M T Hamilton
Affiliation: University of Missouri
- Role of low energy expenditure and sitting in obesity, metabolic syndrome, type 2 diabetes, and cardiovascular diseaseMarc T Hamilton
Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO 65211, USA
Diabetes 56:2655-67. 2007....
- Exercise physiology versus inactivity physiology: an essential concept for understanding lipoprotein lipase regulationMarc T Hamilton
Department of Biomedical Sciences, University of Missouri Columbia, Columbia, MO, USA
Exerc Sport Sci Rev 32:161-6. 2004..The most powerful process known to regulate lipoprotein lipase protein and activity in muscle capillaries may be initiated by inhibitory signals during physical inactivity, independent of changes in lipoprotein lipase messenger RNA...
- Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activityLionel Bey
Department of Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri Columbia, MO, USA
J Physiol 551:673-82. 2003....
- Physical inactivity amplifies the sensitivity of skeletal muscle to the lipid-induced downregulation of lipoprotein lipase activityTheodore W Zderic
E102 VMB, 1600 E Rollins Rd, Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri Columbia, Columbia, Missouri 65211, USA
J Appl Physiol (1985) 100:249-57. 2006..In conclusion, physical inactivity amplifies the ability of plasma lipids to suppress muscle LPL activity. The light ambulatory contractions responsible for NEAT are sufficient for mitigating these deleterious effects...
- Skeletal muscle adaptation to exercise: a century of progressM T Hamilton
Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211 0001, USA
J Appl Physiol (1985) 88:327-31. 2000..Therefore, training studies have had an impact on setting the stage for a potential "preventive medicine reformation" in a society needing a return to a naturally active lifestyle of our ancestors...
- Reduced lipoprotein lipase activity in postural skeletal muscle during agingL Bey
Veterinary Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, Missouri 65211, USA
J Appl Physiol 91:687-92. 2001..In conclusion, LPL regulation in a non-weight-bearing muscle was not affected by aging. However, there was a pronounced reduction in LPL activity and LPL protein mass in postural muscle with aging...
- Effect of antihypertensive agents on the development of type 2 diabetes mellitusCraig S Stump
Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Missouri Columbia, Harry S Truman VA Medical Center, Columbia, MO 65212, USA
Mayo Clin Proc 81:796-806. 2006..This will become even more important as the number of insulin-resistant patients with hypertension increases in parallel with the steady growth in the number of sedentary, obese, and aged persons in our population...
- Plasma triglyceride metabolism in humans and rats during aging and physical inactivityM T Hamilton
Dalton Cardiovascular Research Center, University of Missouri, Columbia 65211, USA
Int J Sport Nutr Exerc Metab 11:S97-104. 2001..Therefore, the poor TG metabolism that is frequently associated with aging may be caused by some of the same processes that lower skeletal muscle LPL activity of young sedentary individuals...
- Exercise training alters effect of high-fat feeding on the ACTH stress response in pigsRyan Jankord
Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA
Appl Physiol Nutr Metab 33:461-9. 2008..Thus, the increase in FFA with high-fat feeding may explain the blunted ACTH response to an acute stressor in sedentary animals, but cannot explain the exaggerated response in exercise trained animals...
- Induction of lipoprotein lipase gene expression in 3T3-L1 preadipocytes by atorvastatin, a cholesterol- and triglyceride-lowering drugLionel Bey
Biomedical Sciences, University of Missouri Columbia, MO 65211, USA
Pharmacology 66:51-6. 2002..Addition of 10 micromol/l atorvastatin for 48 h resulted in a 44% increase of rat LPL promoter activity. This study demonstrates for the first time that a statin can regulate LPL gene expression transcriptionally in preadipocytes...
- Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activityLionel Bey
Biomedical Sciences and Dalton Cardiovascular Research Center, University of Missouri Columbia, Missouri 65211, USA
Physiol Genomics 13:157-67. 2003..This study reveals genes that are the most sensitive to loading/activity in rat skeletal muscle and indicates new targets that may initiate muscle alterations during inactivity...
- Diaphragm unloading via controlled mechanical ventilation alters the gene expression profileKeith C DeRuisseau
Department of Applied Physiology and Kinesiology, University of Florida, Room 25, Florida Gym, Gainesville, Florida 32611, USA
Am J Respir Crit Care Med 172:1267-75. 2005..However, the impact of controlled mechanical ventilation on global mRNA alterations in the diaphragm remains unknown...