Jolanta Grembecka

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Chem Biol 8:277-84. 2012
  2. pmc Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:40690-8. 2010
  3. pmc Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    Aibin Shi
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 120:4461-9. 2012
  4. pmc The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, MI
    Blood 124:3730-7. 2014
  5. doi request reprint Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)
    Dmitry Borkin
    Department of Pathology, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109, United States
    J Med Chem 59:892-913. 2016
  6. pmc Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes
    Jonathan Pollock
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States
    J Med Chem 58:7465-74. 2015
  7. pmc Epigenetic regulation of IL-12-dependent T cell proliferation
    Matthew Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Immunology, Nara Medical University, Nara, Japan and Dermatology Research, Almirall, S A, St Feliu de Llobregat, Spain
    J Leukoc Biol 98:601-13. 2015
  8. pmc Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo
    Dmitry Borkin
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 27:589-602. 2015
  9. pmc Detection of disordered regions in globular proteins using ¹³C-detected NMR
    Felicia L V Gray
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Protein Sci 21:1954-60. 2012
  10. pmc High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction
    Shihan He
    Department of Pathology, University of Michigan, Ann Arbor, 1150 West Medical Center Drive, MSRBI, Room 4510D, Michigan, 48109, United States
    J Med Chem 57:1543-56. 2014

Collaborators

  • Ivan Maillard
  • William F Carson
  • Edyta Dyguda-Kazimierowicz
  • Toshihiro Ito
  • Anastasia K Yocum
  • Dale L Bixby
  • Brad H Nelson
  • Shaun R Stauffer
  • Danielle L Krebs
  • Tomasz Cierpicki
  • Dmitry Borkin
  • Jonathan Pollock
  • Trupta Purohit
  • Marcelo J Murai
  • Shihan He
  • George Lund
  • Hongzhi Miao
  • Matthew Schaller
  • Katarzyna Kempińska
  • Duxin Sun
  • Ting Zhao
  • Bo Wen
  • David S Rogawski
  • Rohit Malik
  • Jay L Hess
  • Andrew G Muntean
  • Steven L Kunkel
  • Ronald M Allen
  • Alexander Sio
  • Nicolai A Kittan
  • Aibin Shi
  • Felicia L V Gray
  • Gireesh Reddy
  • Maksymilian Chruszcz
  • Xiaoqin Li
  • Miao He
  • Shirish Shukla
  • Hyo Je Cho
  • Sergii Dudkin
  • Xiaoju Wang
  • Felix Y Feng
  • Arul M Chinnaiyan
  • Irfan A Asangani
  • Nuria Godessart
  • Jennifer Chase
  • John R Prensner
  • Xiaojun Jing
  • Xuhong Cao
  • Jingya Wang
  • Hongliang Zong
  • Yuanyuan Qiao
  • Amjad P Khan
  • Yashar S Niknafs
  • June Escara-Wilke
  • Juliano Ndoj
  • Moshe Talpaz
  • Pranathi M Krishnamurthy
  • Yali Dou
  • Matthew K Iyer
  • Marcin Cieslik
  • Wendi Ni
  • Lakshmi P Kunju
  • Saravana M Dhanasekaran
  • Gwenn Danet-Desnoyers
  • Nicolai Kittan
  • Xia Jiang
  • Danielle Kroetz
  • Dattatreya Mellacheruvu
  • Karen Cavassani
  • Yi Mi Wu
  • Catherine Ptaschinski
  • Bhavna Malik
  • Alexey I Nesvizhskii
  • Nallasivam Palanisamy
  • Monica L Guzman
  • Morgan Jones
  • Rachell Stender
  • Rocco D Gogliotti
  • Adam Yokom
  • Timothy J Senter
  • Sunil Kumar Upadhyay
  • Craig W Lindsley
  • Changho Han
  • Cory M Hogaboam
  • Kenneth W Harder
  • Abhay Dhaliwal
  • Manreet K Chehal
  • Gabor Jarai
  • Katherine A Gallagher
  • Kevin Tsai

Detail Information

Publications18

  1. pmc Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Chem Biol 8:277-84. 2012
    ..Our findings also highlight a new therapeutic strategy for aggressive leukemias with MLL rearrangements...
  2. pmc Molecular basis of the mixed lineage leukemia-menin interaction: implications for targeting mixed lineage leukemias
    Jolanta Grembecka
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 285:40690-8. 2010
    ....
  3. pmc Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia
    Aibin Shi
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Blood 120:4461-9. 2012
    ....
  4. pmc The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, MI
    Blood 124:3730-7. 2014
    ..Our findings show that the same site on IBD is involved in binding to MLL and HIV-IN, revealing an attractive approach to simultaneously target LEDGF in leukemia and HIV. ..
  5. doi request reprint Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)
    Dmitry Borkin
    Department of Pathology, University of Michigan, 1150 W Medical Center Drive, Ann Arbor, Michigan 48109, United States
    J Med Chem 59:892-913. 2016
    ....
  6. pmc Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes
    Jonathan Pollock
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States
    J Med Chem 58:7465-74. 2015
    ....
  7. pmc Epigenetic regulation of IL-12-dependent T cell proliferation
    Matthew Schaller
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA Department of Immunology, Nara Medical University, Nara, Japan and Dermatology Research, Almirall, S A, St Feliu de Llobregat, Spain
    J Leukoc Biol 98:601-13. 2015
    ..Together, our results demonstrate that the MLL1 gene plays a previously unrecognized but essential role in Th1 cell biology and furthermore, describes a novel pathway through which Mll1 expression is regulated. ..
  8. pmc Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo
    Dmitry Borkin
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Cancer Cell 27:589-602. 2015
    ..Overall, we demonstrate that pharmacologic inhibition of the menin-MLL interaction represents an effective treatment for MLL leukemias in vivo and provide advanced molecular scaffold for clinical lead identification. ..
  9. pmc Detection of disordered regions in globular proteins using ¹³C-detected NMR
    Felicia L V Gray
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Protein Sci 21:1954-60. 2012
    ..Our work provides an efficient way to characterize disordered fragments in globular proteins for structural biology applications...
  10. pmc High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction
    Shihan He
    Department of Pathology, University of Michigan, Ann Arbor, 1150 West Medical Center Drive, MSRBI, Room 4510D, Michigan, 48109, United States
    J Med Chem 57:1543-56. 2014
    ..Our studies provide novel and attractive scaffold as a new potential therapeutic approach for MLL leukemias and demonstrate an example of PPI amenable to inhibition by small molecules. ..
  11. doi request reprint Dysregulated hematopoiesis caused by mammary cancer is associated with epigenetic changes and hox gene expression in hematopoietic cells
    Alexander Sio
    Authors Affiliations Department of Microbiology and Immunology, I3 Research Group, Life Sciences Institute, University of British Columbia, Vancouver Trev and Joyce Deeley Research Centre, British Columbia Cancer Agency, Victoria, British Columbia, Canada and Department of Pathology, University of Michigan, Ann Arbor, Michigan
    Cancer Res 73:5892-904. 2013
    ..Together, our results show that mammary tumor-secreted factors induce profound perturbations in hematopoiesis and expression of key hematopoietic regulatory genes...
  12. pmc Inhibition of CDC25B phosphatase through disruption of protein-protein interaction
    George Lund
    Department of Pathology, University of Michigan, 4510C MSRBI 1150 West Medical Center Drive, Ann Arbor, Michigan 48109 5620, United States
    ACS Chem Biol 10:390-4. 2015
    ....
  13. pmc Crystal structure of menin reveals binding site for mixed lineage leukemia (MLL) protein
    Marcelo J Murai
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 286:31742-8. 2011
    ..It also provides essential structural information for development of inhibitors targeting the menin-MLL interaction as a novel therapeutic strategy in MLL-related leukemias...
  14. pmc Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase
    David S Rogawski
    Department of Pathology, Center for Stem Cell Biology, Life Sciences Institute, Division of Hematology Oncology, Department of Internal Medicine, and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, United States
    Biochemistry 54:5401-13. 2015
    ..Our study illuminates the role of concerted conformational dynamics in ASH1L function and identifies structural features important for ASH1L enzymatic activity. ..
  15. pmc Targeting the MLL complex in castration-resistant prostate cancer
    Rohit Malik
    1 Michigan Center for Translational Pathology, University of Michigan, Ann Arbor, Michigan, USA 2 Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Nat Med 21:344-52. 2015
    ..Taken together, this work identifies the MLL complex as a crucial co-activator of AR and a potential therapeutic target in advanced prostate cancer. ..
  16. pmc Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?
    Tomasz Cierpicki
    Department of Pathology, University of Michigan, Ann Arbor, MI, USA
    Immunol Rev 263:279-301. 2015
    ..Together, our analysis uncovers patterns that should help to advance drug discovery in hematologic malignancies by successful targeting of new PPIs. ..
  17. pmc Challenges and opportunities in targeting the menin-MLL interaction
    Tomasz Cierpicki
    Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA
    Future Med Chem 6:447-62. 2014
    ..This review summarizes the most recent achievements in targeting the menin-MLL interaction as well as discusses potential benefits of blocking menin in cancer. ..
  18. pmc Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes
    Nicolai A Kittan
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 8:e78045. 2013
    ..In addition, we describe a novel role for MLL as marker for classical activation. Our findings provide new insights into MΦ polarization that could be helpful to distinguish MΦ activation states...