Bruce D Hammock

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways
    Kara R Schmelzer
    Department of Entomology and Cancer Research Center, University of California, Davis, California, USA
    Environ Health Perspect 114:1354-60. 2006
  2. pmc Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures
    Bora Inceoglu
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 8:e80922. 2013
  3. pmc Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene
    Shizuo G Kamita
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e28392. 2011
  4. pmc In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens
    Ki Chang Ahn
    Department of Entomology and Cancer Research Center, University of California, Davis, Davis, CA 95616, USA
    Environ Health Perspect 116:1203-10. 2008
  5. pmc Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Nutr Metab (Lond) 9:50. 2012
  6. pmc Rationally designed multitarget agents against inflammation and pain
    S H Hwang
    Department of Entomology and Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616 8584, USA
    Curr Med Chem 20:1783-99. 2013
  7. pmc Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health
    Christophe Morisseau
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California, Davis, California 95616, USA
    Annu Rev Pharmacol Toxicol 53:37-58. 2013
  8. pmc Soluble epoxide hydrolase in atherosclerosis
    Yi Xin Jim Wang
    Arete Therapeutics Inc, 7000 Shoreline Court, Suite 201, South San Francisco, CA 94080, USA
    Curr Atheroscler Rep 12:174-83. 2010
  9. pmc Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus
    R Wudayagiri
    Department of Entomology, University of California, Davis, CA 95616, USA
    BMC Biochem 2:16. 2001
  10. pmc Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors
    Nils Helge Schebb
    Department of Entomology and Cancer Research Center, University of California, One Shields Avenue, Davis, CA 95616 8584, USA
    Anal Bioanal Chem 400:1359-66. 2011

Collaborators

Detail Information

Publications136 found, 100 shown here

  1. pmc The role of inflammatory mediators in the synergistic toxicity of ozone and 1-nitronaphthalene in rat airways
    Kara R Schmelzer
    Department of Entomology and Cancer Research Center, University of California, Davis, California, USA
    Environ Health Perspect 114:1354-60. 2006
    ..The observed synergism between O3 and 1-NN may be causally related to a shift in a T-helper 1 to T-helper 2 immune response in the airways...
  2. pmc Epoxy fatty acids and inhibition of the soluble epoxide hydrolase selectively modulate GABA mediated neurotransmission to delay onset of seizures
    Bora Inceoglu
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, Sacramento, California, United States of America
    PLoS ONE 8:e80922. 2013
    ....
  3. pmc Juvenile hormone (JH) esterase of the mosquito Culex quinquefasciatus is not a target of the JH analog insecticide methoprene
    Shizuo G Kamita
    Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS ONE 6:e28392. 2011
    ..Our findings indicated that JHE is not a molecular target of methoprene. Our findings also do not support the hypothesis that methoprene functions in part by inhibiting the action of JHE...
  4. pmc In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens
    Ki Chang Ahn
    Department of Entomology and Cancer Research Center, University of California, Davis, Davis, CA 95616, USA
    Environ Health Perspect 116:1203-10. 2008
    ..Few studies have evaluated their biological activities in mammalian cells to assess their potential for adverse effects...
  5. pmc Monosodium glutamate (MSG) intake is associated with the prevalence of metabolic syndrome in a rural Thai population
    Tonkla Insawang
    Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand
    Nutr Metab (Lond) 9:50. 2012
    ..Epidemiology and animal models suggest that dietary monosodium glutamate (MSG) may contribute to the onset of obesity and the metabolic syndrome...
  6. pmc Rationally designed multitarget agents against inflammation and pain
    S H Hwang
    Department of Entomology and Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616 8584, USA
    Curr Med Chem 20:1783-99. 2013
    ....
  7. pmc Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health
    Christophe Morisseau
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California, Davis, California 95616, USA
    Annu Rev Pharmacol Toxicol 53:37-58. 2013
    ..Here, we review these results and discuss how the pharmacological stabilization of EETs and other natural epoxy-fatty acids could lead to possible disease therapies...
  8. pmc Soluble epoxide hydrolase in atherosclerosis
    Yi Xin Jim Wang
    Arete Therapeutics Inc, 7000 Shoreline Court, Suite 201, South San Francisco, CA 94080, USA
    Curr Atheroscler Rep 12:174-83. 2010
    ..The broad spectrum of biological action of EETs and sEHIs with multiple biological beneficial actions provides a promising new class of therapeutics for atherosclerosis and other cardiovascular diseases...
  9. pmc Isolation and characterization of a novel lepidopteran-selective toxin from the venom of South Indian red scorpion, Mesobuthus tamulus
    R Wudayagiri
    Department of Entomology, University of California, Davis, CA 95616, USA
    BMC Biochem 2:16. 2001
    ..Scorpion venom contains insect and mammal selective toxins. We investigated the venom of the South Indian red scorpion, Mesobuthus tamulus for the purpose of identifying potent insecticidal peptide toxins...
  10. pmc Development of an online SPE-LC-MS-based assay using endogenous substrate for investigation of soluble epoxide hydrolase (sEH) inhibitors
    Nils Helge Schebb
    Department of Entomology and Cancer Research Center, University of California, One Shields Avenue, Davis, CA 95616 8584, USA
    Anal Bioanal Chem 400:1359-66. 2011
    ..Therefore, enzyme assays using natural substrate, as described here, are indispensable for reliable determination of structure-activity relationships for sEH inhibition...
  11. pmc In vitro glucuronidation of the antibacterial triclocarban and its oxidative metabolites
    N H Schebb
    University of Veterinary Medicine Hannover, Institute for Food Toxicology and Chemical Analysis, Hannover, Germany
    Drug Metab Dispos 40:25-31. 2012
    ..These results present an anomaly where in vivo the predominant urinary metabolites of TCC are N and N'-glucuronides, but these compounds are slowly produced in vitro...
  12. pmc Inhibition of soluble epoxide hydrolase enhances the anti-inflammatory effects of aspirin and 5-lipoxygenase activation protein inhibitor in a murine model
    Jun Yan Liu
    Department of Entomology and UCD Cancer Center, University of California, Davis, CA 95616, United States
    Biochem Pharmacol 79:880-7. 2010
    ....
  13. pmc Pharmacokinetic optimization of four soluble epoxide hydrolase inhibitors for use in a murine model of inflammation
    Jun Yan Liu
    Department of Entomology and UCD Cancer Research Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Br J Pharmacol 156:284-96. 2009
    ..Here we present the evaluation of four sEHIs for improved pharmacokinetic properties and the anti-inflammatory effects of one sEHI...
  14. pmc Beneficial effects of soluble epoxide hydrolase inhibitors in myocardial infarction model: Insight gained using metabolomic approaches
    Ning Li
    Division of Cardiovascular Medicine, University of California, Davis, Davis, CA 95616, USA
    J Mol Cell Cardiol 47:835-45. 2009
    ..Moreover, the oxylipin profiling showed a striking parallel to the changes in inflammatory cytokines in this model. Our study provides evidence for a possible new therapeutic strategy to improve cardiac function post MI...
  15. pmc Pharmacokinetic screening of soluble epoxide hydrolase inhibitors in dogs
    Hsing Ju Tsai
    Department of Entomology and Cancer Center, University of California, Davis, CA 95616, USA
    Eur J Pharm Sci 40:222-38. 2010
    ..Such compounds may also be a valuable lead for the development of veterinary therapeutics...
  16. pmc Orally bioavailable potent soluble epoxide hydrolase inhibitors
    Sung Hee Hwang
    Department of Entomology and UCD Cancer Center, University of California Davis, One Shields Avenue, Davis, CA 95616 8584, USA
    J Med Chem 50:3825-40. 2007
    ..3 +/- 0.05 nM) had excellent oral bioavailability (98%, n = 2) and blood area under the curve in dogs and was effective in vivo to treat hypotension in lipopolysaccharide challenged murine models...
  17. pmc Function of phenylalanine 259 and threonine 314 within the substrate binding pocket of the juvenile hormone esterase of Manduca sexta
    Shizuo G Kamita
    Department of Entomology, UC Davis Cancer Center, USA
    Biochemistry 49:3733-42. 2010
    ..Our findings also demonstrate that chemical bond strength does not necessarily correlate with how reactive the bond will be to metabolism...
  18. pmc Salicylate-urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities
    Takeo Kasagami
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Bioorg Med Chem Lett 19:1784-9. 2009
    ..The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo...
  19. pmc Use of carboxylesterase activity to remove pyrethroid-associated toxicity to Ceriodaphnia dubia and Hyalella azteca in toxicity identification evaluations
    Craig E Wheelock
    Department of Entomology, Cancer Research Center, University of California at Davis, Davis, California 95616, USA
    Environ Toxicol Chem 25:973-84. 2006
    ..These data demonstrate the utility of carboxylesterase treatment as a viable step to detect the presence of pyrethroids in receiving waters...
  20. pmc Design of bioavailable derivatives of 12-(3-adamantan-1-yl-ureido)dodecanoic acid, a potent inhibitor of the soluble epoxide hydrolase
    In Hae Kim
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Bioorg Med Chem 15:312-23. 2007
    ..The esterification of 1 results in compounds that are easier to formulate in animal food and in triglycerides for gavage and other routes of administration, making it easier to study the biological effects of sEH inhibition in vivo...
  21. pmc Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes
    Bora Inceoglu
    Department of Entomology, University of California Davis and UC Davis Cancer Center, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:11390-5. 2012
    ..Overall, these results argue that further efforts in understanding the spectrum of effects of EpFAs will yield novel opportunities in treating neuropathic pain...
  22. pmc Anti-inflammatory effects of ω-3 polyunsaturated fatty acids and soluble epoxide hydrolase inhibitors in angiotensin-II-dependent hypertension
    Arzu Ulu
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA
    J Cardiovasc Pharmacol 62:285-97. 2013
    ....
  23. pmc Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model
    Arzu Ulu
    Department of Entomology, University of California Davis, CA, USA
    J Cardiovasc Pharmacol 52:314-23. 2008
    ..Our data suggest that orally-available sEH inhibitors may be useful in the treatment of patients with atherosclerotic cardiovascular disease...
  24. pmc Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis
    Padmini Sirish
    Division of Cardiovascular Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:5618-23. 2013
    ..Our study provides evidence for a possible unique therapeutic strategy to reduce cardiac fibrosis and improve cardiac function post-MI...
  25. pmc Development of pyrethroid-like fluorescent substrates for glutathione S-transferase
    Huazhang Huang
    Department of Entomology, University of California, Davis, CA 95616, USA
    Anal Biochem 431:77-83. 2012
    ....
  26. ncbi request reprint Development of optically pure pyrethroid-like fluorescent substrates for carboxylesterases
    Huazhang Huang
    Department of Entomology and Cancer Research Center, University of California, Davis, California 95616, USA
    Chem Res Toxicol 18:516-27. 2005
    ....
  27. pmc Inhibition of soluble epoxide hydrolase contributes to the anti-inflammatory effect of antimicrobial triclocarban in a murine model
    Jun Yan Liu
    Department of Entomology and Cancer Center, University of California, Davis, CA 95616, USA
    Toxicol Appl Pharmacol 255:200-6. 2011
    ..It may be a promising starting point for developing new low volume high value applications of TCC. However these biological effects also caution against the general over use of TCC in PCPs...
  28. pmc Alteration in plasma testosterone levels in male mice lacking soluble epoxide hydrolase
    Ayala Luria
    Departmentsof Entomology, University of California, Davis, CA 95616, USA
    Am J Physiol Endocrinol Metab 297:E375-83. 2009
    ....
  29. pmc Soluble epoxide hydrolase deficiency or inhibition attenuates diet-induced endoplasmic reticulum stress in liver and adipose tissue
    Ahmed Bettaieb
    Department of Nutrition, University of California, Davis, California 95616, USA
    J Biol Chem 288:14189-99. 2013
    ..In summary, these findings demonstrate that sEH is a physiological modulator of ER stress and a potential target for mitigating complications associated with obesity...
  30. pmc Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation
    Lukas Kubala
    Department of Internal Medicine, University of California at Davis, Davis, CA 95616, USA
    Free Radic Biol Med 48:1311-20. 2010
    ..Our results demonstrate that MPO modulates the balance of pro- and anti-inflammatory lipid mediators during acute inflammation and, in this way, may control acute inflammatory diseases...
  31. pmc Monitoring of total type ii pyrethroid pesticides in citrus oils and water by converting to a common product 3-phenoxybenzoic acid
    Mark R McCoy
    Department of Entomology and UCD Cancer Center, University of California Davis, Davis, California 95616, USA
    J Agric Food Chem 60:5065-70. 2012
    ..8 μM when detected by LC-MS/MS, gas chromatography-mass spectrometry, and immunoassay, respectively. The limit of detection for pyrethroids in water when detected by immunoassay was 2 nM...
  32. pmc Magnetic bead-based phage anti-immunocomplex assay (PHAIA) for the detection of the urinary biomarker 3-phenoxybenzoic acid to assess human exposure to pyrethroid insecticides
    Hee Joo Kim
    Department of Entomology and UCD Cancer Research Center, University of California, Davis, 95616, USA
    Anal Biochem 386:45-52. 2009
    ..This assay system accurately determined the level of spiked 3-PBA in different urine samples prepared by direct dilution or clean-up with solid-phase extraction after acidic hydrolysis with overall recovery of 80-120%...
  33. pmc Substituted phenyl groups improve the pharmacokinetic profile and anti-inflammatory effect of urea-based soluble epoxide hydrolase inhibitors in murine models
    Jun Yan Liu
    Department of Entomology and UCD Comprehensive Cancer Center, University of California, Davis, CA 95615, USA
    Eur J Pharm Sci 48:619-27. 2013
    ..This indicates a new strategy for development of sEHIs for further study toward clinical trials...
  34. pmc Synthesis and biological evaluation of sorafenib- and regorafenib-like sEH inhibitors
    Sung Hee Hwang
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California, Davis, One Shields Avenue, Davis, CA 95616 8584, USA
    Bioorg Med Chem Lett 23:3732-7. 2013
    ..The data presented suggest a potential rational approach to control the angiogenic responses stemming from sEH inhibition...
  35. pmc Peptidyl-urea based inhibitors of soluble epoxide hydrolases
    Christophe Morisseau
    Department of Entomology and UCD Cancer Center, University of California, Davis, CA 95616, USA
    Bioorg Med Chem Lett 16:5439-44. 2006
    ..While our lead compound 2 showed low apparent bioavailability in dogs and rats, this series of compounds revealed that sEH inhibitor structures could accept large groups that could lead to better orally available drugs...
  36. pmc 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain
    Tristan E Rose
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, California 95616, USA
    J Med Chem 53:7067-75. 2010
    ..This novel sEH inhibitor showed a 1000-fold increase in potency when compared to morphine by reducing hyperalgesia as measured by mechanical withdrawal threshold using the in vivo carrageenan induced inflammatory pain model...
  37. pmc Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity
    Kyung Don Kang
    Department of Entomology and Cancer Research Center, University of California, Davis, CA 95616, USA
    Anal Biochem 344:183-92. 2005
    ..The vastly improved optical properties and synthetic flexibility of the alpha-cyano ether compounds suggest that they are possibly good general P450 substrates...
  38. pmc Inhibition of soluble epoxide hydrolase does not protect against endotoxin-mediated hepatic inflammation
    Kimberly L Fife
    Department of Biopharmaceutical Sciences, University of California, San Francisco, California, USA
    J Pharmacol Exp Ther 327:707-15. 2008
    ..However, LPS did have significant effects on plasma eicosanoid levels and hepatic Ephx2 expression, suggesting that in vivo EET levels are modulated in response to an inflammatory signal...
  39. pmc An immunoassay to evaluate human/environmental exposure to the antimicrobial triclocarban
    Ki Chang Ahn
    Department of Entomology and the UCD Cancer Center, University of California Davis, Davis, California 95616, United States
    Environ Sci Technol 46:374-81. 2012
    ..This immunoassay can be used as a rapid, inexpensive, and convenient tool to aid researchers monitoring human/environmental exposure to TCC to better understand the health effects...
  40. pmc Naturally occurring monoepoxides of eicosapentaenoic acid and docosahexaenoic acid are bioactive antihyperalgesic lipids
    Christophe Morisseau
    Department of Entomology and Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    J Lipid Res 51:3481-90. 2010
    ..Consequently, the DHA and eicosapentaenoic acid epoxides may be responsible for some of the beneficial effects associated with dietary n-3 fatty acid intake...
  41. pmc 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic properties
    In Hae Kim
    Department of Entomology and University of California Davis Cancer Center, University of California, One Shields Avenue, Davis, California 95616, USA
    J Med Chem 50:5217-26. 2007
    ..Furthermore, improved pharmacokinetic properties in murine and canine models were obtained with the resulting inhibitors. These findings will facilitate the usage of sEH inhibitors in animal models of hypertension and inflammation...
  42. pmc Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2
    Kosuke Nishi
    Department of Entomology and UC Davis Cancer Center, University of California, Davis, CA 95616, USA
    Arch Biochem Biophys 445:115-23. 2006
    ....
  43. ncbi request reprint Identification, expression, and purification of a pyrethroid-hydrolyzing carboxylesterase from mouse liver microsomes
    Jeanette E Stok
    Department of Entomology and University of California Davis Cancer Research Center, University of California, Davis, California 95616, USA
    J Biol Chem 279:29863-9. 2004
    ..Both these enzymes could be used as preliminary tools in establishing the relative toxicity of new pyrethroids...
  44. pmc Use of a soluble epoxide hydrolase inhibitor in smoke-induced chronic obstructive pulmonary disease
    Lei Wang
    Center for Health and the Environment, University of California at Davis, Old Davis Road, Davis, CA 95616, USA
    Am J Respir Cell Mol Biol 46:614-22. 2012
    ..To the best of our knowledge, this is the first report to demonstrate that sEHI exerts significant protective effects after repeated, subacute tobacco smoke-induced lung injury in a rat model of COPD...
  45. pmc Electrophoretic build-up of multi nanoparticle array for a highly sensitive immunoassay
    Jin Hee Han
    Department of Mechanical and Aerospace Engineering, University of California, Davis, California, CA 95616, USA
    Biosens Bioelectron 41:302-8. 2013
    ..The EPES/nanoarray system promises to offer a new standard in applications that require portable, point-of-care and real-time monitoring with high sensitivity...
  46. pmc Biologically active ester derivatives as potent inhibitors of the soluble epoxide hydrolase
    In Hae Kim
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Bioorg Med Chem Lett 22:5889-92. 2012
    ..Modifications around the ester function enhanced in vitro metabolic stability of the ester inhibitors up to 32-fold without a decrease in inhibition potency. Further, several compounds had improved physical properties...
  47. pmc Lipid sulfates and sulfonates are allosteric competitive inhibitors of the N-terminal phosphatase activity of the mammalian soluble epoxide hydrolase
    Katherine L Tran
    Department of Entomology and U C Davis Cancer Center, University of California, Davis, California 95616, USA
    Biochemistry 44:12179-87. 2005
    ..This novel site may play a role in the natural in vivo regulation of epoxide hydrolysis by sEH...
  48. pmc Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition
    Benjamin B Davis
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, 95616, USA
    J Pharmacol Exp Ther 316:815-21. 2006
    ..In addition, our results show that caution should be used when attempting to infer conclusions of EET biology based solely on the effects these inhibitors in tissue culture models, especially when used at micromolar concentrations...
  49. ncbi request reprint Investigation of the role of a second conserved serine in carboxylesterases via site-directed mutagenesis
    Jeanette E Stok
    Department of Entomology, University of California, Davis 95616, USA
    Arch Biochem Biophys 430:247-55. 2004
    ....
  50. ncbi request reprint Phage-borne peptidomimetics accelerate the development of polyclonal antibody-based heterologous immunoassays for the detection of pesticide metabolites
    Hee Joo Kim
    Department ofEntomology and UCD Cancer Research Center, University of California, Davis, California 95616, USA
    Environ Sci Technol 42:2047-53. 2008
    ..The data presented here shows a new systematic procedure that enables the fast generation of several competing haptens for the rapid development of sensitive heterologous immunoassays...
  51. pmc Enhancement of antinociception by coadministration of nonsteroidal anti-inflammatory drugs and soluble epoxide hydrolase inhibitors
    Kara R Schmelzer
    Departments of Entomology, Internal Medicine, Anesthesiology and Pain Medicine, and Physiology and Membrane Biology and Cancer Research Center, University of California, Davis, CA 95616
    Proc Natl Acad Sci U S A 103:13646-51. 2006
    ..These data suggest that these drug combinations (NSAIDs and sEHIs) produce a valuable beneficial analgesic and anti-inflammatory effect while prospectively decreasing side effects such as cardiovascular toxicity...
  52. pmc Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP
    Bora Inceoglu
    Department of Entomology and University of California Davis Cancer Center, School of Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:5093-7. 2011
    ..The cross-talk between the two major pathways-one mediated by cAMP and the other by EFAs-paves the way to new approaches to understand and control pain...
  53. pmc Isolation of alpaca anti-hapten heavy chain single domain antibodies for development of sensitive immunoassay
    Hee Joo Kim
    Department of Entomology and UCD Cancer Center, University of California, Davis, California 95616, United States
    Anal Chem 84:1165-71. 2012
    ..In conclusion, a highly specific and sensitive VHH for 3-PBA was developed using sequences from immunized alpaca and phage display technology for antibody selection...
  54. pmc Characterization of Hovi-mEH1, a microsomal epoxide hydrolase from the glassy-winged sharpshooter Homalodisca vitripennis
    Shizuo G Kamita
    Department of Entomology, University of California, Davis, CA, USA
    Arch Insect Biochem Physiol 83:171-9. 2013
    ..On the basis of biochemical, phylogenetic, and transcriptome analyses, we hypothesize that Hovi-mEH1 is a biologically relevant JH-metabolizing enzyme in H. vitripennis...
  55. pmc Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases
    Huazhang Huang
    Department of Entomology and Cancer Research Center, University of California, Davis, California 95616, USA
    Chem Res Toxicol 18:1371-7. 2005
    ..The implications these findings have on the design and use of effective pesticides are discussed...
  56. pmc Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception
    Karen Wagner
    Department of Entomology and UC Davis Cancer Center, University of California Davis, Davis, CA 95616, USA
    Prostaglandins Other Lipid Mediat 96:76-83. 2011
    ....
  57. pmc Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids
    Christophe Morisseau
    Department of Entomology and UCD Cancer Center, One Shields Avenue, University of California, Davis, CA 95616, USA
    Biochem Biophys Res Commun 419:796-800. 2012
    ..These findings also underline possible cellular mechanisms by which both activities of sEH (EH and phosphatase) may have complementary or opposite roles...
  58. pmc Comparative efficacy of 3 soluble epoxide hydrolase inhibitors in rat neuropathic and inflammatory pain models
    Karen Wagner
    Department of Entomology and UC Davis Comprehensive Cancer Center, University of California Davis, One Shields Ave, Davis, CA 95616, USA
    Eur J Pharmacol 700:93-101. 2013
    ..Because of their ability to block diabetic neuropathic pain sEH inhibition is a promising new approach to treat chronic pain conditions...
  59. pmc Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH)
    Craig E Wheelock
    Department of Entomology and Cancer Research Center, University of California, Davis, CA 95616, USA
    Bioorg Med Chem 16:2114-30. 2008
    ..These results provide further information on the nature of the TFK binding interaction and will be useful in increasing our understanding of this basic biochemical process...
  60. pmc Immunoassay for monitoring environmental and human exposure to the polybrominated diphenyl ether BDE-47
    Ki Chang Ahn
    Department of Entomology, University of California, Davis, California 95616, USA
    Environ Sci Technol 43:7784-90. 2009
    ..The ELISA provided quantitative results when performed on small volume/weight samples such as dust furniture foam, and blood/ serum following sample preparation, suggesting a convenient screening tool...
  61. ncbi request reprint Three structurally related, highly potent, peptides from the venom of Parabuthus transvaalicus possess divergent biological activity
    Bora Inceoglu
    Department of Entomology and Cancer Research Center, University of California at Davis, CA 95616, USA
    Toxicon 45:727-33. 2005
    ..Therefore the amino acid sequences presented here can be used to make more specific and effective antivenins. Possible approaches to a systematic nomenclature of toxins are suggested...
  62. pmc Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta
    Mark Wogulis
    Department of Molecular and Cellular Biology, University of California, Davis, California 95616, USA
    Biochemistry 45:4045-57. 2006
    ..Together, these results clarify the binding mechanism of JHE inhibitors and provide useful observations for the development of additional enzyme inhibitors for a variety of enzymes...
  63. pmc Förster resonance energy transfer competitive displacement assay for human soluble epoxide hydrolase
    Kin Sing Stephen Lee
    Department of Entomology and UCD Comprehensive Cancer Center, University of California, Davis, CA 95616, USA
    Anal Biochem 434:259-68. 2013
    ..This assay provides additional data to evaluate the potency of sEH inhibitors...
  64. pmc Synthesis and SAR of conformationally restricted inhibitors of soluble epoxide hydrolase
    Paul D Jones
    Department of Entomology and Cancer Research Center, One Shields Avenue, University of California, Davis, 95616, USA
    Bioorg Med Chem Lett 16:5212-6. 2006
    ..2 microM to 1.1 nM against recombinant sEH. N-(1-Acetylpiperidin-4-yl)-N'-(adamant-1-yl) urea (5a) was found to be a potent inhibitor (IC(50) = 7.0 nM) that was also orally bioavailable in canines...
  65. ncbi request reprint Eu3+-doped Gd2O3 nanoparticles as reporters for optical detection and visualization of antibodies patterned by microcontact printing
    Mikaela Nichkova
    Department of Entomology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Anal Bioanal Chem 384:631-7. 2006
    ..The nanoparticles can be used as fluorescent markers in a variety of immunosensing applications in a microscale format...
  66. ncbi request reprint Pyrethroid tolerance in Culex pipiens pipiens var molestus from Marin County, California
    Rory D McAbee
    Mosquito Control Research Laboratory, Department of Entomology, University of California at Davis, 9240 S Riverbend Avenue, Parlier, CA 93648, USA
    Pest Manag Sci 60:359-68. 2004
    ..This study represents the first report of resistance to pyrethroids in a feral population of a mosquito species in the USA...
  67. ncbi request reprint An immunoassay for a urinary metabolite as a biomarker of human exposure to the pyrethroid insecticide permethrin
    Ki Chang Ahn
    Department of Entomology and UCD Cancer Research Center, University of California, Davis, CA 95616, USA
    Anal Bioanal Chem 384:713-22. 2006
    ..The limit of quantitation of the target analyte was 1.0 microg/L in urine with a limit of detection of 0.1 microg/L in buffer. This assay might be a useful tool for monitoring human exposure to permethrin...
  68. pmc Noncompetitive phage anti-immunocomplex real-time polymerase chain reaction for sensitive detection of small molecules
    Hee Joo Kim
    Department of Entomology and UCD Cancer Center, University of California, Davis, California 95616, United States
    Anal Chem 83:246-53. 2011
    ..The assay was validated with both agricultural drain water and human urine samples, showing its robustness for rapid monitoring of human exposure or environmental contamination...
  69. pmc Sorafenib attenuates p21 in kidney cancer cells and augments cell death in combination with DNA-damaging chemotherapy
    Hiromi Inoue
    Division of Nephrology Department of Internal Medicine, University of California, Davis, CA, USA
    Cancer Biol Ther 12:827-36. 2011
    ....
  70. pmc Sorafenib has soluble epoxide hydrolase inhibitory activity, which contributes to its effect profile in vivo
    Jun Yan Liu
    Division of Nephrology, Department of Internal Medicine, Genome and Biomedical Sciences Facility, University of California, Davis, California 95616, USA
    Mol Cancer Ther 8:2193-203. 2009
    ..Thus, it is likely that soluble epoxide hydrolase inhibition contributes to the beneficial effects from the inhibition of the VEGF receptor and other kinases during treatment with sorafenib...
  71. pmc Tetramethylenedisulfotetramine alters Ca²⁺ dynamics in cultured hippocampal neurons: mitigation by NMDA receptor blockade and GABA(A) receptor-positive modulation
    Zhengyu Cao
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Toxicol Sci 130:362-72. 2012
    ..These rapid throughput in vitro assays may assist in the identification of single agents or combinations that have utility in the treatment of TETS intoxication...
  72. pmc Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis
    Alonso G P Guedes
    Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Anaesth Analg 40:440-8. 2013
    ....
  73. pmc Immunoassays and biosensors for monitoring environmental and human exposure to pyrethroid insecticides
    Ki Chang Ahn
    Department of Entomology, University of California, Davis, Davis, California 95616, United States
    J Agric Food Chem 59:2792-802. 2011
    ..These new technologies alone and in combination result in an improved ability to both determine if effective levels of pyrethroids are being used in the field and evaluate possible contamination...
  74. pmc Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events
    Jun Yan Liu
    Department of Entomology and University of California Davis Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 107:17017-22. 2010
    ....
  75. pmc Development of a noncompetitive phage anti-immunocomplex assay for brominated diphenyl ether 47
    Hee Joo Kim
    Department of Entomology and UCD Cancer Center, University of California, Davis, CA 95616, USA
    Anal Biochem 401:38-46. 2010
    ..0ng/ml), and a blind test with six random extracts of local house furniture foams showed that the results of the PHAIA and dipstick assay were consistent, giving the same positive and negative detection...
  76. pmc Identification of two epoxide hydrolases in Caenorhabditis elegans that metabolize mammalian lipid signaling molecules
    Todd R Harris
    Department of Entomology and Cancer Research Center, University of California, One Shields Avenue, Davis, CA 95616, USA
    Arch Biochem Biophys 472:139-49. 2008
    ..These results suggest that the hydrolases are involved in the metabolism of possible lipid signaling molecules in C. elegans...
  77. pmc Triclocarban enhances testosterone action: a new type of endocrine disruptor?
    Jiangang Chen
    Center for Health and the Environment, University of California, Davis, California 95616, USA
    Endocrinology 149:1173-9. 2008
    ..The data presented here suggest that the bioactivity of endogenous hormones may be amplified by exposure to commercial personal care products containing sufficient levels of TCC...
  78. pmc Immunochemical analysis of 3-phenoxybenzoic acid, a biomarker of forestry worker exposure to pyrethroid insecticides
    Ki Chang Ahn
    Department of Entomology, University of California, Davis, CA 95616, USA
    Anal Bioanal Chem 401:1285-93. 2011
    ..This ELISA method using a 96-well plate was performed as a high-throughput tool for analyzing around 300 urine samples measured in triplicate to provide data for workers exposure assessment...
  79. pmc Mutation of bacterium Vibrio gazogenes for selective preparation of colorants
    Farzaneh Alihosseini
    Div of Textile and Clothing, University of California, Davis, CA 95616, USA
    Biotechnol Prog 26:352-60. 2010
    ..The antibiotic activities of pure colorants are discussed as well. Based on their bio-activity and excellent dyeing capabilities, these colorants could be employed in cosmetic and textile industries...
  80. pmc Triclosan impairs excitation-contraction coupling and Ca2+ dynamics in striated muscle
    Gennady Cherednichenko
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 109:14158-63. 2012
    ....
  81. pmc Individual variation in lipidomic profiles of healthy subjects in response to omega-3 Fatty acids
    Malin L Nording
    Computational Life Science Cluster CLIC, Department of Chemistry, Umea University, Umea, Sweden Department of Entomology, University of California Davis, Davis, California, United States of America
    PLoS ONE 8:e76575. 2013
    ..This may be due to individual variability in response. We used a multi-platform lipidomic approach to investigate both the consistent and inconsistent responses of individuals comprehensively to a defined ω3 intervention...
  82. pmc Novel and highly sensitive fluorescent assay for leucine aminopeptidases
    Huazhang Huang
    Department of Entomology and UC Davis Cancer Center, University of California, Davis, CA 95616, USA
    Anal Biochem 391:11-6. 2009
    ..We also showed that this assay was a useful tool for monitoring LAP activities in extracts from cancer cell lines, as well as for the high-throughput screening of inhibitors, which could lead to new cancer treatments...
  83. doi request reprint Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase
    Kin Sing Stephen Lee
    Department of Entomology and Nematology, UCD Comprehensive Cancer Center, University of California at Davis, One Shields Avenue, Davis, CA 95616, USA
    Arch Biochem Biophys . 2016
    ..Results indicate that the stereochemistry of the epoxide plays a crucial role in dictating the binding orientation of the substrate...
  84. pmc Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
    Sung Hee Hwang
    Department of Entomology and UCD Cancer Center, University of California, One Shields Avenue, Davis, CA 95616 8584, USA
    Bioorg Med Chem Lett 16:5773-7. 2006
    ....
  85. pmc Soluble epoxide hydrolase is a therapeutic target for acute inflammation
    Kara R Schmelzer
    Department of Entomology, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 102:9772-7. 2005
    ..These data suggest that sEH inhibitors have therapeutic efficacy in the treatment and management of acute inflammatory diseases...
  86. pmc Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways
    Bora Inceoglu
    Department of Entomology and UC Davis Cancer Center, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 105:18901-6. 2008
    ..Redirecting the flow of pronociceptive intracellular cAMP toward up-regulation of StARD1 mRNA by concomitantly elevating EETs is a novel path to accomplish pain relief in both inflammatory and neuropathic pain states...
  87. pmc Cardiac-generated prostanoids mediate cardiac myocyte apoptosis after myocardial ischaemia
    Hong Qiu
    Division of Cardiovascular Medicine, Department of Internal Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    Cardiovasc Res 95:336-45. 2012
    ..However, the key question that remains unanswered is whether cardiac-generated eicosanoids are the cause or the consequence of cardiac cell damage in MI...
  88. pmc Photonic crystal lab-on-a-chip for detecting staphylococcal enterotoxin B at low attomolar concentration
    Jin Hee Han
    Department of Mechanical and Aerospace Engineering, University of California, Davis, California 95616, United States
    Anal Chem 85:3104-9. 2013
    ..With very low amounts of sample (less than 10 μL) and fast read-out time, the PC-based system shows great promise for the detection of a wide range of target molecules with close to a single molecule level of sensitivity...
  89. pmc The anti-inflammatory effects of soluble epoxide hydrolase inhibitors are independent of leukocyte recruitment
    Benjamin B Davis
    Center for Health and the Environment, University of California, Davis, CA 95616, USA
    Biochem Biophys Res Commun 410:494-500. 2011
    ..This demonstrates that the widely held belief that sEH inhibition prevents leukocyte recruitment via EET prevention of adhesion molecule expression is not consistently reproducible...
  90. pmc Development of fluorescent substrates for microsomal epoxide hydrolase and application to inhibition studies
    Christophe Morisseau
    Department of Entomology and Cancer Center, University of California Davis, 95616, USA
    Anal Biochem 414:154-62. 2011
    ..7. This new assay permits a significant decrease in labor and cost and also offers the advantage of a continuous readout. However, it should not be used with crude enzyme preparations due to interfering reactions...
  91. pmc Multiplexed immunoassays for proteins using magnetic luminescent nanoparticles for internal calibration
    Mikaela Nichkova
    Department of Entomology and the UC Davis Cancer Center, One Shields Avenue, Davis, CA 95616, USA
    Anal Biochem 369:34-40. 2007
    ..The method uses a standard bench plate reader. It can be applied to disease diagnostics and to the detection of biological threats...
  92. ncbi request reprint Isolation of a strain of Agrobacterium tumefaciens (Rhizobium radiobacter) utilizing methylene urea (ureaformaldehyde) as nitrogen source
    Marja E Koivunen
    Department of Land, Air, and Water Resources, University of California, Davis 95616, USA
    Can J Microbiol 50:167-74. 2004
    ..The result has a practical significance, demonstrating a potential to select for this plant pathogen in soils fertilized with MU...
  93. doi request reprint Gerry Brooks and epoxide hydrolases: four decades to a pharmaceutical
    Christophe Morisseau
    Department of Entomology and UCD, Cancer Center, University of California, Davis, CA 95616, USA
    Pest Manag Sci 64:594-609. 2008
    ..From his seminal work, Dr Brooks opened the field of epoxide hydrolase research in many directions including xenobiotic metabolism, insect physiology and human health, as well as asymmetric organic synthesis...
  94. pmc Occurrence of endocrine-disrupting chemicals in indoor dust
    Hyun Min Hwang
    Department of Civil and Environmental Engineering, University of California, One Shields Ave, Davis, CA 95616, USA
    Sci Total Environ 404:26-35. 2008
    ..This study provides additional information that indoor dust is highly contaminated by persistent and endocrine-disrupting chemicals...
  95. pmc Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors
    Christophe Morisseau
    Department of Entomology and Cancer Center, University of California at Davis, Davis, California 95616, USA
    Environ Health Perspect 117:1867-72. 2009
    ..Whole-animal toxicologic studies cannot yield the necessary throughput in a cost-effective fashion, leading to a critical need for a faster and more cost-effective toxicologic evaluation of xenobiotics...
  96. ncbi request reprint Microarray immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd2O3 nanoparticles as fluorescent labels
    Mikaela Nichkova
    Department of Entomology, University of California Davis, Davis, California 95616, USA
    Anal Chem 77:6864-73. 2005
    ..4 microg L(-1) PBA. This work suggests the potential application of lanthanide oxide nanoparticles as fluorescent probes in microarray and biosensor technology, immunodiagnostics, and high-throughput screening...
  97. ncbi request reprint Application of luminescent Eu:Gd2O3 nanoparticles to the visualization of protein micropatterns
    Dosi Dosev
    University of California Davis, Department of Mechanical and Aeronautical Engineering, Davis, California 95616, USA
    J Biomed Opt 10:064006. 2005
    ..More detailed studies are preformed using atomic-force microscopy (AFM) at a single nanoparticle level. The specific and the nonspecific binding densities of the particles are qualitatively evaluated...
  98. ncbi request reprint PCB-induced oxidative stress in endothelial cells: modulation by nutrients
    Bernhard Hennig
    Cell Nutrition Group, Department of Animal Sciences, University of Kentucky, Lexington, KY 40546, USA
    Int J Hyg Environ Health 205:95-102. 2002
    ....
  99. ncbi request reprint Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage
    Xueying Zhao
    Vascular Biology Center, Department of Physiology, Medical College of Georgia, Augusta, USA
    J Am Soc Nephrol 15:1244-53. 2004
    ..These data demonstrate that SEH inhibition has antihypertensive and renal vascular protective effects in angiotensin hypertension and suggests that SEH inhibitors may be a useful therapeutic intervention for cardiovascular diseases...
  100. ncbi request reprint Design, synthesis, and biological activity of 1,3-disubstituted ureas as potent inhibitors of the soluble epoxide hydrolase of increased water solubility
    In Hae Kim
    Department of Entomology and UC Davis Cancer Center, University of California Davis, One Shields Avenue, Davis, CA 95616, USA
    J Med Chem 47:2110-22. 2004
    ..These properties will make the compounds more bioavailable and more soluble in either water- or oil-based formulations...
  101. ncbi request reprint Development of an enzyme-linked immunosorbent assay for the pyrethroid cypermethrin
    Hu Jang Lee
    Department of Entomology and Cancer Research Center, University of California, Davis, California 95616, USA
    J Agric Food Chem 52:1039-43. 2004
    ..The water samples, fortified with cypermethrin, were analyzed according to this method. Good recoveries and correlation with spike levels were observed...