L H Harrison

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Antigenic shift and increased incidence of meningococcal disease
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 193:1266-74. 2006
  2. pmc Automatic electronic laboratory-based reporting of notifiable infectious diseases at a large health system
    Anil A Panackal
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 8:685-91. 2002
  3. ncbi request reprint Preventing meningococcal infection in college students
    L H Harrison
    Infectious Diseases Epidemiology Research Unit, Departments of Medicine and Epidemiology, University of Pittsburgh School of Medicine PA 15261, USA
    Clin Infect Dis 30:648-51. 2000
  4. ncbi request reprint Serotype distribution of invasive group B streptococcal isolates in Maryland: implications for vaccine formulation. Maryland Emerging Infections Program
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    J Infect Dis 177:998-1002. 1998
  5. ncbi request reprint Risk of meningococcal infection in college students
    L H Harrison
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    JAMA 281:1906-10. 1999
  6. ncbi request reprint Clinical case definitions for Argentine hemorrhagic fever
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    Clin Infect Dis 28:1091-4. 1999
  7. ncbi request reprint Invasive pneumococcal infection in Baltimore, Md: implications for immunization policy
    L H Harrison
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    Arch Intern Med 160:89-94. 2000
  8. ncbi request reprint Invasive meningococcal disease in adolescents and young adults
    L H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    JAMA 286:694-9. 2001
  9. ncbi request reprint Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance
    A E Fiore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 30:71-7. 2000
  10. pmc High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    Scott R Curry
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 48:425-9. 2009

Detail Information

Publications99

  1. ncbi request reprint Antigenic shift and increased incidence of meningococcal disease
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 193:1266-74. 2006
    ..The cyclical nature of endemic meningococcal disease remains unexplained. The purpose of this study was to investigate the mechanisms associated with the increase in the incidence of meningococcal disease...
  2. pmc Automatic electronic laboratory-based reporting of notifiable infectious diseases at a large health system
    Anil A Panackal
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 8:685-91. 2002
    ..Automatic reporting was more rapid and as complete as conventional reporting. Using standardized coding and minimizing free text usage will increase the completeness of electronic laboratory-based reporting...
  3. ncbi request reprint Preventing meningococcal infection in college students
    L H Harrison
    Infectious Diseases Epidemiology Research Unit, Departments of Medicine and Epidemiology, University of Pittsburgh School of Medicine PA 15261, USA
    Clin Infect Dis 30:648-51. 2000
    ..Future studies will need to focus on the potential vaccine prevention of the increased risk of meningococcal infection in persons of high school age, particularly as new conjugate meningococcal vaccines become available...
  4. ncbi request reprint Serotype distribution of invasive group B streptococcal isolates in Maryland: implications for vaccine formulation. Maryland Emerging Infections Program
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    J Infect Dis 177:998-1002. 1998
    ..The serotype distribution differs between pediatric patients and adults and is changing over time. The inclusion of a relatively small number of serotypes in a GBS vaccine could provide protection against the vast majority of isolates...
  5. ncbi request reprint Risk of meningococcal infection in college students
    L H Harrison
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    JAMA 281:1906-10. 1999
    ..However, no published studies have documented the incidence of invasive meningococcal infection in college students or whether the incidence is higher than in the general population of the same age...
  6. ncbi request reprint Clinical case definitions for Argentine hemorrhagic fever
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    Clin Infect Dis 28:1091-4. 1999
    ....
  7. ncbi request reprint Invasive pneumococcal infection in Baltimore, Md: implications for immunization policy
    L H Harrison
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    Arch Intern Med 160:89-94. 2000
    ..Although blacks are known to have a higher incidence of invasive pneumococcal infection than whites, detailed analyses of these differences and their implications for vaccine prevention have not been reported...
  8. ncbi request reprint Invasive meningococcal disease in adolescents and young adults
    L H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    JAMA 286:694-9. 2001
    ..Incidence of invasive meningococcal disease has increased recently in persons aged 15 through 24 years...
  9. ncbi request reprint Clinical outcomes of meningitis caused by Streptococcus pneumoniae in the era of antibiotic resistance
    A E Fiore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 30:71-7. 2000
    ..Empirical use of vancomycin, current prevalence of drug-resistant S. pneumoniae, and degree of nonsusceptibility to cefotaxime may have influenced these findings...
  10. pmc High frequency of rifampin resistance identified in an epidemic Clostridium difficile clone from a large teaching hospital
    Scott R Curry
    Department of Medicine, Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Clin Infect Dis 48:425-9. 2009
    ..difficile-associated disease. Rifampin resistance in C. difficile strains has been reported to be uncommon...
  11. ncbi request reprint The changing epidemiology of meningococcal disease in the United States, 1992-1996
    N E Rosenstein
    Division of Bacterial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 180:1894-901. 1999
    ..Ongoing surveillance is necessary to determine the stability of serogroup and serosubtype distribution...
  12. pmc Correlating epidemiologic trends with the genotypes causing meningococcal disease, Maryland
    M Catherine McEllistrem
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA
    Emerg Infect Dis 10:451-6. 2004
    ..The nonepidemic age-specific increases in serogroup C meningococcal infection in Maryland were clonal in nature and the changes in serogroup Y incidence were associated with a shift in the genotypes of strains causing invasive disease...
  13. ncbi request reprint Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis
    S J Schrag
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 342:15-20. 2000
    ..To assess the effects of the preventive efforts, we analyzed trends in the incidence of group B streptococcal disease from 1993 to 1998...
  14. ncbi request reprint Myelopathy among Brazilians coinfected with human T-cell lymphotropic virus type I and HIV
    L H Harrison
    Department of International Health, Johns Hopkins University School of Hygiene, Baltimore, MD, USA
    Neurology 48:13-8. 1997
    ..To determine whether subjects coinfected with HTLV-I and HIV have a higher frequency of myelopathy than subjects singly infected with HIV...
  15. ncbi request reprint Invasive group B streptococcal disease in Maryland nursing home residents
    K J Henning
    Epidemiology and Disease Control Program, Maryland Department of Health and Mental Hygiene, Baltimore, MD, USA
    J Infect Dis 183:1138-42. 2001
    ..Further evaluation of intra-NH transmission of GBS is warranted...
  16. ncbi request reprint Geographic, demographic, and seasonal differences in penicillin-resistant Streptococcus pneumoniae in Baltimore
    Bernadette A Albanese
    Department of International Health, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD, USA
    Clin Infect Dis 34:15-21. 2002
    ..The incidence of PRSP is increasing in Baltimore, and the seasonality of PRSP suggests that recent antibiotic use, which is more common in winter months, may rapidly affect the prevalence of resistant pneumococcal infections...
  17. ncbi request reprint A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, University of Pittsburgh Medical Center, Presbyterian Campus, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 26:273-80. 2005
    ..difficile infections; of these, 26 resulted in colectomy and 18 resulted in death. We conducted an investigation of a large C. difficile outbreak in our hospital to identify risk factors and characterize the outbreak...
  18. pmc tcdC genotypes associated with severe TcdC truncation in an epidemic clone and other strains of Clostridium difficile
    Scott R Curry
    Department of Medicine, University of Pittsburgh, School of Medicine, PA 15261, USA
    J Clin Microbiol 45:215-21. 2007
    ..Further investigations are required to determine the effect of this and other tcdC genotypes on toxin production and clinical disease...
  19. ncbi request reprint Control of an outbreak of infection with the hypervirulent Clostridium difficile BI strain in a university hospital using a comprehensive "bundle" approach
    Carlene A Muto
    Division of Hospital Epidemiology and Infection Control, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 45:1266-73. 2007
    ..Forty-seven (51%) of 92 HA CD isolates in 2001 were identified as the "epidemic BI strain." A comprehensive CD infection control "bundle" was implemented to control the outbreak of CD infection...
  20. pmc Clonal groups of penicillin-nonsusceptible Streptococcus pneumoniae in Baltimore, Maryland: a population-based, molecular epidemiologic study
    M C McEllistrem
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Clin Microbiol 38:4367-72. 2000
    ..The classification of PNSP strains into clonal groups is essential for future population-based epidemiologic studies of PNSP...
  21. ncbi request reprint Severe respiratory syncytial virus disease in Alaska native children. RSV Alaska Study Group
    R A Karron
    Center for Immunization Research, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205, USA
    J Infect Dis 180:41-9. 1999
    ..2, P=.03). In the YK Delta and at JHH, newborns may be at greater risk for severe RSV illness than previously thought...
  22. pmc Integron-mediated multidrug resistance in a global collection of nontyphoidal Salmonella enterica isolates
    Mary G Krauland
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, Pittsburgh, Pennsylvania 15261, USA
    Emerg Infect Dis 15:388-96. 2009
    ..This study demonstrates that clonal expansion and horizontal gene transfer contribute to the global dissemination of antimicrobial drug resistance in S. enterica...
  23. pmc Effect of pneumococcal conjugate vaccine on pneumococcal meningitis
    Heather E Hsu
    University of Pittsburgh, Pittsburgh, PA 15261, USA
    N Engl J Med 360:244-56. 2009
    ..Invasive pneumococcal disease declined among children and adults after the introduction of the pediatric heptavalent pneumococcal conjugate vaccine (PCV7) in 2000, but its effect on pneumococcal meningitis is unclear...
  24. pmc Epidemiological profile of meningococcal disease in the United States
    Lee H Harrison
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pennsylvania, USA
    Clin Infect Dis 50:S37-44. 2010
    ..Broadly protective vaccines for endemic serogroup B disease are also needed...
  25. pmc Multilocus variable-number tandem-repeat analysis for investigation of Clostridium difficile transmission in Hospitals
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Medical Center, Division of Hospital Epidemiology and Infection Control, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:2558-66. 2006
    ..Thus, MLVA is an objective, portable genotyping method that permits reliable detection of C. difficile outbreaks and can aid epidemiologic investigations of nosocomial transmission...
  26. pmc Prospects for vaccine prevention of meningococcal infection
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, 521 Parran Hall, 130 DeSoto St, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Clin Microbiol Rev 19:142-64. 2006
    ..This review covers the changing epidemiology of meningococcal disease in the United States, issues related to vaccine prevention, and recommendations on the use of the new vaccine...
  27. pmc Erythromycin-nonsusceptible Streptococcus pneumoniae in children, 1999-2001
    M Catherine McEllistrem
    University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    Emerg Infect Dis 11:969-72. 2005
    ..The decline in infection rates was likely due to the pneumococcal 7-valent conjugate vaccine...
  28. doi request reprint Meningococcal group A, C, Y and W-135 conjugate vaccine
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15101, USA
    Nat Rev Drug Discov 9:429-30. 2010
    ....
  29. pmc Emergence and disappearance of a virulent clone of Haemophilus influenzae biogroup aegyptius, cause of Brazilian purpuric fever
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School ofMedicine, Pittsburgh, Pennsylvania 15261, USA
    Clin Microbiol Rev 21:594-605. 2008
    ..After a series of outbreaks and sporadic cases through 1993, no additional cases of BPF have been reported...
  30. pmc Population structure and capsular switching of invasive Neisseria meningitidis isolates in the pre-meningococcal conjugate vaccine era--United States, 2000-2005
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Infect Dis 201:1208-24. 2010
    ..Neisseria meningitidis changes its capsular phenotype through capsular switching, which has implications for vaccines that do not protect against all serogroups...
  31. pmc Deletion of fetA gene sequences in serogroup B and C Neisseria meningitidis isolates
    Jane W Marsh
    University of Pittsburgh School of Medicine, 865 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 45:1333-5. 2007
    ..In this report, we describe the characterization of three meningococcal isolates that have deleted fetA sequences through genetic recombination at repetitive elements...
  32. ncbi request reprint Discordant responses to potent antiretroviral treatment in previously naive HIV-1-infected adults initiating treatment in resource-constrained countries: the antiretroviral therapy in low-income countries (ART-LINC) collaboration
    Suely H Tuboi
    Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 45:52-9. 2007
    ..To assess the frequency of and risk factors for discordant responses at 6 months on highly active antiretroviral therapy (HAART) in previously treatment-naive HIV patients from resource-limited countries...
  33. pmc Screening for Acinetobacter baumannii colonization by use of sponges
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Scaife Hall S829, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Clin Microbiol 49:154-8. 2011
    ..003). The combined sensitivity for the upper arm and leg with a sponge was 89.1%. The novel screening method using sterile sponges was easy to perform and achieved excellent sensitivity for the detection of A. baumannii colonization...
  34. pmc Universal methicillin-resistant Staphylococcus aureus (MRSA) surveillance for adults at hospital admission: an economic model and analysis
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Veterans Affairs Pittsburgh Health Care System, Pittsburgh, Pennsylvania, USA
    Infect Control Hosp Epidemiol 31:598-606. 2010
    ..Although some have recommended universal surveillance for MRSA at hospital admission to identify and to isolate MRSA-colonized patients, there is a need for formal economic studies to determine the cost-effectiveness of such a strategy...
  35. doi request reprint Risk factors for meningococcal disease in students in grades 9-12
    Lee H Harrison
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Pediatr Infect Dis J 27:193-9. 2008
    ..Universal immunization of adolescents with meningococcal conjugate vaccine was recently recommended. We studied risk factors for meningococcal disease in students in grades 9-12...
  36. pmc Multilocus variable-number tandem-repeat analysis and multilocus sequence typing reveal genetic relationships among Clostridium difficile isolates genotyped by restriction endonuclease analysis
    Jane W Marsh
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Clin Microbiol 48:412-8. 2010
    ..difficile disease pathogenesis. This study demonstrates that a combination of MLST and MLVA may prove useful for the investigation and surveillance of emergent C. difficile clones of global public health concern...
  37. pmc Genetic basis of multidrug resistance in Acinetobacter baumannii clinical isolates at a tertiary medical center in Pennsylvania
    Jennifer M Adams-Haduch
    Division of Infectious Diseases, University of Pittsburgh Medical Center, S829 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261
    Antimicrob Agents Chemother 52:3837-43. 2008
    ..Fifty-nine percent of the MDR isolates belonged to a single clonal group over the course of the study period, as demonstrated by pulsed-field gel electrophoresis...
  38. doi request reprint Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
    ....
  39. pmc Should vascular surgery patients be screened preoperatively for methicillin-resistant Staphylococcus aureus?
    Bruce Y Lee
    Section of Decision Sciences and Clinical Systems Modeling, Department of Biomedical Informatics, School of Medicine, and Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 30:1158-65. 2009
    ..Testing all vascular surgery patients preoperatively for MRSA and attempting to decolonize those who have positive results may be a strategy to prevent MRSA infection. The economic value of such a strategy has not yet been determined...
  40. pmc The economic effect of screening orthopedic surgery patients preoperatively for methicillin-resistant Staphylococcus aureus
    Bruce Y Lee
    Public Health Computational and Operations Research PHICOR Group, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Infect Control Hosp Epidemiol 31:1130-8. 2010
    ..We sought to estimate the economic value of routine preoperative MRSA screening and decolonization of orthopedic surgery patients...
  41. pmc Serotype 14 variants of the France 9V(-3) clone from Baltimore, Maryland, can be differentiated by the cpsB gene
    M Catherine McEllistrem
    Infectious Diseases Epidemiology Research Unit, Division of Infectious Diseases, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15229, USA
    J Clin Microbiol 42:250-6. 2004
    ..Although the correlation between serotype and the cpsB sequence was high, the overall diversity of the cpsB gene within a serotype likely will limit the role of this gene in a sequence-based serotyping method...
  42. ncbi request reprint Distribution of penicillin-nonsusceptible pneumococcal clones in the Baltimore metropolitan area and variables associated with drug resistance
    M Catherine McEllistrem
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15213, USA
    Clin Infect Dis 34:704-7. 2002
    ....
  43. ncbi request reprint High incidence and prevalence of HIV-1 infection in high risk population in Calcutta, India
    Phalguni Gupta
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    Int J STD AIDS 14:463-8. 2003
    ..Such a high annual seroincidence rate makes this population well suited for studies of HIV-1 prevention, including vaccine trials...
  44. ncbi request reprint Recurrent invasive pneumococcal disease in individuals with human immunodeficiency virus infection
    M Catherine McEllistrem
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15213 2582, USA
    J Infect Dis 185:1364-8. 2002
    ..Although a substantial proportion of recurrent pneumococcal infections was potentially preventable by vaccine, creating an effective vaccine may be challenging for this population...
  45. ncbi request reprint Human T cell lymphotropic virus type I does not increase human immunodeficiency virus viral load in vivo
    L H Harrison
    Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    J Infect Dis 175:438-40. 1997
    ..HTLV-I did not appear to increase HIV plasma RNA levels in subjects with coinfection. These results do not provide a biologic basis for the hypothesis that HTLV-I accelerates the course of HIV infection...
  46. ncbi request reprint Geographic diversity and temporal trends of antimicrobial resistance in Streptococcus pneumoniae in the United States
    Althea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Med 9:424-30. 2003
    ....
  47. pmc Locus-specific mutational events in a multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7
    Anna C Noller
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, 521 Parran Hall, 130 DeSoto St, Pittsburgh, PA 15261, USA
    J Clin Microbiol 44:374-7. 2006
    ..The remaining four loci had no slippage events detected. The mutation rates were locus specific and may impact the interpretation of MLVA data for epidemiologic investigations...
  48. ncbi request reprint Incident HIV infection in a high-risk, homosexual, male cohort in Rio de Janeiro, Brazil
    L H Harrison
    Departments of Epidemiology and Medicine, University Pittsburgh Graduate School of Public Health, Pennsylvania 15261, USA
    J Acquir Immune Defic Syndr 21:408-12. 1999
    ..These data demonstrate the suitability of this cohort for HIV prevention trials, based on high HIV incidence and retention rates, and a willingness to participate in such trials...
  49. pmc Simplified protocol for pulsed-field gel electrophoresis analysis of Streptococcus pneumoniae
    M C McEllistrem
    Public Health Infectious Diseases Laboratory, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 38:351-3. 2000
    ..pneumoniae. The ES solution may have caused cell lysis by activating N-acetylmuramyl-L-alanine amidase, the pneumococcal autolysin...
  50. ncbi request reprint Predictors of virologic failure in HIV-1-infected patients starting highly active antiretroviral therapy in Porto Alegre, Brazil
    Suely H Tuboi
    Infectious Diseases Epidemiology Research Unit, Graduate School of Public Health and School of Medicine, University of Pittsburgh, PA, USA
    J Acquir Immune Defic Syndr 40:324-8. 2005
    ..To assess predictors of virologic response 6 months after initiation of highly active antiretroviral therapy (HAART) in a cohort of HIV-infected patients in Brazil...
  51. pmc Multilocus variable-number tandem repeat analysis distinguishes outbreak and sporadic Escherichia coli O157:H7 isolates
    Anna C Noller
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Clin Microbiol 41:5389-97. 2003
    ..In addition to being a simple and validated method for E. coli O157:H7 outbreak detection, MLVA appears to have a sensitivity equal to that of PFGE and a specificity superior to that of PFGE...
  52. ncbi request reprint Relapsing bacteremia in patients with ventricular assist device: an emergent complication of extended circulatory support
    R A Vilchez
    Department of Medicine, School of Medicine, University of Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 72:96-101. 2001
    ..Endovascular infection in this setting is difficult to eradicate with antibiotic agents and carries a high mortality. These patients should be considered to have priority for orthotopic heart transplantation...
  53. ncbi request reprint Clinical outcomes of bacteremic pneumococcal pneumonia in the era of antibiotic resistance
    J F Moroney
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 33:797-805. 2001
    ..Factors other than resistance, such as severity of illness at presentation and advance directive status ("do not resuscitate" orders), appear to have a stronger influence on pneumococcal pneumonia outcomes...
  54. pmc Candida dubliniensis fungemia: the first four cases in North America
    M E Brandt
    Centers for Disease Control and Prevention CDC Atlanta, Georgia, USA
    Emerg Infect Dis 6:46-9. 2000
    ..All isolates were susceptible in vitro to commonly used antifungal drugs. This report demonstrates that C. dubliniensis can cause bloodstream infection; however, the incidence of disease is not known...
  55. ncbi request reprint Cluster of serogroup C meningococcal disease associated with attendance at a party
    R Finn
    Infectious Diseases Epidemiology Research Unit, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, 15261, USA
    South Med J 94:1192-4. 2001
    ..Taken together, these findings suggest that some of the recent increase in invasive meningococcal disease may be due to modifiable risk factors...
  56. ncbi request reprint High prevalence of sexually transmitted diseases in young women seeking HIV testing in Rio de Janeiro, Brazil
    Robert L Cook
    Division of General Internal Medicine, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 15213, USA
    Sex Transm Dis 31:67-72. 2004
    ..Few data are available on the prevalence of and risk factors for sexually transmitted diseases (STDs) other than HIV in Brazil...
  57. ncbi request reprint Internet death notices as a novel source of mortality surveillance data
    Marshall B Boak
    University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 21666, USA
    Am J Epidemiol 167:532-9. 2008
    ..The Pittsburgh Post-Gazette Internet death notices provided accurate, timely mortality data for nearly three fourths of all Allegheny County deaths...
  58. pmc Multilocus sequence typing reveals a lack of diversity among Escherichia coli O157:H7 isolates that are distinct by pulsed-field gel electrophoresis
    Anna C Noller
    Department of Infectious Diseases and Microbiology, University of Pittsburgh Graduate School of Public Health and School of Medicine, Pittsburgh, Pennsylvania, USA
    J Clin Microbiol 41:675-9. 2003
    ..E. coli O157:H7 has a striking lack of genetic diversity in the genes we explored, even among isolates that are clearly distinct by PFGE. Other approaches to identify improved molecular subtyping methods for E. coli 0157:H7 are needed...
  59. pmc Creating a text classifier to detect radiology reports describing mediastinal findings associated with inhalational anthrax and other disorders
    Wendy Webber Chapman
    Center for Biomedical Informatics, University of Pittsburgh, Suite 8084 Forbes Tower, Pittsburgh, PA 15213, USA
    J Am Med Inform Assoc 10:494-503. 2003
    ..The aim of this study was to create a classifier for automatic detection of chest radiograph reports consistent with the mediastinal findings of inhalational anthrax...
  60. doi request reprint A multivalent conjugate vaccine for prevention of meningococcal disease in infants
    Lee H Harrison
    JAMA 299:217-9. 2008
  61. doi request reprint Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  62. ncbi request reprint Association between antimicrobial resistance among pneumococcal isolates and burden of invasive pneumococcal disease in the community
    Julia Y Morita
    Division of Bacterial and Mycotic Diseases, National Centers for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 35:420-7. 2002
    ..The proportion of multidrug-resistant pneumococcal isolates did not predict invasive cases among adults. The increasing prevalence of multidrug-resistant pneumococci among children may be leading to an increase in invasive disease...
  63. ncbi request reprint Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United States
    Bernard Beall
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:118-22. 2002
    ..The mosaic pbp2b and divergent ddl sequences were suggestive of interspecies recombination at the ddl-pbp2b chromosomal region...
  64. pmc College and university compliance with a required meningococcal vaccination law
    Amanda D Castel
    The Department of Epidemiology and Biostatistics, George Washington University s School of Public Health and Health Services, Washington, DC 20037, USA
    J Am Coll Health 56:119-27. 2007
    ..The authors sought to identify how Maryland colleges addressed the law and determine whether schools were in full compliance...
  65. ncbi request reprint Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 348:1737-46. 2003
    ..In early 2000, a protein-polysaccharide conjugate vaccine targeting seven pneumococcal serotypes was licensed in the United States for use in young children...
  66. doi request reprint Epidemiology of invasive group B streptococcal disease in the United States, 1999-2005
    Christina R Phares
    Epidemic Intelligence Service Program, Office of Workforce and Career Development, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    JAMA 299:2056-65. 2008
    ..Guidelines for prevention of perinatal disease through intrapartum chemoprophylaxis were revised in 2002. Candidate vaccines are under development...
  67. ncbi request reprint Excess mortality, hospital stay, and cost due to candidemia: a case-control study using data from population-based candidemia surveillance
    Juliette Morgan
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Infect Control Hosp Epidemiol 26:540-7. 2005
    ..Prior studies lack broad patient and hospital representation or cost-related information that accurately reflects current medical practices...
  68. ncbi request reprint Changes in invasive Pneumococcal disease among HIV-infected adults living in the era of childhood pneumococcal immunization
    Brendan Flannery
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Ann Intern Med 144:1-9. 2006
    ..Adults infected with HIV have high rates of invasive pneumococcal disease. Introduction of pneumococcal conjugate vaccine for children could affect disease among HIV-infected adults...
  69. pmc Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Bernard Beall
    Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:999-1017. 2006
    ..Continued genotypic surveillance is warranted, since certain clones not targeted by PCV7 are expanding, and their emergence as significant pathogens could occur with maintained vaccine pressure...
  70. ncbi request reprint Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
    Lauri A Hicks
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1346-54. 2007
    ..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
  71. ncbi request reprint Effectiveness of antiretroviral therapy among patients who attend public HIV clinics in Rio de Janeiro, Brazil
    Cristina B Hofer
    Infectious Diseases Service, Hospital Universitario Clementino Fraga Filho, Department of Preventive Medicine, Universidade Federal do Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 36:967-71. 2004
    ..Brazil provides antiretroviral therapy (ART) to HIV-infected persons free of charge. The objective of this study was to investigate factors associated with ART failure in patients receiving free ART in public clinics in Brazil...
  72. ncbi request reprint Identification of a high-risk heterosexual cohort for HIV vaccine efficacy trials in Rio de Janeiro, Brazil, using a sensitive/less-sensitive assay: an update
    Paulo Feijó Barroso
    J Acquir Immune Defic Syndr 36:880-1. 2004
  73. ncbi request reprint Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae
    Moe H Kyaw
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    N Engl J Med 354:1455-63. 2006
    ..We examined the effect of this vaccine on invasive disease caused by resistant strains...
  74. ncbi request reprint Impact of childhood vaccination on racial disparities in invasive Streptococcus pneumoniae infections
    Brendan Flannery
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, US Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 291:2197-203. 2004
    ....
  75. ncbi request reprint Invasive pneumococcal disease among infants before and after introduction of pneumococcal conjugate vaccine
    Katherine A Poehling
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 2504, USA
    JAMA 295:1668-74. 2006
    ..Streptococcus pneumoniae is a serious infection in young infants. A heptavalent pneumococcal conjugate vaccine (PCV7) was licensed in 2000 and recommended for all children aged 2 to 23 months...
  76. pmc Clonal distribution of invasive pneumococcal isolates from children and selected adults in the United States prior to 7-valent conjugate vaccine introduction
    Robert E Gertz
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4194-216. 2003
    ..In this work, we established the basic genetic structure within individual serotypes prior to PC7V use. The resultant database will be useful for detecting potential selective effects of this vaccine in postvaccine surveillance...
  77. ncbi request reprint Behavioral impact, acceptability, and HIV incidence among homosexual men with access to postexposure chemoprophylaxis for HIV
    Mauro Schechter
    Infectious Diseases Service, Hospital Universitario Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 35:519-25. 2004
    ..Little is known about the behavioral impact, acceptability, and incidence of HIV infection in persons with easy access to post-sexual exposure prophylaxis (PEP) to prevent HIV...
  78. ncbi request reprint Changing epidemiology of invasive pneumococcal disease among older adults in the era of pediatric pneumococcal conjugate vaccine
    Catherine A Lexau
    Minnesota Department of Health, Minneapolis 55155 2538, USA
    JAMA 294:2043-51. 2005
    ..Early after its introduction, incidence of invasive pneumococcal disease declined among older adults, a group at high risk for pneumococcal disease...
  79. ncbi request reprint Declining incidence of invasive Streptococcus pneumoniae infections among persons with AIDS in an era of highly active antiretroviral therapy, 1995-2000
    Richard T Heffernan
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut, USA
    J Infect Dis 191:2038-45. 2005
    ..Our goal was to describe trends in invasive pneumococcal disease incidence among persons with acquired immunodeficiency syndrome (AIDS) since the introduction of highly active antiretroviral therapy (HAART)...
  80. ncbi request reprint Risk factors for severe respiratory syncytial virus infection among Alaska native children
    Lisa R Bulkow
    Arctic Investigations Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Anchorage, Alaska 99508, USA
    Pediatrics 109:210-6. 2002
    ..We conducted this study to better understand factors associated with hospitalization attributable to RSV infection in this high-risk population...
  81. pmc Invasive group A streptococcal disease: risk factors for adults
    Stephanie H Factor
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 9:970-7. 2003
    ..68, p=0.004), diabetes (RR=2.27, p=0.03), cardiac disease (RR=3.24, p=0.006), cancer (RR=3.54, p=0.006), and corticosteroid use (RR=5.18, p=0.03). Thus, host and environmental factors increased the risk for invasive GAS disease...
  82. pmc Genotyping primers for fully automated multilocus variable-number tandem repeat analysis of Escherichia coli O157:H7
    Anna C Noller
    J Clin Microbiol 42:3908. 2004
  83. ncbi request reprint Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: A 60-year follow-up study
    Naomi E Aronson
    Department of Medicine, Infectious Disease Division, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    JAMA 291:2086-91. 2004
    ..The duration of protection from tuberculosis of BCG vaccines is not known...
  84. pmc Incidence of bloodstream infections due to Candida species and in vitro susceptibilities of isolates collected from 1998 to 2000 in a population-based active surveillance program
    Rana A Hajjeh
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 42:1519-27. 2004
    ..7% of isolates, and > or = 2 microg/ml for 0.4% of isolates. Our findings highlight changes in the epidemiology of Candida BSI in the 1990s and provide a basis upon which to conduct further studies of selected high-risk subpopulations...
  85. ncbi request reprint Epidemiology of community-onset candidemia in Connecticut and Maryland
    Andre N Sofair
    Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Infect Dis 43:32-9. 2006
    ..e., community-onset candidemia). We compared the characteristics of patients who developed candidemia by the timing of onset of infection...
  86. ncbi request reprint Determining risk factors for candidemia among newborn infants from population-based surveillance: Baltimore, Maryland, 1998-2000
    Sharmila S Shetty
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Pediatr Infect Dis J 24:601-4. 2005
    ..Our objective was to determine risks factors for late onset candidemia, independent of birth weight, in newborn infants...
  87. pmc Risk factors for pediatric invasive group A streptococcal disease
    Stephanie H Factor
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 11:1062-6. 2005
    ..67, p=0.03) and household member(s) with runny nose (OR=0.09, p=0.002) were associated with decreased risk. Among children, household-level characteristics that influence exposure to GAS most affect development of invasive disease...
  88. ncbi request reprint Multistate surveillance for laboratory-confirmed, influenza-associated hospitalizations in children: 2003-2004
    Stephanie J Schrag
    National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Pediatr Infect Dis J 25:395-400. 2006
    ..We describe laboratory-confirmed, influenza-associated hospitalizations in a population representing almost 6% of children in the United States...
  89. ncbi request reprint Vaccine prevention of meningococcal disease: making slow progress
    Lee H Harrison
    Clin Infect Dis 43:1395-7. 2006
  90. pmc Community-associated methicillin-resistant Staphylococcus aureus and healthcare risk factors
    R Monina Klevens
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Emerg Infect Dis 12:1991-3. 2006
    ..Of patients with HRFs, 18%-28% had a "community-associated" strain, primarily USA300; of patients without HRFs, 26% had a "healthcare-associated" strain, typically USA100...
  91. pmc Prevalence of factor H-binding protein variants and NadA among meningococcal group B isolates from the United States: implications for the development of a multicomponent group B vaccine
    Peter T Beernink
    Center for Immunobiology and Vaccine Development, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    J Infect Dis 195:1472-9. 2007
    ..Antibodies against fHBP are bactericidal against strains within a variant group. There are limited data on the prevalence of strains expressing different fHBP variants in the United States...
  92. ncbi request reprint The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004
    Rosalyn E O'Loughlin
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 45:853-62. 2007
    ..We report the current epidemiologic characteristics of invasive GAS infections and estimate the potential impact of a multivalent GAS vaccine...
  93. ncbi request reprint Methicillin-resistant Staphylococcus aureus disease in three communities
    Scott K Fridkin
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 352:1436-44. 2005
    ..Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. The national burden and clinical effect of this novel presentation of MRSA disease are unclear...
  94. ncbi request reprint Invasive methicillin-resistant Staphylococcus aureus infections in the United States
    R Monina Klevens
    Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    JAMA 298:1763-71. 2007
    ..As the epidemiology of infections with methicillin-resistant Staphylococcus aureus (MRSA) changes, accurate information on the scope and magnitude of MRSA infections in the US population is needed...
  95. ncbi request reprint Adherence to antiretroviral therapy and persistence of HIV RNA in semen
    Paulo F Barroso
    Infectious Diseases Sevice, Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, School of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Acquir Immune Defic Syndr 32:435-40. 2003
    ..Although antiretroviral therapy (ART) reduces HIV seminal shedding, little is known about the relationship between adherence to ART and HIV suppression in semen...
  96. pmc Increase in non-AIDS related conditions as causes of death among HIV-infected individuals in the HAART era in Brazil
    Antonio G Pacheco
    Department of Epidemiology and Quantitative Methods in Health, National School of Public Health Scientific Computing Program, Oswaldo Cruz Foundation FIOCRUZ, Rio de Janeiro, Brazil
    PLoS ONE 3:e1531. 2008
    ....
  97. pmc Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998-2003
    Michael C Thigpen
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 13:1852-9. 2007
    ..95%, p<0.01). In multivariate logistic regression modeling, LTCF residence remained an independent predictor of death. Additional prevention strategies against GAS infection in this high-risk population are urgently needed...
  98. pmc Comparison of visual and spectrophotometric methods of broth microdilution MIC end point determination and evaluation of a sterol quantitation method for in vitro susceptibility testing of fluconazole and itraconazole against trailing and nontrailing Cand
    Beth A Arthington-Skaggs
    Mycotic Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road NE, Atlanta, GA 30333, USA
    Antimicrob Agents Chemother 46:2477-81. 2002
    ..Our results indicate that MIC results determined by either of these end point rules may be more predictive of in vivo outcome for isolates that give unclear visual end points at 48 h due to trailing growth...
  99. ncbi request reprint Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapy
    Guilherme Santoro-Lopes
    Infectious Diseases Clinic, Department of Preventive Medicine, Hospital Universitario Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
    Clin Infect Dis 34:543-6. 2002
    ..The use of highly active antiretroviral therapy in regions with a high prevalence of coinfection with HIV and Mycobacterium tuberculosis may contribute a lower incidence of tuberculosis...