Genomes and Genes
Jeffrey P Gregg
Affiliation: University of California
- Molecular analysis of metastasis in a polyomavirus middle T mouse model: the role of osteopontinKatayoun Alavi Jessen
Department of Pathology, University of California, Davis, School of Medicine, Sacramento, California, USA
Breast Cancer Res 6:R157-69. 2004..In order to study metastatic disease, we employed the use of two related polyomavirus middle T transgenic mouse tumor transplant models of mammary carcinoma (termed Met and Db) that display significant differences in metastatic potential...
- Combining mouse mammary gland gene expression and comparative mapping for the identification of candidate genes for QTL of milk production traits in cattleMicha Ron
Department of Quantitative and Molecular Genetics, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
BMC Genomics 8:183. 2007..Thus, gene expression analysis in the mammary gland of genes positioned in the confidence interval of the QTL can bridge the gap between fine mapping and quantitative trait nucleotide (QTN) determination...
- Gene expression changes in children with autismJeffrey P Gregg
Department of Pathology, University of California at Davis Medical Center, Sacramento, CA 95817, USA University of California at Davis, Davis, CA 95616, USA
Genomics 91:22-9. 2008..05). We conclude that the gene expression data support emerging evidence for abnormalities in peripheral blood leukocytes in autism that could represent a genetic and/or environmental predisposition to the disorder...
- Heterogeneity of mammary lesions represent molecular differencesRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California at Davis, Sacramento, CA 95817, USA
BMC Cancer 6:275. 2006..Each MIN-O line has distinguishable morphologies, metastatic potentials and estrogen dependencies...
- Selective estrogen receptor modulators inhibit growth and progression of premalignant lesions in a mouse model of ductal carcinoma in situRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA
Breast Cancer Res 7:R881-9. 2005..We studied the ovarian-hormone-responsiveness of one of the lines with a particular focus on the effects of two related SERMs, tamoxifen and ospemifene...
- Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growthLily Yen
University of California Davis Cancer Center, Sacramento, CA 95817 2305, USA
Cancer Res 66:11279-86. 2006..Our observations suggest that Nrdp1-mediated ErbB3 degradation suppresses cellular growth and motility, and that Nrdp1 loss in breast tumors may promote tumor progression by augmenting ErbB2/ErbB3 signaling...
- Polyomavirus middle T-induced mammary intraepithelial neoplasia outgrowths: single origin, divergent evolution, and multiple outcomesJeannie E Maglione
Department of Medicine, UCSD Cancer Center, School of Medicine, University of California San Diego, La Jolla, CA, USA
Mol Cancer Ther 3:941-53. 2004..These lines provide an opportunity to study the full range of events occurring secondary to PyV-mT expression in the mammary gland...
- Molecular characterization of the transition to malignancy in a genetically engineered mouse-based model of ductal carcinoma in situRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California Davis, Sacramento, California 95817, USA
Mol Cancer Res 2:453-63. 2004..With consistent tumor latency and molecular profiles, this model provides an experimental platform that can be used to assess functional genomics and molecular pharmacology and to test promising chemoprevention strategies...
- Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situRuria Namba
Department of Pathology and Laboratory Medicine, School of Medicine, University of California, Davis, Sacramento, CA 95817, USA
Clin Cancer Res 12:2613-21. 2006..Both of these models were derived from mammary lesions in Tg(MMTV-PyV-mT) mice...
- Genomic profiles for human peripheral blood T cells, B cells, natural killer cells, monocytes, and polymorphonuclear cells: comparisons to ischemic stroke, migraine, and Tourette syndromeXinli Du
MIND Institute, University of California at Davis, 2805 50th Street, Sacramento, CA 95817, USA
Genomics 87:693-703. 2006..These specific gene expression, cell-type-related profiles will need to be confirmed in larger data sets and could be used to study these and many other neurological diseases...
- Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behaviorAlexander D Borowsky
Department of Medical Pathology and Laboratory Medicine, UC Davis School of Medicine, Sacramento, CA 95817, USA
Clin Exp Metastasis 22:47-59. 2005..Therefore, these two cell lines provide a stable, reproducible resource for the study of metastasis modulators, AKT molecular pathway interactions, and gene target and marker discovery...
- Profiling of gene expression changes caused by p53 gain-of-function mutant alleles in prostate cancer cellsClifford G Tepper
Department of Biochemistry and Molecular Medicine, University of California, Davis School of Medicine, Division of Basic Sciences, UC Davis Cancer Center, Sacramento, California 95817, USA
Prostate 65:375-89. 2005..In this study, we performed gene expression profiling of four LNCaP-p53GOF sublines to test the hypothesis that different p53GOF mutants mediated androgen independence via modulation of a common set of genes...
- Correlations between gene expression and mercury levels in blood of boys with and without autismBoryana Stamova
Department of Neurology, University of California at Davis Medical Center, Sacramento, CA 95817, USA
Neurotox Res 19:31-48. 2011..These findings might suggest different genetic transcriptional programs associated with mercury in AU compared to TD children...
- Gene expression in peripheral blood differs after cardioembolic compared with large-vessel atherosclerotic stroke: biomarkers for the etiology of ischemic strokeHuichun Xu
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 28:1320-8. 2008..These results have wide ranging implications for similar disorders...
- Utilization of lymphoblastoid cell lines as a system for the molecular modeling of autismColin A Baron
Department of Pathology and Laboratory Medicine and MIND Institute, University of California Davis, Sacramento, CA 95817, USA
J Autism Dev Disord 36:973-82. 2006..These genes were then used to identify biochemical pathways potentially involved in autism. This study suggests that lymphoblastoid cell lines may be a viable tool for identifying genes associated with autism...
- Genomic and functional profiling of duplicated chromosome 15 cell lines reveal regulatory alterations in UBE3A-associated ubiquitin-proteasome pathway processesColin A Baron
Department of Pathology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
Hum Mol Genet 15:853-69. 2006..This study provides insight into the direct and indirect effects of copy number gains in chromosome 15 and provides a framework for the study of these effects in neuronal systems...
- Correlations of gene expression with blood lead levels in children with autism compared to typically developing controlsYingfang Tian
Department of Neurology, University of California at Davis, Sacramento, CA 95817, USA
Neurotox Res 19:1-13. 2011..We postulate that this may relate to the underlying genetic differences between the two groups, though other explanations cannot be excluded...
- EMT tumorigenesis in the mouse mammary glandPatrizia Damonte
Center for Comparative Medicine, University of California at Davis, Davis, CA 95616, USA
Lab Invest 87:1218-26. 2007..This suggests that potential EMT tumors are best designated EMT-phenotype tumors...
- Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotypeStephen J Libertini
Department of Medical Microbiology and Immunology, University of California, Davis, Davis, California 95616, USA
Cancer Res 65:10700-8. 2005..Our results suggest that cyclin E-dependent deregulation of calpain may be pivotal in modifying multiple cellular processes that are instrumental in the etiology and progression of breast cancer...
- Molecular characterization of uterine fibroids and its implication for underlying mechanisms of pathogenesisPaul J Hoffman
Department of Pathology, University of California, Davis School of Medicine, Sacramento, CA 95817, USA
Fertil Steril 82:639-49. 2004..To identify genes involved in fibroid development by performing global expression profiling on tissues of normal myometrium and uterine leiomyoma origin using Affymetrix HG-U133A GeneChip microarrays...
- Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray studyYang Tang
MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
J Cereb Blood Flow Metab 26:1089-102. 2006..These data provide insights into the inflammatory responses after stroke in humans, and should be helpful in diagnosis, understanding etiology and pathogenesis, and guiding acute treatment and development of new treatments for stroke...
- Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neuronsDa Zhi Liu
Department of Neurology, MIND Institute, Neuroscience and Genetics Graduate Programs, University of California at Davis, Sacramento, California 95817, USA
Neurobiol Dis 30:201-11. 2008..These results are consistent with the hypotheses that Src kinase inhibitors decrease injury produced by ICH by decreasing thrombin activation of Src kinases and, at least in part, by decreasing Src induced cell cycle re-entry...
- In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasiaCraig K Abbey
Department of Biomedical Engineering, University of California, One Shields Avenue, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:11438-43. 2004..Furthermore, quantitative markers of disease extracted from the images can be used to track proliferation and progression in vivo over multiple time points...
- Validation: the new challenge for pathologyRobert D Cardiff
Center for Comparative Medicine, University of California, Davis, Davis, California 95616, USA
Toxicol Pathol 32:31-9. 2004..The phenotypes can be placed into structural and functional clusters with shared characteristics leading to the concepts of Pathway Pathology: tumor phenotype reflects the genotype...
- Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral bloodBoryana S Stamova
Department of Neurology and M, Institute, University of California at Davis Medical Center, Sacramento, CA 95817, USA
BMC Med Genomics 2:49. 2009..These genes should be useful as normalization genes for microarray and RT-PCR whole blood studies of human physiology, metabolism and disease...
- Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytesReuven Rasooly
U S Department of Agriculture USDA Western Human Nutrition Research Center and Nutrition Department, University of California, Davis, CA, 95616, USA
J Immunol 175:7916-29. 2005..Thus, this effect on Bcl2a1 expression may account for the decreased apoptosis seen in naive T lymphocytes treated with RXR agonists...
- High throughput genetic analysis of congenital myasthenic syndromes using resequencing microarraysLisa Denning
Department of Neurology, University of California at Davis, Davis, California, United States of America
PLoS ONE 2:e918. 2007..We describe the performance of a custom resequencing microarray for mutational analysis of Congenital Myasthenic Syndromes (CMSs), a group of disorders in which the normal process of neuromuscular transmission is impaired...
- Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic menKevin Dawson
Center of Excellence in Nutritional Genomics, University of California Davis, Davis, CA 95616, USA
J Nutr Biochem 23:616-21. 2012..These results provide supporting evidence for the anti-inflammatory effects of DHA supplementation, and reveal previously unrecognized genes that are regulated by DHA and are associated with risk factors of cardiovascular diseases...
- Uncoupling of ATP-mediated calcium signaling and dysregulated interleukin-6 secretion in dendritic cells by nanomolar thimerosalSamuel R Goth
National Institute of Environmental Health Sciences Center for Children s Environmental Health, and Department of Veterinary Molecular Biosciences, University of California Davis, Davis, California, USA
Environ Health Perspect 114:1083-91. 2006..DCs are exquisitely sensitive to THI, with one mechanism involving the uncoupling of positive and negative regulation of Ca2+ signals contributed by RyR1...
- Ospemifene inhibits the growth of dimethylbenzanthracene-induced mammary tumors in Sencar miceGregory T Wurz
University of California, Davis, Department of Internal Medicine, Division of Hematology and Oncology, Cancer Center, Sacramento, 95817, USA
J Steroid Biochem Mol Biol 97:230-40. 2005..The results of these two studies suggest that women taking ospemifene for osteoporosis and/or urogenital atrophy may further benefit from ospemifene's breast cancer chemopreventive effects...
- Contributions of mouse biology to breast cancer researchRobert D Cardiff
University of California, Davis, USA
Comp Med 52:12-31. 2002
- Molecular alterations associated with LNCaP cell progression to androgen independenceXu Bao Shi
Department of Urology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA
Prostate 60:257-71. 2004..This is largely due to lack of information about the molecular mechanisms by which androgen-dependent tumor cells progress to androgen independence. In this study, we investigated molecular alterations occurring in AI LNCaP cells...
- Developmental regulation of gene expression and astrocytic processes may explain selective hippocampal vulnerabilityPierre Lavenex
Department of Psychiatry and Behavioral Sciences, UC Davis, Sacramento, California 95817, USA
Hippocampus 21:142-9. 2011....
- Characterization of MUC1 glycoprotein on prostate cancer for selection of targeting moleculesPatricia A Burke
Radiodiagnosis and Therapy, Internal Medicine, University of California at Davis, Sacramento Medical Center, 95816, USA
Int J Oncol 29:49-55. 2006..These results demonstrated that hypoglycosylated MUC1 expression increased with Gleason grade, thus supporting the targeting of hypoglycosylated MUC1 epitopes in prostate cancer for more specific imaging and therapy applications...
- Detecting the C282Y and H63D mutations of the HFE gene by Holliday Junction-based allele-specific genotyping methodsWendy Yang
Panomics, Inc, Redwood City, CA, USA
Clin Chem 51:210-3. 2005
- Allele-specific Holliday junction formation: a new mechanism of allelic discrimination for SNP scoringQinghong Yang
FreshGene, Inc, Concord, California 94520, USA
Genome Res 13:1754-64. 2003..Using this novel genotyping technology, we were able to convert >95% of SNP sequences into genotyping assays that work well under a universal set of assay conditions and achieved 100% accuracy in clinical samples...
- Chemoprevention in a mouse model of DCISJeffrey Gregg; Fiscal Year: 2007..With the potential of improved efficacy and reduced toxicity over current treatment, these studies will make decided progress toward our goal of the complete eradication of preneoplastic breast disease. ..