Carey E Gleason

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Common Sense Model Factors Affecting African Americans' Willingness to Consult a Healthcare Provider Regarding Symptoms of Mild Cognitive Impairment
    Carey E Gleason
    Wisconsin Alzheimer s Disease Research Center, Madison, WI Division of Geriatrics, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, WI Electronic address
    Am J Geriatr Psychiatry 24:537-46. 2016
  2. pmc Using predictors of hormone therapy use to model the healthy user bias: how does healthy user status influence cognitive effects of hormone therapy?
    Carey E Gleason
    Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI, USA
    Menopause 19:524-33. 2012
  3. pmc A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    Age Ageing 38:86-93. 2009
  4. pmc Increased risk for falling associated with subtle cognitive impairment: secondary analysis of a randomized clinical trial
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    Dement Geriatr Cogn Disord 27:557-63. 2009
  5. pmc Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation
    C E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave, Suite 106, Madison, WI 53705, USA
    Neurology 67:2039-41. 2006
  6. ncbi request reprint Clinical pharmacology and differential cognitive efficacy of estrogen preparations
    Carey E Gleason
    Department of Medicine, University of Wisconsin Medical School, and Geriatric Research, Education and Clinical Center GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Ann N Y Acad Sci 1052:93-115. 2005
  7. ncbi request reprint Neuroprotective effects of female sex steroids in humans: current controversies and future directions
    C E Gleason
    Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    Cell Mol Life Sci 62:299-312. 2005
  8. pmc Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment
    Feng Lin
    School of Nursing, Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    Dement Geriatr Cogn Disord 30:83-92. 2010
  9. pmc Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial
    Whitney Wharton
    University of Wisconsin, School of Medicine and Public Health, William S Middleton Memorial VA Hospital, 2500 Overlook Terrace, GRECC11G Madison, WI 53705, USA
    J Alzheimers Dis 26:495-505. 2011
  10. ncbi request reprint Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 13:187-97. 2008

Research Grants

Collaborators

Detail Information

Publications35

  1. pmc Common Sense Model Factors Affecting African Americans' Willingness to Consult a Healthcare Provider Regarding Symptoms of Mild Cognitive Impairment
    Carey E Gleason
    Wisconsin Alzheimer s Disease Research Center, Madison, WI Division of Geriatrics, Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, WI Electronic address
    Am J Geriatr Psychiatry 24:537-46. 2016
    ..Using the common sense model (CSM) of illness perception, we sought to clarify processes promoting timely diagnosis of mild cognitive impairment (MCI) for African American patients...
  2. pmc Using predictors of hormone therapy use to model the healthy user bias: how does healthy user status influence cognitive effects of hormone therapy?
    Carey E Gleason
    Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI, USA
    Menopause 19:524-33. 2012
    ..This study investigated the phenomenon known as the healthy user bias by equating hormone therapy (HT) use (past or current) with healthy user status...
  3. pmc A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    Age Ageing 38:86-93. 2009
    ..Unfortunately, few studies enrolled adults over the age of 70, and none included older men...
  4. pmc Increased risk for falling associated with subtle cognitive impairment: secondary analysis of a randomized clinical trial
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    Dement Geriatr Cogn Disord 27:557-63. 2009
    ..This study sought to clarify the relationship between subtle cognitive impairment, measured with a widely-used, clinic-based assessment, the Mini Mental State Exam (MMSE), and risk for falls...
  5. pmc Hormone effects on fMRI and cognitive measures of encoding: importance of hormone preparation
    C E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, 2870 University Ave, Suite 106, Madison, WI 53705, USA
    Neurology 67:2039-41. 2006
    ..These preliminary findings emphasize the need to characterize differential neural effects of various HTs...
  6. ncbi request reprint Clinical pharmacology and differential cognitive efficacy of estrogen preparations
    Carey E Gleason
    Department of Medicine, University of Wisconsin Medical School, and Geriatric Research, Education and Clinical Center GRECC, William S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Ann N Y Acad Sci 1052:93-115. 2005
    ....
  7. ncbi request reprint Neuroprotective effects of female sex steroids in humans: current controversies and future directions
    C E Gleason
    Wm S Middleton Memorial Veterans Hospital, Madison, Wisconsin 53705, USA
    Cell Mol Life Sci 62:299-312. 2005
    ..Further, the paper briefly discusses variables that may account for the unexpected findings of WHIMS, and offers suggestions for future research...
  8. pmc Awareness of memory abilities in community-dwelling older adults with suspected dementia and mild cognitive impairment
    Feng Lin
    School of Nursing, Department of Medicine, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    Dement Geriatr Cogn Disord 30:83-92. 2010
    ....
  9. pmc Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial
    Whitney Wharton
    University of Wisconsin, School of Medicine and Public Health, William S Middleton Memorial VA Hospital, 2500 Overlook Terrace, GRECC11G Madison, WI 53705, USA
    J Alzheimers Dis 26:495-505. 2011
    ..Moreover, treatment-related changes in plasma estradiol were positively correlated with improvements in visual memory. Short-term HT that includes the use of estradiol has favorable effects on cognition in women with AD...
  10. ncbi request reprint Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 13:187-97. 2008
    ..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD...
  11. pmc Magnetic resonance imaging characterization of brain structure and function in mild cognitive impairment: a review
    Michele L Ries
    William S Middleton Memorial Veterans Hospital Geriatric Research Education and Clinical Center, Madison, Wisconsin 53705, USA
    J Am Geriatr Soc 56:920-34. 2008
    ..Third, we will make recommendations regarding the current clinical use of MRI in identification of MCI. As a conclusion, we will look to the future of neuroimaging as a tool in early AD detection...
  12. pmc Cognitive benefits of hormone therapy: cardiovascular factors and healthy-user bias
    Whitney Wharton
    School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA
    Maturitas 64:182-7. 2009
    ..The present observational, community-based, case-controlled study examined the 'healthy-user' bias theory by comparing cognitive task performance in two groups of postmenopausal women, who were either HT users or non-users...
  13. pmc Effect of Alzheimer disease risk on brain function during self-appraisal in healthy middle-aged adults
    Sterling C Johnson
    Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Arch Gen Psychiatry 64:1163-71. 2007
    ....
  14. pmc Insulin Resistance is Associated with Increased Levels of Cerebrospinal Fluid Biomarkers of Alzheimer's Disease and Reduced Memory Function in At-Risk Healthy Middle-Aged Adults
    Siobhan M Hoscheidt
    Wisconsin Alzheimer s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Alzheimers Dis 52:1373-83. 2016
    ..The relationship between insulin resistance (IR) and AD pathology remains poorly understood, particularly in midlife prior to the onset of clinical metabolic disease or cognitive decline...
  15. pmc Declining cognition and falls: role of risky performance of everyday mobility activities
    Barbara L Fischer
    B L Fischer, PsyD, Geriatric Research, Education, and Clinical Center GRECC, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terr, Madison, WI 53705 USA
    Phys Ther 94:355-62. 2014
    ..Declining cognition is a risk factor for falls among older adults. The extent to which impaired judgment in performance of daily activities increases fall risk is unclear...
  16. pmc The effects of ramipril in individuals at risk for Alzheimer's disease: results of a pilot clinical trial
    Whitney Wharton
    Alzheimer s Disease Research Center, University of Wisconsin, Madison, WI 53705, USA
    J Alzheimers Dis 32:147-56. 2012
    ....
  17. pmc Biomarker clusters are differentially associated with longitudinal cognitive decline in late midlife
    Annie M Racine
    1 Alzheimer s Disease Research Center, University of Wisconsin School of Medicine and Public Health, USA, Madison, WI 53705, USA 2 Institute on Aging, University of Wisconsin Madison, USA, Madison, WI 53706, USA 3 Neuroscience and Public Policy Program, University of Wisconsin Madison, USA, Madison, WI 53705, USA
    Brain 139:2261-74. 2016
    ..Such biomarker patterns may be useful for identifying at-risk populations to recruit for clinical trials. ..
  18. pmc Cognitive Effects of Soy Isoflavones in Patients with Alzheimer's Disease
    Carey E Gleason
    Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, School of Medicine and Public Health, Madison, WI, USA
    J Alzheimers Dis 47:1009-19. 2015
    ..In a previous trial, treatment with soy isoflavones was associated with improved nonverbal memory, construction abilities, verbal fluency, and speeded dexterity compared to treatment with placebo in cognitively healthy older adults...
  19. pmc Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study
    Carey E Gleason
    School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin, United States of America Wisconsin Alzheimer s Disease Research Center, Madison, Wisconsin, United States of America
    PLoS Med 12:e1001833; discussion e1001833. 2015
    ..The ancillary Cognitive and Affective Study (KEEPS-Cog) of the Kronos Early Estrogen Prevention Study (KEEPS) examined the effects of up to 4 y of MHT on cognition and mood in recently postmenopausal women...
  20. pmc Characterization of vascular disease risk in postmenopausal women and its association with cognitive performance
    N Maritza Dowling
    Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    PLoS ONE 8:e68741. 2013
    ..This study investigated heterogeneity in CV risk factor profiles and its association with demographic, genetic, and cognitive variables...
  21. pmc Rationale and design of the Kronos Early Estrogen Prevention Study (KEEPS) and the KEEPS Cognitive and Affective sub study (KEEPS Cog)
    Whitney Wharton
    Department of Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, WI 53792, USA
    Brain Res 1514:12-7. 2013
    ..Here we also describe the most recent results and ongoing HT-related research studies designed to address similar issues. This article is part of a Special Issue entitled Hormone Therapy...
  22. pmc Longer duration of hormonal contraceptive use predicts better cognitive outcomes later in life
    Kelly R Egan
    University of Wisconsin School of Medicine and Public Health, Health Sciences Learning Center, Madison, Wisconsin 53705, USA
    J Womens Health (Larchmt) 21:1259-66. 2012
    ..The aim of this study is to explore the effect of modification of hormone milieu through use of hormonal contraception in premenopausal women and midlife cognitive function...
  23. pmc Anosognosia in mild cognitive impairment: Relationship to activation of cortical midline structures involved in self-appraisal
    Michele L Ries
    Geriatric Research Education and Clinical Center, William S Middleton VA Hospital, Madison, Wisconsin 53705, USA
    J Int Neuropsychol Soc 13:450-61. 2007
    ..This finding highlights the level of anosognosia in MCI as an important predictor of response to self-appraisal in cortical midline structures, brain regions vulnerable to changes in early AD...
  24. pmc A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele
    Ryan J Haasl
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Med Genet 9:37. 2008
    ....
  25. pmc Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease
    Kelsey E Melah
    Wisconsin Alzheimer s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Alzheimers Dis 50:873-86. 2016
    ..However, overproduction of inflammatory compounds may exacerbate neural damage in AD. AD pathology accumulates years before diagnosis, yet the extent to which neuroinflammation is involved in the earliest disease stages is unknown...
  26. doi request reprint Standardized note template improves screening of firearm access and driving among veterans with dementia
    Noelle K Loconte
    Department of Medicine, Section of Hematology Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA
    Am J Alzheimers Dis Other Demen 23:313-8. 2008
    ..001). In memory assessment clinic, 31.8% had firearms access and 50% were driving. Many patients continued to drive and have access to firearms. The use of templates for the progress note was effective in increasing the screening rate...
  27. pmc Activation of brain regions vulnerable to Alzheimer's disease: the effect of mild cognitive impairment
    S C Johnson
    Geriatric Research Education and Clinical Center, Wm S Middleton VA Hospital, 2500 Overlook Terrace 11G, GRECC, Madison, WI 53705, USA
    Neurobiol Aging 27:1604-12. 2006
    ..Our results suggest that a change in function in the PC may account, in part, for memory recollection failure in AD...
  28. pmc Midlife predictors of Alzheimer's disease
    B B Bendlin
    William S Middleton Memorial Veterans Hospital, Geriatric Research Educational and Clinical Center, Madison, WI, USA
    Maturitas 65:131-7. 2010
    ..Here, we review midlife risk factors for AD, and address the potential for therapeutic intervention in midlife...
  29. ncbi request reprint Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone versus placebo: the Kronos Early Estrogen Prevention Study
    Nanette Santoro
    1Department of Obstetrics and Gynecology 2Department of Biostatistics, University of Colorado School of Medicine, Aurora, CO 3Department of Obstetrics, Gynecology and Women s Health and Neurosciences, Albert Einstein College of Medicine, Bronx, NY 4Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 5Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 6Department of Obstetrics and Gynecology, New York University School of Medicine, New York, NY 7Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA 8Utah Foundation for Biomedical Research, Salt Lake City, UT 9Department of Cardiology, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, CA 10Department of Obstetrics and Gynecology, University of California at San Francisco, San Francisco, CA 11Departments of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI 12Kronos Longevity Research Institute, Phoenix, AZ 13Department of Medicine and Public Health, University of Wisconsin, Madison, WI 14Atherosclerosis Research Unit, University of Southern California, Los Angeles, CA 15Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 16Departments of Surgery and Physiology and Biomedical Engineering, Mayo Clinic, Rochester, All India Institute of Medical Sciences
    Menopause . 2016
    ..The objective of the present study was to compare the efficacy of two forms of menopausal hormone therapy in alleviating vasomotor symptoms, insomnia, and irritability in early postmenopausal women during 4 years...
  30. pmc Insulin Resistance is Associated with Higher Cerebrospinal Fluid Tau Levels in Asymptomatic APOEɛ4 Carriers
    Erika J Starks
    Wisconsin Alzheimer s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA
    J Alzheimers Dis 46:525-33. 2015
    ..However, the extent to which IR is associated with AD pathology in the cognitively asymptomatic stages of preclinical AD remains unclear...
  31. pmc Effect of Cognitive Reserve on Age-Related Changes in Cerebrospinal Fluid Biomarkers of Alzheimer Disease
    Rodrigo P Almeida
    Currently a student at Fluminense Federal University, Niteroi, Brazil2Geriatric Research Education and Clinical Center, William S Middleton Memorial Veterans Hospital, Madison, Wisconsin3Wisconsin Alzheimer s Institute, University of Wisconsin School of
    JAMA Neurol 72:699-706. 2015
    ....
  32. pmc Performance-based assessment of falls risk in older veterans with executive dysfunction
    Barbara L Fischer
    2500 Overlook Terrace, GRECC, Wm S Middleton Memorial VA Hospital, Madison, WI 53705
    J Rehabil Res Dev 51:263-74. 2014
    ..Future research should study the predictive validity of these measures by following patients prospectively. ..
  33. pmc Effects of hormone therapy on brain structure: A randomized controlled trial
    Kejal Kantarci
    From the Departments of Radiology K K, S M Z, J L G, P V, M L S, C R J, Health Sciences Research N T, T G L, K R B, W A R, Internal Medicine L T S, Neurology W A R, and Surgery and Physiology and Biomedical Engineering V M M, Mayo Clinic, Rochester, MN Department of Medicine C E G, S A, School of Medicine and Public Health, University of Wisconsin and Geriatric Research, Education and Clinical Center, William S Middleton Memorial, Veterans Hospital, Madison, WI Department of Neurology W W, Emory University, Atlanta, GA and Department of Biostatistics and Medical Informatics N M D, University of Wisconsin, Madison
    Neurology 87:887-96. 2016
    ..To investigate the effects of hormone therapy on brain structure in a randomized, double-blinded, placebo-controlled trial in recently postmenopausal women...
  34. pmc The mediational effects of FDG hypometabolism on the association between cerebrospinal fluid biomarkers and neurocognitive function
    N Maritza Dowling
    Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, WI, USA Alzheimer s Disease Research Center, University of Wisconsin, Madison, WI, USA Electronic address
    Neuroimage 105:357-68. 2015
    ..While intriguing, the hypothesized mediational relationships require further validation...
  35. ncbi request reprint Estrogen and Alzheimer's disease: the story so far
    Brenna Cholerton
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle Tacoma, Washington, USA
    Drugs Aging 19:405-27. 2002
    ..These important issues must be addressed in order to establish the role of estrogen for the prevention and treatment of AD in women...

Research Grants1

  1. Alzheimer's Disease: Potential Benefit of Isoflavones
    Carey Gleason; Fiscal Year: 2008
    ..In addition, blood, collected at each treatment visit, will be assayed for plasma isoflavone levels, and other neuroendocrine markers of interest. [unreadable] [unreadable]..