D T Graves
Affiliation: University of Pennsylvania
- Animal models to study host-bacteria interactions involved in periodontitisDana T Graves
Department of Periodontics, University of Pennsylvania, Philadelphia, PA, USA
Front Oral Biol 15:117-32. 2012..Thus, each of the models described below can be adapted to test discrete components of the pathological process of periodontal disease, but not necessarily all of them...
- Role of forkhead transcription factors in diabetes-induced oxidative stressBhaskar Ponugoti
School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6030, USA
Exp Diabetes Res 2012:939751. 2012..They are induced by oxidative stress and contribute to ROS-induced cell damage and apoptosis. In this paper, we discuss the role of FOXO transcription factors in mediating oxidative stress-induced cellular response...
- Effect of bacteria on the wound healing behavior of oral epithelial cellsRupa Bhattacharya
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 9:e89475. 2014..05) that are critical for GI/S transition. Further, genes associated with cell migration such as integrin beta-3 and -6 were significantly downregulated by P. gingivalis (p<0.05)...
- P. gingivalis modulates keratinocytes through FOXO transcription factorsShuai Li
Department of Implant Dentistry, Peking University, School and Hospital of Stomatology, Beijing, China Departments of Pathology and Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS ONE 8:e78541. 2013..In addition, a new function for FOXO1 was identified, that of suppressing TLR-2 and TLR-4 and maintaining integrin beta -1, beta -3 and beta -6 basal mRNA levels in keratinocytes. ..
- Abnormal cell responses and role of TNF-α in impaired diabetic wound healingFanxing Xu
School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
Biomed Res Int 2013:754802. 2013..Diabetes-enhanced and prolonged expression of TNF- α also contributes to impaired healing. In this paper, we discuss the abnormal cell responses in diabetic wound healing and the contribution of TNF- α ...
- Diabetes aggravates periodontitis by limiting repair through enhanced inflammationSandra Pacios
Department of Periodontics, University of Pennsylvania, 240 S 40th St, Levy 122, Philadelphia, PA 19104, USA
FASEB J 26:1423-30. 2012..Thus, diabetes prolongs inflammation and osteoclastogenesis in periodontitis and through TNF limits the normal reparative process by negatively modulating factors that regulate bone...
- Inflammation and uncoupling as mechanisms of periodontal bone lossD T Graves
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, USA
J Dent Res 90:143-53. 2011....
- Clinical, radiographic and biochemical assessment of IL-1/TNF-alpha antagonist inhibition of bone loss in experimental periodontitisT W Oates
Department of Periodontics, University of Texas Health Science Center at San Antonio, TX 78229, USA
J Clin Periodontol 29:137-43. 2002....
- Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease SusceptibilityY Wu
State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Dent Res 95:460-6. 2016..gingivalis colonization following inoculation and increased periodontal disease susceptibility, reflected by higher TNF levels and osteoclast numbers in the periodontium of aged versus young mice. ..
- Gene expression dynamics during diabetic periodontitisO M Andriankaja
Department of Periodontics, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Dent Res 91:1160-5. 2012....
- Altered fibroblast proliferation and apoptosis in diabetic gingival woundsT Desta
Department of Periodontics, NJDS UMDNJ, 110 Bergen Street, Newark, NJ 07101 1709, USA
J Dent Res 89:609-14. 2010..05). The results suggest that diabetes may decrease fibroblast numbers through increased apoptosis and reduced proliferation, both of which may be mediated through increased activation of FOXO1...