Ann T Hanna-Mitchell
Affiliation: University of Pittsburgh
- Impact of diabetes mellitus on bladder uroepithelial cellsAnn T Hanna-Mitchell
Univ of Pittsburgh, Dept of Medicine, Pittsburgh, PA 15213, USA
Am J Physiol Regul Integr Comp Physiol 304:R84-93. 2013..Our results show that DM impacts urothelial homeostasis and may contribute to the underlying mechanisms of DBD...
- The hydroosmotic response of frog urinary bladder to serosal hypertonicity is dependent on adenylate cyclase for its maintenance and affected by [Cl-]o changesAnn T Hanna-Mitchell
Department of Physiology, University College Cork, Cork, Ireland
Am J Physiol Regul Integr Comp Physiol 291:R213-23. 2006..The effect of modifying extracellular Cl- concentration, suggests that this anion, possibly functionally linked with Na+/H+ activity, may be involved in invoking the SH hydroosmotic response in anuran urinary bladder...
- The impact of neurotrophin-3 on the dorsal root transitional zone following injuryA T Hanna-Mitchell
Department of Anatomy Neuroscience, Biosciences Institute, National University of Ireland, Cork, Ireland
Spinal Cord 46:804-10. 2008..Morphological and Stereological assessment of the dorsal root transitional zone (DRTZ) following complete crush injury, using light microscopy (LM) and transmission electron microscopy (TEM)...
- Alterations in the non-neuronal acetylcholine synthesis and release machinery in esophageal epitheliumAmanda S Wolf-Johnston
University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA 15261, USA
Life Sci 91:1065-9. 2012..For example, alterations in the ability to synthesize and release acetylcholine may contribute to changes in epithelial sensory and barrier function associated with a number of functional genitourinary and intestinal disorders...
- Beyond neurons: Involvement of urothelial and glial cells in bladder functionLori A Birder
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Neurourol Urodyn 29:88-96. 2010..As estrogen fluctuations may modulate the severity of many chronic pelvic pain syndromes, we also examined whether 17beta-estradiol (E2) alters cell signaling in rat urothelial cells...
- Botulinum neurotoxin serotype A suppresses neurotransmitter release from afferent as well as efferent nerves in the urinary bladderYouko Ikeda
Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Eur Urol 62:1157-64. 2012..However, actions at other sites such as afferent nerve terminals are possible...
- Non-neuronal acetylcholine and urinary bladder urotheliumAnn T Hanna-Mitchell
University of Pittsburgh School of Medicine Department of Medicine, Pittsburgh, PA 15261, USA
Life Sci 80:2298-302. 2007..These observations indicate that acetylcholine release from urothelial cells is mediated by different mechanisms than those such as vesicular storage and exocytosis that underlie the release of neurotransmitters from nerves...
- Corticotropin-releasing factor family peptide signaling in feline bladder urothelial cellsAnn T Hanna-Mitchell
Departments of Medicine Renal Electrolyte DivisionPharmacology and Chemical BiologyUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USADepartment of Veterinary Clinical SciencesThe Ohio State University, Columbus, Ohio, USA
J Endocrinol 222:113-21. 2014..Our findings show evidence of CRF-related peptide signaling in the urothelium. Differences in functional responses between FIC and normal UT indicate that this system is altered in IC/PBS. ..
- Urothelial mucosal signaling and the overactive bladder-ICI-RS 2013Lori A Birder
Departments of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Departments of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Neurourol Urodyn 33:597-601. 2014..When dysfunctional, the proximal urethra may be an interesting target, for example, botulinum toxin injections aiming at eliminating both urgency and incontinence due to detrusor overactivity...
- Expression and function of rat urothelial P2Y receptorsBikramjit Chopra
A1207 Scaife Hall, Dept of Medicine, Univ of Pittsburgh, 3550 Terrace St, Pittsburgh, PA 15261, USA
Am J Physiol Renal Physiol 294:F821-9. 2008..This could lead to the release of bioactive mediators such as additional ATP, nitric oxide, and acetylcholine, which can modulate the micturition reflex by acting on suburothelial myofibroblasts and/or pelvic afferent fibers...