Affiliation: University of California
- B cell exchange across the blood-brain barrier in multiple sclerosisH Christian von Büdingen
Department of Neurology, UCSF, San Francisco, California 94158, USA
J Clin Invest 122:4533-43. 2012..These data also provide a powerful approach to identify and monitor B cells in the PB that correspond to clonally amplified populations in the CNS in MS and other inflammatory states...
- Conformational epitopes of myelin oligodendrocyte glycoprotein are targets of potentially pathogenic antibody responses in multiple sclerosisTil Menge
Neuroimmunology Laboratories, Department of Neurology, University of California San Francisco, CA, USA
J Neuroinflammation 8:161. 2011..Because epitope specificity may be a key factor determining anti-MOG reactivity we aimed at identifying a priori immunodominant MOG epitopes by monoclonal antibodies (mAbs) and at assessing clinical relevance of these epitopes in MS...
- Clonally expanded plasma cells in the cerebrospinal fluid of patients with central nervous system autoimmune demyelination produce "oligoclonal bands"Hans Christian von Büdingen
Dept of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, 8091 Zurich, Switzerland
J Neuroimmunol 218:134-9. 2010..We expand these findings by applying anti-idiotypic antibodies to detect specific heavy chain CDR3 idiotopes of cePC-produced antibodies amongst OCB in the CSF of a patient each with MS and acute disseminated encephalomyelitis...
- Clonally expanded plasma cells in the cerebrospinal fluid of MS patients produce myelin-specific antibodiesHans Christian von Büdingen
Clinical Neuroimmunology Unit, Department of Neurology, University Hospital Zurich, Zurich, Switzerland
Eur J Immunol 38:2014-23. 2008..Our findings provide conclusive evidence for the presence of an antigen-driven B cell response in the CSF of MS patients directed against epitopes present in areas of myelin degradation...
- Live imaging of remyelination after antibody-mediated demyelination in an ex-vivo model for immune mediated CNS damageMelanie D Harrer
University Hospital Zurich, Department of Neurology, Neuroimmunology Unit, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
Exp Neurol 216:431-8. 2009....
- Pathogen specificity and autoimmunity are distinct features of antigen-driven immune responses in neuroborreliosisSandra Kuenzle
Clinical Neuroimmunology Unit, Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, CH 8091 Zurich, Switzerland
Infect Immun 75:3842-7. 2007..Our findings indicate that in NB mechanisms may be at play that induce distinct immune responses specific for pathogen and self antigens independent from "molecular mimicry."..