K F Hauser

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. pmc Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, 40536 0298, USA
    Cerebellum 2:184-95. 2003
  2. pmc Pathobiology of dynorphins in trauma and disease
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Front Biosci 10:216-35. 2005
  3. pmc Molecular targets of opiate drug abuse in neuroAIDS
    K F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Neurotox Res 8:63-80. 2005
  4. ncbi request reprint Impact of opiate-HIV-1 interactions on neurotoxic signaling
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Neuroimmune Pharmacol 1:98-105. 2006
  5. pmc Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation
    K F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Eur J Neurosci 12:1281-93. 2000
  6. pmc Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro
    J A Gurwell
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington 40536-0298, USA
    Neuroscience 102:555-63. 2001
  7. pmc mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism
    K F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536 0084, USA
    Brain Res 720:191-203. 1996
  8. ncbi request reprint Endogenous opioids and oligodendroglial function: possible autocrine/paracrine effects on cell survival and development
    P E Knapp
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 35:156-65. 2001
  9. ncbi request reprint Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons
    V V Adjan
    Department of Anatomy and Neurobiology, 800 Rose Street, MS209, University of Kentucky, Lexington, KY 40536 0298, USA
    Neuroscience 148:724-36. 2007
  10. pmc Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro
    S K Buch
    Department of Anatomy and Neurobiology, University of Kentucky, College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    Neuroscience 146:1546-54. 2007

Collaborators

Detail Information

Publications46

  1. pmc Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, 40536 0298, USA
    Cerebellum 2:184-95. 2003
    ....
  2. pmc Pathobiology of dynorphins in trauma and disease
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Front Biosci 10:216-35. 2005
    ..Evidence outlined in this review suggests that a variety of CNS pathologies alter dynorphin biogenesis. Such alterations are likely maladaptive and contribute to secondary injury and the pathogenesis of disease...
  3. pmc Molecular targets of opiate drug abuse in neuroAIDS
    K F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Neurotox Res 8:63-80. 2005
    ....
  4. ncbi request reprint Impact of opiate-HIV-1 interactions on neurotoxic signaling
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    J Neuroimmune Pharmacol 1:98-105. 2006
    ..Opiate abuse intrinsically modifies the host response to HIV-1. Identification of how this occurs is providing considerable insight toward understanding the mechanisms underlying HIV-1-associated dementia...
  5. pmc Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of mu and delta receptor activation on proliferation and neurite elongation
    K F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Eur J Neurosci 12:1281-93. 2000
    ..The data additionally suggest that perinatal exposure to opiate drugs of abuse directly interfere with cerebellar maturation by disrupting normal opioid signalling and inhibiting the proliferation of granule neuron precursors...
  6. pmc Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro
    J A Gurwell
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington 40536-0298, USA
    Neuroscience 102:555-63. 2001
    ..These findings demonstrate that acute opioid exposure can exacerbate the neurodegenerative effect of HIV-1 Tat protein in striatal neurons, and infer a means by which opioids may hasten the progression of HIV-associated dementia...
  7. pmc mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism
    K F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536 0084, USA
    Brain Res 720:191-203. 1996
    ..This implies a fundamental mechanism by which opioids affect central nervous system maturation...
  8. ncbi request reprint Endogenous opioids and oligodendroglial function: possible autocrine/paracrine effects on cell survival and development
    P E Knapp
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 35:156-65. 2001
    ..e., autocrine and/or paracrine) mechanisms...
  9. ncbi request reprint Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: differential effects on glia and neurons
    V V Adjan
    Department of Anatomy and Neurobiology, 800 Rose Street, MS209, University of Kentucky, Lexington, KY 40536 0298, USA
    Neuroscience 148:724-36. 2007
    ..While normally beneficial, our findings suggest that prodynorphin or its peptide products become maladaptive following SCI and contribute to secondary injury...
  10. pmc Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro
    S K Buch
    Department of Anatomy and Neurobiology, University of Kentucky, College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    Neuroscience 146:1546-54. 2007
    ..Should similar patterns occur in vivo then we predict that immature astroglia and oligodendroglia may be preferentially vulnerable to HIV-1 infection or chronic opiate exposure...
  11. pmc Dynorphin A (1-17) induces apoptosis in striatal neurons in vitro through alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome c release and caspase-3 activation
    I N Singh
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    Neuroscience 122:1013-23. 2003
    ..These findings provide novel evidence that dynorphin-induced striatal neurotoxicity is mediated by a caspase-dependent apoptotic mechanism that largely involves AMPA/kainate receptors...
  12. pmc Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons
    I N Singh
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536 0298, USA
    Neuroscience 135:781-90. 2005
    ....
  13. ncbi request reprint mu-Opioid receptor activation enhances DNA synthesis in immature oligodendrocytes
    P E Knapp
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington 40536 0084, USA
    Brain Res 743:341-5. 1996
    ..The expression of opioid receptors by OLs suggests that the endogenous opioid system is widely distributed among glial types...
  14. ncbi request reprint Endogenous opioid system in developing normal and jimpy oligodendrocytes: mu and kappa opioid receptors mediate differential mitogenic and growth responses
    P E Knapp
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington 40536 0084, USA
    Glia 22:189-201. 1998
    ..If opiate receptors are expressed by OLs in vivo, their pharmacological manipulation might provide a novel pathway for modulating OL and myelin production both during development and in demyelinated conditions...
  15. ncbi request reprint Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia
    A Nath
    Department of Neurology, University of Kentucky, Lexington, USA
    J Psychopharmacol 14:222-7. 2000
    ..Therefore, a thorough understanding of the mechanisms that lead to this selective neurotoxicity of dopaminergic neurons would also likely lead to the development of therapeutic modalities for patients with HIV dementia...
  16. pmc Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: impact on gliogenesis in vivo
    A Stiene-Martin
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    Glia 36:78-88. 2001
    ....
  17. pmc Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine
    J Turchan
    Department of Neurology, University of Kentucky, Lexington, USA
    BMC Neurosci 2:3. 2001
    ..We determined the combined effects of dopaminergic drugs, methamphetamine, or cocaine with neurotoxic HIV proteins, gp120 and Tat...
  18. pmc CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Neuroimmunol 178:9-16. 2006
    ..Thus, CCR2 contributes to local glial activation caused by Tat alone or in the presence of opiates, implicating CCR2 signaling in HIV-1 neuropathogenesis in drug abusers and non-abusers...
  19. pmc Morphine causes rapid increases in glial activation and neuronal injury in the striatum of inducible HIV-1 Tat transgenic mice
    Annadora J Bruce-Keller
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    Glia 56:1414-27. 2008
    ....
  20. pmc Effect of nicotine on cerebellar granule neuron development
    L A Opanashuk
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298, USA
    Eur J Neurosci 13:48-56. 2001
    ..Together these data provide novel evidence that the activation of nAChRs directly affect the development of primary cerebellar neuroblasts and further suggest that the effects are mediated through the alpha3-nAChR subtype...
  21. ncbi request reprint Abnormal Ca(2+) regulation in oligodendrocytes from the dysmyelinating jimpy mouse
    P E Knapp
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, MS207 Chandler Medical Center, Lexington, KY 40536, USA
    Brain Res 847:332-7. 1999
    ..A higher baseline [Ca2+](i) in jp OLs might increase their vulnerability to other insults due to abnormal protein processing or changes in signaling pathways which act as a final trigger for cell death...
  22. ncbi request reprint Chronic nicotine exposure reduces N-methyl-D-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression
    M A Prendergast
    Department of Psychology, University of Kentucky, Lexington 40506 0044, USA
    Neuroscience 102:75-85. 2001
    ....
  23. pmc Effects of chronic expression of the HIV-induced protein, transactivator of transcription, on circadian activity rhythms in mice, with or without morphine
    Marilyn J Duncan
    Dept of Anatomy and Neurobiology, Univ of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1680-7. 2008
    ..In conclusion, these findings suggest that chronic brain expression of Tat decreases locomotor activity and the amplitude of circadian rhythms, but does not affect photic entrainment or reentrainment of the murine circadian pacemaker...
  24. ncbi request reprint In utero nicotine exposure causes persistent, gender-dependant changes in locomotor activity and sensitivity to nicotine in C57Bl/6 mice
    James R Pauly
    Department of Pharmaceutical Sciences, Chandler College of Medicine, University of Kentucky, Lexington, KY 40636 0082, USA
    Int J Dev Neurosci 22:329-37. 2004
    ..This model may be very useful for future studies that try to more accurately define the windows of sensitivity for nicotine exposure and the possible underlying neurochemical mechanisms involved...
  25. ncbi request reprint Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl
    Jadwiga Turchan-Cholewo
    Departments of Anatomy and Neurobiology, University of Kentucky, Lexington, KY 40546, USA
    Neurobiol Dis 23:109-19. 2006
    ..In conclusion, opiate abusers with HIV infection and the ApoE4 allele may be at increased risk of developing dementia. L-deprenyl and a plant estrogen, diosgenin, may have therapeutic potential in this population...
  26. pmc HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse
    Kurt F Hauser
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    J Neurochem 100:567-86. 2007
    ..In this review, we consider astroglial and microglial interactions and dysfunction in the pathogenesis of HIV-1 infection and examine how drug actions in glia contribute to neuroAIDS...
  27. pmc beta-Chemokine production by neural and glial progenitor cells is enhanced by HIV-1 Tat: effects on microglial migration
    Yun Kyung Hahn
    Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
    J Neurochem 114:97-109. 2010
    ..Pathogens such as HIV might usurp this function to create a maladaptive state, especially during development or regeneration, when progenitors are numerous...
  28. pmc Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    Glia 50:91-106. 2005
    ....
  29. ncbi request reprint Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum
    A K Bansal
    Department of Anatomy and Neurobiology, MN 224, University of Kentucky College of Medicine, 800 Rose Street, Lexington, KY 40536, USA
    Brain Res 879:42-9. 2000
    ....
  30. pmc HIV-1 Tat and opiate-induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP-1 and alternative chemokines
    Nazira El-Hage
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0298, USA
    Glia 53:132-46. 2006
    ..Importantly, increased glial expression of MOR can trigger an opiate-driven amplification/positive feedback of MCP-1 production and inflammation...
  31. pmc Morphine and HIV-Tat increase microglial-free radical production and oxidative stress: possible role in cytokine regulation
    Jadwiga Turchan-Cholewo
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    J Neurochem 108:202-15. 2009
    ..Taken together, these data suggest that oxidative stress and proteasome inhibition may be involved in the immunomodulatory properties of opioid receptor activation in microglia...
  32. ncbi request reprint Genetic background regulates semaphorin gene expression and epileptogenesis in mouse brain after kainic acid status epilepticus
    J Yang
    Department of Neurology, University of Kentucky College of Medicine, Lexington, KY, USA
    Neuroscience 131:853-69. 2005
    ..These findings may define biologic principles underlying the role of semaphorin signaling which may broadly apply to other systems undergoing neural regeneration...
  33. ncbi request reprint Dynorphin A toxicity in striatal neurons via an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism
    R J Goody
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY 40536 0298, USA
    Neuroscience 116:807-16. 2003
    ..Our findings suggest that dynorphin A (1-17) can exert toxic effects on striatal neurons via an alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism...
  34. pmc Cell-specific actions of HIV-Tat and morphine on opioid receptor expression in glia
    Jadwiga Turchan-Cholewo
    Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA
    J Neurosci Res 86:2100-10. 2008
    ....
  35. pmc Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy
    John C Gant
    Departments of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, KY, USA
    Epilepsia 50:629-45. 2009
    ..To further understand the role of NPN2 signaling in central nevous system (CNS) plasticity, structural and functional alterations were assessed in NPN2 deficient mice...
  36. pmc Regional heterogeneity and diversity in cytokine and chemokine production by astroglia: differential responses to HIV-1 Tat, gp120, and morphine revealed by multiplex analysis
    Sylvia Fitting
    Department of Anatomy and Neurobiology, Department of Pharmacology and Toxicology, and Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
    J Proteome Res 9:1795-804. 2010
    ..Overall, the chemokine/cytokine release is higher from spinal cord and cortical astroglia than from cerebellar astroglia, paralleling the relatively low incidence of HIV-related neuropathology in the cerebellum...
  37. ncbi request reprint Silencing the PTEN gene is protective against neuronal death induced by human immunodeficiency virus type 1 Tat
    Tianyong Zhao
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurovirol 13:97-106. 2007
    ..These findings indicate that Akt is a critical intermediary in the direct neurotoxicity induced by HIV-1 Tat, and identify Akt regulation as a possible therapeutic strategy for Tat-induced neurotoxicity in HIV encephalitis (HIVE)...
  38. pmc Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G
    Indrapal N Singh
    Department of Anatomy and Neurobiology, University Kentucky College of Medicine, Lexington, 40536, USA
    J Neurovirol 10:141-51. 2004
    ..Collectively, our findings suggest that HIV-1 proteins are intrinsically toxic to striatal neurons and the pathogenesis is mediated through separate actions involving both caspase-3 and endo G...
  39. pmc Preferential vulnerability of astroglia and glial precursors to combined opioid and HIV-1 Tat exposure in vitro
    Valeriya K Khurdayan
    Department of Anatomy and Neurobiology, University of Kentucky College of Medicine, Lexington, KY, USA
    Eur J Neurosci 19:3171-82. 2004
    ..Our results imply that opiates can enhance the cytotoxicity of HIV-1 Tat through direct actions on glial precursors and/or astroglia, suggesting novel cellular targets for HIV-opiate interactions...
  40. ncbi request reprint Molecular basis for interactions of HIV and drugs of abuse
    Avi Nath
    Department of Neurology, John Hopkins University, Baltimore, Maryland 21287, USA
    J Acquir Immune Defic Syndr 31:S62-9. 2002
    ..This article also suggests therapeutic approaches based on our current understanding of the neuropathogenesis of dementia due to HIV infection and drugs of abuse...
  41. ncbi request reprint Translocation of dynorphin neuropeptides across the plasma membrane. A putative mechanism of signal transmission
    Zoya Marinova
    Section of Alcohol and Drug Dependence Research, Department of Clinical Neuroscience, Karolinska Institute, S 17176 Stockholm, Sweden
    J Biol Chem 280:26360-70. 2005
    ..Translocation across the plasma membrane may represent a previously unknown mechanism by which dynorphins can signal information to the cell interior...
  42. ncbi request reprint A novel soluble protein factor with non-opioid dynorphin A-binding activity
    Zoya Marinova
    Alcohol and Drug Dependence Research Section, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Biochem Biophys Res Commun 321:202-9. 2004
    ..Dynorphin A at the sites of its release in the CNS may attenuate this degradation as a competitor when it specifically binds to the enzyme...
  43. ncbi request reprint Prodynorphin storage and processing in axon terminals and dendrites
    Tatiana Yakovleva
    Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    FASEB J 20:2124-6. 2006
    ..Regulation of PDYN storage and processing at synapses by neuronal activity or extracellular stimuli may provide a local mechanism for regulation of synaptic transmission...
  44. ncbi request reprint Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide
    Hanspeter S Fischer
    Division of Neurochemistry, Department of Psychiatry, Innsbruck, Austria
    J Mol Neurosci 18:129-34. 2002
    ..Nitric oxide (NO) is suggested to be involved in this process...
  45. ncbi request reprint NeuroAIDS, drug abuse, and inflammation: building collaborative research activities
    Joan W Berman
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Neuroimmune Pharmacol 1:351-99. 2006
    ..Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( http://www.nida.nih.gov/about/organization/arp/arp-websites.htm )...
  46. ncbi request reprint Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle
    John D Porter
    Department of Ophthalmology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    J Exp Biol 206:3101-12. 2003
    ....