Affiliation: University of Louisville
- Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptorsGeorge Hajishengallis
Center of Excellence in Oral and Craniofacial Biology and Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70119, USA
J Biol Chem 280:38902-13. 2005..Elucidation of pathogen interactions with PRRs at the molecular level may glean insight into host defense mechanisms as well as into microbial strategies that subvert innate immunity...
- Pathogenic microbes and community service through manipulation of innate immunityGeorge Hajishengallis
School of Dentistry, Oral Health and Systemic Disease, University of Louisville, Louisville, KY 40292, USA
Adv Exp Med Biol 946:69-85. 2012..This review summarizes important immune subversive tactics of P. gingivalis which might enable it to exert a supportive impact on the oral microbial community...
- Microbial manipulation of receptor crosstalk in innate immunityGeorge Hajishengallis
University of Louisville, Department of Microbiology and Immunology, Louisville, Kentucky 40292, USA
Nat Rev Immunol 11:187-200. 2011..Understanding how pathogens exploit host receptor crosstalk mechanisms and infiltrate the host signalling network is essential for developing interventions to redirect the host response and achieve protective immunity...
- Complement and periodontitisGeorge Hajishengallis
Department of Microbiology and Immunology, University of Louisville School of Dentistry, Loueisville, KY 40292, USA
Biochem Pharmacol 80:1992-2001. 2010..This information is essential as it may reveal which specific pathways need to be blocked to counteract microbial evasion and inflammatory pathology or, conversely, kept intact to promote host immunity...
- Too old to fight? Aging and its toll on innate immunityGeorge Hajishengallis
Oral Health and Systemic Disease, University of Louisville School of Dentistry, 501 South Preston Street, Louisville, KY 40292, USA
Mol Oral Microbiol 25:25-37. 2010....
- Crosstalk pathways between Toll-like receptors and the complement systemGeorge Hajishengallis
University of Louisville School of Dentistry, Division of Oral Health and Systemic Disease, Louisville, KY, USA
Trends Immunol 31:154-63. 2010..Further elucidation of regulatory links between complement and TLRs is essential for understanding their complex roles in health and disease...
- Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?George Hajishengallis
Department of Periodontics Oral Health and Systemic Disease, School of Dentistry, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
Microbes Infect 11:637-45. 2009..The sophisticated stealth and sabotage tactics used by P. gingivalis may additionally benefit co-habiting organisms occupying the same niche...
- Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in miceGeorge Hajishengallis
Department of Periodontics Oral Health and Systemic Disease, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
J Immunol 181:4141-9. 2008..Thus, although TLR2 may mediate destructive effects, as seen in models of experimental periodontitis and atherosclerosis, we have now shown that the same receptor confers protection against P. gingivalis in acute lung infection...
- Complement receptor 3 blockade promotes IL-12-mediated clearance of Porphyromonas gingivalis and negates its virulence in vivoGeorge Hajishengallis
Division of Oral Health and Systemic Disease Department of Periodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
J Immunol 179:2359-67. 2007..Therefore, CR3 blockade may represent a promising immunomodulatory approach for controlling human periodontitis and possibly associated systemic diseases...
- Porphyromonas gingivalis interactions with complement receptor 3 (CR3): innate immunity or immune evasion?George Hajishengallis
Department of Periodontics Endodondics, Division of Oral Health and Systemic Disease, University of Louisville School of Dentistry, Louisville, KY 40292, USA
Front Biosci 12:4547-57. 2007..gingivalis for evading innate immune clearance becomes a plausible hypothesis...
- Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophagesGeorge Hajishengallis
University of Louisville Health Sciences Center, 501 South Preston Street, Room 206, Louisville, KY 40292, USA
Infect Immun 74:5658-66. 2006..gingivalis internalization within macrophages. It therefore appears that P. gingivalis proactively modulates beta2 integrin adhesive activity for intracellular uptake...
- Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatusGeorge Hajishengallis
Center for Oral Health and Systemic Disease and Department of Periodontics Endodontics, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
Cell Microbiol 8:1557-70. 2006..In summary, TLR2 activation by P. gingivalis LPS or fimbriae involves differential dependence on accessory signalling or ligand-binding receptors, which may differentially influence innate immune responses...
- Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complementGeorge Hajishengallis
Department of Microbiology and Immunology, University of Louisville School of Medicine, KY 40292, USA
Cell Host Microbe 10:497-506. 2011..The identification and targeting of similar low-abundance pathogens with community-wide impact may be important for treating inflammatory diseases of polymicrobial etiology...