Affiliation: University of California
- Cell-based measures of viral persistence are associated with immune activation and programmed cell death protein 1 (PD-1)-expressing CD4+ T cellsHiroyu Hatano
Department of Medicine, San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
J Infect Dis 208:50-6. 2013..Studies aimed at defining the association between host immune responses and human immunodeficiency virus (HIV) persistence during therapy are necessary to develop new strategies for cure...
- Immune activation and HIV persistence: considerations for novel therapeutic interventionsHiroyu Hatano
Department of Medicine, University of California San Francisco, San Francisco, California 94110, USA
Curr Opin HIV AIDS 8:211-6. 2013....
- A randomized controlled trial assessing the effects of raltegravir intensification on endothelial function in treated HIV infectionHiroyu Hatano
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 61:317-25. 2012..To determine whether intensification with raltegravir improves endothelial function in antiretroviral-treated HIV-infected individuals...
- Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapyHiroyu Hatano
San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
J Virol 83:329-35. 2009..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy...
- A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell responseHiroyu Hatano
University of California, San Francisco, USA
J Infect Dis 203:960-8. 2011..We conducted an intensification study to assess whether residual viral replication contributes to replenishment of the latent reservoir and whether mucosal HIV-specific T cell responses limit the reservoir size...
- Evidence of persistent low-level viremia in long-term HAART-suppressed, HIV-infected individualsHiroyu Hatano
Department of Medicine, University of California, San Francisco, California, USA
AIDS 24:2535-9. 2010..HAART can effectively reduce plasma HIV RNA levels to below the level of detection in most HIV-infected patients. The degree to which residual low-level viremia persists during HAART remains unclear...
- Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapyHiroyu Hatano
University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 54:389-93. 2010..Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined...
- A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllersPeter W Hunt
Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 6:e15924. 2011..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion...
- Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patientsPriscilla Y Hsue
Division of Cardiology, Positive Health Program of the Department of Medicine, San Francisco General Hospital, University of California San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
AIDS 23:2021-7. 2009..As endothelial dysfunction is central to the pathogenesis of atherosclerosis, we tested the hypothesis that current treatment with abacavir is associated with impaired endothelial function...
- HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllersPeter W Hunt
Department of Medicine, University of California, San Francisco, California, USA
Clin Infect Dis 52:681-7. 2011..Despite robust immune responses, these individuals never eradicate HIV infection. We hypothesized that HIV-specific CD4(+) T cells might serve as target cells for HIV, contributing to viral persistence in this setting...
- Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollersHiroyu Hatano
aDepartment of Medicine bDepartment of Epidemiology and Biostatistics, University of California cSan Francisco Veterans Affairs Medical Center, San Francisco, California, USA
AIDS 27:2255-60. 2013..HIV-infected controllers have provided novel insights into mechanisms of viral control. We investigated the degree to which HIV DNA and RNA are present in gut-associated lymphoid tissue (GALT) of controllers...
- Immunologic profiles distinguish aviremic HIV-infected adultsChristina M Ramirez
aDepartment of Biostatistics, University of California at Los Angeles, Los AngelesbDepartment of Medicine, University of California at San Francisco, San Francisco, California, USA
AIDS 30:1553-62. 2016..We hypothesized that an unbiased 'discovery-based' approach might identify novel immunologic characteristics of these phenotypes...
- Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllersHiroyu Hatano
Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
PLoS Pathog 9:e1003691. 2013..These data confirm that HIV replication persists in controllers and contributes to a chronic inflammatory state. ART should be considered for these individuals (ClinicalTrials.gov NCT01025427). ..
- A comparison of methods for measuring rectal HIV levels suggests that HIV DNA resides in cells other than CD4+ T cells, including myeloid cellsSteven A Yukl
aSan Francisco Veterans Affairs Medical Center bUniversity of California, San Francisco UCSF, California, USA
AIDS 28:439-42. 2014..HIV DNA levels in total rectal cells were greater than those predicted from levels in sorted CD4 T cells, suggesting a reservoir in non-CD4 T cells, and HIV DNA was detected in sorted myeloid cells (7/7 subjects)...
- Impact of HIV on CD8+ T cell CD57 expression is distinct from that of CMV and agingSulggi A Lee
Departments of Medicine, Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
PLoS ONE 9:e89444. 2014..Whether chronic HIV infection causes similar effects is currently unclear...
- HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus controlBrinda Emu
Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
J Virol 82:5398-407. 2008..Defining mechanisms for virus control in "non-T-cell controllers" might lead to insights into preventing HIV transmission or preventing virus replication...
- Programmed death-1 expression on CD4⁺ and CD8⁺ T cells in treated and untreated HIV diseaseLeslie R Cockerham
aHIV AIDS Division, San Francisco General Hospital bDivision of Experimental Medicine cDepartment Epidemiology and Biostatistics, UCSF, San Francisco, California dVaccine and Gene Therapy Institute of Florida, Port St Lucie, Florida, USA
AIDS 28:1749-58. 2014..However, the impact of HIV infection and antiretroviral treatment (ART) on the expression of PD-1 on T cells is still poorly defined...
- Rate of viral evolution and risk of losing future drug options in heavily pretreated, HIV-infected patients who continue to receive a stable, partially suppressive treatment regimenHiroyu Hatano
University of California San Francisco, San Francisco, CA, USA
Clin Infect Dis 43:1329-36. 2006..The major risk of this approach is ongoing viral evolution and the loss of future drug options...
- Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypesPeilin Li
University of California, San Francisco UCSF, Department of Medicine, San Francisco, CA 94121, USA
J Virol Methods 170:115-20. 2010..765, p<0.0001). This approach to Taqman probe design should be explored further for use in diagnosis and monitoring of HIV in resource-limited settings, especially where several subtypes co-circulate...
- Elite control of HIV: is this the right model for a functional cure?Leslie R Cockerham
HIV AIDS Division, San Francisco General Hospital, University of California, San Francisco, CA, USA
Trends Microbiol 23:71-5. 2015....
- Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptaseZixin Hu
Section of Retroviral Therapeutics, Brigham and Women s Hospital, and Division of AIDS, Harvard Medical School, Boston, MA, USA
J Acquir Immune Defic Syndr 45:494-500. 2007..These results show that Delta70 enhances resistance to certain purine and pyrimidine analogues and contributes to multinucleoside resistance in the appropriate viral genetic background...
- Drug resistant HIVHiroyu Hatano
BMJ 334:1124-5. 2007
- Fitness comparison of thymidine analog resistance pathways in human immunodeficiency virus type 1Zixin Hu
Section of Retroviral Therapeutics, Brigham and Women s Hospital, 65 Landsdowne Street, Cambridge, MA 02139, USA
J Virol 80:7020-7. 2006..These results help explain why T215Y but not T215F usually emerges as the first major TAM, as well as the clustering of L210W with TAM-1 mutations and T215F with TAM-2 mutations...