Paula Grammas

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Microvessels from Alzheimer's disease brains kill neurons in vitro
    P Grammas
    Department of Pathology, The Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Am J Pathol 154:337-42. 1999
  2. ncbi request reprint Retinal endothelial cells are more susceptible to oxidative stress and increased permeability than brain-derived endothelial cells
    Paula Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Microvasc Res 65:18-23. 2003
  3. ncbi request reprint Injured brain endothelial cells release neurotoxic thrombin
    Paula Grammas
    Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    J Alzheimers Dis 6:275-81. 2004
  4. ncbi request reprint A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    P Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA
    Neurobiol Aging 21:199-205. 2000
  5. ncbi request reprint Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    P Grammas
    Department of Pathology, University of Oklahoma Health Sciences Center, 975 N E 10th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 22:837-42. 2001
  6. ncbi request reprint The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice
    Melinda West
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 91:133-43. 2004
  7. ncbi request reprint CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers
    Taunia D Lee
    Department of Pathology, University of Oklahoma Health Sciences Center, P O Box 26901, BMSB 434, Oklahoma City, OK 73190, USA
    Microvasc Res 66:38-48. 2003
  8. ncbi request reprint Functional modulation of smooth muscle cells by the inflammatory mediator CAP37
    Melva L Gonzalez
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Microvasc Res 67:168-81. 2004
  9. ncbi request reprint Vascular inflammatory, oxidative and protease-based processes: implications for neuronal cell death in Alzheimer's disease
    Alexander Christov
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Neurol Res 26:540-6. 2004
  10. ncbi request reprint Anti-inflammatory effects of tocopherol metabolites
    Paula Grammas
    Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Biochem Biophys Res Commun 319:1047-52. 2004

Collaborators

Detail Information

Publications33

  1. pmc Microvessels from Alzheimer's disease brains kill neurons in vitro
    P Grammas
    Department of Pathology, The Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Am J Pathol 154:337-42. 1999
    ..The neurotoxic factor is soluble and likely a protein, because its activity is heat labile and trypsin sensitive. These findings implicate a novel mechanism of vascular-mediated neuronal cell death in Alzheimer's disease...
  2. ncbi request reprint Retinal endothelial cells are more susceptible to oxidative stress and increased permeability than brain-derived endothelial cells
    Paula Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Microvasc Res 65:18-23. 2003
    ..These findings suggest that greater oxidative stress and lower junctional protein levels in retinal endothelial cells may contribute to blood/retinal barrier dysfunction in diabetic retinopathy...
  3. ncbi request reprint Injured brain endothelial cells release neurotoxic thrombin
    Paula Grammas
    Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    J Alzheimers Dis 6:275-81. 2004
    ..These data demonstrate that endothelial cell injury results in thrombin release and suggest that the brain microcirculation could be a source of neurotoxic factors in AD...
  4. ncbi request reprint A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
    P Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK, 73104, USA
    Neurobiol Aging 21:199-205. 2000
    ....
  5. ncbi request reprint Inflammatory factors are elevated in brain microvessels in Alzheimer's disease
    P Grammas
    Department of Pathology, University of Oklahoma Health Sciences Center, 975 N E 10th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 22:837-42. 2001
    ..These results suggest that the cerebral microcirculation contributes inflammatory mediators to the milieu of the AD brain and may be involved in the pathogenesis of neuronal injury and death in this disorder...
  6. ncbi request reprint The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice
    Melinda West
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 91:133-43. 2004
    ..Thus, TNFalpha antagonists and especially 5LOX inhibitors might offer new opportunities for treatment of ALS...
  7. ncbi request reprint CAP37, a neutrophil-derived inflammatory mediator, augments leukocyte adhesion to endothelial monolayers
    Taunia D Lee
    Department of Pathology, University of Oklahoma Health Sciences Center, P O Box 26901, BMSB 434, Oklahoma City, OK 73190, USA
    Microvasc Res 66:38-48. 2003
    ..The cell-specific kinetics of adhesion molecule upregulation by CAP37 may influence selective leukocyte migration in certain inflammatory situations...
  8. ncbi request reprint Functional modulation of smooth muscle cells by the inflammatory mediator CAP37
    Melva L Gonzalez
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Microvasc Res 67:168-81. 2004
    ..We suggest that due to its localization to atherosclerotic plaques and its ability to modulate smooth muscle cells, CAP37 may play a role in the progression of this disease...
  9. ncbi request reprint Vascular inflammatory, oxidative and protease-based processes: implications for neuronal cell death in Alzheimer's disease
    Alexander Christov
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK, USA
    Neurol Res 26:540-6. 2004
    ....
  10. ncbi request reprint Anti-inflammatory effects of tocopherol metabolites
    Paula Grammas
    Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Biochem Biophys Res Commun 319:1047-52. 2004
    ..These results show that the anti-inflammatory effects of tocopherols are highly cell type-, stimulus-, and endpoint-dependent...
  11. pmc Chronic thrombin exposure results in an increase in apolipoprotein-E levels
    Molina Mhatre
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, 73104, USA
    J Neurosci Res 84:444-9. 2006
    ..These findings suggest that thrombin released during brain injury may contribute to an increase in apolipoprotein-E levels. Such increase in Apolipoprotein-E4 isoform facilitates beta-amyloid deposition and cognitive deficits...
  12. pmc Cerebrovascular transforming growth factor-beta contributes to inflammation in the Alzheimer's disease brain
    Paula Grammas
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Am J Pathol 160:1583-7. 2002
    ..Our results suggest that vessel-derived TGF-beta contributes to inflammatory processes in the Alzheimer brain...
  13. ncbi request reprint Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Dis 14:74-80. 2003
    ..Our data support a model wherein TNFalpha acts as a principal driver for neuroinflammation, while several co-stimulating cytokines and chemokines act to potentiate the TNFalpha effects...
  14. ncbi request reprint Oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells
    Ladan Hamdheydari
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    Biochem Biophys Res Commun 311:486-90. 2003
    ..01). These data demonstrate that oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells and could contribute to cerebrovascular dysfunction in Alzheimer's disease...
  15. ncbi request reprint Thrombin, a mediator of neurotoxicity and memory impairment
    Molina Mhatre
    Department of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 25:783-93. 2004
    ..These findings demonstrate that thrombin is a mediator of neurotoxicity and cognitive deficits and suggest that inhibition of thrombin may be a treatment strategy for AD- or head trauma-associated cognitive deficits...
  16. pmc CAP37, a novel inflammatory mediator: its expression in endothelial cells and localization to atherosclerotic lesions
    Taunia D Lee
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Am J Pathol 160:841-8. 2002
    ..We suggest that, because of its induction and location in the endothelium and its known monocyte- and endothelial-activating capabilities, CAP37 has potential to modulate monocyte/endothelial dynamics at the vessel wall in inflammation...
  17. ncbi request reprint New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Reserach Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 36:1-15. 2004
    ..The data argue for thorough experimental and epidemiological reappraisal of desmethyl tocopherols, especially within the contexts of cardiovascular disease and cancer biology...
  18. ncbi request reprint HIV-1 gp120 proteins and gp160 peptides are toxic to brain endothelial cells and neurons: possible pathway for HIV entry into the brain and HIV-associated dementia
    Georgette D Kanmogne
    Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City 73104, USA
    J Neuropathol Exp Neurol 61:992-1000. 2002
    ..This study suggests that HIV proteins and peptides that are shed in vivo may be directly involved in blood-brain barrier damage and neuronal cell death in HIV-associated dementia...
  19. ncbi request reprint Transcriptional and posttranscriptional regulation of angiopoietin-2 expression mediated by IGF and PDGF in vascular smooth muscle cells
    Eric D Phelps
    Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Am J Physiol Cell Physiol 290:C352-61. 2006
    ..These findings demonstrate that VSMCs adjust Ang2 expression through multiple mechanisms, including changes in transcription as well as posttranscriptional mRNA destabilization...
  20. ncbi request reprint Is HIV involved in the pathogenesis of non-infectious pulmonary complications in infected patients?
    Georgette D Kanmogne
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Curr HIV Res 1:385-93. 2003
    ..The possible role that HIV plays in the pathogenesis of these pulmonary disorders is also addressed...
  21. ncbi request reprint VEGF and VEGF receptor levels in retinal and brain-derived endothelial cells
    Talitha T Rajah
    Department of Pathology and the Oklahoma Center for Neuroscience, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Biochem Biophys Res Commun 293:710-3. 2002
    ..The higher level of VEGF receptor expression in retinal endothelial cells suggests that the retinal microcirculation may be more sensitive to the effects of VEGF and this may contribute to the pathogenesis of diabetic retinopathy...
  22. ncbi request reprint Infection of baboon microglia with SIV-HIV recombinant viruses: role of CD4 and chemokine receptors
    Georgette D Kanmogne
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    AIDS Res Hum Retroviruses 18:557-65. 2002
    ..This study demonstrating the feasibility of infecting baboon microglia with SHIV isolates is an important first step in using the baboon as an alternative nonhuman primate model to study HIV neuropathogenesis...
  23. ncbi request reprint The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain
    Kelly S Williamson
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Nitric Oxide 6:221-7. 2002
    ..The findings are discussed in reference to the neuroinflammatory hypothesis of AD and the possible role of gamma-tocopherol as a major lipid-phase scavenger of reactive nitrogen species...
  24. ncbi request reprint Expression of macrophage inflammatory protein 1-alpha is elevated in Alzheimer's vessels and is regulated by oxidative stress
    Debjani Tripathy
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX, USA
    J Alzheimers Dis 11:447-55. 2007
    ..These results suggest that oxidative and lipid insults to the brain microvasculature are likely to contribute to the inflammatory milieu of the AD brain...
  25. ncbi request reprint Cyclin D1, cdk4, and Bim are involved in thrombin-induced apoptosis in cultured cortical neurons
    Haripriya Vittal Rao
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Neurochem 101:498-505. 2007
    ..Thus, cell cycle proteins could be therapeutic targets in diseases such as AD where thrombin has been implicated...
  26. ncbi request reprint Angiogenic proteins are expressed by brain blood vessels in Alzheimer's disease
    Lakshmi Thirumangalakudi
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 10:111-8. 2006
    ....
  27. ncbi request reprint Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis
    Paula Grammas
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Alzheimers Dis 9:51-8. 2006
    ..These data suggest that in AD the cerebral microcirculation is a source of neurotoxic and inflammatory mediators and as such contributory to pathologic processes ongoing in the AD brain...
  28. ncbi request reprint HIV-1 gp120 proteins alter tight junction protein expression and brain endothelial cell permeability: implications for the pathogenesis of HIV-associated dementia
    Georgette D Kanmogne
    Department of Pharmacology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neuropathol Exp Neurol 64:498-505. 2005
    ....
  29. ncbi request reprint The involvement of epoxygenase metabolites of arachidonic acid in cAMP-stimulated steroidogenesis and steroidogenic acute regulatory protein gene expression
    XingJia Wang
    Department of Neuropsychiatry, Garrison Institute on Aging, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA
    J Endocrinol 190:871-8. 2006
    ..This study suggests that cAMP stimulation of MA-10 cells increases epoxygenase-generated AA metabolites and the co-action of these metabolites with PKA significantly increases StAR gene expression and steroid hormone production...
  30. ncbi request reprint Induction of apoptosis and endothelin-1 secretion in primary human lung endothelial cells by HIV-1 gp120 proteins
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    Biochem Biophys Res Commun 333:1107-15. 2005
    ..These data suggest that secreted HIV gp120 proteins induce lung endothelial cell injury and could contribute to the development of HIV-associated pulmonary hypertension...
  31. ncbi request reprint IL-8 induces expression of matrix metalloproteinases, cell cycle and pro-apoptotic proteins, and cell death in cultured neurons
    Lakshmi Thirumangalakudi
    Garrison Institute on Aging and Department of Neuropsychiatry and Behavioral Sciences, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    J Alzheimers Dis 11:305-11. 2007
    ..These results suggest that IL-8 could be an important mediator of neuronal death in AD both via its effects on release of neurotoxins such as MMPs as well as by induction of cell cycle and pro-apoptotic proteins...
  32. pmc Inhibition of thromboxane a synthase activity enhances steroidogenesis and steroidogenic acute regulatory gene expression in MA-10 mouse Leydig cells
    XingJia Wang
    Garrison Institute on Aging, Department of Neuropsychiatry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA
    Endocrinology 149:851-7. 2008
    ....
  33. ncbi request reprint Structural changes in Alzheimer's disease brain microvessels
    Alexander Christov
    Garrison Institute on Aging, Texas Tech University Health Sciences Center, 3601 4th Street Stop 9424, Lubbock, Texas 79430, USA
    Curr Alzheimer Res 5:392-5. 2008
    ..These data demonstrate that changes in the amount and type of collagen occur in AD brain and suggest that cerebral vessel injury is part of AD pathology...