Michael Gravett

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Serious and life-threatening pregnancy-related infections: opportunities to reduce the global burden
    Courtney A Gravett
    Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children s Hospital, Seattle, WA, USA
    PLoS Med 9:e1001324. 2012
  2. pmc Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model
    Michael G Gravett
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Am J Obstet Gynecol 197:518.e1-8. 2007
  3. pmc Global report on preterm birth and stillbirth (2 of 7): discovery science
    Michael G Gravett
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
    BMC Pregnancy Childbirth 10:S2. 2010
  4. pmc Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection
    Michael G Gravett
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Proteome Res 6:89-96. 2007
  5. ncbi request reprint Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeys
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Oregon Health Sciences University, Portland, OR 97201, USA
    Am J Obstet Gynecol 188:252-63. 2003
  6. ncbi request reprint Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA
    Am J Obstet Gynecol 195:1578-89. 2006
  7. pmc Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid
    Jane Hitti
    Department of Obstetrics Gynecology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 203:32.e1-8. 2010
  8. ncbi request reprint Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers
    Michael G Gravett
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Ore, USA
    JAMA 292:462-9. 2004
  9. pmc Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys
    Kristina M Adams Waldorf
    University of Washington, Seattle, WA 98195, USA
    Reprod Sci 15:121-7. 2008
  10. doi request reprint Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques
    Miles J Novy
    Divisions of Reproductive Sciences Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Reprod Sci 16:56-70. 2009

Collaborators

Detail Information

Publications21

  1. pmc Serious and life-threatening pregnancy-related infections: opportunities to reduce the global burden
    Courtney A Gravett
    Global Alliance to Prevent Prematurity and Stillbirth, Seattle Children s Hospital, Seattle, WA, USA
    PLoS Med 9:e1001324. 2012
    b>Michael Gravett and colleagues review the burden of pregnancy-related infections, especially in low- and middle-income countries, and offer suggestions for a more effective intervention strategy.
  2. pmc Immunomodulators plus antibiotics delay preterm delivery after experimental intraamniotic infection in a nonhuman primate model
    Michael G Gravett
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA 98195 6460, USA
    Am J Obstet Gynecol 197:518.e1-8. 2007
    ..The purpose of this study was to determine whether treatment with ampicillin together with dexamethasone and indomethacin delays preterm birth that is induced by intraamniotic group B Streptococcus in a nonhuman primate model...
  3. pmc Global report on preterm birth and stillbirth (2 of 7): discovery science
    Michael G Gravett
    Department of Obstetrics and Gynecology, University of Washington School of Medicine, Seattle, WA, USA
    BMC Pregnancy Childbirth 10:S2. 2010
    ..About two-thirds of late fetal deaths occur during the antepartum period; the other third occur during childbirth. Intrapartum asphyxia is a leading cause of stillbirths in low- and middle-income countries...
  4. pmc Proteomic analysis of cervical-vaginal fluid: identification of novel biomarkers for detection of intra-amniotic infection
    Michael G Gravett
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    J Proteome Res 6:89-96. 2007
    ..Protein expression signatures and immunodetection of specific biomarkers identified can be employed for noninvasive detection of IAI...
  5. ncbi request reprint Dexamethasone or interleukin-10 blocks interleukin-1beta-induced uterine contractions in pregnant rhesus monkeys
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon Regional Primate Research Center, Oregon Health Sciences University, Portland, OR 97201, USA
    Am J Obstet Gynecol 188:252-63. 2003
    ..The purpose of this study was to determine whether treatment with the immune modulators dexamethasone or interleukin-10 prevents interleukin-1beta-induced uterine contractions in a nonhuman primate model...
  6. ncbi request reprint Preterm labor is induced by intraamniotic infusions of interleukin-1beta and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model
    Drew W Sadowsky
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, OR, USA
    Am J Obstet Gynecol 195:1578-89. 2006
    ..The purpose of this study was to determine the relative contributions of individual proinflammatory cytokines and chemokines to the triggering of preterm labor...
  7. pmc Noninvasive diagnosis of intraamniotic infection: proteomic biomarkers in vaginal fluid
    Jane Hitti
    Department of Obstetrics Gynecology, University of Washington, Seattle, WA, USA
    Am J Obstet Gynecol 203:32.e1-8. 2010
    ..We analyzed the vaginal fluid proteome to identify biomarkers of intraamniotic infection among women in preterm labor...
  8. ncbi request reprint Diagnosis of intra-amniotic infection by proteomic profiling and identification of novel biomarkers
    Michael G Gravett
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Ore, USA
    JAMA 292:462-9. 2004
    ..Intra-amniotic infection (IAI) is commonly associated with preterm birth and adverse neonatal sequelae. Early diagnosis of IAI, however, has been hindered by insensitive or nonspecific tests...
  9. pmc Pretreatment with toll-like receptor 4 antagonist inhibits lipopolysaccharide-induced preterm uterine contractility, cytokines, and prostaglandins in rhesus monkeys
    Kristina M Adams Waldorf
    University of Washington, Seattle, WA 98195, USA
    Reprod Sci 15:121-7. 2008
    ..05). Toll-like receptor antagonists, together with antibiotics, may delay or prevent infection-associated preterm birth...
  10. doi request reprint Ureaplasma parvum or Mycoplasma hominis as sole pathogens cause chorioamnionitis, preterm delivery, and fetal pneumonia in rhesus macaques
    Miles J Novy
    Divisions of Reproductive Sciences Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Reprod Sci 16:56-70. 2009
    ..U parvum or M hominis, as sole pathogens, elicit a robust proinflammatory response which contributes to preterm labor and fetal lung injury...
  11. ncbi request reprint Detection of intra-amniotic infection in a rabbit model by proteomics-based amniotic fluid analysis
    Laura L Klein
    Department of Obstetrics and Gynecology, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Obstet Gynecol 193:1302-6. 2005
    ..This study was undertaken to identify intra-amniotic infection caused by several different organisms in a rabbit model by using proteomics...
  12. doi request reprint Choriodecidual inflammation: a harbinger of the preterm labor syndrome
    Peta L Grigsby
    Division of Reproductive Sciences, Oregon National Primate Research Center, Beaverton, Oregon 97006, USA
    Reprod Sci 17:85-94. 2010
    ....
  13. pmc Global report on preterm birth and stillbirth (7 of 7): mobilizing resources to accelerate innovative solutions (Global Action Agenda)
    Craig E Rubens
    Global Alliance to Prevent Prematurity and Stillbirth, an initiative of Seattle Children s, Seattle, Washington, USA
    BMC Pregnancy Childbirth 10:S7. 2010
    ..The primary goal of this GAA is to forge a collaborative effort toward achieving common goals to prevent preterm birth and stillbirth, and to improve related maternal, newborn, and child health outcomes...
  14. ncbi request reprint Amniocentesis results and novel proteomic analysis in a case of occult candidal chorioamnionitis
    Julie T Crawford
    Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA
    J Matern Fetal Neonatal Med 19:667-70. 2006
    ..We hypothesize that since amniotic fluid culture of yeast may take days, novel tests such as proteomic profiling may lead to the development of rapid diagnostic tests for fungal intra-amniotic infections...
  15. pmc Global report on preterm birth and stillbirth (6 of 7): ethical considerations
    Maureen Kelley
    Department of Pediatrics, Bioethics Division, University of Washington School of Medicine, Seattle Children s Hospital, Seattle, Washington, USA
    BMC Pregnancy Childbirth 10:S6. 2010
    ..This analysis identifies ethical issues impacting definitions, discovery, development, and delivery of effective interventions to decrease the global burden of preterm birth and stillbirth...
  16. doi request reprint Insights into the multifactorial nature of preterm birth: proteomic profiling of the maternal serum glycoproteome and maternal serum peptidome among women in preterm labor
    Leonardo Pereira
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, OR, USA
    Am J Obstet Gynecol 202:555.e1-10. 2010
    ..The purpose of this study was to identify peptide classifiers that predict spontaneous preterm birth (SPTB) among women in preterm labor (PTL) and to demonstrate specific protein pathways that are activated in PTL...
  17. ncbi request reprint Identification of matrix metalloproteinase-9 in amniotic fluid and amniochorion in spontaneous labor and after experimental intrauterine infection or interleukin-1 beta infusion in pregnant rhesus monkeys
    Felipe Vadillo-Ortega
    Department of Research Direction and Electron Microscopy, Instituto Nacional de Perinatologia, Mexico City, Mexico
    Am J Obstet Gynecol 186:128-38. 2002
    ..The purpose of this study was to examine the roles of intrauterine infection, inflammation, and spontaneous labor on the expression of matrix metalloproteinase-9 in fetal membranes and amniotic fluid of late pregnant rhesus monkeys...
  18. ncbi request reprint Identification of novel protein biomarkers of preterm birth in human cervical-vaginal fluid
    Leonardo Pereira
    Department of Pediatrics and Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Proteome Res 6:1269-76. 2007
    ..Further characterization and quantification of these markers in a larger cohort of subjects may provide the basis for new tests for the early, noninvasive positive prediction of SPTB...
  19. ncbi request reprint Comprehensive proteomic analysis of human cervical-vaginal fluid
    Surendra Dasari
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Proteome Res 6:1258-68. 2007
    ..This data set provides a foundation for evaluation of these proteins as potential CVF biomarkers for noninvasive diagnosis of pregnancy-related disorders...
  20. ncbi request reprint Proteomic analysis of maternal serum in down syndrome: identification of novel protein biomarkers
    Srinivasa R Nagalla
    Department of Pediatrics, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Proteome Res 6:1245-57. 2007
    ..Further characterization and quantification of these markers in a larger cohort of subjects may provide the basis for new tests for improved DS screening...
  21. ncbi request reprint Comprehensive proteomic analysis of the human amniotic fluid proteome: gestational age-dependent changes
    John Edward A Michaels
    ProteoGenix, Inc, Portland, Oregon 97213, USA
    J Proteome Res 6:1277-85. 2007
    ..A systematic analysis of proteins present both in AF and maternal serum could lead to the development of new noninvasive diagnostic procedures to monitor fetal status...