Affiliation: University of Pennsylvania
- Regional differences in the coupling between resting cerebral blood flow and metabolism may indicate action preparedness as a default stateRuben C Gur
Section of Neuropsychiatry, Department of Psychiatry and the Philadelphia Veterans Administration Medical Center, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
Cereb Cortex 19:375-82. 2009..Whether greater left hemispheric hyperperfusion reflects lateral dominance needs further examination...
- Regional structural characterization of the brain of schizophrenia patientsPaul Yushkevich
Department of Radiology, 3600 Market Street, Suite 370, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Acad Radiol 12:1250-61. 2005..We study morphologic characteristics and age-related changes in patients with schizophrenia to investigate whether abnormal neurodevelopment and brain structure have a role in the pathophysiological course of this disease...
- Memory in health and in schizophreniaRuben C Gur
Neuropsychiatry Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA
Dialogues Clin Neurosci 15:399-410. 2013..Impairment in schizophrenia is more severe in patients with negative symptoms-especially flat affect-who also show deficits in measures of social cognition. This evidence implicates medial temporal and frontal regions in schizophrenia. ..
- Age group and sex differences in performance on a computerized neurocognitive battery in children age 8-21Ruben C Gur
Brain Behavior Laboratory, Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA19104, USA
Neuropsychology 26:251-65. 2012..Such information is needed to incorporate behavioral data as neuropsychological "biomarkers" in large-scale genomic studies...
- General and specific responsiveness of the amygdala during explicit emotion recognition in females and malesBirgit Derntl
MR Centre of Excellence, Medical University of Vienna, Lazarettgasse 14, 1090 Vienna, Austria
BMC Neurosci 10:91. 2009..Stimuli were color photographs of emotional Caucasian and African American faces...
- Challenges and opportunities for genomic developmental neuropsychology: examples from the Penn-Drexel collaborative batteryRuben C Gur
Neuropsychiatry Section, Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
Clin Neuropsychol 25:1029-41. 2011..The study illustrates what will hopefully become a major component of the work of clinical and research neuropsychologists as invaluable participants in the dawning age of Big Science neuropsychological genomics...
- A cognitive neuroscience-based computerized battery for efficient measurement of individual differences: standardization and initial construct validationRuben C Gur
Brain Behavior Laboratory, Section of Neuropsychiatry, Department of Psychiatry, Philadelphia, PA 19104 4283, United States
J Neurosci Methods 187:254-62. 2010..These results encourage the use of this battery in studies needing an efficient assessment of major neurocognitive domains such as multi-site genetic studies and clinical trials...
- Identifying sub-populations via unsupervised cluster analysis on multi-edge similarity graphsMadhura Ingalhalikar
Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
Med Image Comput Comput Assist Interv 15:254-61. 2012..The two classes in ASD agree with underlying diagnostic labels with 92% accuracy and the SCZ clustering agrees with 78% accuracy, indicating a greater heterogeneity in the SCZ population...
- Working memory deficits predict short-term smoking resumption following brief abstinenceFreda Patterson
Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, United States
Drug Alcohol Depend 106:61-4. 2010....
- Characterization of brain plasticity in schizophrenia using template deformationAbraham Dubb
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA
Acad Radiol 12:3-9. 2005..Abnormal neurodevelopment may play a role in the pathophysiology of schizophrenia. We used deformation-based morphometry to examine voxel-wise age-related changes in patients with schizophrenia compared with healthy brains...
- Nicotine withdrawal alters neural responses to psychosocial stressRebecca L Ashare
Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, 3535 Market St, Suite 4100, Philadelphia, PA, 19104, USA
Psychopharmacology (Berl) 233:2459-67. 2016..The current study investigated the neural correlates of psychosocial stress during acute nicotine withdrawal in chronic smokers...
- Working memory-related neural activity predicts future smoking relapseJames Loughead
Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Neuropsychopharmacology 40:1311-20. 2015..The combination of abstinence-induced decreases in left DLPFC activation and reduced suppression of PCC may be a prognostic marker for poor outcome, specifically early smoking relapse...
- DTI based diagnostic prediction of a disease via pattern classificationMadhura Ingalhalikar
Section of Biomedical Image Analysis, University of Pennsylvania, Philadelphia, PA, USA
Med Image Comput Comput Assist Interv 13:558-65. 2010..58% classification accuracy was obtained. The abnormality scores clearly separate the groups and the high classification accuracy indicates the prospect of using the scores as a diagnostic and prognostic marker...
- Convergent patterns of association between phenylalanine hydroxylase variants and schizophrenia in four independent samplesMichael E Talkowski
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Am J Med Genet B Neuropsychiatr Genet 150:560-9. 2009..047, OR = 1.46). Our analyses suggest several associations at PAH, with consistent evidence for rs1522305. Further analyses, including additional variations and environmental influences such as phenylalanine exposure are warranted...
- Age-related differences in working memory deficits during nicotine withdrawalMary Falcone
Department of Pharmacology, University of Pennsylvania, Philadelphia, PA, USA Center for Interdisciplinary Research on Nicotine Addiction, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Addict Biol 19:907-17. 2014....
- Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal womenC Neill Epperson
University of Pennsylvania, Department of Psychiatry, USA
Psychoneuroendocrinology 37:372-82. 2012..These results provide preliminary evidence that serotonergic effects directly mediate the impact of estrogen on brain activation during working memory and affective processing...
- Neuroimaging, genetics and the treatment of nicotine addictionRiju Ray
Trandisciplinary Tobacco Use Research Center, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Behav Brain Res 193:159-69. 2008..The purpose of this review is to provide an outline of the work in neuroimaging, genetics, and nicotine dependence, and to explore the potential for increased integration of these approaches to improve nicotine dependence treatment...
- The effects of geometric distortion correction on motion realignment in fMRIMark A Elliott
Department of Radiology, University of Pennsylvania, B1 Stellar Chance Labs, Philadelphia, PA 19104, USA
Acad Radiol 11:1005-10. 2004..This masking, when applied to subsequent images in the fMRI time series, can clip the effects of motion, resulting in inaccurate estimation and correction of motion-based changes in the images...
- Mapping glutamate in subcortical brain structures using high-resolution GluCEST MRIKejia Cai
University of Pennsylvania, Radiology, Philadelphia, PA, USA
NMR Biomed 26:1278-84. 2013..These findings suggest that high-resolution GluCEST MRI of subcortical brain structures may prove to be a useful tool in diagnosis of brain disorders or treatment responses...
- Characterization of sexual dimorphism in the human corpus callosumAbraham Dubb
Department of Bioengineering, Psychiatry, and Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Neuroimage 20:512-9. 2003..Our results demonstrate significant morphologic differences in the corpus callosum between genders and a possible sex difference in the neuro-developmental cycle...
- Adapting Experimental Cognitive and Affective Tasks for SchizophreniaRuben C Gur; Fiscal Year: 2010..We will evaluate a dataset from an existing battery to fine tune available measures and adapt new tasks to augment the battery. ..
- The Neurobiology of Affective Dysfunction in SchizophreniaRuben C Gur; Fiscal Year: 2010..We expect the results to shed light on mechanisms for affective dysfunction in schizophrenia that can lead to improved identification of vulnerability and treatment. ..