Thomas Hatsukami

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc MRI in the early identification and classification of high-risk atherosclerotic carotid plaques
    Thomas S Hatsukami
    Department of Surgery, Vascular Imaging Lab, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA, Tel 1 206 543 3061
    Imaging Med 2:63-75. 2010
  2. pmc Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 12:105. 2013
  3. pmc Quantitative evaluation of high intensity signal on MIP images of carotid atherosclerotic plaques from routine TOF-MRA reveals elevated volumes of intraplaque hemorrhage and lipid rich necrotic core
    Kiyofumi Yamada
    Department of Radiology, University of Washington, Seattle, WA 98109 4325, USA
    J Cardiovasc Magn Reson 14:81. 2012
  4. pmc Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Lipids Health Dis 8:52. 2009
  5. pmc The added value of longitudinal black-blood cardiovascular magnetic resonance angiography in the cross sectional identification of carotid atherosclerotic ulceration
    Wei Yu
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 11:31. 2009
  6. pmc Cardiovascular magnetic resonance in carotid atherosclerotic disease
    Li Dong
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 11:53. 2009
  7. pmc Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study
    Hunter R Underhill
    Department of Radiology University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 10:31. 2008
  8. pmc High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
    Tobias Saam
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Cardiovasc Magn Reson 11:41. 2009
  9. pmc The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study
    Feiyu Li
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 12:37. 2010
  10. pmc Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress
    Chun Yang
    School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
    Biomed Eng Online 10:61. 2011

Research Grants

  1. MRI IDENTIFICATION OF FIBROUS CAP ATROPHY AND RUPTURE
    Thomas Hatsukami; Fiscal Year: 2001
  2. Magnetic Resonance Imaging of Vulnerable Plaque
    Thomas Hatsukami; Fiscal Year: 2006

Collaborators

Detail Information

Publications62

  1. pmc MRI in the early identification and classification of high-risk atherosclerotic carotid plaques
    Thomas S Hatsukami
    Department of Surgery, Vascular Imaging Lab, University of Washington, 815 Mercer Street, Box 358050, Seattle, WA 98109, USA, Tel 1 206 543 3061
    Imaging Med 2:63-75. 2010
    ..This article will provide a summary of the histological validation of carotid MRI, and highlight its application in prospective clinical studies aimed at early identification of the high-risk atherosclerotic carotid plaque...
  2. pmc Correlations between carotid plaque progression and mechanical stresses change sign over time: a patient follow up study using MRI and 3D FSI models
    Dalin Tang
    School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, China
    Biomed Eng Online 12:105. 2013
    ..Long-term patient follow up was used to gather data and investigate if the correlations identified above were reproducible...
  3. pmc Quantitative evaluation of high intensity signal on MIP images of carotid atherosclerotic plaques from routine TOF-MRA reveals elevated volumes of intraplaque hemorrhage and lipid rich necrotic core
    Kiyofumi Yamada
    Department of Radiology, University of Washington, Seattle, WA 98109 4325, USA
    J Cardiovasc Magn Reson 14:81. 2012
    ..The aim of this study was to evaluate the quantitative relationships between high intensity signals (HIS) in the plaque on TOF-MRA and IPH or LRNC volumes as measured by multicontrast weighted CMR...
  4. pmc Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA
    Lipids Health Dis 8:52. 2009
    ....
  5. pmc The added value of longitudinal black-blood cardiovascular magnetic resonance angiography in the cross sectional identification of carotid atherosclerotic ulceration
    Wei Yu
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 11:31. 2009
    ..This study evaluates the efficacy of adding longitudinal black-blood (BB) cardiovascular magnetic resonance (CMR) angiography to cross-sectional CMR images in the identification of carotid atherosclerotic ulceration...
  6. pmc Cardiovascular magnetic resonance in carotid atherosclerotic disease
    Li Dong
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 11:53. 2009
    ..This review summarizes the current state of knowledge regarding carotid vessel wall CMR and its potential clinical application for management of carotid atherosclerotic disease...
  7. pmc Differences in carotid arterial morphology and composition between individuals with and without obstructive coronary artery disease: a cardiovascular magnetic resonance study
    Hunter R Underhill
    Department of Radiology University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 10:31. 2008
    ....
  8. pmc High resolution carotid black-blood 3T MR with parallel imaging and dedicated 4-channel surface coils
    Tobias Saam
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Cardiovasc Magn Reson 11:41. 2009
    ..The purpose of this study was to evaluate a multi-sequence, black-blood MR protocol using parallel imaging and a dedicated 4-channel surface coil for vessel wall imaging of the carotid arteries at 3 T...
  9. pmc The association of lesion eccentricity with plaque morphology and components in the superficial femoral artery: a high-spatial-resolution, multi-contrast weighted CMR study
    Feiyu Li
    Department of Radiology, University of Washington, Seattle, WA, USA
    J Cardiovasc Magn Reson 12:37. 2010
    ..This study investigated associations of plaque eccentricity with plaque components and morphology in the proximal superficial femoral artery using cardiovascular magnetic resonance (CMR)...
  10. pmc Impact of flow rates in a cardiac cycle on correlations between advanced human carotid plaque progression and mechanical flow shear stress and plaque wall stress
    Chun Yang
    School of Mathematical Sciences, Beijing Normal University, Lab of Math and Complex Systems, Ministry of Education, Beijing, China
    Biomed Eng Online 10:61. 2011
    ..It has been well-accepted that atherosclerosis initiation and early progression correlate negatively with flow wall shear stresses (FSS). However, mechanisms governing advanced plaque progression are not well understood...
  11. pmc Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study
    Dalin Tang
    Worcester Polytechnic Institute, Mathematical Sciences Department 100 Institute Road, Worcester, MA, USA
    Biomed Eng Online 8:15. 2009
    ..However, large-scale studies based on in vivo patient data combining mechanical stress analysis, plaque morphology and composition for carotid plaque vulnerability assessment are lacking in the current literature...
  12. ncbi request reprint Carotid plaque morphology and clinical events
    T S Hatsukami
    Seattle Veterans Affairs Medical Center, WA 98108, USA
    Stroke 28:95-100. 1997
    ..Constituents examined were chosen based on their potential for identification by current diagnostic imaging modalities such as ultrasound or MRI...
  13. pmc Carotid plaque assessment using fast 3D isotropic resolution black-blood MRI
    Niranjan Balu
    Department of Radiology, University of Washington, Seattle, Washington 98019, USA
    Magn Reson Med 65:627-37. 2011
    ..3D-MERGE is a promising new tool for fast and accurate plaque burden assessment in patients with atherosclerotic plaque...
  14. doi request reprint MRI of carotid atherosclerosis
    William S Kerwin
    Department of Radiology, University of Washington, Seattle, WA
    AJR Am J Roentgenol 200:W304-13. 2013
    ..This article summarizes the state of evidence for a clinical role for MRI of carotid atherosclerosis...
  15. ncbi request reprint Magnetic resonance imaging of carotid atherosclerosis: plaque analysis
    William Kerwin
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Top Magn Reson Imaging 18:371-8. 2007
    ..The purpose of this investigation was to assess the performance of CASCADE compared with manual outlining...
  16. ncbi request reprint Effect of contrast enhancement on the measurement of carotid arterial lumen and wall volume using MRI
    Binh An P Phan
    Department of Medicine, University of Washington, Seattle, Washington 98103 8771, USA
    J Magn Reson Imaging 23:481-5. 2006
    ..To investigate whether gadolinium (Gd)-based contrast enhancement (CE) affects high-resolution magnetic resonance imaging (MRI) measurements of carotid arterial wall volume...
  17. pmc MRI of carotid atherosclerosis
    Chun Yuan
    Vascular Imaging Laboratory, Department of Radiology, University of Washington, Seattle 98019, USA
    J Nucl Cardiol 15:266-75. 2008
  18. ncbi request reprint Quantitative magnetic resonance imaging analysis of neovasculature volume in carotid atherosclerotic plaque
    William Kerwin
    Department of Radiology, University of Washington, Seattle 98195, USA
    Circulation 107:851-6. 2003
    ..The aim of the present investigation was to determine whether the amount of neovasculature present in advanced carotid plaques can be noninvasively measured by dynamic, contrast-enhanced MRI...
  19. ncbi request reprint Improved suppression of plaque-mimicking artifacts in black-blood carotid atherosclerosis imaging using a multislice motion-sensitized driven-equilibrium (MSDE) turbo spin-echo (TSE) sequence
    Jinnan Wang
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Magn Reson Med 58:973-81. 2007
    ....
  20. pmc Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk
    James Ronald
    Department of Medicine, Division of Medical Genetics, University of Washington Medical Center Box 357720, Seattle, WA 98195 7720, USA
    Stroke 42:2-9. 2011
    ..The relationship between genetic variation in the LPA gene region and CAAD risk remains unknown...
  21. pmc Circulating inflammatory cells are associated with vein graft stenosis
    Katherine Moreno
    Division of Vascular Surgery, VA Puget Sound Health Care System and the University of Washington School of Medicine, Seattle, Wash, USA
    J Vasc Surg 54:1124-30. 2011
    ..We therefore hypothesized that elevated levels of platelet-monocyte aggregates (PMA) might be associated with stenosis, and could possibly discriminate between patients with or without vein graft stenosis...
  22. ncbi request reprint Carotid atherosclerotic wall imaging by MRI
    Chun Yuan
    Department of Radiology, Box 357115, University of Washington, Seattle, WA 91895, USA
    Neuroimaging Clin N Am 12:391-401, vi. 2002
    ..This article focuses on the current state-of-the-art in MR carotid atherosclerotic plaque imaging to evaluate plaque morphology and composition...
  23. ncbi request reprint Measurement of carotid wall volume and maximum area with contrast-enhanced 3D MR imaging: initial observations
    Shaoxiong Zhang
    Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Radiology 228:200-5. 2003
    ....
  24. ncbi request reprint Hemorrhage in the atherosclerotic carotid plaque: a high-resolution MRI study
    Baocheng Chu
    Department of Radiology, University of Washington, USA
    Stroke 35:1079-84. 2004
    ..The aim of this study was to develop criteria for the identification of the stages of intraplaque hemorrhage using high-resolution MRI...
  25. pmc Comparison between 2D and 3D high-resolution black-blood techniques for carotid artery wall imaging in clinically significant atherosclerosis
    Niranjan Balu
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 27:918-24. 2008
    ..To compare two- (2D) and three-dimensional (3D) black-blood imaging methods for morphological measurements of the carotid artery wall and atherosclerotic plaque...
  26. ncbi request reprint Determination of carotid artery atherosclerotic lesion type and distribution in hypercholesterolemic patients with moderate carotid stenosis using noninvasive magnetic resonance imaging
    Baocheng Chu
    Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Stroke 35:2444-8. 2004
    ....
  27. doi request reprint Prevalence of American Heart Association type VI carotid atherosclerotic lesions identified by magnetic resonance imaging for different levels of stenosis as measured by duplex ultrasound
    Tobias Saam
    Department of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Am Coll Cardiol 51:1014-21. 2008
    ....
  28. doi request reprint Effect of rosuvastatin therapy on carotid plaque morphology and composition in moderately hypercholesterolemic patients: a high-resolution magnetic resonance imaging trial
    Hunter R Underhill
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Am Heart J 155:584.e1-8. 2008
    ..Magnetic resonance imaging (MRI) can noninvasively assess changes in atherosclerotic plaque morphology and composition. The ORION trial assessed the effects of rosuvastatin on carotid plaque volume and composition...
  29. ncbi request reprint Ex vivo measures of LDL oxidative susceptibility predict carotid artery disease
    Audrey Hendrickson
    Division of Medical Genetics, The University of Washington Department of Medicine, Seattle, WA 98195, USA
    Atherosclerosis 179:147-53. 2005
    ..The purpose of the study was to assess whether ex vivo measures of low-density lipoprotein (LDL) oxidation improved prediction of carotid artery disease (CAAD) case-control status compared to standard lipid and smoking measures...
  30. ncbi request reprint Accuracy and uniqueness of three in vivo measurements of atherosclerotic carotid plaque morphology with black blood MRI
    Ying Luo
    Department of Electrical Engineering, University of Washington, Seattle, Washington 98195, USA
    Magn Reson Med 50:75-82. 2003
    ..3). Black blood MRI technique is a potentially powerful clinical tool to characterize the severity of atherosclerotic plaque. It can provide accurate measurements on different aspects of the plaque, from plaque burden to lumen narrowing...
  31. ncbi request reprint Detecting objects in image sequences using rule-based control in an active contour model
    Han Chao
    Department of Radiology, AA 010 Health Sciences Bldg, University of Washington, Box 357115, Seattle, WA 98195 7115, USA
    IEEE Trans Biomed Eng 50:705-10. 2003
    ..Evolution of contour segments is controlled by separate processes based on whether the segment is judged to be inside, outside, or near the boundary of the object, leading to robust boundary detection...
  32. ncbi request reprint Paraoxonase activity, but not haplotype utilizing the linkage disequilibrium structure, predicts vascular disease
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 23:1465-71. 2003
    ..The effects of paraoxonase (PON1) activity and of genetic variation in the PON1 promoter and coding region on carotid artery disease (CAAD) were investigated...
  33. pmc Predictors of carotid atherosclerotic plaque progression as measured by noninvasive magnetic resonance imaging
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, WA, USA
    Atherosclerosis 194:e34-42. 2007
    ..Findings from this study suggest that increased normalized wall index and the use of statin therapy are associated with reduced rates of plaque progression amongst individuals with advanced, asymptomatic carotid atherosclerosis...
  34. ncbi request reprint Vitamin C and E intake is associated with increased paraoxonase activity
    Gail P Jarvik
    Department of Medicine, Division of Medical Genetics, University of Washington 98195, USA
    Arterioscler Thromb Vasc Biol 22:1329-33. 2002
    ..Vitamins C and E, dietary antioxidants, scavenge free-oxygen radical products that may depress PON1 activity. Therefore, we evaluated the relationship between dietary vitamin C and E intake and PON1 activity...
  35. ncbi request reprint In vivo accuracy of multisequence MR imaging for identifying unstable fibrous caps in advanced human carotid plaques
    Lee M Mitsumori
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 17:410-20. 2003
    ..To evaluate the in vivo accuracy of a multisequence MRI technique for prospectively identifying one feature of the vulnerable plaque-an unstable fibrous cap-in human carotid atherosclerosis...
  36. ncbi request reprint Quantitative evaluation of carotid atherosclerotic plaques by magnetic resonance imaging
    Chun Yuan
    Division of Cardiology, University of Washington, Box 358771, 1914 North 34th Street, Suite 105, Seattle, WA 98103, USA
    Curr Atheroscler Rep 4:351-7. 2002
    ..MRI allows direct visualization of the diseased vessel wall and is capable of characterizing the morphology of individual atherosclerotic carotid plaques...
  37. ncbi request reprint Contrast-enhanced high resolution MRI for atherosclerotic carotid artery tissue characterization
    Chun Yuan
    University of Washington, School of Medicine, Seattle, Washington 98195 7115, USA
    J Magn Reson Imaging 15:62-7. 2002
    ..Although high-resolution magnetic resonance imaging (MRI) has been used to identify plaque constituents in advanced atherosclerosis, some constituents, such as neovascularized tissue, defy detection...
  38. ncbi request reprint Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke
    Chun Yuan
    Department of Radiology, University of Washington, Seattle 98195, USA
    Circulation 105:181-5. 2002
    ..The aim of this study was to determine whether MRI identification of fibrous cap thinning or rupture is associated with a history of recent transient ischemic attack (TIA) or stroke...
  39. pmc Carotid plaque morphology and composition: initial comparison between 1.5- and 3.0-T magnetic field strengths
    Hunter R Underhill
    Department of Radiology, University of Washington, 815 Mercer St, Box 358050, Seattle, WA 98109, USA
    Radiology 248:550-60. 2008
    ..To prospectively compare the interpretation and quantification of carotid vessel wall morphology and plaque composition at 1.5-T with those at 3.0-T magnetic resonance (MR) imaging...
  40. ncbi request reprint Testing the hypothesis of atherosclerotic plaque lipid depletion during lipid therapy by magnetic resonance imaging: study design of Carotid Plaque Composition Study
    Xue Qiao Zhao
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, WA 98103, USA
    Am Heart J 154:239-46. 2007
    ..In vivo testing of the lipid depletion hypothesis in human beings during lipid-modifying therapy has not been possible until recent developments in magnetic resonance imaging (MRI)...
  41. ncbi request reprint Intra- and interreader reproducibility of magnetic resonance imaging for quantifying the lipid-rich necrotic core is improved with gadolinium contrast enhancement
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, Washington, USA
    J Magn Reson Imaging 24:203-10. 2006
    ....
  42. ncbi request reprint Images in cardiovascular medicine. Serial high-spatial-resolution, multisequence magnetic resonance imaging studies identify fibrous cap rupture and penetrating ulcer into carotid atherosclerotic plaque
    Baocheng Chu
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Circulation 113:e660-1. 2006
  43. ncbi request reprint Presence of intraplaque hemorrhage stimulates progression of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, USA
    Circulation 111:2768-75. 2005
    ..We have shown that MRI can accurately identify carotid intraplaque hemorrhage and precisely measure plaque volume. We tested the hypothesis that hemorrhage into carotid atheroma stimulates plaque progression...
  44. ncbi request reprint TagSNP analyses of the PON gene cluster: effects on PON1 activity, LDL oxidative susceptibility, and vascular disease
    Christopher S Carlson
    The Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, The University of Washington, Seattle, USA
    J Lipid Res 47:1014-24. 2006
    ....
  45. ncbi request reprint Automated in vivo segmentation of carotid plaque MRI with Morphology-Enhanced probability maps
    Fei Liu
    Department of Radiology, University of Washington, Seattle, WA 98109, USA
    Magn Reson Med 55:659-68. 2006
    ..71, 0.76, 0.33, and 0.78, respectively. These results show that in vivo automatic segmentation of carotid MRI is feasible and comparable to or possibly more accurate than manual review for quantifying plaque composition...
  46. ncbi request reprint Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI--initial results
    Norihide Takaya
    Department of Radiology, University of Washington, Seattle, WA, USA
    Stroke 37:818-23. 2006
    ..We tested the hypothesis that the characteristics of carotid plaque, as assessed by MRI, are possible predictors of future ipsilateral cerebrovascular events...
  47. ncbi request reprint Sample size calculation for clinical trials using magnetic resonance imaging for the quantitative assessment of carotid atherosclerosis
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Cardiovasc Magn Reson 7:799-808. 2005
    ..The percent lipid-rich/necrotic core (%LR/NC) and calcification (%Ca) were measured as a proportion of the vessel wall. For %LR/NC and %Ca, only those subjects that exhibited LR/NC or Ca components were used in the analysis...
  48. ncbi request reprint Images in cardiovascular medicine. Detection of carotid atherosclerotic plaque ulceration, calcification, and thrombosis by multicontrast weighted magnetic resonance imaging
    Baocheng Chu
    Department of Radiology, University of Washington, 1959 NE Pacific St, Seattle, WA 98195, USA
    Circulation 112:e3-4. 2005
  49. ncbi request reprint The correlation of paraoxonase (PON1) activity with lipid and lipoprotein levels differs with vascular disease status
    Laura S Rozek
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    J Lipid Res 46:1888-95. 2005
    ..We found that PON1 activity was correlated with HDL traits in controls and with LDL- and VLDL-related traits in cases. We hypothesize differences in the joint regulation of PON1 and lipoproteins in cases and controls...
  50. pmc Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging
    Tobias Saam
    Department of Radiology, University of Washington, 815 Mercer St, Box 358050, Seattle, WA 98109, USA
    Radiology 240:464-72. 2006
    ..To retrospectively determine if in vivo magnetic resonance (MR) imaging can simultaneously depict differences between symptomatic and asymptomatic carotid atherosclerotic plaque...
  51. pmc Inflammation in carotid atherosclerotic plaque: a dynamic contrast-enhanced MR imaging study
    William S Kerwin
    Department of Radiology, Division of Cardiology, and Department of Surgery, University of Washington, 815 Mercer St, Seattle, WA 98109, USA
    Radiology 241:459-68. 2006
    ..To prospectively evaluate if there is an association between plaque enhancement at magnetic resonance (MR) imaging and proinflammatory cardiovascular risk factors and plaque content...
  52. ncbi request reprint Reader and platform reproducibility for quantitative assessment of carotid atherosclerotic plaque using 1.5T Siemens, Philips, and General Electric scanners
    Tobias Saam
    Department of Clinical Radiology, University of Munich, Munich, Germany
    J Magn Reson Imaging 26:344-52. 2007
    ..To evaluate the platform and reader reproducibility of quantitative carotid plaque measurements...
  53. ncbi request reprint The vulnerable, or high-risk, atherosclerotic plaque: noninvasive MR imaging for characterization and assessment
    Tobias Saam
    Department of Radiology, University of Washington, Seattle, Washington, USA
    Radiology 244:64-77. 2007
    ..The use of MR imaging in animal models and in human disease in various vascular beds, particularly the carotid arteries, is presented...
  54. ncbi request reprint TagSNP evaluation for the association of 42 inflammation loci and vascular disease: evidence of IL6, FGB, ALOX5, NFKBIA, and IL4R loci effects
    Christopher S Carlson
    Division of Public Health Sciences, The Fred Hutchinson Cancer Research Center, The University of Washington, Seattle, WA, USA
    Hum Genet 121:65-75. 2007
    ..The NFKBIA and IL10RA expression levels significantly differed between subjects with CAAD and controls. These results support a role for genetic variation related to inflammation in CAAD and a causal role for specific gene products...
  55. ncbi request reprint Association of high-density lipoprotein levels and carotid atherosclerotic plaque characteristics by magnetic resonance imaging
    Binh An P Phan
    Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA, 98103 8771, USA
    Int J Cardiovasc Imaging 23:337-42. 2007
    ..81 +/- 19 mm(3), P = 0.05) compared with patients with HDL levels > 35 mg/dL. Among CAD patients, low HDL-C levels were significantly associated with increased carotid atherosclerotic plaque burden and lipid content by MRI...
  56. ncbi request reprint MRI of atherosclerosis in clinical trials
    Chun Yuan
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    NMR Biomed 19:636-54. 2006
    ..Also, the results of validation studies for measuring lesion size, composition and inflammation will be summarized. Finally, the status of several clinical trials involving MRI of atherosclerosis will be reviewed...
  57. ncbi request reprint Feasibility of in vivo, multicontrast-weighted MR imaging of carotid atherosclerosis for multicenter studies
    Baocheng Chu
    Department of Radiology, University of Washington, Seattle, Washington 98195, USA
    J Magn Reson Imaging 21:809-17. 2005
    ..To test the image quality (ImQ) and interscan coverage of MRI for measuring carotid atherosclerosis across multiple centers...
  58. ncbi request reprint Classification of human carotid atherosclerotic lesions with in vivo multicontrast magnetic resonance imaging
    Jian Ming Cai
    Department of Radiology, University of Washington, Seattle, Wash 98195 7115, USA
    Circulation 106:1368-73. 2002
    ..The purpose of this study was to determine whether in vivo high-resolution multicontrast MRI could accurately classify human carotid atherosclerotic plaque according to the American Heart Association classification...
  59. pmc A negative correlation between human carotid atherosclerotic plaque progression and plaque wall stress: in vivo MRI-based 2D/3D FSI models
    Dalin Tang
    Mathematical Sciences Department, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609, USA
    J Biomech 41:727-36. 2008
    ..637). These pilot studies suggest that both lower PWS and lower FSS may contribute to continued plaque progression and should be taken into consideration in future investigations of diseases related to atherosclerosis...
  60. ncbi request reprint In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology
    Jianming Cai
    Department of Radiology, University of Washington, Seattle, WA, USA
    Circulation 112:3437-44. 2005
    ..The goal of this study was to assess whether CEMRI can be used to accurately measure the dimensions of the intact FC and LR-NC...
  61. ncbi request reprint Plaque rupture in the carotid artery is localized at the high shear stress region: a case report
    Harald C Groen
    Biomedical Engineering, Biomechanics Laboratory, Erasmus MC, CA Rotterdam, The Netherlands
    Stroke 38:2379-81. 2007
    ..Our data suggest that high WSS influences plaque vulnerability and therefore may become a potential parameter for predicting future events...
  62. ncbi request reprint Automated measurement of mean wall thickness in the common carotid artery by MRI: a comparison to intima-media thickness by B-mode ultrasound
    Hunter R Underhill
    Department of Radiology, University of Washington, Seattle, Washington 98109, USA
    J Magn Reson Imaging 24:379-87. 2006
    ..To determine whether the mean wall thickness (MWT) of the common carotid artery (CCA) measured by MRI is comparable to B-mode ultrasound (US) measurement of the intima-media thickness (IMT), an established marker of cardiovascular risk...

Research Grants2

  1. MRI IDENTIFICATION OF FIBROUS CAP ATROPHY AND RUPTURE
    Thomas Hatsukami; Fiscal Year: 2001
    ..We will also determine whether ischemic neurological events or plaque rupture assessed by histological evaluation of excised plaques correlates with fibrous cap thinning. ..
  2. Magnetic Resonance Imaging of Vulnerable Plaque
    Thomas Hatsukami; Fiscal Year: 2006
    ..abstract_text> ..