Affiliation: University of California
- In the thick of it: HCM-causing mutations in myosin binding proteins of the thick filamentSamantha P Harris
Department of Neurobiology, Physiology, and Behavior College of Biological Sciences, University of California, One Shields Ave, Davis, CA 95616, USA
Circ Res 108:751-64. 2011..Additional work is still needed to determine the mechanisms by which individual mutations induce hypertrophic phenotypes...
- Functional differences between the N-terminal domains of mouse and human myosin binding protein-CJustin F Shaffer
Department of Neurobiology, Physiology and Behavior, University of California Davis, Davis, CA 95616 8519, USA
J Biomed Biotechnol 2010:789798. 2010..These results suggest that species-specific differences between homologous cMyBP-C isoforms confer differential effects that could fine-tune cMyBP-C function in hearts of different species...
- Contribution of the myosin binding protein C motif to functional effects in permeabilized rat trabeculaeMaria V Razumova
Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
J Gen Physiol 132:575-85. 2008..These results suggest that the C1 domain plus the motif constitute a functional unit of MyBP-C that can activate the thin filament...
- Species-specific differences in the Pro-Ala rich region of cardiac myosin binding protein-CJustin F Shaffer
Department of Bioengineering, University of Washington, Seattle, WA, USA
J Muscle Res Cell Motil 30:303-6. 2009....
- The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive mannerJustin F Shaffer
Department of Neurobiology, Physiology, and Behavior, University of California, Davis, California 95616, USA
J Biol Chem 284:12318-27. 2009..Reversible interactions with actin could contribute to effects of cMyBP-C to increase cross-bridge cycling...
- Identification of novel protein kinase A phosphorylation sites in the M-domain of human and murine cardiac myosin binding protein-C using mass spectrometry analysisWeitao Jia
Department of Molecular and Cellular Biology, University of California, Davis, One Shields Avenue, Davis, California 95616, USA
J Proteome Res 9:1843-53. 2010..Future studies are needed to investigate the phosphorylation state of murine and human cMyBP-C in vivo...