THOMAS HAWN

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway
    Thomas R Hawn
    Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Microbes Infect 4:763-71. 2002
  2. ncbi request reprint Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 179:6981-7. 2007
  3. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008
  4. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
  5. ncbi request reprint Tuberculosis vaccines and prevention of infection
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Microbiol Mol Biol Rev 78:650-71. 2014
  6. pmc Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction
    Elizabeth A Misch
    University of Washington School of Medicine, Seattle, Washington, USA
    PLoS Negl Trop Dis 2:e231. 2008
  7. pmc Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants
    April Kaur Randhawa
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002174. 2011
  8. ncbi request reprint A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA, and Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Eur J Immunol 37:2280-9. 2007
  9. ncbi request reprint A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle WA 98195, USA
    J Infect Dis 194:1127-34. 2006
  10. ncbi request reprint Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Infect Dis 193:1693-702. 2006

Research Grants

  1. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
  2. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009

Detail Information

Publications34

  1. ncbi request reprint Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway
    Thomas R Hawn
    Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Microbes Infect 4:763-71. 2002
    ..Examination of promoter activation is a powerful tool for understanding the early events in macrophage activation for anti-inflammatory pathogens such as Leishmania that have mechanisms to downregulate transcription and translation...
  2. ncbi request reprint Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Immunol 179:6981-7. 2007
    ..Thus, TLR5 mediates recognition of Lp in AMs and performs a distinct role during the in vivo pulmonary immune response through regulation of early PMN recruitment and subsequent later development of pneumonia...
  3. pmc Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Infect Dis 197:253-61. 2008
    ..The goal of the present study was to assess the effect of Toll-like receptor 2 (TLR2) polymorphisms on susceptibility to and clinical presentation of leprosy...
  4. pmc The influence of host and bacterial genotype on the development of disseminated disease with Mycobacterium tuberculosis
    Maxine Caws
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, District 5, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000034. 2008
    ..The study provides evidence that M. tuberculosis genotype influences clinical disease phenotype and demonstrates, for the first time, a significant interaction between host and bacterial genotypes and the development of tuberculosis...
  5. ncbi request reprint Tuberculosis vaccines and prevention of infection
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Microbiol Mol Biol Rev 78:650-71. 2014
    ..Together, these points support expanding the focus of TB vaccine development efforts to include prevention of infection as a primary goal along with vaccines or other interventions that reduce the rate of transmission and reactivation...
  6. pmc Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction
    Elizabeth A Misch
    University of Washington School of Medicine, Seattle, Washington, USA
    PLoS Negl Trop Dis 2:e231. 2008
    ..Our findings suggest that TLR1 deficiency influences adaptive immunity during leprosy infection to affect clinical manifestations such as nerve damage and disability...
  7. pmc Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants
    April Kaur Randhawa
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Pathog 7:e1002174. 2011
    ..These findings could potentially guide novel adjuvant vaccine strategies as well as have implications for IFN-γ-based diagnostic testing for TB...
  8. ncbi request reprint A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA, and Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    Eur J Immunol 37:2280-9. 2007
    ....
  9. ncbi request reprint A polymorphism in Toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle WA 98195, USA
    J Infect Dis 194:1127-34. 2006
    ....
  10. ncbi request reprint Myeloid differentiation primary response gene (88)- and toll-like receptor 2-deficient mice are susceptible to infection with aerosolized Legionella pneumophila
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Infect Dis 193:1693-702. 2006
    ..Although pathogens are typically recognized by multiple TLRs, the specific roles of individual TLRs in mediating host protection during in vivo infection are not well understood...
  11. pmc Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women
    Thomas R Hawn
    Department of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5990. 2009
    ..Although behavioral risk factors are strongly associated with urinary tract infection (UTI) risk, the role of genetics in acquiring this disease is poorly understood...
  12. ncbi request reprint Hyper-IgE syndrome is not associated with defects in several candidate toll-like receptor pathway genes
    Thomas R Hawn
    University of Washington School of Medicine, Seattle, WA 98103 8904, USA
    Hum Immunol 66:842-7. 2005
    ..No unique mutations or polymorphisms were observed in several candidate genes from the TLR pathway. Our studies do not support a role for a defective TLR response in HIES individuals...
  13. pmc A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, 1959 Northeast Pacific Street, Seattle, WA 98105, USA
    Proc Natl Acad Sci U S A 102:10593-7. 2005
    ..These data support a role for flagellated bacteria and the innate immune response in the development of SLE with implications for novel immunomodulatory treatment strategies...
  14. pmc Genetic variation of the human urinary tract innate immune response and asymptomatic bacteriuria in women
    Thomas R Hawn
    Department of Medicine, University of Washington, Seattle, Washington, USA
    PLoS ONE 4:e8300. 2009
    ..We examined whether candidate gene polymorphisms were associated with altered urine inflammatory profiles in asymptomatic women with or without bacteriuria...
  15. pmc Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
    Thomas R Hawn
    Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 102:2487-9. 2005
    ..This protective association illustrates that an innate immune receptor can mediate either beneficial or deleterious inflammatory responses and that these outcomes vary with different pathogens...
  16. pmc A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease
    Thomas R Hawn
    Institute for Systems Biology, 1441 N 34th St, Seattle, WA 98103, USA
    J Exp Med 198:1563-72. 2003
    ..Together, these observations suggest that TLR5392STOP increases human susceptibility to infection through an unusual dominant mechanism that compromises TLR5's essential role as a regulator of the lung epithelial innate immune response...
  17. pmc Differential role of MyD88 in macrophage-mediated responses to opportunistic fungal pathogens
    Kieren A Marr
    Fred Hutchinson Cancer Research Center and University of Washington, Seattle, 98109, USA
    Infect Immun 71:5280-6. 2003
    ..albicans, but not A. fumigatus. The differential role of MyD88 may represent one mechanism by which macrophages regulate innate responses specific to different pathogenic fungi...
  18. ncbi request reprint Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
    Pierre Yves Bochud
    Institute for Systems Biology, Seattle, WA 98103 8904, USA
    J Immunol 170:3451-4. 2003
    ....
  19. pmc Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles
    Nguyen Thuy Thuong Thuong
    Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
    PLoS Pathog 4:e1000229. 2008
    ....
  20. ncbi request reprint Host susceptibility and clinical outcomes in toll-like receptor 5-deficient patients with typhoid fever in Vietnam
    Sarah J Dunstan
    Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
    J Infect Dis 191:1068-71. 2005
    ..TLR5 may not play an important role in TLR-stimulated innate immune responses to human infection with Salmonella enterica serovar Typhi. Initiation of these responses may rely on other TLRs that recognize different bacterial ligands...
  21. pmc Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia
    Amy E Morris
    Harborview Medical Center, Seattle, WA 98104, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1112-9. 2009
    ..aeruginosa and contributes to antibacterial resistance in a manner that is partially inoculum dependent. These data are the first to demonstrate a unique role for TLR5 in the innate immune response to P. aeruginosa lung infection...
  22. pmc The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury
    Paul L Bollyky
    Benaroya Research Institute, Seattle, Washington, United States of America
    PLoS ONE 4:e5063. 2009
    ..These data suggest that Myd88 signaling and certain TLR ligands mediate a homeostatic effect on beta-cells primarily in the setting of injury...
  23. ncbi request reprint Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection
    Erica Andersen-Nissen
    Institute for Systems Biology, Seattle, WA 98103, USA
    J Immunol 178:4717-20. 2007
    ..Together, these data represent the first evidence that TLR5 regulates the innate immune response in the urinary tract and is essential for an effective murine in vivo immune response to an extracellular pathogen...
  24. ncbi request reprint Toll-like receptors: their roles in bacterial recognition and respiratory infections
    April Kaur Randhawa
    Department of Medicine Division of Allergy and Infections Diseases, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Expert Rev Anti Infect Ther 6:479-95. 2008
    ..Moreover, we will highlight recent advances in the role of TLRs in pulmonary infections from a human immunogenetics perspective...
  25. ncbi request reprint Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    Francis Kim
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Circ Res 100:1589-96. 2007
    ....
  26. pmc Mycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter?
    William R Berrington
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, WA 98195 0001, USA
    Immunol Rev 219:167-86. 2007
    ..We emphasize recent discoveries in human genetic studies and correlate these findings with efforts to understand how these variants alter the molecular and cellular functions that regulate the macrophage response to MTb...
  27. pmc Toll-like receptor signaling in airborne Burkholderia thailandensis infection
    T Eoin West
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    Infect Immun 77:5612-22. 2009
    ..TLR signaling in B. thailandensis infection is substantially comparable to signaling induced by virulent B. pseudomallei. These studies provide additional insights into the host-pathogen interaction in pneumonic Burkholderia infection...
  28. pmc Family history and risk of recurrent cystitis and pyelonephritis in women
    Delia Scholes
    Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98101, USA
    J Urol 184:564-9. 2010
    ..Family history variables indicative of genetic risk merit further investigation. We evaluated the risk of recurrent cystitis and pyelonephritis in women with and those without a family history of urinary tract infection...
  29. pmc Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages
    D Shane O'Mahony
    Departments of Medicine, University of Washington, Seattle, WA 98195, USA
    Int J Med Sci 5:1-8. 2008
    ..TLR5 was down-regulated by inflammatory cytokines in monocytes. These results suggest a potential role for IFN- gamma and/or GM-CSF as therapeutic immunomodulators of the host defense to infection...
  30. ncbi request reprint Toll-like receptor polymorphisms and susceptibility to human disease
    E Ann Misch
    Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA
    Clin Sci (Lond) 114:347-60. 2008
    ..In this review, we summarize studies of common TLR polymorphisms and how this work is beginning to illuminate the influence of human variation on inflammation and disease susceptibility...
  31. pmc The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    David M Tobin
    Department of Microbiology, University of Washington, Box 357242, Seattle, WA 98195, USA
    Cell 140:717-30. 2010
    ..Our results suggest conserved roles for balanced eicosanoid production in vertebrate resistance to mycobacterial infection...
  32. ncbi request reprint Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome
    Mehdi Yeganeh
    Immunology, Asthma and Allergy Research Institute, Medical Sciences University of Tehran, Tehran, Iran
    Int Arch Allergy Immunol 146:190-4. 2008
    ..Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES...
  33. ncbi request reprint Pyogenic bacterial infections in humans with IRAK-4 deficiency
    Capucine Picard
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université René Descartes INSERM U550, Faculte Necker, 156 rue de Vaugirard, 75015 Paris, France
    Science 299:2076-9. 2003
    ..These findings suggest that, in humans, the TIR-IRAK signaling pathway is crucial for protective immunity against specific bacteria but is redundant against most other microorganisms...
  34. ncbi request reprint Towards subtlety: understanding the role of Toll-like receptor signaling in susceptibility to human infections
    Stuart E Turvey
    Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, Canada BC V5Z 4H4
    Clin Immunol 120:1-9. 2006
    ....

Research Grants2

  1. Toll-like Receptors and the Innate Immune Response
    THOMAS HAWN; Fiscal Year: 2003
    ..tuberculosis and L. major will reveal novel insights about innate immunity and infectious diseases that will have implications for vaccine development. ..
  2. TLR5 and Pulmonary Innate Immunity
    THOMAS HAWN; Fiscal Year: 2009
    ..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..