Genomes and Genes
Matthew R Grimmer
Affiliation: University of California
- Childhood tumors of the nervous system as disorders of normal developmentMatthew R Grimmer
Department of Neurology, University of California, San Francisco, CA 94143, USA
Curr Opin Pediatr 18:634-8. 2006..We provide a detailed discussion of two pediatric neural tumors, medulloblastoma and neuroblastoma, addressing tumorigenic causality and similarities within a pharmacological context...
- Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYCFredrik J Swartling
University of California, Department of Neurology, Brain Tumor Research Center and Helen Diller Family Comprehensive Cancer Center, San Francisco, CA 94158, USA
Cancer Cell 21:601-13. 2012..These differences were regulated in part by the transcription factor SOX9, activated in the SHH subclass of human medulloblastoma. Our results demonstrate context-dependent transformation of NSCs in response to a common oncogenic signal...
- Pleiotropic role for MYCN in medulloblastomaFredrik J Swartling
University of California at San Francisco, San Francisco, California 94158, USA
Genes Dev 24:1059-72. 2010..Targeted expression of MYCN thus contributes to initiation, progression, and maintenance of MB, suggesting a central role for MYCN in pathogenesis...
- BMPs oppose Math1 in cerebellar development and in medulloblastomaMatthew R Grimmer
Department of Neurology, University of California at San Francisco, San Francisco, California 94143, USA
Genes Dev 22:693-9. 2008