Leon Grayfer

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogens
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Viruses 4:1075-92. 2012
  2. pmc The amphibian (Xenopus laevis) type I interferon response to frog virus 3: new insight into ranavirus pathogenicity
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Virol 88:5766-77. 2014
  3. pmc Characterization of Frog Virus 3 knockout mutants lacking putative virulence genes
    Francisco De Jesús Andino
    Department of Microbiology and Immunology, University of Rochester Medical Center Rochester, NY 14642, United States
    Virology 485:162-70. 2015
  4. pmc Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs
    Francisco De Jesús Andino
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 432:435-43. 2012
  5. pmc Nonclassical MHC-Restricted Invariant Vα6 T Cells Are Critical for Efficient Early Innate Antiviral Immunity in the Amphibian Xenopus laevis
    Eva Stina Edholm
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642
    J Immunol 195:576-86. 2015
  6. pmc Inflammation-induced reactivation of the ranavirus Frog Virus 3 in asymptomatic Xenopus laevis
    Jacques Robert
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, United States of America
    PLoS ONE 9:e112904. 2014
  7. pmc Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver
    Leon Grayfer
    Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, N Y, USA
    J Innate Immun 5:531-42. 2013
  8. doi request reprint Mechanisms of amphibian macrophage development: characterization of the Xenopus laevis colony-stimulating factor-1 receptor
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, USA
    Int J Dev Biol 58:757-66. 2014
  9. pmc Divergent antiviral roles of amphibian (Xenopus laevis) macrophages elicited by colony-stimulating factor-1 and interleukin-34
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Leukoc Biol 96:1143-53. 2014
  10. pmc Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Virol 89:5072-82. 2015

Collaborators

Detail Information

Publications14

  1. pmc Immune evasion strategies of ranaviruses and innate immune responses to these emerging pathogens
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Viruses 4:1075-92. 2012
    ..This review focuses on the recent advances in the understanding of the RV immune evasion strategies with emphasis on the roles of the innate immune system in ranaviral infections...
  2. pmc The amphibian (Xenopus laevis) type I interferon response to frog virus 3: new insight into ranavirus pathogenicity
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Virol 88:5766-77. 2014
    ....
  3. pmc Characterization of Frog Virus 3 knockout mutants lacking putative virulence genes
    Francisco De Jesús Andino
    Department of Microbiology and Immunology, University of Rochester Medical Center Rochester, NY 14642, United States
    Virology 485:162-70. 2015
    ..Notably, Δ64R-, Δ18K- and ΔvIF-2α- but not Δ52L-FV3 triggered more apoptosis than WT FV3. These data suggest that vCARD (64R) and vβ-HSD (52L) genes contribute to viral pathogenesis. ..
  4. pmc Susceptibility of Xenopus laevis tadpoles to infection by the ranavirus Frog-Virus 3 correlates with a reduced and delayed innate immune response in comparison with adult frogs
    Francisco De Jesús Andino
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Virology 432:435-43. 2012
    ..Furthermore, greater proportions of larval than adult PLs were infected by FV3. Our study suggests that tadpole susceptibility to FV3 infection is partially due to poor virus-elicited innate immune responses...
  5. pmc Nonclassical MHC-Restricted Invariant Vα6 T Cells Are Critical for Efficient Early Innate Antiviral Immunity in the Amphibian Xenopus laevis
    Eva Stina Edholm
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642
    J Immunol 195:576-86. 2015
    ....
  6. pmc Inflammation-induced reactivation of the ranavirus Frog Virus 3 in asymptomatic Xenopus laevis
    Jacques Robert
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, United States of America
    PLoS ONE 9:e112904. 2014
    ....
  7. pmc Colony-stimulating factor-1-responsive macrophage precursors reside in the amphibian (Xenopus laevis) bone marrow rather than the hematopoietic subcapsular liver
    Leon Grayfer
    Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, N Y, USA
    J Innate Immun 5:531-42. 2013
    ..Together, our findings indicate that in contrast to all other vertebrates studied to date, committed Xenopus macrophage precursor populations are not present at the central site of hematopoiesis, but reside in the bone marrow. ..
  8. doi request reprint Mechanisms of amphibian macrophage development: characterization of the Xenopus laevis colony-stimulating factor-1 receptor
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, USA
    Int J Dev Biol 58:757-66. 2014
    ..This work marks a step towards garnering greater understanding of the unique mechanisms governing amphibian macrophage biology...
  9. pmc Divergent antiviral roles of amphibian (Xenopus laevis) macrophages elicited by colony-stimulating factor-1 and interleukin-34
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Leukoc Biol 96:1143-53. 2014
    ..This marks the first report of the disparate roles of CSF-1 and IL-34 in vertebrate antiviral immunity. ..
  10. pmc Prominent amphibian (Xenopus laevis) tadpole type III interferon response to the frog virus 3 ranavirus
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Virol 89:5072-82. 2015
    ..Thus, in contrast to previous assumptions, tadpoles possess intact antiviral defenses reliant on type III IFNs, which are overcome by FV3 pathogens...
  11. pmc Evolution of nonclassical MHC-dependent invariant T cells
    Eva Stina Edholm
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, 14642, USA
    Cell Mol Life Sci 71:4763-80. 2014
    ..Parallels with the mammalian iNKT and MAIT cells underline the crucial biological roles of these evolutionarily ancient immune subsets...
  12. pmc Negative effects of low dose atrazine exposure on the development of effective immunity to FV3 in Xenopus laevis
    Jason Sifkarovski
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, USA
    Dev Comp Immunol 47:52-8. 2014
    ..Thus, even at low doses, atrazine exposure culminates in impaired development of amphibian antiviral defenses...
  13. pmc Distinct functional roles of amphibian (Xenopus laevis) colony-stimulating factor-1- and interleukin-34-derived macrophages
    Leon Grayfer
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    J Leukoc Biol 98:641-9. 2015
    ..This work marks an advance in our understanding of the possible mechanisms governing vertebrate Mϕ functional heterogeneity. ..
  14. pmc Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians
    Eva Stina Edholm
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 110:14342-7. 2013
    ....