PETER HAGGIE

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Correctors and Potentiators Rescue Function of the Truncated W1282X-CFTR Translation Product
    Peter M Haggie
    UCSF, United States
    J Biol Chem . 2016
  2. pmc X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis
    Cathleen D Valentine
    Department of Nephrology, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 9:e1003576. 2013
  3. pmc Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis
    Peter M Haggie
    1246 Health Sciences East Tower, Box 0521, Univ of California, San Francisco, San Francisco, CA 94143 0521, USA
    Am J Physiol Lung Cell Mol Physiol 296:L859-67. 2009
  4. pmc Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis
    Peter M Haggie
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:7681-6. 2009
  5. pmc Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging
    Peter M Haggie
    Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    J Biol Chem 283:23510-3. 2008
  6. ncbi request reprint Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras
    Peter M Haggie
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:16419-25. 2002
  7. ncbi request reprint Submucosal gland dysfunction as a primary defect in cystic fibrosis
    Danieli Salinas
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    FASEB J 19:431-3. 2005
  8. ncbi request reprint Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex
    Peter M Haggie
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California San Francisco, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    J Biol Chem 277:40782-8. 2002
  9. pmc Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels
    Songwan Jin
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Biophys J 93:1079-88. 2007
  10. ncbi request reprint Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages
    Peter M Haggie
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 282:31422-8. 2007

Collaborators

  • Walter E Finkbeiner
  • Gergely L Lukacs
  • As Verkman
  • Cathleen D Valentine
  • Jay R Thiagarajah
  • Songwan Jin
  • Stanley W Botchway
  • Danieli Salinas
  • Yuanlin Song
  • Devin K Binder
  • Feroz R Papa
  • Marc O Anderson
  • Kevin M Brindle
  • Simon Peter Williams
  • Rebecca Harmston
  • Dennis W Nielson
  • Ignasi Barba
  • Alexandra M Fulton
  • Kristina Rosbe
  • Randolf Jordan
  • Anthony W Parker
  • Marios C Papadopoulos

Detail Information

Publications15

  1. pmc Correctors and Potentiators Rescue Function of the Truncated W1282X-CFTR Translation Product
    Peter M Haggie
    UCSF, United States
    J Biol Chem . 2016
    ....
  2. pmc X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis
    Cathleen D Valentine
    Department of Nephrology, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Pathog 9:e1003576. 2013
    ..In summary, this study reveals a novel and unconventional role for XBP1s in regulating host cell cytotoxic responses to bacterial acyl homoserine lactones. ..
  3. pmc Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis
    Peter M Haggie
    1246 Health Sciences East Tower, Box 0521, Univ of California, San Francisco, San Francisco, CA 94143 0521, USA
    Am J Physiol Lung Cell Mol Physiol 296:L859-67. 2009
    ..Indeed, there is an expanding body of evidence supporting the involvement of non-CFTR chloride channels in organellar acidification. We conclude that biologically significant involvement of CFTR in organellar acidification is unlikely...
  4. pmc Unimpaired lysosomal acidification in respiratory epithelial cells in cystic fibrosis
    Peter M Haggie
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:7681-6. 2009
    ..As such, alternative mechanisms are needed to explain increased ceramide in CF airways. Non-CFTR mechanisms, such as ClC-type chloride channels, are likely involved in maintaining electroneutrality during organellar acidification...
  5. pmc Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging
    Peter M Haggie
    Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA 94143, USA
    J Biol Chem 283:23510-3. 2008
    ..These results provide direct evidence for monomeric CFTR in live cells...
  6. ncbi request reprint Diffusional mobility of the cystic fibrosis transmembrane conductance regulator mutant, delta F508-CFTR, in the endoplasmic reticulum measured by photobleaching of GFP-CFTR chimeras
    Peter M Haggie
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 277:16419-25. 2002
    ....
  7. ncbi request reprint Submucosal gland dysfunction as a primary defect in cystic fibrosis
    Danieli Salinas
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    FASEB J 19:431-3. 2005
    ..Our results suggest that defective airway submucosal gland function is an early, primary defect in CF. Therapies directed at normalizing gland fluid secretion early in CF may thus reduce lung disease...
  8. ncbi request reprint Diffusion of tricarboxylic acid cycle enzymes in the mitochondrial matrix in vivo. Evidence for restricted mobility of a multienzyme complex
    Peter M Haggie
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California San Francisco, 1246 Health Sciences East Tower, San Francisco, CA 94143 0521, USA
    J Biol Chem 277:40782-8. 2002
    ....
  9. pmc Single-particle tracking of membrane protein diffusion in a potential: simulation, detection, and application to confined diffusion of CFTR Cl- channels
    Songwan Jin
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA
    Biophys J 93:1079-88. 2007
    ..Our data provide the first measurement of actin elasticity, to the best of our knowledge, that does not involve application of an external force...
  10. ncbi request reprint Cystic fibrosis transmembrane conductance regulator-independent phagosomal acidification in macrophages
    Peter M Haggie
    Department of Medicine, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 282:31422-8. 2007
    ....
  11. ncbi request reprint A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways
    Jay R Thiagarajah
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, California, USA
    FASEB J 18:875-7. 2004
    ....
  12. ncbi request reprint Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif
    Peter M Haggie
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, California 94143 0521, USA
    J Biol Chem 279:5494-500. 2004
    ..PDZ-domain interactions of CFTR are thus dynamic and occur on a time scale of seconds or faster...
  13. pmc Tracking of quantum dot-labeled CFTR shows near immobilization by C-terminal PDZ interactions
    Peter M Haggie
    Department of Medicine and Physiology, University of California, San Francisco, San Francisco, CA 94143 0521, USA
    Mol Biol Cell 17:4937-45. 2006
    ..Our data demonstrate remarkable and previously unrecognized immobilization of CFTR in the plasma membrane and provide direct evidence that C-terminal coupling to the actin skeleton via EBP50/ezrin is responsible for its immobility...
  14. ncbi request reprint In vivo measurement of brain extracellular space diffusion by cortical surface photobleaching
    Devin K Binder
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143 0521, USA
    J Neurosci 24:8049-56. 2004
    ....
  15. pmc A novel method for observing proteins in vivo using a small fluorescent label and multiphoton imaging
    Stanley W Botchway
    Central Laser Facility, Rutherford Appleton Laboratory, Chilton, Didcot, Oxfordshire OX11 0QX, UK
    Biochem J 390:787-90. 2005
    ..The method is demonstrated in this paper with images of a labelled protein in yeast cells...