A A Leslie Gunatilaka

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum
    Bharat P Bashyal
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 68:724-8. 2005
  2. pmc Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence
    A A Leslie Gunatilaka
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, Tucson, 85706 6800, USA
    J Nat Prod 69:509-26. 2006
  3. doi request reprint Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 71:218-22. 2008
  4. pmc Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 75:361-9. 2012
  5. doi request reprint Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii
    Shuhao Wang
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    Chem Biol 15:1328-38. 2008
  6. ncbi request reprint Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159
    Yuquan Xu
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706 6800, USA
    J Nat Prod 70:1467-71. 2007
  7. doi request reprint Structure-activity relationships for withanolides as inducers of the cellular heat-shock response
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706, United States
    J Med Chem 57:2851-63. 2014
  8. pmc Maximizing chemical diversity of fungal metabolites: biogenetically related Heptaketides of the endolichenic fungus Corynespora sp. (1)
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    J Nat Prod 73:1156-9. 2010
  9. pmc Smardaesidins A-G, isopimarane and 20-nor-isopimarane diterpenoids from Smardaea sp., a fungal endophyte of the moss Ceratodon purpureus
    Xiao Ning Wang
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, United States
    J Nat Prod 74:2052-61. 2011
  10. pmc Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus
    Yuquan Xu
    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA
    Appl Environ Microbiol 79:2038-47. 2013

Collaborators

  • A Elizabeth Arnold
  • Jixun Zhan
  • Yuquan Xu
  • Istvan Molnar
  • Luke Whitesell
  • Jana M U'ren
  • James J La Clair
  • Stanley H Faeth
  • Donna D Zhang
  • Wei Zhang
  • Min Lin
  • Song Gao
  • Tong Zhou
  • Susan Lindquist
  • Angela M Hoffman
  • S Patricia Stock
  • Shuhao Wang
  • Brian P Wellensiek
  • Maysa Furlan
  • Jian He
  • E M Kithsiri Wijeratne
  • Bharat P Bashyal
  • Joseph Tillotson
  • Eli Chapman
  • G M Kamal B Gunaherath
  • Manping X Liu
  • Marilyn T Marron
  • Eric C Lau
  • Malkanthi K Gunatilaka
  • Priyani A Paranagama
  • Thomas J Turbyville
  • Damian J Mason
  • Celestina Mesa
  • Jian Guang Luo
  • Fabian de la Cruz
  • Anna M Burns
  • MinJin Kang
  • Shasha Tao
  • Han Wei
  • Tongde Wu
  • Patricia Espinosa-Artiles
  • Min Jin Kang
  • Danilo D Rocha
  • Xiao Ning Wang
  • Guang Xiong Zhou
  • Gisele B Messiano
  • Neil E Jacobsen
  • Harvinder S Saini
  • Catherine A McLellan
  • Henriete S Vieira
  • Anne Fritz
  • Linda C Meade-Tollin
  • Hans D VanEtten
  • Dustin C Sandberg
  • Donna Bigelow
  • Leland S Pierson
  • Angela R Araujo
  • Taoda Shi
  • Vanessa M Chapla
  • MinJing Kang
  • Robert V Brown
  • Jiang guang Luo
  • Nicole Eichhorst
  • Pearce Engelder
  • Sandro Santagata
  • Leticia V Costa-Lotufo
  • Rajesh Ramakrishnan
  • Nafees Ahmad
  • Raphael Gruener
  • Ruth Scherz-Shouval
  • Scott G Franzblau
  • Hongping He
  • Lucia M X Lopes
  • Jeanne E Pemberton
  • Chistopher J Seliga
  • Blanca E Barragán-Huerta
  • Ariel Lebrón-Paler
  • Raina M Maier
  • Vanderlan da S Bolzani
  • Refugio R Vázquez
  • Joaquim Corsino
  • Elizabeth Vierling
  • Arthur Kerschen
  • Christine Queitsch
  • Jacqueline A Takahashi
  • Steven P McLaughlin
  • Christopher J Seliga
  • Maria Amélia D Boaventura
  • Libia A Luevano
  • Cynthia L David

Detail Information

Publications52

  1. ncbi request reprint Globosumones A-C, cytotoxic orsellinic acid esters from the Sonoran desert endophytic fungus Chaetomium globosum
    Bharat P Bashyal
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 68:724-8. 2005
    ..Only globosumones A (1) and B (2) were found to be moderately active...
  2. pmc Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence
    A A Leslie Gunatilaka
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, Tucson, 85706 6800, USA
    J Nat Prod 69:509-26. 2006
    ..Some significant biological and ecological implications of their occurrence are also reviewed...
  3. doi request reprint Sesquiterpene quinones and related metabolites from Phyllosticta spinarum, a fungal strain endophytic in Platycladus orientalis of the Sonoran Desert
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 71:218-22. 2008
    ..When tested in a flow cytometry-based assay, tauranin induced apoptosis in PC-3M and NIH 3T3 cell lines...
  4. pmc Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 75:361-9. 2012
    ....
  5. doi request reprint Functional characterization of the biosynthesis of radicicol, an Hsp90 inhibitor resorcylic acid lactone from Chaetomium chiversii
    Shuhao Wang
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    Chem Biol 15:1328-38. 2008
    ..chiversii radicicol locus yields dechloro-radicicol (monocillin I). Inactivation of a cytochrome P450 epoxidase furnishes pochonin D, a deepoxy-dihydro radicicol analog...
  6. ncbi request reprint Cytotoxic and Antihaptotactic beauvericin analogues from precursor-directed biosynthesis with the insect pathogen Beauveria bassiana ATCC 7159
    Yuquan Xu
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706 6800, USA
    J Nat Prod 70:1467-71. 2007
    ..Replacement of one, two, or all three N-methyl-L-phenylalanine residues of beauvericin with N-methyl-L-3-fluorophenylalanine moieties (beauvericins H(1-3), compounds 5-7) increased cytotoxicity without affecting antihaptotactic activity...
  7. doi request reprint Structure-activity relationships for withanolides as inducers of the cellular heat-shock response
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706, United States
    J Med Chem 57:2851-63. 2014
    ....
  8. pmc Maximizing chemical diversity of fungal metabolites: biogenetically related Heptaketides of the endolichenic fungus Corynespora sp. (1)
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    J Nat Prod 73:1156-9. 2010
    ..The structures of all new compounds were determined by interpretation of their spectroscopic data and chemical interconversions...
  9. pmc Smardaesidins A-G, isopimarane and 20-nor-isopimarane diterpenoids from Smardaea sp., a fungal endophyte of the moss Ceratodon purpureus
    Xiao Ning Wang
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, United States
    J Nat Prod 74:2052-61. 2011
    ..More importantly, sphaeropsidin A (8) showed cell-type selectivity in the cytotoxicity assay and inhibited migration of metastatic breast adenocarcinoma (MDA-MB-231) cells at subcytotoxic concentrations...
  10. pmc Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus
    Yuquan Xu
    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona, USA
    Appl Environ Microbiol 79:2038-47. 2013
    ....
  11. ncbi request reprint Sorbifolivaltrates A-D, diene valepotriates from Valeriana sorbifolia(1)
    Ya ming Xu
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, AZ 85706 6800, USA
    J Nat Prod 70:2045-8. 2007
    ..All compounds exhibited weak to moderate cytotoxicity against the human metastatic prostate cancer cell line, PC-3M...
  12. ncbi request reprint Heptaketides from Corynespora sp. inhabiting the cavern beard lichen, Usnea cavernosa: first report of metabolites of an endolichenic fungus
    Priyani A Paranagama
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 70:1700-5. 2007
    ..Dehydroherbarin (5) inhibited migration of both cell lines at concentrations not toxic to these cell lines. This is the first report of metabolites from an endolichenic fungus...
  13. pmc Search for cell motility and angiogenesis inhibitors with potential anticancer activity: beauvericin and other constituents of two endophytic strains of Fusarium oxysporum
    Jixun Zhan
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706 6800, USA
    J Nat Prod 70:227-32. 2007
    ..Interestingly, 6-deoxybikaverin (7) was completely devoid of activity, suggesting the requirement of the C-6 hydroxy group of bikaverin for its cytotoxic activity...
  14. pmc Withaferin A Analogs That Target the AAA+ Chaperone p97
    Shasha Tao
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, 1703 East Mabel Street, P O Box 210207, Tucson, Arizona 85721, United States
    ACS Chem Biol 10:1916-24. 2015
    ..Through this endeavor, we highlight how the parallel integration of medicinal chemistry with chemical biology offers a potent solution to one of natures' intriguing molecular puzzles. ..
  15. pmc Diversity-oriented combinatorial biosynthesis of benzenediol lactone scaffolds by subunit shuffling of fungal polyketide synthases
    Yuquan Xu
    Biotechnology Research Institute, The Chinese Academy of Agricultural Sciences, Beijing 100081, P R China Natural Products Center, School of Natural Resources and the Environment, University of Arizona, Tucson, AZ 85706
    Proc Natl Acad Sci U S A 111:12354-9. 2014
    ..The success of such a plug and play approach to biosynthesize novel chemical diversity bodes well for bioprospecting unnatural polyketides for drug discovery. ..
  16. doi request reprint Synthesis and biological evaluation of novobiocin analogues as potential heat shock protein 90 inhibitors
    G M Kamal B Gunaherath
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706, United States
    Bioorg Med Chem 21:5118-29. 2013
    ..Our most potent new analogue 19 demonstrated biological activities consistent with known HSP90-binding agents, but with greater potency than NB. ..
  17. ncbi request reprint A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity
    E M Kithsiri Wijeratne
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    Bioorg Med Chem 14:7917-23. 2006
    ....
  18. ncbi request reprint Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii
    Priyani A Paranagama
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, AZ 85706 6800, USA
    J Nat Prod 70:1939-45. 2007
    ..Compounds 1- 7 and 12 were evaluated for their potential to inhibit Hsp90 and antiproliferative activity toward the cancer cell lines NCI-H460, MCF-7, and SF-268. Only compounds 6, 7, and 8 exhibited significant activity in both assays...
  19. pmc Biomimetic conversion of (-)-fusoxypyridone and (-)-oxysporidinone to (-)-sambutoxin: further evidence for the structure of the tricyclic pyridone alkaloid, (-)-fusoxypyridone
    E M Kithsiri Wijeratne
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    Bioorg Med Chem Lett 21:2327-9. 2011
    ..Oxidation of 4 with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) yielded a hitherto unknown sambutoxin analogue, (-)-4,2'-anhydrosambutoxin (5)...
  20. doi request reprint 2,3-Dihydrowithaferin A-3beta-O-sulfate, a new potential prodrug of withaferin A from aeroponically grown Withania somnifera
    Ya ming Xu
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706, USA
    Bioorg Med Chem 17:2210-4. 2009
    ....
  21. pmc Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii
    E M Kithsiri Wijeratne
    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 79:340-52. 2016
    ..Additional biochemical and cellular assays suggested that 2 was a reversible, non-ATP competitive, and specific inhibitor of p97. ..
  22. doi request reprint Selective inhibition of p97 by chlorinated analogues of dehydrocurvularin
    Joseph Tillotson
    College of Pharmacy, Department of Pharmacology and Toxicology, The University of Arizona, Tucson, Arizona 85721, USA
    Org Biomol Chem 14:5918-21. 2016
    ..Interestingly, cellular studies revealed both DHC and its monochloro analogue interfere with both the proteasome and p97, whereas its dichloro analogue showed p97 specificity. ..
  23. pmc Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp
    Han Wei
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706, United States
    Phytochemistry 118:102-8. 2015
    ..Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC50s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity...
  24. pmc Functional chromatographic technique for natural product isolation
    Eric C Lau
    College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721 0207, USA
    Org Biomol Chem 13:2255-9. 2015
    ..We now describe a technique, referred to herein as functional chromatography, that deploys biological affinity as the matrix for compound isolation. ..
  25. pmc Secoemestrin D, a cytotoxic epitetrathiodioxopiperizine, and emericellenes A-E, five sesterterpenoids from Emericella sp. AST0036, a fungal endophyte of Astragalus lentiginosus1
    Ya ming Xu
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 76:2330-6. 2013
    ..More importantly, secoemestrin D (1) exhibited significant cytotoxicity with IC50 values ranging from 0.06 to 0.24 μM and moderate selectivity to human glioma (SF-268) and metastatic breast adenocarcinoma (MDA-MB-231) cell lines. ..
  26. doi request reprint Biosynthesis of the cyclooligomer depsipeptide beauvericin, a virulence factor of the entomopathogenic fungus Beauveria bassiana
    Yuquan Xu
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    Chem Biol 15:898-907. 2008
    ..Comparative infection assays with a BbBEAS knockout B. bassiana strain against three insect hosts revealed that beauvericin plays a highly significant but not indispensable role in virulence...
  27. doi request reprint Microbial transformations of aryltetralone and aryltetralin lignans by Cunninghamella echinulata and Beauveria bassiana
    Gisele B Messiano
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, United States
    J Nat Prod 73:1933-7. 2010
    ..The structures of all new compounds were established by detailed analysis of their spectroscopic data...
  28. pmc Phomapyrrolidones A-C, antitubercular alkaloids from the endophytic fungus Phoma sp. NRRL 46751
    E M Kithsiri Wijeratne
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 76:1860-5. 2013
    ..The planar structures and relative configurations of 1-4 were elucidated by extensive spectroscopic analysis. Phomapyrrolidones B (2) and C (3) exhibited weak antitubercular activity at subcytotoxic concentrations. ..
  29. doi request reprint Combinatorial mutasynthesis of scrambled beauvericins, cyclooligomer depsipeptide cell migration inhibitors from Beauveria bassiana
    Yuquan Xu
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, The University of Arizona, 250 E Valencia Rd, Tucson, AZ 85706 6800, USA
    Chembiochem 10:345-54. 2009
    ..The effects of the introduced structural changes on the antiproliferative and cell migration inhibitory activities of these analogues were evaluated...
  30. ncbi request reprint Zinagrandinolides A-C, cytotoxic delta-elemanolide-type sesquiterpene lactones from Zinnia grandiflora
    Bharat P Bashyal
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    J Nat Prod 69:1820-2. 2006
    ..All compounds exhibited strong cytotoxicity against the cancer cell lines NCI-H460, MCF-7, SF-268, and MIA Pa Ca-2 and the normal human fibroblast cell type WI-38, but none showed significant selectivity...
  31. doi request reprint Microbial metabolism of 1-aminoanthracene by Beauveria bassiana
    Jixun Zhan
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706 6800, USA
    Bioorg Med Chem 16:5085-9. 2008
    ..Formation of these metabolites suggests that the metabolic pathways of 1-aminoanthracene in B. bassiana ATCC 7159 involve acetylation, oxidation, hydroxylation, and O-methylglucosylation...
  32. ncbi request reprint Biomimetic synthesis of xuxuarines Ealpha and Ebeta: structure revision of Rzedowskia bistriterpenoids
    Neil E Jacobsen
    Department of Chemistry, College of Arts and Sciences, The University of Arizona, Tucson, AZ 85721, USA
    Bioorg Med Chem 16:1884-9. 2008
    ..Complete 1H, and 13C NMR spectral assignments of xuxuarines Ealpha and Ebeta have been made by the application of 1D and 2D NMR techniques...
  33. pmc Asperpyrone D and other metabolites of the plant-associated fungal strain Aspergillus tubingensis
    Jixun Zhan
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, AZ 85706 6800, USA
    Phytochemistry 68:368-72. 2007
    ....
  34. doi request reprint 17β-Hydroxy-18-acetoxywithanolides from Aeroponically Grown Physalis crassifolia and Their Potent and Selective Cytotoxicity for Prostate Cancer Cells
    Ya ming Xu
    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 79:821-30. 2016
    ..The cytotoxicity data obtained for 12-15, 17, and 19 have provided additional structure-activity relationship information for the 17β-hydroxy-18-acetoxywithanolides. ..
  35. doi request reprint Anteaglonialides A-F and Palmarumycins CE(1)-CE(3) from Anteaglonium sp. FL0768, a Fungal Endophyte of the Spikemoss Selaginella arenicola
    Ya ming Xu
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 78:2738-47. 2015
    ..4, 0.5, and 1.6 μM, respectively. ..
  36. doi request reprint Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors
    Ya ming Xu
    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706, United States
    J Med Chem 58:6984-93. 2015
    ....
  37. pmc Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert
    Thomas J Turbyville
    SW Center for Natural Products Research and Commercialization, University of Arizona, Tucson, Arizona 85706 6800, USA
    J Nat Prod 69:178-84. 2006
    ..Isolation of radicicol and monocillin I in this study provides evidence that we have developed an effective strategy for discovering natural product-based Hsp90 inhibitors with potential anticancer activity...
  38. pmc Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierrei
    Song Gao
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 74:852-6. 2011
    ..Pierreiones A (1) and B (2) demonstrated solid tumor selectivity with minimal cytotoxicity, while pierreione C (3) exhibited no activity...
  39. ncbi request reprint Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159
    Jixun Zhan
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, Tucson, Arizona 85706 6800, USA
    J Nat Prod 69:1525-7. 2006
    ..The efficiency of these conversions suggests that microbial biotransformation reactions offer an attractive alternative to chemical 4'-O-methyl-glucosylation of amino- and hydroxyanthraquinones...
  40. doi request reprint Montagnuphilones A-G, Azaphilones from Montagnulaceae sp. DM0194, a Fungal Endophyte of Submerged Roots of Persicaria amphibia
    Jian Guang Luo
    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod . 2017
    ..7 macrophage cells. Among these, none were found to be cytotoxic to RAW264.7 cells up to 100.0 μM, but 8, 5, and 2 showed NO inhibitory activity with IC50 values of 9.2 ± 0.9, 25.5 ± 1.1, and 39.6 ± 1.8 μM, respectively...
  41. pmc Altertoxins with potent anti-HIV activity from Alternaria tenuissima QUE1Se, a fungal endophyte of Quercus emoryi
    Bharat P Bashyal
    Southwest Center for Natural Products Research, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706, United States
    Bioorg Med Chem 22:6112-6. 2014
    ..50, 2.20, 0.30, and 1.50 μM, respectively. Our findings suggest that the epoxyperylene structural scaffold in altertoxins may be manipulated to produce potent anti-HIV therapeutics...
  42. pmc Thielavialides A-E, nor-spiro-azaphilones, and a bis-spiro-azaphilone from Thielavia sp. PA0001, an endophytic fungus isolated from aeroponically grown Physalis alkekengi
    E M Kithsiri Wijeratne
    Southwest Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706, United States
    J Nat Prod 77:1467-72. 2014
    ..Possible biosynthetic pathways to thielavialides A-E (1- 5) from pestafolide A (6), some involving a Favorskii-like rearrangement, are proposed. ..
  43. doi request reprint Unusual withanolides from aeroponically grown Withania somnifera
    Ya ming Xu
    SW Center for Natural Products Research and Commercialization, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    Phytochemistry 72:518-22. 2011
    ..Reaction of withaferin A with uracil afforded 1 and its epimer, 3β-(uracil-1-yl)-2,3-dihydrowithaferin A (4). The structures of these compounds were elucidated on the basis of their high resolution mass and NMR spectroscopic data...
  44. pmc Functional chromatography reveals three natural products that target the same protein with distinct mechanisms of action
    Min Jin Kang
    College of Pharmacy, Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85721 0207 USA
    Chembiochem 15:2125-31. 2014
    ..This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high-throughput or phenotypic screening platforms. ..
  45. ncbi request reprint Microbial transformation of curvularin
    Jixun Zhan
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, The University of Arizona, 250 East Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 68:1271-3. 2005
    ..bassiana ATCC 7159 without any added substrate suggested that hydroxylase, glucosyl transferase, and methylase are constitutive enzymes of this organism...
  46. ncbi request reprint Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES
    Linda C Meade-Tollin
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    J Nat Prod 67:2-4. 2004
    ....
  47. ncbi request reprint Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert
    Guang Xiong Zhou
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 67:328-32. 2004
    ..All compounds exhibited weak to moderate cytotoxicity against NCI-H460, MCF-7, and SF-268 cancer cell lines, but none showed significant selectivity...
  48. ncbi request reprint Cytotoxic and other metabolites of Aspergillus inhabiting the rhizosphere of Sonoran desert plants
    Jian He
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 67:1985-91. 2004
    ..Compounds 4 and 5 displayed considerable cytotoxicity, whereas 1, 6, 9, and 14 were found to be moderately active, with 6 and 9 exhibiting selective cytotoxicity against cancer cell lines compared with the normal fibroblast cells...
  49. ncbi request reprint Cytotoxic constituents of Aspergillus terreus from the rhizosphere of Opuntia versicolor of the Sonoran Desert
    E M Kithsiri Wijeratne
    SW Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, Arizona 85706 6800, USA
    J Nat Prod 66:1567-73. 2003
    ..A pathway for the biosynthetic origin of asterredione (1) from asterriquinone D (7) is proposed...
  50. doi request reprint Efficient purification of the biosurfactant viscosin from Pseudomonas libanensis strain M9-3 and its physicochemical and biological properties
    Harvinder S Saini
    Department of Microbiology, Guru Nanak Dev University, Amritsar 143005, Punjab, India
    J Nat Prod 71:1011-5. 2008
    ..Viscosin inhibited migration of the metastatic prostate cancer cell line, PC-3M, without visible toxicity. These properties suggest the potential of viscosin in environmental and biomedical applications...
  51. ncbi request reprint 1H and 13C NMR signal assignments of a novel Baeyer-Villiger originated diterpene lactone
    Henriete S Vieira
    Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Av Antonio Carlos, 6627, CEP 31270 901, Belo Horizonte, MG, Brazil
    Magn Reson Chem 44:146-50. 2006
    ..The complete 1H and 13C NMR assignment is presented for this novel compound that showed discrete in vitro antibacterial activity...
  52. pmc A rhizosphere fungus enhances Arabidopsis thermotolerance through production of an HSP90 inhibitor
    Catherine A McLellan
    FAS Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA
    Plant Physiol 145:174-82. 2007
    ..Finally, cocultivation of P. quadriseptata with Arabidopsis enhanced plant heat stress tolerance. These data demonstrate that HSP90-inhibitory compounds produced by fungi can influence plant growth and responses to the environment...