterology 148:1353-61.e3. 2015
    ..We aimed to determine the incidence and outcomes of drug-induced ALF in an integrated health care system that approximates a population-based cohort...
  20. pmc Validation of a coding algorithm to identify bladder cancer and distinguish stage in an electronic medical records database
    Ronac Mamtani
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pennsylvania
    Cancer Epidemiol Biomarkers Prev 24:303-7. 2015
    ..THIN is a valid and novel database for the study of bladder cancer. Our algorithm can be used to examine the epidemiology of muscle-invasive bladder cancer or outcomes following cystectomy for patients with muscle invasion...
  21. pmc Administration of Antibiotics to Children Before Age 2 Years Increases Risk for Childhood Obesity
    Frank I Scott
    Division of Gastroenterology, Department of Medicine, University of Colorado Denver, Aurora, Colorado Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Electronic address
    Gastroenterology 151:120-129.e5. 2016
    ..We performed a population-based cohort study to assess the association between antibiotic exposure before age 2 years and obesity at age 4 years...
  22. pmc Serum glucose and hemoglobin A1C levels at cancer diagnosis and disease outcome
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA Tel Aviv University, Tel Aviv, Israel Electronic address
    Eur J Cancer 59:90-8. 2016
    ..We aimed to evaluate associations between glucose, hemoglobin A1C (HbA1C), and survival among individuals with diabetes and diabetes associated cancers...
  23. doi request reprint Risk of Nonmelanoma Skin Cancer Associated With the Use of Immunosuppressant and Biologic Agents in Patients With a History of Autoimmune Disease and Nonmelanoma Skin Cancer
    Frank I Scott
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia2Division of Gastroenterology, University of Pennsylvania, Philadelphia
    JAMA Dermatol 152:164-72. 2016
    ..Drug-induced immunosuppression is a risk factor for nonmelanoma skin cancer (NMSC), particularly squamous cell tumors. For patients with a history of NMSC, data are limited on the effect of these drugs on the risk of additional NMSCs...
  24. doi request reprint Use of demographic and pharmacy data to identify patients included within both the Clinical Practice Research Datalink (CPRD) and The Health Improvement Network (THIN)
    Dena M Carbonari
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 24:999-1003. 2015
    ....
  25. pmc Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study
    Alexis Ogdie
    Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Rheum Dis 74:326-32. 2015
    ....
  26. pmc Association between longer therapy with thiazolidinediones and risk of bladder cancer: a cohort study
    Ronac Mamtani
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Natl Cancer Inst 104:1411-21. 2012
    ..In this study, we assessed the risk of bladder cancer associated with the use of TZDs and between pioglitazone and rosiglitazone, an alternative TZD...
  27. pmc Increasing use of prescription drugs in the United Kingdom
    Frank Zhang
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, United States
    Pharmacoepidemiol Drug Saf 25:628-36. 2016
    ..Prescription drugs are a central component of healthcare worldwide. We investigated changes in drug-prescribing patterns over time in the general population...
  28. doi request reprint A Risk Prediction Model for Sporadic CRC Based on Routine Lab Results
    Ben Boursi
    Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, 733 Blockley Hall, 423 Guardian Drive, Philadelphia, PA, 19104 6021, USA
    Dig Dis Sci 61:2076-86. 2016
    ..Current risk scores for colorectal cancer (CRC) are based on demographic and behavioral factors and have limited predictive values...
  29. doi request reprint A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-onset Diabetes
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA Tel Aviv University, Tel Aviv, Israel
    Gastroenterology . 2016
    ..Screening individuals with new-onset diabetes might therefore allow earlier diagnosis of PDA. We sought to develop and validate a PDA risk prediction model to identify high-risk individuals among those with new-onset diabetes...
  30. pmc Validation of a coding algorithm for intra-abdominal surgeries and adhesion-related complications in an electronic medical records database
    Frank I Scott
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 25:405-12. 2016
    ..We tested the accuracy of recording of these surgeries and complications within The Health Improvement Network (THIN), a primary care database within the UK...
  31. pmc Incidence of bladder cancer in patients with type 2 diabetes treated with metformin or sulfonylureas
    Ronac Mamtani
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA
    Diabetes Care 37:1910-7. 2014
    ..Previous studies evaluating the effect of metformin on cancer risk have been impacted by time-related biases. To avoid these biases, we examined the incidence of bladder cancer in new users of metformin and sulfonylureas (SUs)...
  32. pmc Tumor necrosis factor α inhibitor therapy and cancer risk in chronic immune-mediated diseases
    Kevin Haynes
    University of Pennsylvania, Department of Epidemiology and Biostatistics, Philadelphia, PA 19104, USA
    Arthritis Rheum 65:48-58. 2013
    ..To compare the incidence of cancer following tumor necrosis factor α (TNFα) inhibitor therapy to that with commonly used alternative therapies across multiple immune-mediated diseases...
  33. pmc Ion channel blockers and glioblastoma risk and outcome: a nested case-control and retrospective cohort studies
    Ben Boursi
    Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 25:1179-1185. 2016
    ..We sought to evaluate the association between the use of specific ion channel blockers such as digoxin, amiodarone, diltiazem and verapamil and GBM risk and survival...
  34. ncbi request reprint An association between newly diagnosed cutaneous T cell lymphoma and prior impetigo: a nested case-control study
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    Arch Dermatol Res 308:661-664. 2016
    ..09, 95 % CI 0.35-3.37). Our results suggest a possible association between SA colonization and CTCL initiation that might serve as an important etiological factor for the disease...
  35. doi request reprint Pernicious anemia and colorectal cancer risk - A nested case-control study
    Ben Boursi
    Division of Gastroenterology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Tel Aviv University, Tel Aviv, Israel
    Dig Liver Dis 48:1386-1390. 2016
    ..Hypergastrinemia was shown to stimulate colonic epithelial cell proliferation...
  36. doi request reprint Reappraisal of risk factors for monoclonal gammopathy of undetermined significance
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Am J Hematol 91:581-4. 2016
    ..Am. J. Hematol. 91:581-584, 2016. © 2016 Wiley Periodicals, Inc. ..
  37. pmc Parkinson's disease and colorectal cancer risk-A nested case control study
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA Tel Aviv University, Tel Aviv, Israel
    Cancer Epidemiol 43:9-14. 2016
    ..We sought to evaluate the association between Parkinson's disease and CRC...
  38. pmc Assessing the risk of incident hypertension and chronic kidney disease after exposure to shock wave lithotripsy and ureteroscopy
    Michelle R Denburg
    The Children s Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA Electronic address
    Kidney Int 89:185-92. 2016
    ..42 for HTN, an individual who undergoes SWL to the kidney can be expected to have a significantly increased hazard ratio for HTN of 1.96 (1.67, 2.29) compared with an individual without urolithiasis. ..
  39. doi request reprint Anti-depressant therapy and cancer risk: a nested case-control study
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur Neuropsychopharmacol 25:1147-57. 2015
    ..Odds ratios (ORs) and 95% CIs were estimated for each anti-depressant class using conditional logistic-regression analysis, adjusted for potential confounders, such as obesity, smoking history and alcohol consumption...
  40. pmc Determinants of saxagliptin use among patients with type 2 diabetes mellitus treated with oral anti-diabetic drugs
    M Elle Saine
    Department of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA, USA
    BMC Pharmacol Toxicol 16:8. 2015
    ....
  41. pmc Recurrent antibiotic exposure may promote cancer formation--Another step in understanding the role of the human microbiota?
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Tel Aviv University, Tel Aviv, Israel
    Eur J Cancer 51:2655-64. 2015
    ..In a recent animal model, tumour susceptibility was transmitted using faecal transplantation. Our aim was to evaluate possible association between antibiotic exposure and cancer risk...
  42. pmc Antibiotic Exposure and Juvenile Idiopathic Arthritis: A Case-Control Study
    Daniel B Horton
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania Division of Rheumatology, Nemours Alfred I duPont Hospital for Children, Wilmington, Delaware
    Pediatrics 136:e333-43. 2015
    ..Recent evidence has linked childhood antibiotic use and microbiome disturbance to autoimmune conditions. This study tested the hypothesis that antibiotic exposure was associated with newly diagnosed juvenile idiopathic arthritis (JIA)...
  43. pmc Thyroid dysfunction, thyroid hormone replacement and colorectal cancer risk
    Ben Boursi
    Division of Gastroenterology BB, YXY, Center for Clinical Epidemiology and Biostatistics BB, KH, RM, YXY, Department of Biostatistics and Epidemiology BB, KH, RM, YXY, Division of Hematology Oncology RM, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel BB
    J Natl Cancer Inst 107:djv084. 2015
    ..We sought to determine the risk of developing CRC in patients with thyroid dysfunction, with and without thyroid hormone replacement (THR)...
  44. doi request reprint Impact of antibiotic exposure on the risk of colorectal cancer
    Ben Boursi
    Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Tel Aviv University, Tel Aviv, Israel
    Pharmacoepidemiol Drug Saf 24:534-42. 2015
    ..Our aim was to evaluate the association between the type and cumulative duration of antibiotic exposure and CRC risk...
  45. pmc The effect of past antibiotic exposure on diabetes risk
    Ben Boursi
    Perelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania, USAThe Integrated Cancer Prevention CenterTel Aviv Sourasky Medical Center, Tel Aviv, IsraelTel Aviv UniversityTel Aviv, Israel Perelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania, USAThe Integrated Cancer Prevention CenterTel Aviv Sourasky Medical Center, Tel Aviv, IsraelTel Aviv UniversityTel Aviv, Israel Perelman School of Medicine at the University of PennsylvaniaPhiladelphia, Pennsylvania, USAThe Integrated Cancer Prevention CenterTel Aviv Sourasky Medical Center, Tel Aviv, IsraelTel Aviv UniversityTel Aviv, Israel
    Eur J Endocrinol 172:639-48. 2015
    ..Antibiotic therapy can alter the microbiota, and is commonly used in western countries. We sought to evaluate whether past antibiotic exposure increases diabetes risk...
  46. pmc Digoxin use and the risk for colorectal cancer
    Ben Boursi
    Division of Gastroenterology, University of Pennsylvania, Philadelphia, PA, USA Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA, USA Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA The Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel Tel Aviv University, Tel Aviv, Israel
    Pharmacoepidemiol Drug Saf 23:1147-53. 2014
    ..Cardiac glycosides affect several pathways central for tumor formation. We sought to evaluate the association between digoxin use and colorectal cancer (CRC) risk...
  47. pmc Risk of fracture in urolithiasis: a population-based cohort study using the health improvement network
    Michelle R Denburg
    Children s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Clin J Am Soc Nephrol 9:2133-40. 2014
    ..This study sought to determine whether urolithiasis is associated with increased fracture risk across the lifespan and to delineate sex effects...
  48. pmc Comparative effectiveness of infliximab and adalimumab for Crohn's disease
    Mark T Osterman
    Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    Clin Gastroenterol Hepatol 12:811-817.e3. 2014
    ..This study compared the effectiveness of infliximab and adalimumab, the 2 most commonly used anti-tumor necrosis factor agents, in patients with CD...
  49. pmc Proton pump inhibitors do not impair the effectiveness of metformin in patients with diabetes
    James Flory
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Center for Pharmacoepidemiology Research and Training, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA Division of Endocrinology, Weill Cornell Medical College, New York, NY
    Br J Clin Pharmacol 79:330-6. 2015
    ..This pharmacoepidemiologic study looked for evidence of a clinical effect of such an interaction...
  50. pmc Height as an independent anthropomorphic risk factor for colorectal cancer
    Ben Boursi
    aDepartment of Epidemiology and Biostatistics, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine bDivision of Gastroenterology cDivision of Hematology Medical Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA dThe Integrated Cancer Prevention Center, Tel Aviv Sourasky Medical Center eTel Aviv University, Tel Aviv, Israel
    Eur J Gastroenterol Hepatol 26:1422-7. 2014
    ..None of those studies adjusted the association for known risk factors, such as diabetes mellitus and chronic exposure to aspirin/NSAIDs. Only two studies evaluated the risk among male individuals...
  51. pmc Diagnosis of pernicious anemia and the risk of pancreatic cancer
    Pari Shah
    From the Department of Medicine, Gastroenterology and Nutrition Service, Memorial Sloan Kettering Cancer Center, New York, NY and Division of Gastroenterology, Department of Medicine, and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
    Pancreas 43:422-6. 2014
    ..Pernicious anemia (PA) is a clinical condition characterized by chronic hypergastrinemia. The aim of this study was to determine if PA is a risk factor for pancreatic cancer...
  52. pmc Metformin and survival in pancreatic cancer: a retrospective cohort study
    Allen L Hwang
    From the Division of Gastroenterology, Hospital at the University of Pennsylvania and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Pancreas 42:1054-9. 2013
    ..Our aim was to determine the effect of metformin exposure on survival in patients with advanced pancreatic adenocarcinoma (PAC)...
  53. doi request reprint Emergent renal dysfunction with colistin pharmacotherapy
    Julie M Collins
    Temple University Hospital, Philadelphia, Pennsylvania, USA
    Pharmacotherapy 33:812-6. 2013
    ..To evaluate the association between the administration of intravenous (IV) colistin and the emergence of renal dysfunction...
  54. pmc Distinguishing incident and prevalent diabetes in an electronic medical records database
    Ronac Mamtani
    Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
    Pharmacoepidemiol Drug Saf 23:111-8. 2014
    ..To develop a method to identify incident diabetes mellitus (DM) using an electronic medical records (EMR) database and test this classification by comparing incident and prevalent DM with common outcomes related to DM duration...
  55. pmc Prevalence and treatment patterns of psoriatic arthritis in the UK
    Alexis Ogdie
    Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 8 Penn Tower, 1 Convention Ave, Philadelphia, PA 19104, USA
    Rheumatology (Oxford) 52:568-75. 2013
    ....
  56. doi request reprint Discontinuation rates of anticholinergic medications used for the treatment of lower urinary tract symptoms
    Manish Gopal
    Division of Urogynecology, University of Pennsylvania, Philadelphia, Pennsylvania 08901, USA
    Obstet Gynecol 112:1311-8. 2008
    ..To estimate the discontinuation rates of anticholinergic medications used for the treatment of lower urinary tract symptoms in women...
  57. pmc Clinical and economic benefits of fidaxomicin compared to vancomycin for Clostridium difficile infection
    Jason C Gallagher
    Department of Pharmacy Practice, Temple University, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 59:7007-10. 2015
    ..Fidaxomicin use for CDI treatment prevented readmission and decreased hospital costs compared to use of oral vancomycin. ..
  58. pmc Risk of community-acquired pneumonia in patients with a diagnosis of pernicious anemia: a population-based retrospective cohort study
    Christopher V Almario
    aCedars Sinai Center for Outcomes Research and Education CS CORE bDepartment of Medicine, Division of Gastroenterology, Cedars Sinai Medical Center cDepartment of Medicine, Division of Digestive Diseases, University of California Los Angeles, Los Angeles, California dDepartment of Medicine, Division of Gastroenterology, Hospital of the University of Pennsylvania eDepartment of Biostatistics and Epidemiology, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Eur J Gastroenterol Hepatol 27:1259-64. 2015
    ..We conducted a population-based study to determine whether individuals with PA are at an increased risk for community-acquired pneumonia (CAP)...
  59. pmc Endometrial cancer after endometrial ablation vs medical management of abnormal uterine bleeding
    Robert L Dood
    Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia Electronic address
    J Minim Invasive Gynecol 21:744-52. 2014
    ..To investigate whether endometrial ablation is associated with increased risk or delayed diagnosis of endometrial cancer compared with medical management of abnormal uterine bleeding...
  60. pmc Comparison of prior authorization and prospective audit with feedback for antimicrobial stewardship
    Jimish M Mehta
    Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
    Infect Control Hosp Epidemiol 35:1092-9. 2014
    ..We compared these core ASP strategies at an academic medical center...
  61. pmc Case-case-control study of patients with carbapenem-resistant and third-generation-cephalosporin-resistant Klebsiella pneumoniae bloodstream infections
    Jason C Gallagher
    Temple University School of Pharmacy, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 58:5732-5. 2014
    ..5; 95% CI, 2.9 to 62.8) and the use of antibiotics in the past 90 days (OR, 5.9; 95% CI, 1.3 to 26.5) were independent risk factors. Similar factors put patients at risk for these two types of K. pneumoniae BSIs. ..
  62. doi request reprint Effect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: an ACTTION study
    John T Farrar
    Department of Biostatistics and Epidemiology, Anesthesiology, and Neurology, University of Pennsylvania, Philadelphia, PA, USA Electronic address
    Pain 155:1622-31. 2014
    ....
  63. pmc Validation of The Health Improvement Network (THIN) database for epidemiologic studies of chronic kidney disease
    Michelle R Denburg
    Division of Nephrology, Department of Pediatrics, The Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 20:1138-49. 2011
    ..The Health Improvement Network (THIN) in the UK represents a unique resource for population-based studies of CKD. We compiled a valid list of Read codes to identify subjects with moderate to advanced CKD...
  64. doi request reprint Physician attitudes toward regionalization of adult critical care: a national survey
    Jeremy M Kahn
    Division of Pulmonary, Allergy, and Critical Care, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Crit Care Med 37:2149-54. 2009
    ..Regionalization has been proposed as a method to improve outcomes for patients with critical illness. We sought to determine intensivist physician attitudes and potential barriers to the regionalization of adult critical care...
  65. ncbi request reprint Use of antiepileptic drugs in patients with kidney disease
    Rubeen K Israni
    Renal Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Semin Dial 19:408-16. 2006
    ..Monitoring of drug levels when available, careful clinical assessment of patients taking AEDs, and close collaboration with neurologists is essential to the management of patients taking AEDs...
  66. pmc Standards for head injury management in acute hospitals: evidence from the six million population of the Eastern region
    H M Seeley
    Neurosciences Department, Addenbrooke s Hospital, Cambridge, UK
    Emerg Med J 23:128-32. 2006
    ..To develop standards of care for head injury and thereby identify and prioritize areas of the service needing development; to report the findings from a survey of compliance with such standards in the Eastern region of UK...