Genomes and Genes
Affiliation: University of Minnesota
- A phase II study of the oral VEGF receptor tyrosine kinase inhibitor vatalanib (PTK787/ZK222584) in myelodysplastic syndrome: Cancer and Leukemia Group B study 10105 (Alliance)Pankaj Gupta
University of Minnesota, Minneapolis, MN, USA
Invest New Drugs 31:1311-20. 2013..We examined whether vatalanib induces hematological responses in MDS and/or delays progression to acute myeloid leukemia (AML) or death...
- Impairment of the activity of glycosaminoglycan-binding cytokines by functionally abnormal heparan sulfates: a novel mechanism underlying disease pathophysiologyPankaj Gupta
Veterans Affairs Medical Center, Hematology Oncology Transplantation Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, USA
ScientificWorldJournal 6:452-6. 2006
- Functional abnormalities of heparan sulfate in mucopolysaccharidosis-I are associated with defective biologic activity of FGF-2 on human multipotent progenitor cellsChendong Pan
Associate Professor of Medicine, University of Minnesota Medical School, Hematology Oncology Section 111E, VA Medical Center, One Veterans Dr, Minneapolis, MN 55417
Blood 106:1956-64. 2005..Similar mechanisms may operate in the pathogenesis of other diseases where structurally abnormal GAGs accumulate...
- Intracerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of mucopolysaccharidosis type I (MPS-I)Zhenhong Nan
Department of Neurosurgery, University of Minnesota, Minneapolis, MN 55455, USA
Cell Transplant 21:1577-93. 2012....
- Direct gene transfer to the CNS prevents emergence of neurologic disease in a murine model of mucopolysaccharidosis type IDaniel A Wolf
Department of Genetics, Institute of Human Genetics, University of Minnesota, Minneapolis, MN 55455, USA
Neurobiol Dis 43:123-33. 2011..The results suggest the potential of improved outcome for MPSs and other neurological diseases when a high level of gene expression can be achieved by direct, early administration of vector to the CNS...
- Endogenous heparan sulfate and heparin modulate bone morphogenetic protein-4 signaling and activityShaukat A Khan
Hematology and Oncology Section, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
Am J Physiol Cell Physiol 294:C1387-97. 2008....
- Expression and phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 in B-cell lymphomas and reactive lymphoid tissuesDhatri Kodali
Hematology Oncology Section, Departments of Medicine, Veterans Administration Medical Center, Minneapolis, Minnesota, USA
Arch Pathol Lab Med 135:365-71. 2011..eIF-4F activity is controlled by a repressor binding protein (4E-BP1), which promotes translation when phosphorylated...
- Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon systemElena L Aronovich
Department of Genetics, Cell Biology and Development, Center for Genome Engineering, University of Minnesota, Minneapolis, 55455, USA
Mol Ther 17:1136-44. 2009....
- Elevated granulocyte colony-stimulating factor, non-infectious leukocytosis and fevers in a patient with multiple myelomaMeghan M Sebasky
University of Minnesota Medical Center, Minneapolis, MN, USA
J Gen Intern Med 23:2134-5. 2008..We report the case of a 56-year-old male with multiple myeloma in whom recurrent fevers and leukocytosis delayed potentially effective chemotherapy due to concern for active infection...
- The effects of Gremlin1 on human umbilical cord blood hematopoietic progenitorsLaurie L Shekels
Hematology Oncology Section, Minneapolis VA Health Care System, Minneapolis, MN, USA Hematology Oncology Transplantation Division, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Blood Cells Mol Dis 54:103-9. 2015..These results also suggest that Gremlin1 (and possibly its mimetics that may be developed for therapeutic use) may not adversely affect normal human hematopoietic stem cell survival, though they may reduce their myelopoietic potential...
- Opioid requirement, opioid receptor expression, and clinical outcomes in patients with advanced prostate cancerDylan Zylla
Division of Hematology Oncology Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota Hematology Oncology Section, Department of Medicine, Minneapolis VA Health Care System, Minneapolis, Minnesota
Cancer 119:4103-10. 2013..Although MOR is overexpressed in several human malignancies, the effect of chronic opioid requirement on cancer progression or survival has not been examined in humans...
- Emergence of imatinib resistance associated with downregulation of c-kit expression in recurrent gastrointestinal stromal tumor (GIST): optimal timing of resectionVikas Dudeja
Division of Surgical Oncology, Department of Surgery, Minneapolis VAMC and University of Minnesota, Minneapolis, MN 55455, USA
J Gastrointest Surg 14:557-61. 2010..This favorable response to imatinib, however, is plagued with development of secondary resistance during the course of therapy...
- Adjuvant chemotherapy for stage III colon cancer in the oldest old: results beyond clinical guidelinesAnasooya Abraham
Surgical Outcomes Research Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer 119:395-403. 2013..The generalizability of these studies to a growing elderly population remains unknown...
- "Burned out" testicular seminoma presenting as a primary gastric malignancyHector Mesa
Department of Pathology 113, VA Medical Center, Minneapolis, MN 55417, USA
Int J Clin Oncol 14:74-7. 2009....
- Morphine promotes renal pathology in sickle miceMarc L Weber
Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
Int J Nephrol Renovasc Dis 5:109-18. 2012..These results suggest that clinically relevant doses of morphine induce renal pathology and that OR antagonists may be effective for ameliorating morphine-induced renal disease...
- Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoidsDivyanshoo R Kohli
Vascular Biology Center, Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis 55455, USA
Blood 116:456-65. 2010..Importantly, cannabinoids attenuate pain in mice expressing HbS...
- Characterization of an immunodeficient mouse model of mucopolysaccharidosis type I suitable for preclinical testing of human stem cell and gene therapyMayra F Garcia-Rivera
Department of Neurosurgery, University of Minnesota, Minneapolis, MN, USA
Brain Res Bull 74:429-38. 2007....
- The microenvironment of AFT024 cells maintains primitive human hematopoiesis by counteracting contact mediated inhibition of proliferationMichael Punzel
Department of Medicine, Division of Hematology and Stem Cell Institute, University of Minnesota, Minneapolis, MN, USA
Cell Commun Adhes 9:149-59. 2002..In conclusion, AFT024 cells produce factor(s), that counteract contact induced growth inhibition of primitive human hematopoietic progenitors, leading to expansion of these cells in contact with the microenvironment...
- Effect of systemic heparan sulfate haploinsufficiency on steady state hematopoiesis and engraftment of hematopoietic stem cellsLaurie L Shekels
Hematology Oncology Section, Minneapolis VA Health Care System, Minneapolis, MN, United States Hematology Oncology Transplantation Division, Department of Medicine, University of Minnesota, Minneapolis, MN, United States
Blood Cells Mol Dis 55:3-9. 2015..03). HS deficiency did not re-direct donor engraftment from bone marrow to spleen or liver. Normal HS levels in the stromal microenvironment and HSPC are required for HSPC engraftment following non-myeloablative conditioning...
- Rapid and complete resolution of chemotherapy-induced thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) with rituximabBrett L Gourley
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
Cancer Chemother Pharmacol 65:1001-4. 2010..The purpose of this report is to describe the successful treatment of gemcitabine-induced TTP/HUS with rituximab, a CD20 monoclonal antibody that has been used for the treatment of refractory idiopathic TTP/HUS...
- Prognostication of diffuse large B-cell lymphoma in the rituximab eraMary J Ninan
Division of Hematology, Department of Medicine, University of Minnesota and Hematology Oncology Section, VA Medical Center, Minneapolis, MN 55417, USA
Leuk Lymphoma 52:360-73. 2011....
- Thrombocytosis in myelodysplastic and myelodysplastic/myeloproliferative syndromesDhatri Kodali
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, MN 55417, USA
Leuk Lymphoma 48:2375-80. 2007..03), equivalent risk of transformation to acute myeloid leukemia (AML), and a trend (P = 0.07) towards longer overall survival (median 35.4 months compared to 27.6 months for controls)...
- Mactinin, a fragment of cytoskeletal alpha-actinin, is a novel inducer of heat shock protein (Hsp)-90 mediated monocyte activationSharon D Luikart
Hematology Oncology Section 111E, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
BMC Cell Biol 10:60. 2009..We therefore sought to determine the mechanism by which mactinin stimulates monocytes...
- MDA-7 regulates cell growth and radiosensitivity in vitro of primary (non-established) human glioma cellsAdly Yacoub
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, Virginia 23298 0058, USA
Cancer Biol Ther 3:739-51. 2004....
- Mechanisms of acute myocardial infarction study (MAMIS)Ram B Singh
Medical Hospital and Research Center, Moradabad, India
Biomed Pharmacother 58:S111-5. 2004....
- Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancerLuni Emdad
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Physiol 208:298-306. 2006..The present studies support the use of IR in combination with mda-7/IL-24 as a means of augmenting the therapeutic benefit of this gene in ovarian cancer, particularly in the context of tumors displaying resistance to radiation therapy...
- BiP/GRP78 is an intracellular target for MDA-7/IL-24 induction of cancer-specific apoptosisPankaj Gupta
Department of Pathology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
Cancer Res 66:8182-91. 2006....
- Targeted combinatorial therapy of non-small cell lung carcinoma using a GST-fusion protein of full-length or truncated MDA-7/IL-24 with TarcevaPankaj Gupta
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Cell Physiol 215:827-36. 2008..This approach highlights a potential new combinatorial strategy, which may prove beneficial for NSCLC patients with acquired resistance to EGFR inhibitors...
- Caspase-, cathepsin-, and PERK-dependent regulation of MDA-7/IL-24-induced cell killing in primary human glioma cellsAdly Yacoub
Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
Mol Cancer Ther 7:297-313. 2008....
- Regulation of GST-MDA-7 toxicity in human glioblastoma cells by ERBB1, ERK1/2, PI3K, and JNK1-3 pathway signalingAdly Yacoub
Department of Biochemistry, Virginia Commonwealth University, Richmond, VA 23298 0035, USA
Mol Cancer Ther 7:314-29. 2008....
- MDA-7/IL-24 plus radiation enhance survival in animals with intracranial primary human GBM tumorsAdly Yacoub
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298 0035, USA
Cancer Biol Ther 7:917-33. 2008....
- Identification of an MIP-1alpha -binding heparan sulfate oligosaccharide that supports long-term in vitro maintenance of human LTC-ICsSally E Stringer
Paterson Institute for Cancer Research, Manchester, United Kingdom
Blood 101:2243-5. 2003..This oligosaccharide had the structure required for MIP-1alpha binding, which we have recently described. The present study defines the minimum size and structural features of LTC-IC supportive HS...
- Correction of neural abnormalities in Hurler syndromePankaj Gupta; Fiscal Year: 2003....
- Correction of Hurler syndrome by multipotent stem cellsPankaj Gupta; Fiscal Year: 2007..If MAPC transplantation is of benefit in the Hurler model, similar strategies may be developed for treating diverse neurodegenerative disorders. ..